Information on EC 2.6.1.34 - UDP-N-acetylbacillosamine transaminase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Bacteria

EC NUMBER
COMMENTARY
2.6.1.34
-
RECOMMENDED NAME
GeneOntology No.
UDP-N-acetylbacillosamine transaminase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
UDP-N-acetylbacillosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate
show the reaction diagram
; A pyridoxal-phosphate protein; A pyridoxal-phosphate protein.
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
UDP-N,N'-diacetylbacillosamine biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N'-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [2-4] and O-linked glycosylation of certain L-serine residues in Neisseria species [5].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
aminotransferase, uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose
-
-
-
-
Cj1121c
Q0P9D3
-
PglE
Campylobacter jejuni NCTC 11168
-
-
-
UDP-4-keto-6-deoxy-GlcNAc C4 aminotransferase
Q0P9D3
-
uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37277-89-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
type XIV, ATCC 6314
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate
UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate
show the reaction diagram
-
-
-
-
?
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate
UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate
show the reaction diagram
-, Q0P9D3
the enzyme (Cj1121c) is involved in biosynthesis of bacillosamine
-
-
?
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate
UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate
show the reaction diagram
-
the enzyme is involved in the biosynthesis of an undecaprenyl diphosphate-linked disaccharide
-
-
?
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate
UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate
show the reaction diagram
-, Q0P9D3
the enzyme (Cj1121c) does not utilize UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose as substrate
-
-
?
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate
UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate
show the reaction diagram
Campylobacter jejuni NCTC 11168
-
-
-
-
?
UDP-2-acetamido-4-keto-2,6-dideoxyhexose + L-glutamate
UDP-2-acetamido-4-amino-2,4,6-trideoxyhexose + 2-oxoglutarate
show the reaction diagram
-
-, glutamate can only partially be replaced by glutamine and cannot be replaced by asparagine and aspartate
-
r
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate
UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate
show the reaction diagram
-
-
-
-
?
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate
UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate
show the reaction diagram
-, Q0P9D3
the enzyme (Cj1121c) is involved in biosynthesis of bacillosamine
-
-
?
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate
UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate
show the reaction diagram
-
the enzyme is involved in the biosynthesis of an undecaprenyl diphosphate-linked disaccharide
-
-
?
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate
UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate
show the reaction diagram
Campylobacter jejuni NCTC 11168
-
-
-
-
?
UDP-2-acetamido-4-keto-2,6-dideoxyhexose + L-glutamate
UDP-2-acetamido-4-amino-2,4,6-trideoxyhexose + 2-oxoglutarate
show the reaction diagram
-
-
-
r
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-, Q0P9D3
a pyridoxal 5'-phosphate protein
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
not affected by MgCl2 at 0.01 M
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
absolute requirement
additional information
-
not affected by EDTA
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.048
-
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose
-, Q0P9D3
pH 7.7, 37°C
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2.4
-
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose
-, Q0P9D3
pH 7.7, 37°C
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.7
-
-, Q0P9D3
assay at
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
37
-
-, Q0P9D3
assay at
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-15°C, stable for at least 3 weeks
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
type XIV, ATCC 6314, partial
-
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expression in Escherichia coli
-