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Information on EC 2.5.1.156 - geranylfarnesylglycerol-phosphate geranylfarnesyltransferase

for references in articles please use BRENDA:EC2.5.1.156
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EC Tree
IUBMB Comments
The enzyme, characterized from the archaeon Aeropyrum pernix, carries out the second prenyltransfer reaction involved in the formation of C25,C25 membrane diether-lipids in some archaea. Requires a divalent metal cation, such as Mg2+. The enzyme cannot accept sn-3-(O-geranylgeranyl)glycerol 1-phosphate as the prenyl donor. cf. EC 2.5.1.42, geranylgeranylglycerol-phosphate geranylgeranyltransferase.
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The expected taxonomic range for this enzyme is: Aeropyrum pernix
Reaction Schemes
+
sn-3-O-(farnesylgeranyl)glycerol 1-phosphate
=
2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate
+
Synonyms
2,3-bis-O-(farnesylgeranyl)-sn-glycerol 1-phosphate synthase, 2,3-di-O-farnesylgeranylglyceryl synthase, DGFGP synthase, digeranylfarnesylglyceryl phosphate synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
all-trans-pentaprenyl diphosphate + sn-3-O-(farnesylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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