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Information on EC 2.7.1.137 - phosphatidylinositol 3-kinase and Organism(s) Schizosaccharomyces pombe and UniProt Accession O14356

for references in articles please use BRENDA:EC2.7.1.137
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IUBMB Comments
One mammalian isoform is known.
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This record set is specific for:
Schizosaccharomyces pombe
UNIPROT: O14356
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The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The enzyme appears in selected viruses and cellular organisms
Synonyms
pi3k, phosphatidylinositol 3-kinase, pi3 kinase, vps34, phosphoinositide-3-kinase, phosphatidylinositol 3 kinase, ptdins 3-kinase, pik3c3, phosphatidylinositide 3-kinase, hvps34, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
kinase (phosphorylating), phosphatidylinositol 3-
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kinase, phosphatidylinositol 3- (phosphorylating)
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p85/p110 phosphoinositide 3-kinase
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phosphatidylinositol 3'-kinase
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phosphatidylinositol 3-kinase
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phosphoinositide 3'-kinase
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phosphoinositide 3-kinase
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PI 3-kinase
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PI3K
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PtdIns 3'-kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
One mammalian isoform is known.
CAS REGISTRY NUMBER
COMMENTARY hide
115926-52-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
additional information
?
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essential for normal cell growth and vacuole morphology
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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essential for normal cell growth and vacuole morphology
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?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (O14356), Schizosaccharomyces pombe (P50520), Schizosaccharomyces pombe (Q9Y7K2)
Manually annotated by BRENDA team
Kimura, K.; Miyake, S.; Makuuchi, M.; Morita, R.; Usui, T.; Yoshida, M.; Horinouchi, S.; Fukui, Y.
Phosphatidylinositol-3 kinase in fission yeast: a possible role in stress responses
Biosci. Biotechnol. Biochem.
59
678-682
1995
Schizosaccharomyces pombe (P50520), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Takegawa, K.; DeWald, D.B.; Emr, S.D.
Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology
J. Cell Sci.
108
3745-3756
1995
Schizosaccharomyces pombe (P50520)
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Manually annotated by BRENDA team
Volinia, S.; Hiles, I.; Ormondroyd, E.; Nizetic, D.; Antonacci, R.; Rocchi, M.; Waterfield, M.D.
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene
Genomics
24
472-477
1994
Schizosaccharomyces pombe (O14356), Schizosaccharomyces pombe (Q9Y7K2), Homo sapiens (P42336), Homo sapiens
Manually annotated by BRENDA team
Weisman, R.; Choder, M.
The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine
J. Biol. Chem.
276
7027-7032
2001
Schizosaccharomyces pombe (O14356)
Manually annotated by BRENDA team