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Information on EC 2.7.1.107 - diacylglycerol kinase (ATP) and Organism(s) Drosophila melanogaster and UniProt Accession Q01583

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IUBMB Comments
Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Activity is stimulated by certain phospholipids [4,7]. In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. cf. EC 2.7.1.174, diacylglycerol kinase (CTP).
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This record set is specific for:
Drosophila melanogaster
UNIPROT: Q01583
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dgk, diacylglycerol kinase, dag kinase, dg kinase, dgkzeta, dagk, dgkalpha, dgk-zeta, diglyceride kinase, dgkepsilon, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1,2-diacylglycerol kinase
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adenosine 5'-triphosphate:1,2-diacylglycerol 3-phosphotransferase
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arachidonoyl-specific diacylglycerol kinase
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ATP:diacylglycerol phosphotransferase
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DAGK
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DAGKalpha
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DG kinase
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DGK-alpha
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DGK-theta
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DGKbeta
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DGKdelta
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DGKgamma
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DGKiota
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DGKksi
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diacylglycerol kinase
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diacylglycerol kinase (ATP dependent)
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diacylglycerol:ATP kinase
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diglyceride kinase
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eye-specific diacylglycerol kinase
UniProt
kinase (phosphorylating), 1,2-diacylglycerol
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kinase, 1,2-diacylglycerol (phosphorylating)
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sn-1,2-diacylglycerol kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:1,2-diacyl-sn-glycerol 3-phosphotransferase
Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Activity is stimulated by certain phospholipids [4,7]. In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. cf. EC 2.7.1.174, diacylglycerol kinase (CTP).
CAS REGISTRY NUMBER
COMMENTARY hide
60382-71-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
the enzyme may have an important function in the adult nervous system and muscle and during the development of the embryonic nervous system
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?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
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-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
additional information
?
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complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
the enzyme may have an important function in the adult nervous system and muscle and during the development of the embryonic nervous system
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
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the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid
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?
additional information
?
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complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
R59022
a specific pharmacological enzyme inhibitor
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
rhabdomeral membrane, the enzyme is located predominantly in the cytoplasmic subrhabdomeral cisternae, a cytoplasmic membrane system located at close distance from the microvilli. Excised membrane patches retain a functional enzyme DGK
Manually annotated by BRENDA team
additional information
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subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DGK1_DROME
1211
0
132960
Swiss-Prot
other Location (Reliability: 2)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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structure-function relationships of isozyme domain motifs, overview
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Masai, I.; Hosoya, T.; Kojima, S.I.; Hotta, Y.
Molecular cloning of a Drosophila diacylglycerol kinase gene that is expressed in the nervous system and muscle
Proc. Natl. Acad. Sci. USA
89
6030-6034
1992
Drosophila melanogaster (Q01583), Drosophila melanogaster
Manually annotated by BRENDA team
Luo, B.; Regier, D.S.; Prescott, S.M.; Topham, M.K.
Diacylglycerol kinases
Cell. Signal.
16
983-989
2004
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mammalia, no activity in Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cai, J.; Abramovici, H.; Gee, S.H.; Topham, M.K.
Diacylglycerol kinases as sources of phosphatidic acid
Biochim. Biophys. Acta
1791
942-948
2009
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Sus scrofa, Mus musculus (Q80UP3)
Manually annotated by BRENDA team
Delgado, R.; Munoz, Y.; Pena-Cortes, H.; Giavalisco, P.; Bacigalupo, J.
Diacylglycerol activates the light-dependent channel TRP in the photosensitive microvilli of Drosophila melanogaster photoreceptors
J. Neurosci.
34
6679-6686
2014
Drosophila melanogaster (Q09103), Drosophila melanogaster, Drosophila melanogaster Oregon-R (Q09103)
Manually annotated by BRENDA team