Reference on EC 2.6.1.21 - D-amino-acid transaminase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ashiuchi, M.; Tani, K.; Soda, K.; Misono, H.
Properties of glutamate racemase from Bacillus subtilis IFO 3336 producing poly-gamma-glutamate
J. Biochem.
123
1156-1163
1998
Bacillus subtilis NBRC 3336
Pucci, M.J.; Thanassi, J.A.; Ho, H.T.; Falk, P.J.; Dougherty, T.J.
Staphylococcus haemolyticus contains two D-glutamic acid biosynthetic activities, a glutamate racemase and a D-amino acid transaminase
J. Bacteriol.
177
336-342
1995
Staphylococcus haemolyticus, Bacteria, Pediococcus, Staphylococcus aureus, Bacillus, Escherichia coli
Martinez-Carrion, M.; Jenkins, W.T.
D-Alanine-D-glutamate transaminase. I. Purification and characterization
J. Biol. Chem.
240
3538-3546
1965
Bacillus subtilis
Martinez-Carrion, M.; Jenkins, W.T.
D-Alanine-D-glutamate transaminase. II. Inhibitors and the mechanism of transamination of D-amino acids
J. Biol. Chem.
240
3547-3552
1965
Bacillus subtilis
Ogawa, T.; Fukuda, M.
Occurrence of D-amino acid aminotransferase in pea seedlings
Biochem. Biophys. Res. Commun.
52
998-1002
1973
Pisum sativum
Soper, T.S.; Jones, W.M.; Lerner, B.; Trop, M.; Manning, J.M.
Inactivation of bacterial D-amino acid transaminase by beta-chloro-D-alanine
J. Biol. Chem.
252
3170-3175
1977
Lysinibacillus sphaericus
Soper, T.S.; Manning, J.M.; Marcotte, P.A.; Walsh, C.T.
Inactivation of bacterial D-amino acid transaminases by the olefinic amino acid D-vinylglycine
J. Biol. Chem.
252
1571-1575
1977
Bacillus subtilis, Lysinibacillus sphaericus
Gosling, J.P.; Fottrell, P.F.
The partial purification and some properties of D-alanine aminotransferase from Rhizobium japonicum
Biochem. Soc. Trans.
1
252-254
1973
Bradyrhizobium japonicum
-
Yonaha, K.; Misono, H.; Yamamoto, T.; Soda, K.
D-amino acid aminotransferase of Bacillus sphaericus. Enzymologic and spectrometric properties
J. Biol. Chem.
250
6983-6989
1975
Lysinibacillus sphaericus
Kishimoto, K.; Yoshimura, T.; Esaki, N.; Sugio, S.; Manning, J.M.; Soda, K.
Role of leucine 201 of thermostable D-amino acid aminotransferase from a thermophile, Bacillus sp. YM-1
J. Biochem.
117
691-696
1995
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) YM-1
Sugio, S.; Petsko, G.A.; Manning, J.M.; Soda, K.; Ringe, D.
Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity
Biochemistry
34
9661-9669
1995
Bacillus sp. (in: Bacteria), Lysinibacillus sphaericus
Ro, H.S.; Hong, S.P.; Seo, H.J.; Yoshimura, T.; Esaki, N.; Soda, K.; Kim, H.S.; Sung, M.H.
Site-directed mutagenesis of the amino acid residues in beta-strand III [Val30-Val36] of D-amino acid aminotransferase of Bacillus sp. YM-1
FEBS Lett.
398
141-145
1996
Bacillus sp. (in: Bacteria)
Fuchikami, Y.; Yoshimura, T.; Gutierrez, A.; Soda, K.; Esaki, N.
Construction and properties of a fragmentary D-amino acid aminotransferase
J. Biochem.
124
905-910
1998
BRENDA: Bacillus sp. (in: Bacteria)
Textmining: plasmids
Gutierrez, A.; Yoshimura, T.; Fuchikami, Y.; Soda, K.; Esaki, N.
A mutant D-amino acid aminotransferase with broad substrate specificity: construction by replacement of the interdomain loop Pro119-Arg120-Pro121 by Gly-Gly-Gly
Protein Eng.
11
53-58
1998
Bacillus sp. (in: Bacteria)
Sugio, S.; Kashima, A.; Kishimoto, K.; Peisach, D.; Petsko, G.A.; Ringe, D.; Yoshimura, T.; Esaki, N.
Crystal structures of L201A mutant of D-amino acid aminotransferase at 2.0 A resolution: implication of the structural role of Leu201 in transamination
Protein Eng.
11
613-619
1998
Bacillus sp. (in: Bacteria)
Peisach, D.; Chipman, D.M.; Van Ophem, P.W.; Manning, J.M.; Ringe, D.
Crystallographic study of steps along the reaction pathway of D-amino acid aminotransferase
Biochemistry
37
4958-4967
1998
Bacillus sp. (in: Bacteria) (P19938), Bacillus sp. (in: Bacteria)
Gutierrez, A.; Yoshimura, T.; Fuchikami, Y.; Esaki, N.
Modulation of activity and substrate specificity by modifying the backbone length of the distant interdomain loop of D-amino acid aminotransferase
Eur. J. Biochem.
267
7218-7223
2000
Bacillus sp. (in: Bacteria)
Ro, H.S.
Effects of salts on the conformation and catalytic properties of D-amino acid aminotransferase
J. Biochem. Mol. Biol.
35
306-312
2002
Bacillus sp. (in: Bacteria)
Yennawar, N.; Dunbar, J.; Conway, M.; Hutson, S.; Farber, G.
The structure of human mitochondrial branched-chain aminotransferase
Acta Crystallogr. Sect. D
57
506-515
2001
Homo sapiens, Escherichia coli
Schtzle, S.; Steffen-Munsberg, F.; Thontowi, A.; Hhne, M.; Robins, K.; Bornscheuer, U.
Enzymatic asymmetric synthesis of enantiomerically pure aliphatic, aromatic and arylaliphatic amines with (R)-selective amine transaminases
Adv. Synth. Catal.
353
2439-2445
2011
Aspergillus fischeri, Aspergillus fumigatus, Aspergillus oryzae, Aspergillus terreus, Fusarium graminearum, Penicillium chrysogenum, Mycolicibacterium vanbaalenii
-
Awasthy, D.; Bharath, S.; Subbulakshmi, V.; Sharma, U.
Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice
Microbiology
158
319-327
2012
Listeria
Du, Y.; Dong, W.; Jiang, J.; Chen, Q.; Feng, J.; Wu, Q.; Zhu, D.
[Expression and characterization of a novel ?-transaminase from Burkholderia phytofirmans PsJN].
Sheng Wu Gong Cheng Xue Bao
32
912-926
2016
Paraburkholderia phytofirmans, Paraburkholderia phytofirmans PsJN
Mortuza, R.; Aung, H.L.; Taiaroa, G.; Opel-Reading, H.K.; Kleffmann, T.; Cook, G.M.; Krause, K.L.
Overexpression of a newly identified D-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion
Mol. Microbiol.
107
198-213
2018
Mycolicibacterium smegmatis (A0R4D5), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc2155 (A0R4D5)
Voss, M.; Xiang, C.; Esque, J.; Nobili, A.; Menke, M.J.; Andre, I.; Hoehne, M.; Bornscheuer, U.T.
Creation of (R)-amine transaminase activity within an alpha-amino acid transaminase scaffold
ACS Chem. Biol.
15
416-424
2020
Bacillus sp. (in: Bacteria) (P19938), Bacillus sp. (in: Bacteria) YM-1 (P19938)
Yu, Y.; Yang, J.; Zheng, L.; Sheng, Q.; Li, C.; Wang, M.; Zhang, X.; McMinn, A.; Zhang, Y.; Song, X.; Chen, X.
Diversity of D-amino acid utilizing bacteria from Kongsfjorden, Arctic, and the metabolic pathways for seven D-amino acids
Front. Microbiol.
10
2983
2020
Halomonas titanicae (A0A558JDR6), Halomonas titanicae SM1922 (A0A558JDR6)
Suarez, J.; Hener, C.; Lehnhardt, V.A.; Hummel, S.; Stahl, M.; Kolukisaoglu, U.e.
AtDAT1 is a key enzyme of D-amino acid stimulated ethylene production in Arabidopsis thaliana
Front. Plant Sci.
10
1609
2019
BRENDA: Arabidopsis thaliana (Q8L493), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q8L493)
Textmining: insertion sequences, Arabidopsis, plant
Khrenova, M.; Zavyalova, S.; Bezsudnova, E.
Molecular mechanism of stereospecificity toward D-leucine of the transaminase from Desulfohalobium retbaense revealed by molecular dynamic simulations
Moscow Univ. Chem. Bull.
75
167-171
2020
Desulfohalobium retbaense (C8X272), Desulfohalobium retbaense ATCC 49708 (C8X272), Desulfohalobium retbaense DSM 5692 (C8X272), Desulfohalobium retbaense HR100 (C8X272), Desulfohalobium retbaense JCM 16813 (C8X272)
-
Fotheringham, IG; Bledig, SA; Taylor, PP
Characterization of the genes encoding D-amino acid transaminase and glutamate racemase, two D-glutamate biosynthetic enzymes of Bacillus sphaericus ATCC 10208.
J Bacteriol
180
4319-23
1998
Lysinibacillus sphaericus, Bacteria, Bacillus, Bacillus sp. (in: Bacteria), Pediococcus, Staphylococcus, Lactobacillus, Sulfolobus yangmingensis
Gosling, JP; Fottrell, PF
Purification and characterisation of D-amino acid aminotransferase from Rhizobium japonicum.
Biochim Biophys Acta
522
84-9
1978
Bradyrhizobium japonicum
Tanizawa, K; Asano, S; Masu, Y; Kuramitsu, S; Kagamiyama, H; Tanaka, H; Soda, K
The primary structure of thermostable D-amino acid aminotransferase from a thermophilic Bacillus species and its correlation with L-amino acid aminotransferases.
J Biol Chem
264
2450-4
1989
Bacillus, Escherichia coli
Tanizawa, K; Masu, Y; Asano, S; Tanaka, H; Soda, K
Thermostable D-amino acid aminotransferase from a thermophilic Bacillus species. Purification, characterization, and active site sequence determination.
J Biol Chem
264
2445-9
1989
Bacillus, Bacillus sp. (in: Bacteria), Lysinibacillus sphaericus
Soda, K; Yonaha, K; Misono, H
Purification and crystallization of D-amino acid aminotransferase of Bacillus sphaericus.
FEBS Lett
46
359-63
1974
Lysinibacillus sphaericus
Liu, L; Yoshimura, T; Endo, K; Kishimoto, K; Fuchikami, Y; Manning, JM; Esaki, N; Soda, K
Compensation for D-glutamate auxotrophy of Escherichia coli WM335 by D-amino acid aminotransferase gene and regulation of murI expression.
Biosci Biotechnol Biochem
62
193-5
1998
Escherichia coli, Bacteria
Bakunova, AK; Nikolaeva, AY; Rakitina, TV; Isaikina, TY; Khrenova, MG; Boyko, KM; Popov, VO; Bezsudnova, EY
The Uncommon Active Site of D-Amino Acid Transaminase from Haliscomenobacter hydrossis: Biochemical and Structural Insights into the New Enzyme.
Molecules
26
2021
Haliscomenobacter hydrossis
Okada, K; Hirotsu, K; Sato, M; Hayashi, H; Kagamiyama, H
Three-dimensional structure of Escherichia coli branched-chain amino acid aminotransferase at 2.5 A resolution.
J Biochem (Tokyo)
121
637-41
1997
Escherichia coli
Galkin, A; Kulakova, L; Yoshimura, T; Soda, K; Esaki, N
Synthesis of optically active amino acids from alpha-keto acids with Escherichia coli cells expressing heterologous genes.
Appl Environ Microbiol
63
4651-6
1997
Escherichia coli, plasmids
Thompson, RJ; Bouwer, HG; Portnoy, DA; Frankel, FR
Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth.
Infect Immun
66
3552-61
1998
Listeria monocytogenes
Senger, RS; Papoutsakis, ET
Genome-scale model for Clostridium acetobutylicum: Part II. Development of specific proton flux states and numerically determined sub-systems.
Biotechnol Bioeng
101
1053-71
2008
Clostridium acetobutylicum, Clostridium acetobutylicum ATCC 824
Dodds, D; Bose, JL; Deng, MD; Dub, GR; Grossman, TH; Kaiser, A; Kulkarni, K; Leger, R; Mootien-Boyd, S; Munivar, A; Oh, J; Pestrak, M; Rajpura, K; Tikhonov, AP; Turecek, T; Whitfill, T
Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using d-Alanine Auxotrophy.
mSphere
5
2020
Staphylococcus epidermidis
Opel-Reading, HK; Mortuza, R; Krause, KL
Detection of D-glutamate production from the dual Function enzyme, 4-amino-4-deoxychorismate Lyase/D-amino Acid Transaminase, in Mycobacterium smegmatis.
Bio Protoc
9
e3135
2019
Mycolicibacterium smegmatis
Stoddard, B; Howell, L; Asano, S; Soda, K; Tanizawa, K; Ringe, D; Petsko, GA
Preliminary X-ray data for a D-amino acid amino-transferase from a novel thermophilic Bacillus.
J Mol Biol
196
441-2
1987
Bacillus
Jeong, KJ; Choi, JH; Yoo, WM; Keum, KC; Yoo, NC; Lee, SY; Sung, MH
Constitutive production of human leptin by fed-batch culture of recombinant rpoS- Escherichia coli.
Protein Expr Purif
36
150-6
2004
Homo sapiens, Parageobacillus toebii, Escherichia coli, Saccharomyces cerevisiae
Funakoshi, M; Sekine, M; Katane, M; Furuchi, T; Yohda, M; Yoshikawa, T; Homma, H
Cloning and functional characterization of Arabidopsis thaliana D-amino acid aminotransferase--D-aspartate behavior during germination.
FEBS J
275
1188-200
2008
Arabidopsis thaliana, eukaryota, plant
Schumann, B; Reppe, K; Kaplonek, P; Wahlbrink, A; Anish, C; Witzenrath, M; Pereira, CL; Seeberger, PH
Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.
ACS Cent Sci
4
357-361
2018
Oryctolagus cuniculus
Futaki, S; Ueno, H; Martinez del Pozo, A; Pospischil, MA; Manning, JM; Ringe, D; Stoddard, B; Tanizawa, K; Yoshimura, T; Soda, K
Substitution of glutamine for lysine at the pyridoxal phosphate binding site of bacterial D-amino acid transaminase. Effects of exogenous amines on the slow formation of intermediates.
J Biol Chem
265
22306-12
1990
Gossypium hirsutum, Transformation
Merola, M; Martínez del Pozo, A; Ueno, H; Recsei, P; Di Donato, A; Manning, JM; Tanizawa, K; Masu, Y; Asano, S; Tanaka, H
Site-directed mutagenesis of the cysteinyl residues and the active-site serine residue of bacterial D-amino acid transaminase.
Biochemistry
28
505-9
1989
Bacillus
Martínez del Pozo, A; Merola, M; Ueno, H; Manning, JM; Tanizawa, K; Nishimura, K; Asano, S; Tanaka, H; Soda, K; Ringe, D
Activity and spectroscopic properties of bacterial D-amino acid transaminase after multiple site-directed mutagenesis of a single tryptophan residue.
Biochemistry
28
510-6
1989
Gossypium hirsutum
Soper, TS; Ueno, H; Manning, JM
Substrate-induced changes in sulfhydryl reactivity of bacterial D-amino acid transaminase.
Arch Biochem Biophys
240
1-8
1985
Lysinibacillus sphaericus
Soper, TS; Manning, JM
Different modes of action of inhibitors of bacterial D-amino acid transaminase. A target enzyme for the design of new antibacterial agents.
J Biol Chem
256
4263-8
1981
Lysinibacillus sphaericus, Dialysis
Bhatia, MB; Martinez del Pozo, A; Ringe, D; Yoshimura, T; Soda, K; Manning, JM
Role reversal for substrates and inhibitors. Slow inactivation of D-amino acid transaminase by its normal substrates and protection by inhibitors.
J Biol Chem
268
17687-94
1993
Bhatia
Bhatia, MB; Futaki, S; Ueno, H; Manning, JM; Ringe, D; Yoshimura, T; Soda, K
Kinetic and stereochemical comparison of wild-type and active-site K145Q mutant enzyme of bacterial D-amino acid transaminase.
J Biol Chem
268
6932-8
1993
Bacillus sp. (in: Bacteria)
van Ophem, PW; Erickson, SD; Martinez del Pozo, A; Haller, I; Chait, BT; Yoshimura, T; Soda, K; Ringe, D; Petsko, G; Manning, JM
Substrate inhibition of D-amino acid transaminase and protection by salts and by reduced nicotinamide adenine dinucleotide: isolation and initial characterization of a pyridoxo intermediate related to inactivation.
Biochemistry
37
2879-88
1998
Bhatia
Hutson, SM; Bledsoe, RK; Hall, TR; Dawson, PA
Cloning and expression of the mammalian cytosolic branched chain aminotransferase isoenzyme.
J Biol Chem
270
30344-52
1995
Escherichia coli, Haemophilus influenzae, Saccharomyces cerevisiae, Mus musculus, Rattus
Joseph, PK; Kasinath, RT
Hypoglycemic and hypolipidemic effects of diacetodibutyl disulphide.
Indian J Clin Biochem
15
68-75
2000
Allium sativum, Rattus
Nishimura, K; Ito, J; Yoshimura, T; Esaki, N; Soda, K
A simple method for determination of stereospecificity of aminotransferases for C-4' hydrogen transfer of the coenzyme.
Bioorg Med Chem
2
605-7
1994
Bacillus sp. (in: Bacteria), Sus scrofa, Escherichia coli
Jones, WM; Ringe, D; Soda, K; Manning, JM
Determination of free D-amino acids with a bacterial transaminase: their depletion leads to inhibition of bacterial growth.
Anal Biochem
218
204-9
1994
Escherichia coli
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