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IUBMB CommentsThe enzyme, characterized from the thermophilic archaeon Hyperthermus butylicus, can also synthesize norspermine from norspermidine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.23, sym-norspermidine synthase and EC 2.5.1.126, norspermine synthase, this enzyme shows no activity with propane-1,3-diamine.
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S-adenosyl 3-(methylthio)propylamine:norspermine 3-aminopropyltransferase
The enzyme, characterized from the thermophilic archaeon Hyperthermus butylicus, can also synthesize norspermine from norspermidine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.23, sym-norspermidine synthase and EC 2.5.1.126, norspermine synthase, this enzyme shows no activity with propane-1,3-diamine.
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2 S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldoheptamine
S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldohexamine
S-adenosyl 3-(methylthio)propylamine + norspermidine
S-methyl-5'-thioadenosine + norspermine
S-adenosyl 3-(methylthio)propylamine + norspermine
S-methyl-5'-thioadenosine + caldopentamine
S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine
S-methyl-5'-thioadenosine + norspermidine
at 2% of the specific activity compared to norspermine
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-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + thermospermine + H+
2 S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldoheptamine
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-
-
?
2 S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldoheptamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
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-
?
2 S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldoheptamine
-
-
-
?
2 S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldoheptamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldohexamine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldohexamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldohexamine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldohexamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + norspermidine
S-methyl-5'-thioadenosine + norspermine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + norspermidine
S-methyl-5'-thioadenosine + norspermine
at 57% of the specific activity compared to norspermine
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-
?
S-adenosyl 3-(methylthio)propylamine + norspermidine
S-methyl-5'-thioadenosine + norspermine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + norspermine
S-methyl-5'-thioadenosine + caldopentamine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + norspermine
S-methyl-5'-thioadenosine + caldopentamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + thermospermine + H+
spermidine is not the most preferred substrate for any enzyme. Nevertheless, in vivo the enzyme can be responsible for the synthesis of thermospermine, if spermidine is present in a high concentration in competition to other accepted polyamines
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-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + thermospermine + H+
at 16% of the specific activity compared to norspermine
-
-
?
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2 S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldoheptamine
S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldohexamine
S-adenosyl 3-(methylthio)propylamine + norspermidine
S-methyl-5'-thioadenosine + norspermine
S-adenosyl 3-(methylthio)propylamine + norspermine
S-methyl-5'-thioadenosine + caldopentamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + thermospermine + H+
spermidine is not the most preferred substrate for any enzyme. Nevertheless, in vivo the enzyme can be responsible for the synthesis of thermospermine, if spermidine is present in a high concentration in competition to other accepted polyamines
-
-
?
2 S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldoheptamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
2 S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldoheptamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldohexamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldohexamine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + norspermidine
S-methyl-5'-thioadenosine + norspermine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + norspermidine
S-methyl-5'-thioadenosine + norspermine
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
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2.5.1.127 caldopentamine synthase
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