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Information on EC 2.5.1.18 - glutathione transferase and Organism(s) Ascaris suum and UniProt Accession P46436

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IUBMB Comments
A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
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This record set is specific for:
Ascaris suum
UNIPROT: P46436
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The taxonomic range for the selected organisms is: Ascaris suum
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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RX
+
glutathione
=
HX
+
R-S-glutathione
+
=
+
Synonyms
gst, glutathione s-transferase, gstm1, gstp1, gstt1, glutathione-s-transferase, glutathione transferase, gsta1, gst pi, gstm3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glutathione S-transferase
-
glutathione S-alkyl transferase
-
-
-
-
glutathione S-aralkyltransferase
-
-
-
-
glutathione S-aryltransferase
-
-
-
-
glutathione S-transferase
-
-
-
-
glutathione S-transferase X
-
-
-
-
GSH S-transferase
-
-
-
-
GSHTase-P
-
-
-
-
S-(hydroxyalkyl)glutathione lyase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aryl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
RX:glutathione R-transferase
A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
CAS REGISTRY NUMBER
COMMENTARY hide
50812-37-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
show the reaction diagram
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + hexa-2,4-dienal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid
-
albendazole
-
bilirubin
-
bithionol
-
Bromosulphthalein
-
Hexachlorophene
-
protoporphyrin IX
-
Triphenyltin chloride
-
2,3,4,5-tetrahydroxy-6H-benzo[7]annulen-6-one
-
50% inhibition at 0.0052 mM
albendazole
-
50% inhibition at 0.52 mM
alizarin
-
50% inhibition at 0.0042 mM
bilirubin
-
50% inhibition at 0.009 mM
bithionol
-
50% inhibition at 0.0077 mM
bromosulfophthalein
-
50% inhibition at 0.001 mM
chalcone
-
50% inhibition at 0.045 mM
Cibacron blue
-
50% inhibition at 0.00009 mM
ellagic acid
-
50% inhibition at 0.0006 mM
Hexachlorophene
-
50% inhibition at 0.00034 mM
lithocholate
-
50% inhibition at 0.1 mM
protoporphyrin IX
-
50% inhibition at 0.03 mM
quercetin
-
50% inhibition at 0.0006 mM
Triphenyltin chloride
-
50% inhibition at 0.0003 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.67
1-chloro-2,4-dinitrobenzene
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.52
albendazole
Ascaris suum
-
0.009
bilirubin
Ascaris suum
-
0.0077
bithionol
Ascaris suum
-
0.001
Bromosulphthalein
Ascaris suum
-
0.00009
Cibacron blue 3GA
Ascaris suum
-
0.00034
Hexachlorophene
Ascaris suum
-
0.03
protoporphyrin IX
Ascaris suum
-
0.0003
Triphenyltin chloride
Ascaris suum
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.26
-
with ethacrynic acid as substrate
0.312
-
with cumene hydroperoxide as substrate
38.2
-
with 1,2-dichloro-4-nitrobenzene as substrate
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GST1_ASCSU
206
0
23585
Swiss-Prot
other Location (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant protein after expression in E. coli
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liebau, E.; Eckelt, V.H.O.; Wildenburg, G.; Teesdale-Spittle, P.; Brophy, P.M.; Walter, R.D.; Henkle-Duhrsen, K.
Structural and functional analysis of a glutathione S-transferase from Ascaris sum
Biochem. J.
324
659-666
1997
Ascaris suum
-
Manually annotated by BRENDA team
Torres-Rivera, A.; Landa, A.
Glutathione transferases from parasites: a biochemical view
Acta Trop.
105
99-112
2008
Homo sapiens, Echinococcus granulosus (O16058), Rattus norvegicus (P04905), Schistosoma mansoni (P15964), Mus musculus (P24472), Schistosoma japonicum (P26624), Onchocerca volvulus (P46427), Ascaris suum (P46436), Fasciola hepatica (P56598), Sus scrofa (P80031), Clonorchis sinensis (Q1L2C7), Taenia solium (Q3ZJN3), Ancylostoma caninum (Q6J1M5), Plasmodium yoelii (Q7REH6), Wuchereria bancrofti (Q86LL8), Plasmodium falciparum (Q8MU52)
Manually annotated by BRENDA team