Information on EC 2.7.1.118 - ADP-thymidine kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.1.118
-
RECOMMENDED NAME
GeneOntology No.
ADP-thymidine kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ADP + thymidine = AMP + dTMP
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ADP:thymidine 5'-phosphotransferase
The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.114 (AMP---thymidine kinase) and EC 2.7.4.9 (dTMP kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
82114-39-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Herpes simplex virus
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ADP + thymidine
AMP + dTMP
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ADP + thymidine
AMP + dTMP
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
Herpes simplex virus
-
10% residual activity in absence of Mg2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
9-(2-Hydroxyethoxymethyl)guanino monophosphate
Herpes simplex virus
-
i.e. acyclo-GMP
9-beta-D-Arabinofuranosyladenine 5'-monophosphate
Herpes simplex virus
-
-
EDTA
Herpes simplex virus
-
-
N-ethylmaleimide
Herpes simplex virus
-
-
p-chloromercuribenzoate
Herpes simplex virus
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.012 - 0.019
ADP
0.0005 - 0.0008
thymidine
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0048
Herpes simplex virus
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5 - 7.5
Herpes simplex virus
-
Herpes simplex virus type 1
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
75200
Herpes simplex virus
-
virus type 1, glycerol gradient centrifugation
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
virus type 1, partial
Herpes simplex virus
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