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Information on EC 2.6.1.13 - ornithine aminotransferase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9FNK4

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.13 ornithine aminotransferase
IUBMB Comments
A pyridoxal-phosphate protein.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9FNK4
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
ornithine aminotransferase, ornithine-delta-aminotransferase, ornithine transaminase, ornithine delta-aminotransferase, psoat, delta-oat, ornithine amino transferase, l-ornithine:2-oxoacid aminotransferase, taoat, ornithine delta-transaminase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L-ornithine:2-oxoacid aminotransferase
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ornithine delta-aminotransferase
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aminotransferase, ornithine-keto acid
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-
-
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L-ornithine 5-aminotransferase
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-
-
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L-ornithine aminotransferase
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-
-
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L-ornithine:alpha-ketoglutarate delta-aminotransferase
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-
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OAT
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-
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ornithine 5-aminotransferase
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-
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ornithine aminotransferase
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-
-
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ornithine delta-aminotransferase
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ornithine delta-transaminase
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-
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ornithine transaminase
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-
-
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ornithine-2-oxoacid aminotransferase
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-
-
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ornithine-alpha-ketoglutarate aminotransferase
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-
-
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ornithine-keto acid aminotransferase
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-
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ornithine-keto acid transaminase
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-
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ornithine-ketoglutarate aminotransferase
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ornithine-oxo acid aminotransferase
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-
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ornithine-oxo-acid transaminase
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-
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ornithine:alpha-oxoglutarate transaminase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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amino group transfer
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-
-
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
L-ornithine:2-oxo-acid aminotransferase
A pyridoxal-phosphate protein.
CAS REGISTRY NUMBER
COMMENTARY hide
9030-42-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
show the reaction diagram
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
ornithine aminotransferase feeds pyrroline-5-carboxylate exclusively into the catabolic branch of proline metabolism, which yields glutamate as an end product. Proline biosynthesis occurs predominantly or exclusively via the glutamate pathway in Arabidopsis thaliana and does not depend on glutamate produced by arginine and ornithine catabolism
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
show the reaction diagram
-
-
-
?
additional information
?
-
-
ornithine aminotransferase feeds pyrroline-5-carboxylate exclusively into the catabolic branch of proline metabolism, which yields glutamate as an end product. Proline biosynthesis occurs predominantly or exclusively via the glutamate pathway in Arabidopsis thaliana and does not depend on glutamate produced by arginine and ornithine catabolism
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-amino-1,3-cyclohexadienyl carboxylic acid
gabaculine
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
OAT activity increases by salt-stress treatment in Arabidopsis thaliana
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
87 - 91
L-ornithine
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
enzyme is implicated in salt tolerance in higher plants, enzyme is implicated in proline biosynthesis and accumulation via pyrroline-5-carboxylate, OAT is essential for nitrogen recycling from arginine but not for the stress-induced proline accumulation, OAT probably links the degradation pathways for arginine and proline
malfunction
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deltaOAT and proline dehydrogenases (ProDH1 and ProDH2) are involved in the defence against non-host pathogens. Mutants for these genes compromise non-host resistance and show a decrease in non-host pathogen-induced reactive oxygen species
physiological function
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deltaOAT is involved in effector-triggered immunity (ETI) and plays a critical role in inducing early oxidative burst and other defence pathways in plants, conceivably by accumulating P5C in mitochondria
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
OAT_ARATH
475
0
52178
Swiss-Prot
Mitochondrion (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
enzyme deletion mutants accumulate urea cycle intermediates when fed with arginine or ornithine and are not able to utilize nitrogen provided as arginine or ornithine. Utilisation of urea and stress induced proline accumulation are not affected in T-DNA insertion mutants with a complete loss of ornithine aminotransferase expression
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Nicotiana plumbaginifolia plants overexpressing OAT from Arabidopsis synthesize more proline than the control plants and show a higher biomass and a higher germination rate under osmotic stress conditions
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
deltaOAT and proline dehydrogenases are induced upon non-host pathogen infection
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biotechnology
genetic engineering of plants for increased production of the osmoprotectant proline, transgenic plants overexpressing OAT display enhanced tolerance to salt and drought due to increased proline content
agriculture
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expression of enzyme in Oryza sativa, transgenic plants are significantly taller than control, and more resistant to high salinity and drought
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Roosens, N.H.; Bitar, F.A.; Loenders, K.; Angenon, G.; Jacobs, M.
Overexpression of ornithine-delta-aminotransferase increases proline biosynthesis and confers osmotolerance in transgenic plants
Mol. Breed.
9
73-80
2002
Arabidopsis thaliana
Manually annotated by BRENDA team
Roosens, N.H.C.J.; Thu, T.T.; Iskandar, H.M.; Jacobs, M.
Isolation of the ornithine-d-aminotransferase cDNA and effect of salt stress on its expression in Arabidopsis thaliana
Plant Physiol.
117
263-271
1998
Arabidopsis thaliana
Manually annotated by BRENDA team
Wu, L.; Fan, Z.; Guo, L.; Li, Y.; Chen, Z.L.; Qu, L.J.
Over-expression of the bacterial nhaA gene in rice enhances salt and drought tolerance
Plant Sci.
168
297-302
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Funck, D.; Stadelhofer, B.; Koch, W.
Ornithine-delta-aminotransferase is essential for arginine catabolism but not for proline biosynthesis
BMC Plant Biol.
8
40
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Stranska, J.; Kopecny, D.; Tylichova, M.; Snegaroff, J.; Sebela, M.
Ornithine delta-aminotransferase: An enzyme implicated in salt tolerance in higher plants
Plant Signal. Behav.
3
929-935
2008
Cucurbita pepo, Homo sapiens, Nicotiana plumbaginifolia, Oryza sativa, Pisum sativum (B1A0U3), Vigna aconitifolia (P31893), Arabidopsis thaliana (Q9FNK4)
Manually annotated by BRENDA team
Senthil-Kumar, M.; Mysore, K.S.
Ornithine-delta-aminotransferase and proline dehydrogenase genes play a role in non-host disease resistance by regulating pyrroline-5-carboxylate metabolism-induced hypersensitive response
Plant Cell Environ.
35
1329-1343
2012
Arabidopsis thaliana, Nicotiana benthamiana
Manually annotated by BRENDA team