Information on EC 2.6.1.5 - tyrosine transaminase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.6.1.5
-
RECOMMENDED NAME
GeneOntology No.
tyrosine transaminase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
amino group transfer
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-
-
-
PATHWAY
KEGG Link
MetaCyc Link
(S)-reticuline biosynthesis I
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4-hydroxyphenylpyruvate biosynthesis
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Biosynthesis of secondary metabolites
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Cysteine and methionine metabolism
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Isoquinoline alkaloid biosynthesis
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Metabolic pathways
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Novobiocin biosynthesis
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Phenylalanine metabolism
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Phenylalanine, tyrosine and tryptophan biosynthesis
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rosmarinic acid biosynthesis I
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Tropane, piperidine and pyridine alkaloid biosynthesis
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tyrosine biosynthesis I
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tyrosine degradation I
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tyrosine degradation II
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tyrosine degradation III
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Tyrosine metabolism
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Ubiquinone and other terpenoid-quinone biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
L-tyrosine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae [8].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
aminotransferase, tyrosine
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-
-
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At5g36160
Q9LVY1
gene name
At5g53970
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gene name
beta-phenylalanine aminotransferase
H8WR05
-
glutamic phenylpyruvic aminotransferase
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-
-
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glutamic-hydroxyphenylpyruvic transaminase
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-
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L-phenylalanine 2-oxoglutarate aminotransferase
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L-tyrosine aminotransferase
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mTAT
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phenylalanine aminotransferase
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phenylalanine transaminase
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-
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phenylalanine-alpha-ketoglutarate transaminase
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-
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phenylpyruvate transaminase
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-
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phenylpyruvic acid transaminase
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-
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Sar2028
Q6GFC0
-
TAT
Vitis vinifera x Vitis riparia, Vitis vinifera x Vitis vinifera
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TATase
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-
TATc
-
-
tyrosine aminotransferase
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-
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tyrosine aminotransferase
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tyrosine aminotransferase
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tyrosine aminotransferase
-
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tyrosine aminotransferase
-
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tyrosine aminotransferase
-
-
tyrosine aminotransferase
-
-
tyrosine aminotransferase
Vitis vinifera x Vitis riparia, Vitis vinifera x Vitis vinifera
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tyrosine-2-ketoglutarate aminotransferase
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-
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tyrosine-2-oxoglutarate aminotransferase
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-
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tyrosine-alpha-ketoglutarate aminotransferase
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tyrosine-alpha-ketoglutarate transaminase
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L-tyrosine-2-oxoglutarate aminotransferase
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-
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additional information
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the mitochondrial enzyme may be identical with EC 2.6.1.1 and with EC 2.6.1.57
CAS REGISTRY NUMBER
COMMENTARY
9014-55-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
rainbow lizard
-
-
Manually annotated by BRENDA team
chicken
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-
Manually annotated by BRENDA team
enzyme is not suppressed during cell proliferation
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-
Manually annotated by BRENDA team
4 enzyme forms from kidney, heart and brain
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-
Manually annotated by BRENDA team
4 forms, one of them is probably identical to mitochondrial L-aspartate aminotransferase EC 2.6.1.1
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-
Manually annotated by BRENDA team
induction of enzyme by dexamethasone
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-
Manually annotated by BRENDA team
epimastigote
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-
Manually annotated by BRENDA team
Vitis vinifera x Vitis riparia
-
-
-
Manually annotated by BRENDA team
Vitis vinifera x Vitis vinifera
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-
-
Manually annotated by BRENDA team
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-
first step in tyrosine pathway leading to the formation of rosmarinic acid (alpha-O-caffeoyl-3,4-dihydroxyphenyllactic acid)
-
?
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
medicine
Q4E4E7
tyrosine aminotransferase is not directly associated with resistance to benznidazole, but may act as a general secondary compensatory mechanism or stress response factor. In Trypanosoma cruzi strains resistant o benznidazole, no amplification of the tyrosine aminotransferase gene is observed, and all strain show similar levels of tyrosine aminotransferase mRNA