Information on EC 2.6.1.65 - N6-acetyl-beta-lysine transaminase

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The expected taxonomic range for this enzyme is: Pseudomonas sp.

EC NUMBER
COMMENTARY
2.6.1.65
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RECOMMENDED NAME
GeneOntology No.
N6-acetyl-beta-lysine transaminase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
6-acetamido-3-aminohexanoate + 2-oxoglutarate = 6-acetamido-3-oxohexanoate + L-glutamate
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Lysine degradation
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SYSTEMATIC NAME
IUBMB Comments
6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
aminotransferase, epsilon-acetyl-beta-lysine
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-
-
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CAS REGISTRY NUMBER
COMMENTARY
71768-10-0
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
6-acetamido-3-aminohexanoate + 2-oxoglutarate
6-acetamido-3-oxohexanoate + L-glutamate
show the reaction diagram
-
i.e. 6-N-acetyl-L-beta-lysine
-
?
6-acetamido-3-aminohexanoate + 2-oxoglutarate
6-acetamido-3-oxohexanoate + L-glutamate
show the reaction diagram
-
inducible enzyme of lysine catabolism
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-
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6-acetamido-3-aminohexanoate + pyruvate
6-acetamido-3-oxohexanoate + L-alanine
show the reaction diagram
-
at 6% the rate of 2-oxoglutarate
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
6-acetamido-3-aminohexanoate + 2-oxoglutarate
6-acetamido-3-oxohexanoate + L-glutamate
show the reaction diagram
-
inducible enzyme of lysine catabolism
-
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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requirement, pyridoxal phosphate protein
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
1.5
-
2-oxoglutarate
-
35C
5
-
6-Acetamido-3-aminohexanoate
-
35C
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.3
0.5
-
crude enzyme extract, 35C
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
8
9.4
-
about half-maximal activity at pH 8 and pH 9.4
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20C, about 5% loss of activity per month
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