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IUBMB CommentsA pyridoxal-phosphate protein. While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly. Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor. This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.
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L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
L-glutamine + pyruvate
2-oxoglutaramate + L-alanine
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broad substrate specificity, preference in decreasing order: L-arginine, L-lysine, L-methionine, L-leucine, L-ornithine, L-glutamine
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L-glutamine + pyruvate
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L-leucine + pyruvate
4-methyl-2-oxopentanoate + L-alanine
L-lysine + pyruvate
DELTA1-piperideine-2-carboxylate + L-alanine
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product identification by mass spectrometry
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L-lysine + pyruvate
DELTA1-piperidine-2-carboxylate + L-alanine
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broad substrate specificity, preference in decreasing order: L-arginine, L-lysine, L-methionine, L-leucine, L-ornithine, L-glutamine
mass spectrometry analysis, implies that AruH may have broader physiological functions in amino acid catabolism
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L-methionine + pyruvate
4-methylthio-2-oxo-butanoate + L-alanine
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L-methionine + pyruvate
4-methylthio-2-oxobutanoate + L-alanine
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broad substrate specificity, preference in decreasing order: L-arginine, L-lysine, L-methionine, L-leucine, L-ornithine, L-glutamine
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?
L-ornithine + pyruvate
5-amino-2-oxopentanoate + L-alanine
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broad substrate specificity, preference in decreasing order: L-arginine, L-lysine, L-methionine, L-leucine, L-ornithine, L-glutamine
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L-ornithine + pyruvate
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additional information
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L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
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L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
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product identification by mass spectrometry
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?
L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
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AruH catalyzes the first step of the arginine transaminase pathway, representing one of the multiple pathways for L-arginine catabolism
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L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
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broad substrate specificity, preference in decreasing order: L-arginine, L-lysine, L-methionine, L-leucine, L-ornithine, L-glutamine
detected by HPLC and mass spectrometry
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L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
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AruH catalyzes the first step in the arginine transaminase pathway, converting the substrates L-arginine and pyruvate into 2-ketoarginine and L-alanine, AruH may have a broader physiological function in amino acid catabolism
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?
L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
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L-leucine + pyruvate
4-methyl-2-oxopentanoate + L-alanine
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?
L-leucine + pyruvate
4-methyl-2-oxopentanoate + L-alanine
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broad substrate specificity, preference in decreasing order: L-arginine, L-lysine, L-methionine, L-leucine, L-ornithine, L-glutamine
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additional information
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arginine utilization proceeds via multiple catabolic pathways in the organism, the enzyme is involved in the arginine transaminase pathway, regulation of arginine-responsive induction of the arginine transaminase pathway, arginine metabolism, overview
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additional information
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arginine utilization proceeds via multiple catabolic pathways in the organism, the enzyme is involved in the arginine transaminase pathway, regulation of arginine-responsive induction of the arginine transaminase pathway, arginine metabolism, overview
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additional information
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AruH is also an L-ATase, overview
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additional information
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AruH is also an L-ATase, overview
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additional information
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broad substrate specificity in an descending order of preference: Arg, Lys, Met, Leu, Orn, Gln
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additional information
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knockout of aruH and aruI, which encode an arginine:pyruvate transaminase and a 2-ketoarginine decarboxylase in an operon, also abolishes the ability of the aruF mutant to grow on L-arginine
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additional information
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knockout of aruH and aruI, which encode an arginine:pyruvate transaminase and a 2-ketoarginine decarboxylase in an operon, also abolishes the ability of the aruF mutant to grow on L-arginine
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additional information
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arginine utilization proceeds via multiple catabolic pathways in the organism, the enzyme is involved in the arginine transaminase pathway, regulation of arginine-responsive induction of the arginine transaminase pathway, arginine metabolism, overview
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?
additional information
?
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AruH is also an L-ATase, overview
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?
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L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
additional information
?
-
L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
-
AruH catalyzes the first step of the arginine transaminase pathway, representing one of the multiple pathways for L-arginine catabolism
-
-
?
L-arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
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AruH catalyzes the first step in the arginine transaminase pathway, converting the substrates L-arginine and pyruvate into 2-ketoarginine and L-alanine, AruH may have a broader physiological function in amino acid catabolism
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-
?
additional information
?
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arginine utilization proceeds via multiple catabolic pathways in the organism, the enzyme is involved in the arginine transaminase pathway, regulation of arginine-responsive induction of the arginine transaminase pathway, arginine metabolism, overview
-
-
?
additional information
?
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arginine utilization proceeds via multiple catabolic pathways in the organism, the enzyme is involved in the arginine transaminase pathway, regulation of arginine-responsive induction of the arginine transaminase pathway, arginine metabolism, overview
-
-
?
additional information
?
-
-
knockout of aruH and aruI, which encode an arginine:pyruvate transaminase and a 2-ketoarginine decarboxylase in an operon, also abolishes the ability of the aruF mutant to grow on L-arginine
-
-
?
additional information
?
-
knockout of aruH and aruI, which encode an arginine:pyruvate transaminase and a 2-ketoarginine decarboxylase in an operon, also abolishes the ability of the aruF mutant to grow on L-arginine
-
-
?
additional information
?
-
-
arginine utilization proceeds via multiple catabolic pathways in the organism, the enzyme is involved in the arginine transaminase pathway, regulation of arginine-responsive induction of the arginine transaminase pathway, arginine metabolism, overview
-
-
?
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