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Disease on EC 2.5.1.60 - protein geranylgeranyltransferase type II

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Rab11a regulates Syntaxin 3 localization and microvillus assembly in enterocytes.
Barrett Esophagus
Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus.
Blindness
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Breast Neoplasms
MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A.
The Lipid Kinase PI4KIII? Is Highly Expressed in Breast Tumors and Activates Akt in Cooperation with Rab11a.
Tumor-suppressive microRNA-452 inhibits migration and invasion of breast cancer cells by directly targeting RAB11A.
Carcinogenesis
c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis.
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.
The Lipid Kinase PI4KIII? Is Highly Expressed in Breast Tumors and Activates Akt in Cooperation with Rab11a.
Carcinoma
Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression.
Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus.
Studies of the mouse Rab geranylgeranyl transferase beta subunit: gene structure, expression and regulation.
Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase.
Carcinoma, Ductal
Rab11a differentially modulates epidermal growth factor-induced proliferation and motility in immortal breast cells.
Carcinoma, Hepatocellular
Rab11a regulates MMP2 expression by activating the PI3K/AKT pathway in human hepatocellular carcinoma cells.
Carcinoma, Intraductal, Noninfiltrating
Rab11a differentially modulates epidermal growth factor-induced proliferation and motility in immortal breast cells.
Carcinoma, Non-Small-Cell Lung
Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer.
Carcinoma, Squamous Cell
Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression.
Cholestasis
Hormonal Modulation of Hepatic cAMP Prevents Estradiol 17?-D-Glucuronide-Induced Cholestasis in Perfused Rat Liver.
Choroideremia
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein.
Choroideremia gene testing.
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with Rab geranylgeranyl transferase.
Deficient geranylgeranylation of Ram/Rab27 in choroideremia.
Identification of yeast component A: reconstitution of the geranylgeranyltransferase that modifies Ypt1p and Sec4p.
Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.
Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase.
[Structure and properties of Rab proteins]
Crohn Disease
TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.
Cysts
Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.
Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
Cytomegalovirus Infections
Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes.
Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.
Diabetic Retinopathy
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Enteritis
1,25-Dihydroxyvitamin D3 and dietary vitamin D reduce inflammation in mice lacking intestinal epithelial cell Rab11a.
Esophageal Neoplasms
RAB11A mediates the proliferation and motility of esophageal cancer cells via WNT signaling pathway.
Genetic Diseases, Inborn
Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.
Rab GTPases, intracellular traffic and disease.
[Structure and properties of Rab proteins]
Hermanski-Pudlak Syndrome
[Structure and properties of Rab proteins]
Infections
Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity.
Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase.
Intracellular Colocalization of Influenza Viral RNA and Rab11A Is Dependent upon Microtubule Filaments.
Proteomic and metabolomic responses in hepatopancreas of whiteleg shrimp Litopenaeus vannamei infected by microsporidian Enterocytozoon hepatopenaei.
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association.
Rab11a is required for porcine reproductive and respiratory syndrome virus induced autophagy to promote viral replication.
Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes.
Infertility
Rab11a drives adhesion molecules to the surface of endometrial epithelial cells.
Influenza, Human
Activation of Dendritic Cells Alters the Mechanism of MHC Class II Antigen Presentation to CD4 T Cells.
Host factor Rab11a is critical for efficient assembly of influenza A virus genomic segments.
Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes.
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.
Intracellular Colocalization of Influenza Viral RNA and Rab11A Is Dependent upon Microtubule Filaments.
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association.
RAB11A is essential for transport of the influenza virus genome to the plasma membrane.
Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes.
Leber Congenital Amaurosis
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Lung Injury
Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils.
Lung Neoplasms
Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer.
Malaria
Bioaffinity Mass Spectrometry Screening.
Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A.
Neoplasm Metastasis
Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling.
Neoplasms
Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.
Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors.
Extracellular vesicles: eat glutamine and spit acidic bubbles.
Glutamine deprivation alters the origin and function of cancer cell exosomes.
Identification of Pan-Cancer Prognostic Biomarkers Through Integration of Multi-Omics Data.
Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors.
MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A.
MiR-150 Inhibits Cell Growth In Vitro and In Vivo by Restraining the RAB11A/WNT/?-Catenin Pathway in Thyroid Cancer.
Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.
Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.
Rab11a differentially modulates epidermal growth factor-induced proliferation and motility in immortal breast cells.
Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling.
RAB11A mediates the proliferation and motility of esophageal cancer cells via WNT signaling pathway.
Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer.
Rab11a regulates MMP2 expression by activating the PI3K/AKT pathway in human hepatocellular carcinoma cells.
Rab11a sustains GSK3?/Wnt/?-catenin signaling to enhance cancer progression in pancreatic cancer.
RAB11A-mediated YAP localization to adherens and tight junctions is essential for colonic epithelial integrity.
Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.
Searching for non-RET molecular alterations in medullary thyroid carcinoma: expression analysis by mRNA differential display.
Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase.
Tumor-suppressive microRNA-452 inhibits migration and invasion of breast cancer cells by directly targeting RAB11A.
Osteoporosis
Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.
Pancreatic Neoplasms
Rab11a sustains GSK3?/Wnt/?-catenin signaling to enhance cancer progression in pancreatic cancer.
Porcine Reproductive and Respiratory Syndrome
Rab11a is required for porcine reproductive and respiratory syndrome virus induced autophagy to promote viral replication.
protein geranylgeranyltransferase type ii deficiency
Host factor Rab11a is critical for efficient assembly of influenza A virus genomic segments.
Rab11a regulates Syntaxin 3 localization and microvillus assembly in enterocytes.
Retinal Degeneration
Identification of yeast component A: reconstitution of the geranylgeranyltransferase that modifies Ypt1p and Sec4p.
Nucleotide bound to rab11a controls localization in rod cells but not interaction with rhodopsin.
Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase.
Retinal Diseases
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Sepsis
Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function.
Skin Neoplasms
c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis.
Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.
Starvation
The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A.
Stomach Neoplasms
Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling.
Thrombocytosis
Cell-specific abnormal prenylation of Rab proteins in platelets and melanocytes of the gunmetal mouse.
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis.
Virus Diseases
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.