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ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
?
ADP + beta-D-fructose 2,6-bisphosphate
ATP + beta-D-fructose 6-phosphate
-
reverse reaction, at 50% the rate of forward reaction
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
ATP + D-psicose 6-phosphate
?
-
-
-
-
?
ATP + D-tagatose 6-phosphate
?
-
-
-
-
?
ATP + L-sorbose 6-phosphate
?
-
-
-
-
?
GTP + beta-D-fructose 6-phosphate
GDP + beta-D-fructose 2,6-bisphosphate
-
less effective than ATP
-
-
?
MgATP2- + beta-D-fructose 6-phosphate
?
-
-
-
-
?
additional information
?
-
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
via phosphorylenzyme intermediate
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
via phosphorylenzyme intermediate
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
-
via phosphorylenzyme intermediate
r
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
transfers gamma-phosphoryl group of ATP to hydroxyl group at C-2 of fructose 6-phosphate
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
transfers gamma-phosphoryl group of ATP to hydroxyl group at C-2 of fructose 6-phosphate
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
no substrates are diphosphate, glucose 6-phosphate
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
sugar phosphate specificity
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
not: ribose 5-phosphate
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
not: ribose 5-phosphate
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
not: 1-O-methyl-D-fructose 6-phosphate, alpha-/beta-methyl-D-fructofuranoside 6-phosphate, 2,5-anhydro-D-mannitol 6-phosphate, D-arabinose 5-phosphate
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
enzyme plays an indirect yet key role in the regulation of glucose metabolism
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
enzyme plays an indirect yet key role in the regulation of glucose metabolism
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
enzyme plays an indirect yet key role in the regulation of glucose metabolism
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
enzyme plays an indirect yet key role in the regulation of glucose metabolism
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
responsible for regulation of fructose 2,6-bisphosphate-concentration
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
responsible for regulation of fructose 2,6-bisphosphate-concentration
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
responsible for regulation of fructose 2,6-bisphosphate-concentration
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
responsible for regulation of fructose 2,6-bisphosphate-concentration
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
responsible for regulation of fructose 2,6-bisphosphate-concentration
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
responsible for regulation of fructose 2,6-bisphosphate-concentration
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
responsible for regulation of fructose 2,6-bisphosphate-concentration
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
enzyme plays an important role in the regulation of hepatic carbohydrate metabolism
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
bifunctional enzyme catalyzes the forward and reverse reaction using different catalytic sites
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
-
site-directed mutant study and inhibition kinetics suggest that the reaction will be catalyzed most efficiently by the protein when the substrates bind to the active pocket in an ordered manner in which ATP binds first
-
-
?
ATP + beta-D-fructose 6-phosphate
ADP + beta-D-fructose 2,6-bisphosphate
phosphorylation of PFK-2 on Ser-32, inhibition of hepatic glucose metabolism
-
-
?
additional information
?
-
the enzyme binds to glucokinase in the cytoplasm
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
-
-
?
additional information
?
-
-
isotope exchange reaction between ATP and ADP in the absence of fructose 6-phosphate
-
-
?
additional information
?
-
-
isotope exchange reaction between ATP and ADP in the absence of fructose 6-phosphate
-
-
?
additional information
?
-
-
with discrete catalytic sites
-
-
?
additional information
?
-
-
with discrete catalytic sites
-
-
?
additional information
?
-
-
with discrete catalytic sites
-
-
?
additional information
?
-
-
allosteric bifunctional enzyme, not heart
-
-
?
additional information
?
-
-
isotope exchange between fructose 6-phosphate and fructose 2,6-bisphosphate in the absence of adenine nucleotides
-
-
?
additional information
?
-
-
role of the enzyme in catalysis and regulation of glycolysis/gluconeogenesis and related enzymes, overview
-
-
?
additional information
?
-
-
coordinate roles for glucokinase and PFK2 in the elevated hepatic glycolysis in fa/fa rats
-
-
?
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Loiseau, A.M.; Rider, M.H.; Hue, L.
Purification and properties of 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase from rat hepatoma cells
Biochem. Soc. Trans.
15
384-385
1987
Rattus norvegicus
-
brenda
El-Maghrabi, M.R.; Correia, J.J.; Heil, P.J.; Pate, T.M.; Cobb, C.E.; Pilkis, S.J.
Tissue distribution, immunoreactivity, and physical properties of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Proc. Natl. Acad. Sci. USA
83
5005-5009
1986
Bos taurus, Canis lupus familiaris, Rattus norvegicus
brenda
Sakurai, T.; Johnson, J.H.; Uyeda, K.
Islet fructose 6-phosphate, 2-kinase: fructose 2,6-bisphosphatase: isozymic form, expression, and characterization
Biochem. Biophys. Res. Commun.
218
159-163
1996
Bos taurus, Rattus norvegicus
brenda
Van Schaftingen, E.; Hers, H.G.
Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP
Biochem. Biophys. Res. Commun.
101
1078-1084
1981
Rattus norvegicus
brenda
El-Maghrabi, M.R.; Claus, T.H.; Pilkis, J.; Pilkis, S.J.
Partial purification of a rat liver enzyme that catalyzes the formation of fructose 2,6-bisphosphate
Biochem. Biophys. Res. Commun.
101
1071-1077
1981
Rattus norvegicus
brenda
El-Maghrabi, M.R.; Fox, E.; Pilkis, J.; Pilkis, S.J.
Cyclic AMP-dependent phosphorylation of rat liver 6-phosphofructo 2-kinase, fructose 2,6-bisphosphatase
Biochem. Biophys. Res. Commun.
106
794-802
1982
Rattus norvegicus
brenda
Kretschmer, M.; Hofmann, E.
Inhibition of rat liver phosphofructokinase-2 by phosphoenolpyruvate and ADP
Biochem. Biophys. Res. Commun.
124
793-796
1984
Rattus norvegicus
brenda
Sakakibara, R.; Kitajima, S.; Uyeda, K.
Differences in kinetic properties of phospho and dephospho forms of fructose-6-phosphate, 2-kinase and fructose 2,6-bisphosphatase
J. Biol. Chem.
259
41-46
1984
Rattus norvegicus
brenda
Pilkis, S.J.; Regen, D.M.; Stewart, H.B.; Pilkis, J.; Pate, T.M.; El-Maghrabi, M.R.
Evidence for two catalytic sites on 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase. Dynamics of substrate exchange and phosphoryl enzyme formation
J. Biol. Chem.
259
949-958
1984
Rattus norvegicus
brenda
Kitajima, S.; Sakakibara, R.; Uyeda, K.
Kinetic studies of fructose 6-phosphate,2-kinase and fructose 2,6-bisphosphatase
J. Biol. Chem.
259
6896-6903
1984
Rattus norvegicus
brenda
Laloux, M.; Van Schaftingen, E.; Francois, J.; Hers, H.G.
Phosphate dependency of phosphofructokinase 2
Eur. J. Biochem.
148
155-159
1985
Saccharomyces cerevisiae, Rattus norvegicus, Spinacia oleracea
brenda
Sakakibara, R.; Tanaka, T.; Uyeda, K.; Richards, E.G.; Thomas, H.
Studies of the structure of fructose-6-phosphate 2-kinase:fructose-2,6-bisphosphatase
Biochemistry
24
6818-6824
1985
Rattus norvegicus
brenda
Kountz, P.D.; McCain, R.W.; El-Maghrabi, M.R.; Pilkis, S.J.
Hepatic 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase: phosphate dependence and effects of other oxyanions
Arch. Biochem. Biophys.
251
110-113
1986
Rattus norvegicus
-
brenda
Lively, M.O.; El-Maghrabi, M.R.; Pilkis, J.; D'Angelo, G.; Colosia, A.D.; Ciavola, J.A.; Fraser, B.A.; Pilkis, S.J.
Complete amino acid sequence of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
J. Biol. Chem.
263
839-849
1988
Rattus norvegicus
brenda
Martn-Sanz, P.; Cascales, M.; Bosc, L.
Characterization of 6-phosphofructo-2-kinase from foetal-rat liver
Biochem. J.
281
457-463
1992
Rattus norvegicus
-
brenda
Van Schaftingen, E.; Davies, D.R.; Hers, H.G.
Inactivation of phosphofructokinase 2 by cyclic AMP - dependent protein kinase
Biochem. Biophys. Res. Commun.
103
362-368
1981
Rattus norvegicus
brenda
Kitamura, K.; Uyeda, K.; Kangawa, K.; Matsuo, H.
Purification and characterization of rat skeletal muscle fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase
J. Biol. Chem.
264
9799-9806
1989
Rattus norvegicus
brenda
Pilkis, S.J.; Pilkis, J.; El-Maghrabi, M.R.; Claus, T.H.
The sugar phosphate specificity of rat hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
J. Biol. Chem.
260
7551-7556
1985
Rattus norvegicus
brenda
Rider, M.H.; Foret, D.; Hue, L.
Comparison of purified bovine heart and rat liver 6-phosphofructo-2-kinase. Evidence for distinct isoenzymes
Biochem. J.
231
193-196
1985
Bos taurus, Rattus norvegicus
brenda
Kountz, P.D.; El-Maghrabi, M.R.; Pilkis, S.J.
Isolation and characterization of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from bovine liver
Arch. Biochem. Biophys.
238
531-543
1985
Bos taurus, Rattus norvegicus
brenda
Rider, M.H.; Vandamme, J.; Lebeau, E.; Vertommen, D.; Vidal, H.; Rousseau, G.G.; Vanderkerkhove, J.; Hue, L.
The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing
Biochem. J.
285
405-411
1992
Bos taurus, Rattus norvegicus
-
brenda
Kitamura, K.; Uyeda, K.
Purification and characterization of myocardial fructose-6-phosphate,2-kinase and fructose-2,6-bisphosphatase [published erratum appears in J Biol Chem 1989 Jan 25;264(3):1901]
J. Biol. Chem.
263
9027-9033
1988
Bos taurus, Rattus norvegicus
brenda
Lange, A.J.; Li, L.; Vargas, A.M.; Pilkis, S.J.
Expression of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in Escherichia coli. Role of N-2 proline in degradation of the protein
J. Biol. Chem.
268
8078-8084
1993
Homo sapiens, Rattus norvegicus
brenda
Rider, M.H.
Regulation of fructose-2,6-bisphosphate synthesis and breakdown in heart and skeletal muscle
Biochem. Soc. Trans.
15
988-991
1987
Bos taurus, Columba sp., Rattus norvegicus
brenda
Li, L.; Lange, A.J.; Pilkis, S.J.
Isolation of a cDNA for chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase [published erratum appears in Biochem Biophys Res Commun 1999 Jun 16;259(3):711]
Biochem. Biophys. Res. Commun.
190
397-405
1993
Gallus gallus, Rattus norvegicus
brenda
Rider, M.H.; Hue, L.
Bifunctionality of muscle and heart 6-phosphofructo-2-kinase: skeletal muscle 6-phosphofructo-2-kinase catalyses fructose 2,6-bisphosphate hydrolysis whereas heart 6-phophofructo-2-kinase contains little fructose-2,6-bisphphophatase
Biochem. Soc. Trans.
15
379-380
1987
Rattus norvegicus
-
brenda
Kurland, I.J.; Chapman, B.; El-Maghrabi, M.R.
N- and C-termini modulate the effects of pH and phosphorylation on hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Biochem. J.
347
459-467
2000
Escherichia coli, Rattus norvegicus
brenda
Hasemann, C.A.; Istvan, E.S.; Uyeda, K.; Deisenhofer, J.
The crystal structure of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase reveals distinct domain homologies
Structure
4
1017-1029
1996
Rattus norvegicus
brenda
Watanabe, F.; Jameson, D.M.; Uyeda, K.
Enzymic and fluorescence studies of four single-tryptophan mutants of rat testis fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase
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Rattus norvegicus
brenda
Mizuguchi, H.; Cook, P.F.; Hasemann, C.A.; Uyeda, K.
Chemical mechanism of the fructose-6-phosphate,2-kinase reaction from the pH dependence of kinetic parameters of site-directed mutants of active site basic residues
Biochemistry
36
8775-8784
1997
Rattus norvegicus
brenda
Tominaga, N.; Tsujikawa, T.; Minami, Y.; Wu, R.F.; Watanabe, F.; Sakakibara, R.; Uyeda, K.
Effect of replacement of the amino and the carboxyl termini of rat testis fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase with those of the liver and heart isozymes
Arch. Biochem. Biophys.
347
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1997
Bos taurus, Rattus norvegicus
brenda
Yuen, M.H.; Wang, X.L.; Mizuguchi, H.; Uyeda, K.; Hasemann, C.A.
A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Biochemistry
38
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1999
Rattus norvegicus (P25114)
brenda
Sakakibara, R.; Okudaira, T.; Fujiwara, K.; Kato, M.; Hirata, T.; Yamanaka, S.; Naito, M.; Fukasawa, M.
Tissue distribution of placenta-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Biochem. Biophys. Res. Commun.
257
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1999
Homo sapiens, Rattus norvegicus
brenda
Harada, Y.; Tominaga, N.; Watanabe, M.; Shimokawa, R.; Ishiguro, M.; Sakakibara, R.
Inhibition of fructose-6-phosphate,2-kinase by N-bromoacetylethanolamine phosphate in vitro and in vivo
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121
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1997
Mus musculus, Rattus norvegicus
brenda
Zhu, Z.; Ling, S.; Yang, Q.H.; Li, L.
Involvement of the chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase sequence His444-Arg-Glu-Arg in modulation of the bisphosphatase activity by its kinase domain
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357
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2001
Gallus gallus, Rattus norvegicus
brenda
Bruni, P.; Vandoolaeghe, P.; Rousseau, G.G.; Hue, L.; Rider, M.H.
Expression and regulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isozymes in white adipose tissue
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259
756-761
1999
Rattus norvegicus
brenda
Goldstein, B.N.; Maevsky, A.A.
Critical switch of the metabolic fluxes by phosphofructo-2-kinase:fructose-2,6-bisphosphatase. A kinetic model
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2002
Rattus norvegicus
brenda
Payne, V.A.; Arden, C.; Wu, C.; Lange, A.J.; Agius, L.
Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes
Diabetes
54
1949-1957
2005
Rattus norvegicus
brenda
Payne, V.A.; Arden, C.; Lange, A.J.; Agius, L.
Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats
Am. J. Physiol. Regul. Integr. Comp. Physiol.
293
R618-R625
2007
Rattus norvegicus
brenda
Kim, S.G.; Cavalier, M.; El-Magrabi, M.R.; Lee, Y.M.
A direct substratesubstrate interaction found in the kinase domain of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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370
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2007
Rattus norvegicus
brenda
Smith, W.E.; Langer, S.; Wu, C.; Baltrusch, S.; Okar, D.A.
Molecular coordination of hepatic glucose metabolism by the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase:glucokinase complex
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2007
Rattus norvegicus
brenda
Mukhtar, M.H.; Payne, V.A.; Arden, C.; Harbottle, A.; Khan, S.; Lange, A.J.; Agius, L.
Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R766-R774
2008
Rattus norvegicus (Q9JJH5)
brenda
Mykhalchenko, V.G.; Minchenko, D.O.; Tsuchihara, K.; Moenner, M.; Komisarenko, S.V.; Bikfalvi, A.; Esumi, H.; Minchenko, O.H.
Expression of mouse 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 mRNA alternative splice variants in hypoxia
Ukr. Biokhim. Zh.
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2008
Rattus norvegicus (A7UAK3), Mus musculus (A7UAK4), Mus musculus (A7UAK5), Mus musculus (A7UAK6), Mus musculus
brenda
Gomez, M.; Navarro-Sabate, A.; Manzano, A.; Duran, J.; Obach, M.; Bartrons, R.
Switches in 6-phosphofructo-2-kinase isoenzyme expression during rat sperm maturation
Biochem. Biophys. Res. Commun.
387
330-335
2009
Rattus norvegicus
brenda
Langer, S.; Kaminski, M.T.; Lenzen, S.; Baltrusch, S.
Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent
Mol. Endocrinol.
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1988-1997
2010
Rattus norvegicus
brenda
Baltrusch, S.; Schmitt, H.; Brix, A.; Langer, S.; Lenzen, S.
Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260
Biochem. Pharmacol.
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1300-1306
2012
Rattus norvegicus
brenda
Langer, S.; Okar, D.A.; Schultz, J.; Lenzen, S.; Baltrusch, S.
Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation
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586
1419-1425
2012
Rattus norvegicus (P07953)
brenda
Novellasdemunt, L.; Tato, I.; Navarro-Sabate, A.; Ruiz-Meana, M.; Mendez-Lucas, A.; Perales, J.C.; Garcia-Dorado, D.; Ventura, F.; Bartrons, R.; Rosa, J.L.
Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids
J. Biol. Chem.
288
10640-10651
2013
Homo sapiens (O60825), Homo sapiens, Rattus norvegicus (Q9JJH5), Rattus norvegicus Sprague-Dawley (Q9JJH5)
brenda
Cullen, K.S.; Al-Oanzi, Z.H.; OHarte, F.P.; Agius, L.; Arden, C.
Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein
Biochim. Biophys. Acta
1843
1123-1134
2014
Rattus norvegicus (P07953), Rattus norvegicus Wistar (P07953)
brenda