Information on EC 2.5.1.29 - geranylgeranyl diphosphate synthase

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The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria

EC NUMBER
COMMENTARY hide
2.5.1.29
-
RECOMMENDED NAME
GeneOntology No.
geranylgeranyl diphosphate synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alkenyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
-
-
Biosynthesis of secondary metabolites
-
-
brassicicene C biosynthesis
-
-
fusicoccin A biosynthesis
-
-
geranylgeranyl diphosphate biosynthesis
-
-
isoprenoid biosynthesis
-
-
Metabolic pathways
-
-
methyl phomopsenoate biosynthesis
-
-
ophiobolin F biosynthesis
-
-
paspaline biosynthesis
-
-
plaunotol biosynthesis
-
-
stellatic acid biosynthesis
-
-
Terpenoid backbone biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase
Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-58-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
ssp. creticus
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
MF730-N6
-
-
Manually annotated by BRENDA team
MF730-N6
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GGS1
UniProt
Manually annotated by BRENDA team
Methanothermobacter thermautotrophicum
SF-4
-
-
Manually annotated by BRENDA team
Methanothermobacter thermautotrophicum SF-4
SF-4
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
bifunctional geranyl diphosphate synthase and geranylgeranyl diphosphate synthase
UniProt
Manually annotated by BRENDA team
gene PVX_092040
-
-
Manually annotated by BRENDA team
two populations collected in Japan, gene RsGGPPS
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
HB8
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Vitis vinifera x Vitis riparia
-
-
-
Manually annotated by BRENDA team
Vitis vinifera x Vitis vinifera
-
-
-
Manually annotated by BRENDA team
a basidiomycetous yeast, the sexual state of Phaffia rhodozyma, gene crtE
-
-
Manually annotated by BRENDA team
Xanthophyllomyces dendrorhous CBS6938, ATCC96594
a basidiomycetous yeast, the sexual state of Phaffia rhodozyma, gene crtE
-
-
Manually annotated by BRENDA team
cv. B73
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
-
depletion of geranylgeranyl diphosphate by inhibitor statins leads to accumulation of farnesyl diphosphate, which activates nuclear hormone receptors stimulating osteoblast differentiation and bone formation. Statins directly inhibit HMG-CoA reductase, the first step of the isoprenoid biosynthesis pathway
metabolism
physiological function
additional information
GGPPS gene can be a good model to study the regulatory mechanisms controlling phorbol esters accumulation at the transcriptional level
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E)-3,7-dimethyl-2-octenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
62% of activity with geranyl diphosphate
-
-
?
(2E)-3-methyl-2,6-heptadienyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
24% of activity with geranyl diphosphate
-
-
?
(2E)-3-methyl-2-butenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
21.5% of activity with geranyl diphosphate
-
-
?
(2E)-3-methyl-2-hexenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
95% of activity with geranyl diphosphate
-
-
?
(2E)-3-methyl-2-pentenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
63% of activity with geranyl diphosphate
-
-
?
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
(E)-3-methyl-2-dodecenyl diphosphate + isopentenyl diphosphate
(2E,5E)-3,6-dimethylpentadeca-2,5-dien-1-yl diphosphate + diphosphate
show the reaction diagram
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
3,8-dimethyl-2-nonenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
59% of activity with dimethylallyl diphosphate
-
-
?
3-methyl-2-alkenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
a number of 3-methyl-2-alkenyl diphosphates ranging in carbon number from 6 to 13 act as substrates
-
-
?
6,7-dihydrogeranyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
87% of activity with dimethylallyl diphosphate
-
-
?
8,8'-bisnorgeranyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
107% of activity with dimethylallyl diphosphate
-
-
?
cis-3-methyl-2-hexenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
cyclopentylideneethyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
dimethylallyl diphosphate + 3 isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
-
geranyl diphosphate activity of enzyme leads to additional production of geranyl diphosphate. The ratio of geranyl diphosphate to geranylgeranyl diphosphate produced averages approximately 9:1. No synthesis of farnesyl diphosphate
-
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + 3 diphosphate
show the reaction diagram
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
dimethylallyl diphosphate + isopentenyl diphosphate
? + diphosphate
show the reaction diagram
bifunctional enzyme EC2.5.1.29/EC2.5.1.10, the FPP/GGPP product ratio increases with the rise of the reaction temperature
-
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
geranyl diphosphate + farnesyl diphosphate + geranylgeranyl diphosphate + diphosphate
show the reaction diagram
large subunit alone
-
-
?
E-3-methyl-2-undecenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
53% of the activity with farnesyl diphosphate
-
-
?
farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
-
-
-
?
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + 2 diphosphate
show the reaction diagram
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
geranyl diphosphate + dimethylallyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
-
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + trans,trans-farnesyl diphosphate
show the reaction diagram
trans,trans-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
trans-3-methyl-2-octenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
similar activity as with dimethylallyl diphosphate
-
-
?
trans-3-methyl-2-pentenyl diphosphate + isopentenyl diphosphate
?
show the reaction diagram
-
33% of activity with dimethylallyl diphosphate
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
Q9V305
-
-
-
?
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + 3 diphosphate
show the reaction diagram
dimethylallyl diphosphate + 3 isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
Q9V305
-
-
-
?
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + 2 diphosphate
show the reaction diagram
geranyl diphosphate + 2 isopentenyl diphosphate
geranylgeranyl diphosphate + diphosphate
show the reaction diagram
geranyl diphosphate + isopentenyl diphosphate
diphosphate + trans,trans-farnesyl diphosphate
show the reaction diagram
Q76CZ2
bifunctional enzyme EC2.5.1.29/EC2.5.1.10, the FPP/GGPP product ratio increases with the rise of the reaction temperature. The enzyme contributes to adjust the membrane composition to the cell growth temperature modulating its substrate and product specificities
-
-
?
trans,trans-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + geranylgeranyl diphosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
activates, less effective than Mg2+
MgCl2
-
Km value 0.51 mM for isoform GGPPS1, 0.19 mM for isoform GGPPS2
additional information
Methanothermobacter thermautotrophicum
-
monovalent cations at low concentrations, i.e. 50 mM, enhance activity, at high concentrations, i.e. 400 mM, they are inhibitory, except for K+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E,6E)-farnesyl-bis(phosphonic acid)
-
both inhibition of in vitro reaction as well as of cellular geranylgeranylation
(2E,6E)-farnesyl-geranyl-bis(phosphonic acid)
-
both inhibition of in vitro reaction as well as of cellular geranylgeranylation
(2E,6Z)-farnesyl-bis(phosphonic acid)
-
both inhibition of in vitro reaction as well as of cellular geranylgeranylation
(3E,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
-
-
(3Z,7E)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
-
-
(3Z,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
-
-
(6Z,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate
-
-
(6Z,11Z)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate
-
-
(E,E,E)-geranylgeranyl diphosphate
(Z)-2,8,12-trimethyltrideca-2,7,11-triene-5,5-diyldiphosphonate
-
-
(Z,E,E)-Geranylgeranyl diphosphate
1-hydroxydecane-1,1-bisphosphonate
-
IC50: 720 nM
3-azafarnesyl diphosphate
-
0.00074 mM, 50% inhibition
3-azageranyl diphosphate
-
0.24 mM, 50% inhibition
3-azageranylgeranyl diphosphate
3-azahomofarnesyl diphosphate
-
0.00031 mM, 50% inhibition
3-azahomogeranylgeranyl diphosphate
-
0.00037 mM, 50% inhibition
4-[(5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
-
a dual prenyl transferase inhibitor that has advanced to clinical trials
Aminophenylethyl diphosphate
-
-
bis[(6E)-2,6-dimethylnona-2,6-diene-9,9-diyl]bis(phosphonic acid)
-
both inhibition of in vitro reaction as well as of cellular geranylgeranylation
digeranyl bisphosphonate
diphosphate
EDTA
-
-
farnesyl diphosphate
geranylgeranyl diphosphate
homorisedronate
-
i.e. NE58051, 0.41 mM, 50% inhibition
ibandronate
Li+
Methanothermobacter thermautotrophicum
-
400 mM, 72% inhibition, slight activation at 50 mM
N-([5-[(1H-imidazol-4-ylmethyl)amino]-2'-methylbiphenyl-2-yl]carbonyl)-L-leucine
-
-
N-[methyl(4-phenylbutyl)]-3-aminopropyl-1-hydroxy-1,1-bisphosphonate
-
the bisphosphonate binds only to the GGPP product inhibitory site
NH4+
-
20 mM, 20% inhibition
nitrogen-containing bisphosphonates
nitrogeneous biphosphonates
-
-
-
p-chloromercuribenzoate
Methanothermobacter thermautotrophicum
-
1 mM, 90% inhibition, 30% inhibition in the presence of 800 mM KCl
pamidronate
-
0.18 mM, 50% inhibition
risedronate
SDS
Methanothermobacter thermautotrophicum
-
1%, 97% inhibition
Triton X-100
-
stimulates farnesyl-transferring activity, inhibits dimethylallyl-transferring activity
zoledronate
[(6E,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyl]bis(phosphonic acid)
-
-
[1-hydroxy-2-(1,1':4',1''-terphenyl-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
-
-
[1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid
-
a nitrogen-containing bisphosphonate
[1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
-
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NH4+
Methanothermobacter thermautotrophicum
-
50 mM, enhances activity approx. 13fold
octyl glucoside
Triton X-100
Tween 20
-
at 0.2%
Tween 80
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0018 - 0.0073
(2E,6E)-farnesyl diphosphate
0.0014 - 0.0044
(E,E)-farnesyl diphosphate
0.00095 - 0.39
dimethylallyl diphosphate
0.0005 - 0.121
farnesyl diphosphate
0.00072 - 0.022
geranyl diphosphate
0.0003 - 0.267
isopentenyl diphosphate
0.0034 - 0.035
Mg2+
0.0004 - 0.055
trans,trans-farnesyl diphosphate
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.8
(2E,6E)-farnesyl diphosphate
Plasmodium vivax
-
pH 7.7, 37C, recombinant PvGGPPS
0.000042 - 0.025
(E,E)-farnesyl diphosphate
0.5 - 1.4
dimethylallyl diphosphate
3.3
farnesyl diphosphate
Taxus canadensis
-
-
0.5 - 2.1
geranyl diphosphate
0.8
isopentenyl diphosphate
Plasmodium vivax
-
pH 7.7, 37C, recombinant PvGGPPS
0.204 - 8.4
trans,trans-farnesyl diphosphate
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
100
(2E,6E)-farnesyl diphosphate
Plasmodium vivax
-
pH 7.7, 37C, recombinant PvGGPPS
81
200
dimethylallyl diphosphate
Plasmodium vivax
-
pH 7.7, 37C, recombinant PvGGPPS
157
300
geranyl diphosphate
Plasmodium vivax
-
pH 7.7, 37C, recombinant PvGGPPS
175
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0012
(E,E,E)-geranylgeranyl diphosphate
0.025
geranylgeranyl diphosphate
-
pH 7.7, 37C, recombinant enzyme, versus trans,trans-farnesyl diphosphate
0.000016
ibandronate
-
pH 7.7, 37C, recombinant PvGGPPS
0.0000107
zoledronate
-
pH 7.7, 37C, recombinant PvGGPPS
0.0000124
[1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid
-
pH 7.7, 37C, recombinant PvGGPPS
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0001
(2E,6E)-farnesyl-bis(phosphonic acid)
Homo sapiens
-
pH 7.5, 37C
0.0003
(2E,6E)-farnesyl-geranyl-bis(phosphonic acid)
Homo sapiens
-
pH 7.5, 37C
0.0006
(2E,6Z)-farnesyl-bis(phosphonic acid)
0.04
(3Z,7E)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
Homo sapiens
-
-
0.07
(3Z,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
Homo sapiens
-
-
0.006
(6Z,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate
Homo sapiens
-
-
0.003
(6Z,11Z)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate
Homo sapiens
-
-
0.007
(Z)-2,8,12-trimethyltrideca-2,7,11-triene-5,5-diyldiphosphonate
Homo sapiens
-
-
0.00072
1-hydroxydecane-1,1-bisphosphonate
Homo sapiens
-
IC50: 720 nM
0.0002
bis[(6E)-2,6-dimethylnona-2,6-diene-9,9-diyl]bis(phosphonic acid)
0.0000619
ibandronate
Plasmodium vivax
-
pH 7.7, 37C, recombinant PvGGPPS
0.000074
risedronate
Toxoplasma gondii
Q197X6
-
0.0000433 - 0.1
zoledronate
0.0000475
[1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid
Plasmodium vivax
-
pH 7.7, 37C, recombinant PvGGPPS
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000279
-
-
0.000176
-
carboxy-terminal deletion mutant DELTA-8
0.00461
-
-
0.0087
pH and temperature not specified in the publication
0.017
-
-
0.0306
-
carboxy-terminal deletion mutant DELTA-8
0.098
-
-
0.0983
-
carboxy-terminal deletion mutant DELTA-4
0.117
-
wild-type enzyme
0.123
recombinant enzyme
0.133
-
purified recombinant enzyme
0.14
Methanothermobacter thermautotrophicum
-
with farnesyl diphosphate
0.289
Methanothermobacter thermautotrophicum
-
with geranyl diphosphate
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.9 - 7.2
-
-
8 - 9
recombinant enzyme
8
assay at; assay at
8.2
Methanothermobacter thermautotrophicum
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5 - 10.5
activity range
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60
Methanothermobacter thermautotrophicum
-
assay at
65
Methanothermobacter thermautotrophicum
-
-
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30 - 72
Methanothermobacter thermautotrophicum
-
approx. 30% of maximal activity at 30C, approx. 80% of maximal activity at 72C
37
the enzyme maintains significant activity at 37C
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
of sapling
Manually annotated by BRENDA team
epidermal secretory cells; epidermal secretory cells; epidermal secretory cells; of the frontal gland; of the frontal gland; of the frontal gland
Manually annotated by BRENDA team
expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
expression level of 1a-type mRNA, encoding the active enzyme form is the same as that of 1b-type mRNA, encoding an inactive enzyme form. During testis development the total GGPS mRNSA expression level increases, accompanied by an increase in 1 n-type mRNA, the expression level pf 1a-type mRNA remains kept unchanges
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
-
myeloma cell line
Manually annotated by BRENDA team
expression is restricted to wood and bark
Manually annotated by BRENDA team
expression level of 1a-type mRNA, encoding the active enzyme form is the same as that of 1b-type mRNA, encoding an inactive enzyme form
Manually annotated by BRENDA team
expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form
Manually annotated by BRENDA team
of sapling
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
isform PaxG
Manually annotated by BRENDA team
additional information
-
enzyme seems to be membrane associated
-
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
39000
Methanothermobacter thermautotrophicum
-
native PAGE
66000
-
gel filtration
70000
-
gel filtration
72000
-
gel filtration
76000
-
gel filtration
78000
Methanothermobacter thermautotrophicum
-
gel filtration
130000
-
tetramer, non-denaturing PAGE
150000
-
Superose 12, gel filtration
190000
-
Superdex 200, gel filtration
200000
-
about, gel filtration
240000
-
octamer, non-denaturing PAGE
300000
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexamer
-
three dimers join together to form a propeller-bladed hexameric molecule, quaternary structure, overview
octamer
-
the active form of GGPS in the solution is an octamer (comprising of four dimers) rather than hexamer or dimer
tetramer
-
enzyme forms a heterotetramer of two catalytic large plus two regulatory small subunits, crystallization data.
additional information