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Information on EC 2.6.1.19 - 4-aminobutyrate-2-oxoglutarate transaminase and Organism(s) Schizosaccharomyces pombe and UniProt Accession O13837

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase
IUBMB Comments
Requires pyridoxal phosphate. Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate. cf. EC 2.6.1.120, beta-alanine---2-oxoglutarate transaminase.
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This record set is specific for:
Schizosaccharomyces pombe
UNIPROT: O13837
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Word Map
The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
gaba-t, gaba transaminase, gaba-transaminase, gaba-at, 4-aminobutyrate aminotransferase, gaba aminotransferase, gamma-aminobutyric acid transaminase, gabat, gamma-aminobutyric acid aminotransferase, gamma-aminobutyrate transaminase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4-aminobutyrate aminotransferase
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-
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4-aminobutyrate-2-ketoglutarate aminotransferase
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-
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4-aminobutyrate-2-oxoglutarate aminotransferase
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4-aminobutyrate-2-oxoglutarate transaminase
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4-aminobutyric acid 2-ketoglutaric acid aminotransferase
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4-aminobutyric acid aminotransferase
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aminobutyrate aminotransferase
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aminobutyrate transaminase
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aminotransferase, aminobutyrate
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beta-alanine aminotransferase
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beta-alanine transaminase
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beta-alanine-oxoglutarate aminotransferase
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beta-alanine-oxoglutarate transaminase
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GABA aminotransferase
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GABA transaminase
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GABA transferase
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-
-
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GABA-2-oxoglutarate aminotransferase
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-
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GABA-2-oxoglutarate transaminase
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-
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GABA-alpha-ketoglutarate aminotransferase
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-
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GABA-alpha-ketoglutarate transaminase
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GABA-alpha-ketoglutaric acid transaminase
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GABA-alpha-oxoglutarate aminotransferase
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GABA-oxoglutarate aminotransferase
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GABA-oxoglutarate transaminase
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gamma-aminobutyrate aminotransaminase
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gamma-aminobutyrate transaminase
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gamma-aminobutyrate-alpha-ketoglutarate aminotransferase
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gamma-aminobutyrate-alpha-ketoglutarate transaminase
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gamma-aminobutyrate:alpha-oxoglutarate aminotransferase
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gamma-aminobutyric acid aminotransferase
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gamma-aminobutyric acid pyruvate transaminase
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gamma-aminobutyric acid transaminase
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gamma-aminobutyric acid-2-oxoglutarate transaminase
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gamma-aminobutyric acid-alpha-ketoglutarate transaminase
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gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase
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gamma-aminobutyric transaminase
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glutamate-succinic semialdehyde transaminase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
4-aminobutanoate:2-oxoglutarate aminotransferase
Requires pyridoxal phosphate. Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate. cf. EC 2.6.1.120, beta-alanine---2-oxoglutarate transaminase.
CAS REGISTRY NUMBER
COMMENTARY hide
9037-67-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-aminobutanoate + 2-oxoglutarate
4-oxobutanoate + L-glutamate
show the reaction diagram
-
-
-
?
beta-alanine + 2-oxoglutarate
malonic semialdehyde + L-glutamate
show the reaction diagram
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-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.14
substrate beta-alanine, discontinuous determination of glutamate using glutamate dehydrogenase in the presence of 10 M hydrazine, pH 8.0, 30°C
3.67
continuous assay using malonic semialdehyde decarboxylase and alcohol dehydrogenase, pH 8.0, 30°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isoform Uga1
UniProt
Manually annotated by BRENDA team
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 12 days, 57% residual activity
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression as His-tagged protein
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Andersen, G.; Andersen, B.; Dobritzsch, D.; Schnackerz, K.D.; Piskur, J.
A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast
FEBS J.
274
1804-1817
2007
Lachancea kluyveri, Lachancea kluyveri (A5H0J5), Lachancea kluyveri (A5H0J6), Schizosaccharomyces pombe (O13837), Schizosaccharomyces pombe, Saccharomyces cerevisiae (P17649), Saccharomyces cerevisiae
Manually annotated by BRENDA team