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Information on EC 2.6.1.85 - aminodeoxychorismate synthase and Organism(s) Bacillus subtilis and UniProt Accession P28820

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.85 aminodeoxychorismate synthase
IUBMB Comments
The enzyme is composed of two parts, a glutaminase (PabA in Escherichia coli) and an aminotransferase (PabB). In the absence of PabA and glutamine (but in the presence of Mg2+), PabB can convert ammonia and chorismate into 4-amino-4-deoxychorismate. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. In many organisms, including plants, the genes encoding the two proteins have fused to encode a single bifunctional protein. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form 4-aminobenzoate. cf. EC 2.6.1.123, 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming).
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Bacillus subtilis
UNIPROT: P28820
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Word Map
The taxonomic range for the selected organisms is: Bacillus subtilis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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Synonyms
aminodeoxychorismate synthase, pabab, 4-amino-4-deoxychorismate synthase, adc synthase, pvadcs, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4-amino-4-deoxychorismate synthase
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PabB
subunit of 4-amino-4-deoxychorismate synthase
4-amino-4-deoxychorismate synthase
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-
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ADC synthase
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-
-
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PabB
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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-
-
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PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
chorismate:L-glutamine aminotransferase
The enzyme is composed of two parts, a glutaminase (PabA in Escherichia coli) and an aminotransferase (PabB). In the absence of PabA and glutamine (but in the presence of Mg2+), PabB can convert ammonia and chorismate into 4-amino-4-deoxychorismate. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. In many organisms, including plants, the genes encoding the two proteins have fused to encode a single bifunctional protein. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form 4-aminobenzoate. cf. EC 2.6.1.123, 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming).
CAS REGISTRY NUMBER
COMMENTARY hide
132264-37-0
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
atrop-abyssomicin C
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PabB heterologously overexpressed in Escherichia coli
SwissProt
Manually annotated by BRENDA team
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Keller, S.; Schadt, H.S.; Ortel, I.; Suessmuth, R.D.
Action of atrop-abyssomicin C as an inhibitor of 4-amino-4-deoxychorismate synthase PabB
Angew. Chem. Int. Ed. Engl.
46
8284-8286
2007
Bacillus subtilis (P28820)
Manually annotated by BRENDA team