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The taxonomic range for the selected organisms is: Lactobacillus johnsonii
The enzyme appears in selected viruses and cellular organisms
Synonyms
deoxyguanosine kinase, dguok, 2'-deoxyguanosine kinase,
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deoxyadenosine kinase/deoxyguanosine kinase
abbrevation: dAK/dGK
(dihydroxypropoxymethyl)guanine kinase
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2'-deoxyguanosine kinase
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kinase, deoxyguanosine (phosphorylating)
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NTP-deoxyguanosine 5'-phosphotransferase
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phospho group transfer
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ATP:deoxyguanosine 5'-phosphotransferase
Deoxyinosine can also act as acceptor.
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ATP + deoxyguanosine
ADP + dGMP
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?
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dGTP
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dGTP
0.5 mM, 95% of recombinant dGK
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0.087 - 0.55
deoxyguanosine
0.087
deoxyguanosine
pH 8.0, 20°C
0.34
deoxyguanosine
pH 8.0, 20°C, D84N mutant enzyme
0.36
deoxyguanosine
pH 8.0, 20°C, D84A mutant enzyme
0.55
deoxyguanosine
pH 8.0, 20°C, D84E mutant enzyme
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strain R-26, heterodimeric enzyme, deoxyadenosine kinase/deoxguanosine kinase
UniProt
brenda
strain R-26, heterodimeric enzyme, deoxyadenosine kinase/deoxguanosine kinase, i.e. dAK/dGK
UniProt
brenda
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D84A
1% of wild-type activity
D84E
41% of wild-type activity, not inhibited by dGTP and dATP
D84N
5% of wild-type activity
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expression of dAK/dGK in Escherichia coli
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Park, I.; Ives, D.H.
Mutations within the putative active site of heterodimeric deoxyguanosine kinase block the allosteric activation of the deoxyadenosine kinase subunit
J. Biochem. Mol. Biol.
35
244-247
2002
Lactobacillus johnsonii (Q74HC2), Lactobacillus johnsonii NCC 533 (Q74HC2)
brenda
Ma, G.T.; Hong, Y.S.; Ives, D.H.
Cloning and expression of the heterodimeric deoxyguanosine kinase/deoxyadenosine kinase of Lactobacillus acidophilus R-26
J. Biol. Chem.
270
6595-6601
1995
Lactobacillus johnsonii (Q74HC2), Lactobacillus johnsonii NCC 533 (Q74HC2)
brenda
2.7.1.113 deoxyguanosine kinase
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