Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
ATP + 1,2-dipalmitoyl-sn-glycerol
ADP + 1,2-dipalmitoyl-sn-glycerol 3-phosphate
preferred substrate for isoform DGKzeta
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol
ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
additional information
?
-
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
1,2-diacyl-sn-glycerol 3-phosphate is phosphatidic acid
-
ir
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
DAGKalpha is stimulated vby Src-like kinase-dependent phosphoinositide 3 kinase activation in lymphocytes. In vivo the increase in cellular levels of Src-like kinase-dependent phosphoinositide 3 kinase products is sufficient to induce DAGKalpha activation, allowing DAGKalpha relocation to the intact lymphocyte
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
high level expression of DGKalpha is induced following a signal transmitted through the pre-T-cell-receptor and the protein tyrosine kinase lck. Activity of DGKalpha contributes to survival in CD4+ 8+ double positive thymocytes as pharmacological inhibition of DGK activity results in death of this cell population both in cell suspension and thymic explants. DGKalpha promotes survival in theses thymocytes through a Bcl-regulated pathway
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
DGKepsilon exhibits specificity for diacylglcerol substrates containing an arachidonoyl chain in the sn-2 position
-
-
?
additional information
?
-
activation of a Ca2+-independent protein kinase C isozyme by 1,2-diacylglycerol, which is generated by phospholipase Cbeta and phospholipase D activation and inactivated by phosphorylation via diacylglycerol kinase, is responsible for the endothelin-1-induced decreases in Ca2+ transients and cell shortening
-
-
?
additional information
?
-
-
activation of a Ca2+-independent protein kinase C isozyme by 1,2-diacylglycerol, which is generated by phospholipase Cbeta and phospholipase D activation and inactivated by phosphorylation via diacylglycerol kinase, is responsible for the endothelin-1-induced decreases in Ca2+ transients and cell shortening
-
-
?
additional information
?
-
diacylglycerol kinase zeta and syntrophins play a role at multiple stages of the cell fusion process. Potential link between changes in the lipid content of the membranebilayer and reorganization of the actin cytoskeleton during myoblast fusion
-
-
?
additional information
?
-
-
diacylglycerol kinase zeta is a key determinant of cell cycle progression and differentiation of C2C12 cells
-
-
?
additional information
?
-
diacylglycerol kinase zeta is a key determinant of cell cycle progression and differentiation of C2C12 cells
-
-
?
additional information
?
-
-
diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling
-
-
?
additional information
?
-
-
diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii
-
-
?
additional information
?
-
diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii
-
-
?
additional information
?
-
-
nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts
-
-
?
additional information
?
-
nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts
-
-
?
additional information
?
-
-
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha
-
-
?
additional information
?
-
-
diacylglycerol kinases alpha and zeta synergistically promote T cell maturation in the thymus
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-dipalmitoyl-sn-glycerol
ADP + 1,2-dipalmitoyl-sn-glycerol 3-phosphate
preferred substrate for isoform DGKzeta
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
additional information
?
-
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
DAGKalpha is stimulated vby Src-like kinase-dependent phosphoinositide 3 kinase activation in lymphocytes. In vivo the increase in cellular levels of Src-like kinase-dependent phosphoinositide 3 kinase products is sufficient to induce DAGKalpha activation, allowing DAGKalpha relocation to the intact lymphocyte
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
high level expression of DGKalpha is induced following a signal transmitted through the pre-T-cell-receptor and the protein tyrosine kinase lck. Activity of DGKalpha contributes to survival in CD4+ 8+ double positive thymocytes as pharmacological inhibition of DGK activity results in death of this cell population both in cell suspension and thymic explants. DGKalpha promotes survival in theses thymocytes through a Bcl-regulated pathway
-
-
?
additional information
?
-
activation of a Ca2+-independent protein kinase C isozyme by 1,2-diacylglycerol, which is generated by phospholipase Cbeta and phospholipase D activation and inactivated by phosphorylation via diacylglycerol kinase, is responsible for the endothelin-1-induced decreases in Ca2+ transients and cell shortening
-
-
?
additional information
?
-
-
activation of a Ca2+-independent protein kinase C isozyme by 1,2-diacylglycerol, which is generated by phospholipase Cbeta and phospholipase D activation and inactivated by phosphorylation via diacylglycerol kinase, is responsible for the endothelin-1-induced decreases in Ca2+ transients and cell shortening
-
-
?
additional information
?
-
diacylglycerol kinase zeta and syntrophins play a role at multiple stages of the cell fusion process. Potential link between changes in the lipid content of the membranebilayer and reorganization of the actin cytoskeleton during myoblast fusion
-
-
?
additional information
?
-
-
diacylglycerol kinase zeta is a key determinant of cell cycle progression and differentiation of C2C12 cells
-
-
?
additional information
?
-
diacylglycerol kinase zeta is a key determinant of cell cycle progression and differentiation of C2C12 cells
-
-
?
additional information
?
-
-
diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling
-
-
?
additional information
?
-
-
diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii
-
-
?
additional information
?
-
diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii
-
-
?
additional information
?
-
-
nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts
-
-
?
additional information
?
-
nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts
-
-
?
additional information
?
-
-
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha
-
-
?
additional information
?
-
-
diacylglycerol kinases alpha and zeta synergistically promote T cell maturation in the thymus
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
C20S
-
mutation in sterile alpha-motif, mutant forms an oligomer
D43G
-
mutation in sterile alpha-motif, mutant is largely monomeric in solution
E35G
-
mutation in sterile alpha-motif, mutant is largely monomeric in solution
G53D
-
mutation in sterile alpha-motif, mutant is largely monomeric in solution
K45E
-
mutation in sterile alpha-motif, mutant forms an oligomer
K56E
-
mutation in sterile alpha-motif, mutant is largely monomeric in solution
T57P
-
mutant with reduced activity, used for construcution of fusion protein for genetic selection of soluble mutants
V52E
-
mutation in sterile alpha-motif, mutant is largely monomeric in solution
additional information
-
deficiency for diacylglycerol kinase zeta results in impaired interleukin 12 and tumor necrosis factor alpha production following toll-like receptor stimulation in vitro and in vivo, increased resistance to endotoxin shock, and enhanced susceptibility to Toxoplasma gondii infection. Deficiency results in increased activation of the phosphatidylinositol 3-kinase-Akt pathway. Inhibition of phosphatidylinositol 3-kinase activity or treatment with phosphatidic acid can restore lipopolysaccharide-induced interleukin 12 production by diacylglycerol kinase zeta-deficient mice
additional information
deficiency for diacylglycerol kinase zeta results in impaired interleukin 12 and tumor necrosis factor alpha production following toll-like receptor stimulation in vitro and in vivo, increased resistance to endotoxin shock, and enhanced susceptibility to Toxoplasma gondii infection. Deficiency results in increased activation of the phosphatidylinositol 3-kinase-Akt pathway. Inhibition of phosphatidylinositol 3-kinase activity or treatment with phosphatidic acid can restore lipopolysaccharide-induced interleukin 12 production by diacylglycerol kinase zeta-deficient mice
additional information
generation of double transgenic mice with cardiac-specific overexpression of both diacylglycerol kinase zeta and G-protein subunit alphaq. Diacylglycerol kinase zeta prevents cardiac dysfunction, determined by dilatation of left ventricular dimensions, reduction of left ventricular fractional shortening, and marked increases in left ventricular end-diastolic pressure in G-protein subunit alphaq transgenic mice. Translocation of protein kinase C isoforms, phosphorylation activity of c-jun N-terminal kinase and p38 mitogen-activated protein kinase in G-protein subunit alphaq transgenic mice are attenuated by diacylglycerol kinase zeta?. Diacylglycerol kinase zeta improves the survival rate of G-protein subunit alphaq transgenic mice
additional information
-
generation of double transgenic mice with cardiac-specific overexpression of both diacylglycerol kinase zeta and G-protein subunit alphaq. Diacylglycerol kinase zeta prevents cardiac dysfunction, determined by dilatation of left ventricular dimensions, reduction of left ventricular fractional shortening, and marked increases in left ventricular end-diastolic pressure in G-protein subunit alphaq transgenic mice. Translocation of protein kinase C isoforms, phosphorylation activity of c-jun N-terminal kinase and p38 mitogen-activated protein kinase in G-protein subunit alphaq transgenic mice are attenuated by diacylglycerol kinase zeta?. Diacylglycerol kinase zeta improves the survival rate of G-protein subunit alphaq transgenic mice
additional information
in mouse ventricular myocytes overexpressing diaclyglycerol kinase zeta, the effect induced by endothelin-1 on Ca2+ transients and cell shortening are abolished
additional information
-
in mouse ventricular myocytes overexpressing diaclyglycerol kinase zeta, the effect induced by endothelin-1 on Ca2+ transients and cell shortening are abolished
additional information
-
overexpression of diacylglycerol kinase zeta blocks cells in G1 phase of cell cycle. Cell cycle arrest is accompanied by decreased levels of retinoblastoma protein phosphorylated on Ser-807/811. Down-regulation by siRNA increases the number of cells in both the S and G2/M phases of the cell cycle and prevents the cell cycle block characterizing C2C12 cell myogenic differentiation
additional information
overexpression of diacylglycerol kinase zeta blocks cells in G1 phase of cell cycle. Cell cycle arrest is accompanied by decreased levels of retinoblastoma protein phosphorylated on Ser-807/811. Down-regulation by siRNA increases the number of cells in both the S and G2/M phases of the cell cycle and prevents the cell cycle block characterizing C2C12 cell myogenic differentiation
additional information
transgenic mice with cardiac-specific overexpression of diacylglycerol kinase zeta. Left ventricular chamber dilatation, reduction of left ventricular systolic function and increases in left ventricular weight and lung weight at 4 weeks after myocardial infarction are attenuated in transgenic mice compared with wild-type mice. In the noninfarct area, fibrosis fraction and upregulation of profibrotic genes, such as transforming growth factor-1, collagen type I, and collagen type III, are blocked in transgenic mice. Survival rate at 4 weeks after myocardial infarction is higher in transgenic mice than in wild-type
additional information
-
transgenic mice with cardiac-specific overexpression of diacylglycerol kinase zeta. Left ventricular chamber dilatation, reduction of left ventricular systolic function and increases in left ventricular weight and lung weight at 4 weeks after myocardial infarction are attenuated in transgenic mice compared with wild-type mice. In the noninfarct area, fibrosis fraction and upregulation of profibrotic genes, such as transforming growth factor-1, collagen type I, and collagen type III, are blocked in transgenic mice. Survival rate at 4 weeks after myocardial infarction is higher in transgenic mice than in wild-type
additional information
nuclear export signal mutant forms of DGK-zeta accumulate in the nucleus to a much greater extent than wild type DGK-zeta
additional information
-
nuclear export signal mutant forms of DGK-zeta accumulate in the nucleus to a much greater extent than wild type DGK-zeta
additional information
construction of mutant protein lacking the regulatory N-terminus and both C1 domains. Mutant is enzymatically active. deletion analysis reveals that the C1 domains are essential for plasma membrane targeting in intact cells but unnecessary for catalytic activity. The C-terminal sequence is required for membrane-binding in a phosphatidic acid-dependent manner. In the absence of the calcium binding domain, receptor-dependent translocation of the truncated protein is regulated by phosphorylation of residue Y335
additional information
-
creation of thoracic transverse aortic constriction in transgenic mice with cardiac-specific overexpression of diacylglycerol kinase zeta and wild-type mice. Increases in heart weight at 4 weeks after thoracic transverse aortic constriction are attenuated in diacylglycerol kinase zeta transgenic mice compared with wild-type mice. Increases in interventricular septal thickness, dilatation of the left ventricular cavity, and decreases in left ventricular systolic function in wild-type mice are observed at 4 weeks after surgery and are attenuated in diacylglycerol kinase zetatransgenic mice. Contrary to wild-type, cardiac fibrosis and gene induction of type I and type III collagens, but not transforming growth factor are blocked in diacylglycerol kinase zeta transgenic mice
additional information
-
diacylglycerol kinase delta knock-down mice reveal abnormal epiletic discharges and electrographic seizures in three out of six homozygotes
additional information
-
expression of isolated His-tagged sterile alpha-motif domain of diacylglycerol kinase delta1, comprised of residues 1097-1164. The domain forms large aggregates with a molecular weight of 250000 Dalton or greater, while calculated monomer molecular weight is 9500 Dalton
additional information
-
generation of heterozygous diacylglycerol kinase delta whole-body knockout mice. Diacylglycerol kinase delta haploinsufficiency increases diacylglycerol content, reduces peripheral insulin sensitivity, insulin signaling, and glucose transport, and leads to age-dependent obesity. Metabolic flexibility is impaired
additional information
-
generation of mice lacking both diacylglycerol kinase alpha and zeat. Absence of both diacylglycerol kinases results in a severe decrease in the number of CD4+CD8- and CD4-CD8+ single-positive thymocytes correlating with increased diacylglycerol kinase-mediated signaling. Positive selection, but not negative selection, is impaired in diacylglycerol kinase alpha-/- zeta -/- mice. The developmental blockage in diacylglycerol kinase alpha-/- zeta -/- mice can be partially overcome by treatment with phosphatidic acid. Decreased diacylglycerol kinase activity also promotes thymic lymphomagenesis accompanying elevated Ras and Erk1/2 activation
additional information
-
generation of enzyme-deficient DGKdelta-KO mouse embryonic fibroblasts
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Outram, S.V.; Crompton, T.; Merida, I.; Varas, A.; Martinez, A.C.
Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development
Immunology
105
391-398
2002
Mus musculus
brenda
Cipres, A.; Carrasco, S.; Merino, E.; Diaz, E.; Krishna, U.M.; Falck, J.R.; Martinez-A, C.; Merida, I.
Regulation of Diacylglycerol Kinase a by Phosphoinositide 3-Kinase Lipid Products
J. Biol. Chem.
278
35629-35635
2003
Mus musculus
brenda
Evangelisti, C.; Tazzari, P.L.; Riccio, M.; Fiume, R.; Hozumi, Y.; fala, F.; Goto, K.; Manzoli, L.; Cocco, L.; Martelli, A.M.
Nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts
FASEB J.
21
3297-3307
2007
Mus musculus, Mus musculus (Q80UP3)
brenda
Evangelisti, C.; Bortul, R.; Fala, F.; Tabellini, G.; Goto, K.; Martelli, A.M.
Nuclear diacylglycerol kinases: emerging downstream regulators in cell signalling networks
Histol. Histopathol.
22
573-579
2007
Chlorocebus aethiops, Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Liu, C.H.; Machado, F.S.; Guo, R.; Nichols, K.E.; Burks, A.W.; Aliberti, J.C.; Zhong, X.P.
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii
J. Exp. Med.
204
781-792
2007
Mus musculus, Mus musculus (Q80UP3)
brenda
Zha, Y.; Marks, R.; Ho, A.W.; Peterson, A.C.; Janardhan, S.; Brown, I.; Praveen, K.; Stang, S.; Stone, J.C.; Gajewski, T.F.
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha
Nat. Immunol.
7
1166-1173
2006
Mus musculus
brenda
Crotty, T.; Cai, J.; Sakane, F.; Taketomi, A.; Prescott, S.M.; Topham, M.K.
Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling
Proc. Natl. Acad. Sci. USA
103
15485-15490
2006
Mus musculus
brenda
Leach, N.T.; Sun, Y.; Michaud, S.; Zheng, Y.; Ligon, K.L.; Ligon, A.H.; Sander, T.; Korf, B.R.; Lu, W.; Harris, D.J.; Gusella, J.F.; Maas, R.L.; Quade, B.J.; Cole, A.J.; Kelz, M.B.; Morton, C.C.
Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice
Am. J. Hum. Genet.
80
792-799
2007
Mus musculus, Homo sapiens (Q16760), Homo sapiens
brenda
Niizeki, T.; Takeishi, Y.; Arimoto, T.; Takahashi, H.; Shishido, T.; Koyama, Y.; Goto, K.; Walsh, R.A.; Kubota, I.
Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction
Am. J. Physiol.
292
H1105-H1112
2007
Mus musculus (Q80UP3), Mus musculus
brenda
Takahashi, N.; Nagamine, M.; Tanno, S.; Motomura, W.; Kohgo, Y.; Okumura, T.
A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells
Biochem. Biophys. Res. Commun.
360
244-250
2007
Mus musculus
brenda
Bilim, O.; Takeishi, Y.; Kitahara, T.; Arimoto, T.; Niizeki, T.; Sasaki, T.; Goto, K.; Kubota, I.
Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus
Cardiovasc. Diabetol.
7
2
2008
Mus musculus (Q80UP3), Mus musculus
brenda
Chibalin, A.V.; Leng, Y.; Vieira, E.; Krook, A.; Bjoernholm, M.; Long, Y.C.; Kotova, O.; Zhong, Z.; Sakane, F.; Steiler, T.; Nylen, C.; Wang, J.; Laakso, M.; Topham, M.K.; Gilbert, M.; Wallberg-Henriksson, H.; Zierath, J.R.
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance
Cell
132
375-386
2008
Mus musculus, Rattus norvegicus, Homo sapiens (Q16760), Homo sapiens
brenda
Abramovici, H.; Gee, S.H.
Morphological changes and spatial regulation of diacylglycerol kinase-zeta, syntrophins, and Rac1 during myoblast fusion
Cell Motil. Cytoskeleton
64
549-567
2007
Mus musculus (Q80UP3)
brenda
Harada, M.; Takeishi, Y.; Arimoto, T.; Niizeki, T.; Kitahara, T.; Goto, K.; Walsh, R.A.; Kubota, I.
Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy
Circ. J.
71
276-282
2007
Mus musculus
brenda
Niizeki, T.; Takeishi, Y.; Kitahara, T.; Arimoto, T.; Koyama, Y.; Goto, K.; Mende, U.; Kubota, I.
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice
Circ. J.
72
309-317
2008
Mus musculus (Q80UP3), Mus musculus
brenda
Merino, E.; Sanjuan, M.A.; Moraga, I.; Cipres, A.; Merida, I.
Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells
J. Biol. Chem.
282
35396-35404
2007
Mus musculus (O88673)
brenda
Hasegawa, H.; Nakano, T.; Hozumi, Y.; Takagi, M.; Ogino, T.; Okada, M.; Iseki, K.; Kondo, H.; Watanabe, M.; Martelli, A.M.; Goto, K.
Diacylglycerol kinase zeta is associated with chromatin, but dissociates from condensed chromatin during mitotic phase in NIH3T3 cells
J. Cell. Biochem.
105
756-765
2008
Mus musculus (Q80UP3)
brenda
Nishimaru, K.; Arimoto, T.; Takeishi, Y.; Kubota, I.; Ishii, K.; Endoh, M.
Overexpression of diacylglycerol kinase zeta inhibits endothelin-1-induced decreases in Ca2+ transients and cell shortening in mouse ventricular myocytes
J. Mol. Cell. Cardiol.
44
520-526
2008
Mus musculus (Q80UP3), Mus musculus
brenda
Guo, R.; Wan, C.K.; Carpenter, J.H.; Mousallem, T.; Boustany, R.M.; Kuan, C.T.; Burks, A.W.; Zhong, X.P.
Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta
Proc. Natl. Acad. Sci. USA
105
11909-11914
2008
Mus musculus
brenda
Harada, B.T.; Knight, M.J.; Imai, S.; Qiao, F.; Ramachander, R.; Sawaya, M.R.; Gingery, M.; Sakane, F.; Bowie, J.U.
Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta 1
Structure
16
380-387
2008
Mus musculus
brenda
Merida, I.; Avila-Flores, A.; Garcia, J.; Merino, E.; Almena, M.; Torres-Ayuso, P.
Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression
Adv. Enzyme Regul.
49
174-188
2009
Mus musculus (O88673), Homo sapiens (P23743)
brenda
Niizeki, T.; Takeishi, Y.; Kitahara, T.; Arimoto, T.; Ishino, M.; Bilim, O.; Suzuki, S.; Sasaki, T.; Nakajima, O.; Walsh, R.A.; Goto, K.; Kubota, I.
Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade
Am. J. Physiol. Heart Circ. Physiol.
295
H245-H255
2008
Mus musculus (Q9R1C6), Mus musculus
brenda
Topham, M.K.; Epand, R.M.
Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms
Biochim. Biophys. Acta
1790
416-424
2009
Mus musculus (O88673), Mus musculus (Q80UP3), Mus musculus (Q9R1C6)
brenda
Cai, J.; Abramovici, H.; Gee, S.H.; Topham, M.K.
Diacylglycerol kinases as sources of phosphatidic acid
Biochim. Biophys. Acta
1791
942-948
2009
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Sus scrofa, Mus musculus (Q80UP3)
brenda
Evangelisti, C.; Gaboardi, G.C.; Billi, A.M.; Ognibene, A.; Goto, K.; Tazzari, P.L.; McCubrey, J.A.; Martelli, A.M.
Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta
Cell Cycle
9
384-388
2010
Mus musculus (Q80UP3), Mus musculus
brenda
Evangelisti, C.; Astolfi, A.; Gaboardi, G.C.; Tazzari, P.; Pession, A.; Goto, K.; Martelli, A.M.
TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-zeta-dependent cell cycle arrest
Cell. Signal.
21
801-809
2009
Mus musculus (Q80UP3), Mus musculus
brenda
Kim, K.; Yang, J.; Kim, E.
Diacylglycerol kinases in the regulation of dendritic spines
J. Neurochem.
112
577-587
2010
Rattus norvegicus (O08560), Mus musculus (Q80UP3)
brenda
Abramovici, H.; Mojtabaie, P.; Parks, R.J.; Zhong, X.P.; Koretzky, G.A.; Topham, M.K.; Gee, S.H.
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI
Mol. Biol. Cell
20
2049-2059
2009
Mus musculus (Q80UP3)
brenda
Tu-Sekine, B.; Goldschmidt, H.; Petro, E.; Raben, D.
Diacylglycerol kinase ?: regulation and stability.
Adv. Biol. Regul.
53
118-126
2013
Mus musculus (Q6P5E8)
brenda
Shulga, Y.V.; Loukov, D.; Ivanova, P.T.; Milne, S.B.; Myers, D.S.; Hatch, G.M.; Umeh, G.; Jalan, D.; Fullerton, M.D.; Steinberg, G.R.; Topham, M.K.; Brown, H.A.; Epand, R.M.
Diacylglycerol kinase delta promotes lipogenesis
Biochemistry
52
7766-7776
2013
Mus musculus
brenda
Mizuno, S.; Kado, S.; Goto, K.; Takahashi, D.; Sakane, F.
Diacylglycerol kinase zeta generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation
Biochem. Biophys. Rep.
8
352-359
2016
Mus musculus (Q80UP3)
brenda
Lu, Q.; Murakami, C.; Hoshino, F.; Murakami, Y.; Sakane, F.
Diacylglycerol kinase delta destabilizes serotonin transporter protein through the ubiquitin-proteasome system
Biochim. Biophys. Acta
1865
158608
2020
Mus musculus (E9PUQ8)
brenda
Sakai, H.; Murakami, C.; Matsumoto, K.I.; Urano, T.; Sakane, F.
Diacylglycerol kinase delts controls down-regulation of cyclin D1 for C2C12 myogenic differentiation
Biochimie
151
45-53
2018
Mus musculus (E9PUQ8)
brenda
Hayashi, D.; Wang, L.; Ueda, S.; Yamanoue, M.; Ashida, H.; Shirai, Y.
The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase alpha
Sci. Rep.
10
11790
2020
Mus musculus (O88673)
brenda
Hayashi, D.; Yagi, K.; Song, C.; Ueda, S.; Yamanoue, M.; Topham, M.; Suzaki, T.; Saito, N.; Emoto, N.; Shirai, Y.
Diacylglycerol kinase alpha is involved in the vitamin E-induced amelioration of diabetic nephropathy in mice
Sci. Rep.
7
2597
2017
Mus musculus (O88673)
brenda