Information on EC 2.5.1.29 - geranylgeranyl diphosphate synthase

Word Map on EC 2.5.1.29
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria

EC NUMBER
COMMENTARY hide
2.5.1.29
-
RECOMMENDED NAME
GeneOntology No.
geranylgeranyl diphosphate synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alkenyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
-
-
Biosynthesis of secondary metabolites
-
-
brassicicene C biosynthesis
-
-
fusicoccin A biosynthesis
-
-
geranylgeranyl diphosphate biosynthesis
-
-
Metabolic pathways
-
-
methyl phomopsenoate biosynthesis
-
-
ophiobolin F biosynthesis
-
-
paspaline biosynthesis
-
-
plaunotol biosynthesis
-
-
stellatic acid biosynthesis
-
-
Terpenoid backbone biosynthesis
-
-
isoprenoid biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase
Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-58-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
gene ape_1385
SwissProt
Manually annotated by BRENDA team
gene ape_1385
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
ssp. creticus
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
; gene crtE
-
-
Manually annotated by BRENDA team
gene DR1395
UniProt
Manually annotated by BRENDA team
gene DR1395
UniProt
Manually annotated by BRENDA team
gene DbGGPS
-
-
Manually annotated by BRENDA team
gene crtE
UniProt
Manually annotated by BRENDA team
gene crtE
UniProt
Manually annotated by BRENDA team
gene ggpS
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
cv. Nongdafu 14, gene IbGGPS
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
MF730-N6
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GGS1
UniProt
Manually annotated by BRENDA team
gene GGPS1
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
bifunctional geranyl diphosphate synthase and geranylgeranyl diphosphate synthase
UniProt
Manually annotated by BRENDA team
gene PF3D7_1128400
UniProt
Manually annotated by BRENDA team
gene PF3D7_1128400
UniProt
Manually annotated by BRENDA team
gene PVX_092040
-
-
Manually annotated by BRENDA team
two populations collected in Japan, gene RsGGPPS
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
HB8
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Vitis vinifera x Vitis vinifera
-
-
-
Manually annotated by BRENDA team
a basidiomycetous yeast, the sexual state of Phaffia rhodozyma, gene crtE
-
-
Manually annotated by BRENDA team
a basidiomycetous yeast, the sexual state of Phaffia rhodozyma, gene crtE
-
-
Manually annotated by BRENDA team
cv. B73
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E)-3,7-dimethyl-2-octenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
62% of activity with geranyl diphosphate
-
-
?
(2E)-3-methyl-2,6-heptadienyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
24% of activity with geranyl diphosphate
-
-
?
(2E)-3-methyl-2-butenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
21.5% of activity with geranyl diphosphate
-
-
?
(2E)-3-methyl-2-hexenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
95% of activity with geranyl diphosphate
-
-
?
(2E)-3-methyl-2-pentenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
63% of activity with geranyl diphosphate
-
-
?
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
(E)-3-methyl-2-dodecenyl diphosphate + isopentenyl diphosphate
(2E,5E)-3,6-dimethylpentadeca-2,5-dien-1-yl diphosphate + diphosphate
show the reaction diagram
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
3,8-dimethyl-2-nonenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
59% of activity with dimethylallyl diphosphate
-
-
?
3-methyl-2-alkenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
a number of 3-methyl-2-alkenyl diphosphates ranging in carbon number from 6 to 13 act as substrates
-
-
?
6,7-dihydrogeranyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
87% of activity with dimethylallyl diphosphate
-
-
?
8,8'-bisnorgeranyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
107% of activity with dimethylallyl diphosphate
-
-
?
cis-3-methyl-2-hexenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
cyclopentylideneethyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
dimethylallyl diphosphate + 2 isopentenyl diphosphate
2 diphosphate + (2Z,6Z)-farnesyl diphosphate
show the reaction diagram
dimethylallyl diphosphate + 3 isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
-
geranyl diphosphate activity of enzyme leads to additional production of geranyl diphosphate. The ratio of geranyl diphosphate to geranylgeranyl diphosphate produced averages approximately 9:1. No synthesis of farnesyl diphosphate
-
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + 3 diphosphate
show the reaction diagram
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
dimethylallyl diphosphate + isopentenyl diphosphate
? + diphosphate
show the reaction diagram
bifunctional enzyme EC2.5.1.29/EC2.5.1.10, the FPP/GGPP product ratio increases with the rise of the reaction temperature
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
geranyl diphosphate + farnesyl diphosphate + geranylgeranyl diphosphate + diphosphate
show the reaction diagram
large subunit alone
-
-
?
E-3-methyl-2-undecenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
53% of the activity with farnesyl diphosphate
-
-
?
farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
-
-
-
?
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + 2 diphosphate
show the reaction diagram
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
geranyl diphosphate + 3-desmethylisopentenyl diphosphate
diphosphate + 3-desmethylfarnesyl diphosphate
show the reaction diagram
-
i.e. but-3-enyl diphosphate
-
-
?
geranyl diphosphate + 3-ethylbut-3-enyl diphosphate
diphosphate + 3-ethylfarnesyl diphosphate
show the reaction diagram
-
-
-
-
?
geranyl diphosphate + 3-propylbut-3-enyl diphosphate
diphosphate 3-propylfarnesyl diphosphate
show the reaction diagram
-
-
-
-
?
geranyl diphosphate + dimethylallyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
-
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
the enzyme also performs the synthesis of farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, reaction of EC 2.5.1.10. The enzyme prefers farnesyl diphosphate over other allylic substrates for coupling with IPP, it behaves like a type-III geranylgeranyl diphosphate synthase. Ligand binding strutcure, overview
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2E,6E)-farnesyl diphosphate
show the reaction diagram
geranyl diphosphate + isopentenyl diphosphate
diphosphate + trans,trans-farnesyl diphosphate
show the reaction diagram
trans,trans-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
trans-3-methyl-2-octenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
similar activity as with dimethylallyl diphosphate
-
-
?
trans-3-methyl-2-pentenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
33% of activity with dimethylallyl diphosphate
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
Q9V305
-
-
-
?
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + 3 diphosphate
show the reaction diagram
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
Q9V305
-
-
-
?
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + 2 diphosphate
show the reaction diagram
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
geranyl diphosphate + isopentenyl diphosphate
diphosphate + trans,trans-farnesyl diphosphate
show the reaction diagram
Q76CZ2
bifunctional enzyme EC2.5.1.29/EC2.5.1.10, the FPP/GGPP product ratio increases with the rise of the reaction temperature. The enzyme contributes to adjust the membrane composition to the cell growth temperature modulating its substrate and product specificities
-
-
?
trans,trans-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
about 10% of the activity with Mg2+
Co2+
-
activates, less effective than Mg2+
Cu2+
about 5% of the activity with Mg2+
MgCl2
-
Km value 0.51 mM for isoform GGPPS1, 0.19 mM for isoform GGPPS2
additional information
-
monovalent cations at low concentrations, i.e. 50 mM, enhance activity, at high concentrations, i.e. 400 mM, they are inhibitory, except for K+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
((((6E,11E)-9-((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraen-9-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
-
-
((((E)-1((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pialoxy)methoxy)phosphoryl)-4,8-dimethylnona-3,7-dien-1-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
-
-
((((E)-2-((((R)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-5,9-dimethyldeca-4,8-dien-2-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
-
-
((((E)-2-((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-5,9-dimethyldeca-4,8-dien-2-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
-
-
((((E)-4-((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-7,11-dimethyldodeca-1,6,10-trien-4-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
-
-
((((E)-5-((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-2,8,12-trimethyltrideca-2,7,11-trien-5-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
-
-
(2-[1-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-1,2,3-triazol-4-yl]ethane-1,1-diyl)bis(phosphonic acid)
-
a mixture of olefin isomers
(2-[1-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-1H-1,2,3-triazol-4-yl]ethane-1,1-diyl)bis(phosphonic acid)
-
identification of a potent triazole bisphosphonate inhibitor of geranylgeranyl diphosphate synthase with very good selectivity for this enzyme over farnesyl diphosphate synthase. This compound also potently disrupts geranylgeranylation and induces cytotoxicity in human myeloma cells at submicromolar levels, suggesting that it may serve as a lead compound for treatment of malignancies characterized by excessive protein secretion
(2E,6E)-farnesyl diphosphate
the enzyme shows substrate inhibition by its FPP substrate at low IPP concentration, suggesting the existence of a mechanism that may regulate intracellular FPP pools
(2E,6E)-farnesyl-bis(phosphonic acid)
-
both inhibition of in vitro reaction as well as of cellular geranylgeranylation
(2E,6E)-farnesyl-geranyl-bis(phosphonic acid)
-
both inhibition of in vitro reaction as well as of cellular geranylgeranylation
(2E,6Z)-farnesyl-bis(phosphonic acid)
-
both inhibition of in vitro reaction as well as of cellular geranylgeranylation
(3E,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
-
-
(3Z,7E)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
-
-
(3Z,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
-
-
(6Z,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate
-
-
(6Z,11Z)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate
-
-
(E)-(2-(1-((3-methyl-3-(4-methylpent-3-en-1-yl)oxiran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)ethane-1,1-diyl)bis(phosphonate)
-
-
-
(E)-(2-(1-(3,7-dimethylocta-2,6-dien-1-yl)-1H-1,2,3-triazol-4-yl)ethane-1,1-diyl)bis(phosphonate)
-
-
(E)-dimethyl (4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
-
-
(E)-methyl (4,8-dimethylnona-3,7-dien-1-yl)phosphonochloridate
-
-
-
(E,E,E)-geranylgeranyl diphosphate
(R)-3,7-dimethyloct-6-en-1-yl methyl ((E)-1-(dimethoxyphosphoryl)-4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
-
-
(R)-3,7-dimethyloct-6-en-1-yl methyl ((E)-2-(dimethoxyphosphoryl)-5,9-dimethyldeca-4,8-dien-2-yl)phosphonate
-
-
-
(R)-3,7-dimethyloct-6-en-1-yl methyl ((E)-4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
-
-
(S)-3,7-dimethyloct-6-en-1-yl methyl ((6E,11E)-9-(dimethoxyphosphoryl)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraen-9-yl)phosphonate
-
-
-
(S)-3,7-dimethyloct-6-en-1-yl methyl ((E)-1-(dimethoxyphosphoryl)-4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
-
-
(S)-3,7-dimethyloct-6-en-1-yl methyl ((E)-2-(dimethoxyphosphoryl)-5,9-dimethyldeca-4,8-dien-2-yl)phosphonate
-
-
-
(S)-3,7-dimethyloct-6-en-1-yl methyl ((E)-4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
-
-
(S)-3,7-dimethyloct-6-en-1-yl methyl ((E)-4-(dimethoxyphosphoryl)-7,11-dimethyldeca-1,6,10-trien-4-yl)phosphonate
-
-
-
(S)-3,7-dimethyloct-6-en-1-yl methyl ((E)-5-(dimethoxyphosphoryl)-2,8,12-trimethyltrideca-2,7,11-trien-5-yl)phosphonate
-
-
-
(Z)-(2-(1-((3-methyl-3-(4-methylpent-3-en-1-yl)oxiran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)ethane-1,1-diyl)bis(phosphonate)digeranyl bisphosphonate
-
cell treatment with inhibitor DGBP results in the accumulation of unmodified Rap1a and Rab6
-
(Z)-(2-(1-(3,7-dimethylocta-2,6-dien-1-yl)-1H-1,2,3-triazol-4-yl)ethane-1,1-diyl)bis(phosphonate)
-
-
-
(Z)-2,8,12-trimethyltrideca-2,7,11-triene-5,5-diyldiphosphonate
-
-
(Z,E,E)-Geranylgeranyl diphosphate
1-hydroxydecane-1,1-bisphosphonate
-
IC50: 720 nM
3-azafarnesyl diphosphate
-
0.00074 mM, 50% inhibition
3-azageranyl diphosphate
-
0.24 mM, 50% inhibition
3-azageranylgeranyl diphosphate
3-azahomofarnesyl diphosphate
-
0.00031 mM, 50% inhibition
3-azahomogeranylgeranyl diphosphate
-
0.00037 mM, 50% inhibition
4-[(5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
-
a dual prenyl transferase inhibitor that has advanced to clinical trials
Aminophenylethyl diphosphate
-
-
bis[(6E)-2,6-dimethylnona-2,6-diene-9,9-diyl]bis(phosphonic acid)
-
both inhibition of in vitro reaction as well as of cellular geranylgeranylation
digeranyl bisphosphonate
diphosphate
EDTA
-
-
ETA
complete inhibition
-
farnesyl diphosphate
geranylgeranyl diphosphate
homorisedronate
-
i.e. NE58051, 0.41 mM, 50% inhibition
ibandronate
K+
-
inhibitory at 50-400 mM
Li+
-
400 mM, 72% inhibition, slight activation at 50 mM
Mn2+
required, activates up to 5 mM, inhibitory above 5 mM
N-([5-[(1H-imidazol-4-ylmethyl)amino]-2'-methylbiphenyl-2-yl]carbonyl)-L-leucine
-
-
N-[methyl(4-phenylbutyl)]-3-aminopropyl-1-hydroxy-1,1-bisphosphonate
-
the bisphosphonate binds only to the GGPP product inhibitory site
NH4+
-
20 mM, 20% inhibition
nitrogen-containing bisphosphonates
-
nitrogeneous biphosphonates
-
-
-
p-chloromercuribenzoate
-
1 mM, 90% inhibition, 30% inhibition in the presence of 800 mM KCl
pamidronate
risedronate
Triton X-100
-
stimulates farnesyl-transferring activity, inhibits dimethylallyl-transferring activity
zoledronate
[(6E)-2,6-dimethyl-10-[1-(4-methylpent-3-en-1-yl)-1H-1,2,3-triazol-4-yl]deca-2,6-diene-9,9-diyl]bis(phosphonic acid)
-
-
[(6E,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyl]bis(phosphonic acid)
-
-
[1-hydroxy-2-(1,1':4',1''-terphenyl-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
-
-
[1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid
-
a nitrogen-containing bisphosphonate
[1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
-
-
[2-[1-(4-methylpent-3-en-1-yl)-1H-1,2,3-triazol-4-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NH4+
-
50 mM, enhances activity approx. 13fold
octyl glucoside
Triton X-100
Tween 20
-
at 0.2%
Tween 80
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00061 - 0.0467
(2E,6E)-farnesyl diphosphate
0.0014 - 0.0044
(E,E)-farnesyl diphosphate
0.00095 - 0.39
dimethylallyl diphosphate
0.0005 - 0.121
farnesyl diphosphate
0.00072 - 0.022
geranyl diphosphate
0.0003 - 0.267
isopentenyl diphosphate
0.0034 - 0.035
Mg2+
0.0004 - 0.055
trans,trans-farnesyl diphosphate
additional information
additional information
-