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Disease on EC 2.4.99.2 - beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
(n-acetylneuraminyl)-galactosylglucosylceramide n-acetylgalactosaminyltransferase deficiency
GM3 synthase deficiency due to ST3GAL5 variants in two Korean female siblings: Masquerading as Rett syndrome-like phenotype.
ST3GAL5-Related Disorders: A Deficiency in Ganglioside Metabolism and a Genetic Cause of Intellectual Disability and Choreoathetosis.
Adenocarcinoma
Knockdown of ?2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion.
alpha-n-acetylgalactosaminide alpha-2,6-sialyltransferase deficiency
Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.
Atherosclerosis
Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity.
beta-d-galactosyl-(1->3)-n-acetyl-beta-d-galactosaminide alpha-2,3-sialyltransferase deficiency
Diseases of ganglioside biosynthesis: An expanding group of congenital disorders of glycosylation.
Enhanced Susceptibility to Chemoconvulsant-Induced Seizures in Ganglioside GM3 Synthase Knockout Mice.
Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.
The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development.
Breast Neoplasms
An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
Cyclooxygenase-2 enzyme induces the expression of the ?-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.
Cyclooxygenase-2 induces the expression of the alpha 2,3 sialyltransferase-3 (ST3Gal-I) in breast cancer.
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer.
O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR.
Over-expression of ST3Gal-I promotes mammary tumorigenesis.
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells.
Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
Sialylation of vasorin by ST3Gal1 facilitates TGF-?1-mediated tumor angiogenesis and progression.
The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.
Carcinogenesis
Analysis of differentially expressed genes in human rectal carcinoma using suppression subtractive hybridization.
Development of Monoclonal Antibodies against CMP-N-Acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3Gal-I) Recombinant Protein Expressed in E. coli.
Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.
Over-expression of ST3Gal-I promotes mammary tumorigenesis.
Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
Carcinoma
"Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".
Altered mRNA expressions of sialyltransferases in ovarian cancers.
Apoptosis of human breast carcinoma cells in the presence of cis-platin and L-/D-PPMP: IV. Modulation of replication complexes and glycolipid: Glycosyltransferases.
Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line.
Cloning and expression of SAT-3 involved in SA-Le(x) biosynthesis: inhibition studies with polyclonal antibody against GST-SAT-3 fusion protein.
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer.
Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4.
MiR-193a-3p and miR-224 mediate renal cell carcinoma progression by targeting alpha-2,3-sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway.
Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-Sialyltransferase is related to poor patient survival in human colorectal carcinomas.
Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-?1-induced EMT and confers paclitaxel resistance in ovarian cancer.
TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX.
Carcinoma, Basal Cell
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Carcinoma, Hepatocellular
High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma.
MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5.
Overexpression of ST3Gal-I promotes migration and invasion of HCCLM3 in vitro and poor prognosis in human hepatocellular carcinoma.
Carcinoma, Renal Cell
MiR-193a-3p and miR-224 mediate renal cell carcinoma progression by targeting alpha-2,3-sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway.
The lncRNA MEG3 mediates renal cell cancer progression by regulating ST3Gal1 transcription and EGFR sialylation.
Carcinoma, Squamous Cell
Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis.
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Choriocarcinoma
Different enzyme activities of sialyltransferases in gynecological cancer cell lines.
Congenital Disorders of Glycosylation
Diseases of ganglioside biosynthesis: An expanding group of congenital disorders of glycosylation.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Diseases of ganglioside biosynthesis: An expanding group of congenital disorders of glycosylation.
Total loss of GM3 synthase activity by a normally processed enzyme in a novel variant and in all ST3GAL5 variants reported to cause a distinct congenital disorder of glycosylation.
Endometrial Neoplasms
Different enzyme activities of sialyltransferases in gynecological cancer cell lines.
Epilepsy
Congenital Disorders of Glycosylation from a Neurological Perspective.
Gangliosides of the Vertebrate Nervous System.
Glioblastoma
ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis.
Graves Ophthalmopathy
Identification and Functional Characterization of ST3GAL5 and ST8SIA1 Variants in Patients with Thyroid-Associated Ophthalmopathy.
Heart Failure
Aberrant sialylation causes dilated cardiomyopathy and stress-induced heart failure.
HIV Infections
Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line.
Hypersensitivity
Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites.
Hypertension
Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity.
Infections
Inhibition of ganglioside GD1a synthesis suppresses the differentiation of human mesenchymal stem cells into osteoblasts.
Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase.
Reactive oxygen species-mediated endoplasmic reticulum stress response induces apoptosis of Mycobacterium avium-infected macrophages by activating regulated IRE1-dependent decay pathway.
Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis.
The function annotations of ST3GAL4 in human LAMP1 and Lassa virus GP-C interaction from the perspective of systems virology.
The glycosyltransferase ST3GAL2 is regulated by miR-615-3p in the intestinal tract of Campylobacter jejuni infected mice.
The glycosyltransferase ST3GAL2 modulates virus proliferation and the inflammation response in porcine reproductive and respiratory syndrome virus infection.
Influenza in Birds
Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase.
Influenza, Human
Analyses of chicken sialyltransferases related to O-glycosylation.
CMAS and ST3GAL4 Play an Important Role in the Adsorption of Influenza Virus by Affecting the Synthesis of Sialic Acid Receptors.
Sia?2-3Gal?1- Receptor Genetic Variants Are Associated with Influenza A(H1N1)pdm09 Severity.
Insulin Resistance
Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.
Intellectual Disability
Congenital Disorders of Ganglioside Biosynthesis.
Keratoacanthoma
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Keratosis, Actinic
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Leukemia, Erythroblastic, Acute
Selective Exo-Enzymatic Labeling Detects Increased Cell Surface Sialoglycoprotein Expression upon Megakaryocytic Differentiation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1.
Leukemia, Myeloid, Acute
Effect of ST3GAL 4 and FUT 7 on sialyl Lewis X synthesis and multidrug resistance in human acute myeloid leukemia.
Liver Neoplasms
Overexpression of ST3Gal-I promotes migration and invasion of HCCLM3 in vitro and poor prognosis in human hepatocellular carcinoma.
Lung Neoplasms
Modification of ?2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
Melanoma
Microarray analysis of differentially expressed genes regulating lipid metabolism during melanoma progression.
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
The plasma exosomal miR-1180-3p serves as a novel potential diagnostic marker for cutaneous melanoma.
Mouth Neoplasms
"Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".
Multiple Myeloma
Targeting Selectins and Their Ligands in Cancer.
Neoplasm Metastasis
"Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".
A Novel Function of CD82/KAI1 in Sialyl Lewis Antigen-Mediated Adhesion of Cancer Cells: Evidence for an Anti-Metastasis Effect by Down-Regulation of Sialyl Lewis Antigens.
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Knockdown of ?2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion.
Overexpression of ST3Gal-I promotes migration and invasion of HCCLM3 in vitro and poor prognosis in human hepatocellular carcinoma.
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
Neoplasms
A Novel Function of CD82/KAI1 in Sialyl Lewis Antigen-Mediated Adhesion of Cancer Cells: Evidence for an Anti-Metastasis Effect by Down-Regulation of Sialyl Lewis Antigens.
Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1.
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
Characterization of Cancer Associated Mucin Type O-Glycans Using the Exchange Sialylation Properties of Mammalian Sialyltransferase ST3Gal-II.
Correlation between Heterogeneous Expression of Sialyltransferases and MUC16 in Ovarian Tumor Tissues.
Cyclooxygenase-2 enzyme induces the expression of the ?-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.
Cyclooxygenase-2 induces the expression of the alpha 2,3 sialyltransferase-3 (ST3Gal-I) in breast cancer.
Development of Monoclonal Antibodies against CMP-N-Acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3Gal-I) Recombinant Protein Expressed in E. coli.
Different enzyme activities of sialyltransferases in gynecological cancer cell lines.
Downregulation of ST3GAL5 is associated with muscle invasion, high grade and a poor prognosis in patients with bladder cancer.
Expression analysis of ST3GAL4 transcripts in cervical cancer cells.
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions.
Glyco-genes change expression in cancer through aberrant methylation.
Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer.
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates.
Over-expression of ST3Gal-I promotes mammary tumorigenesis.
Overexpression of ST3Gal-I promotes migration and invasion of HCCLM3 in vitro and poor prognosis in human hepatocellular carcinoma.
Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1.
Potential targets identified in adenoid cystic carcinoma point out new directions for further research.
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells.
Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9.
Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
Sialylation of vasorin by ST3Gal1 facilitates TGF-?1-mediated tumor angiogenesis and progression.
Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-?1-induced EMT and confers paclitaxel resistance in ovarian cancer.
Soyasaponin-I-modified invasive behavior of cancer by changing cell surface sialic acids.
ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis.
Targeting Selectins and Their Ligands in Cancer.
The expression and functional analysis of the sialyl-T antigen in prostate cancer.
The lncRNA MEG3 mediates renal cell cancer progression by regulating ST3Gal1 transcription and EGFR sialylation.
The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.
The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features.
TNF up-regulates ST3GAL4 and sialyl-Lewisx expression in lung epithelial cells through an intronic ATF2-responsive element.
Weighted gene correlation network analysis identifies the critical long non-coding RNAs participate in the progression of osteosarcoma.
Neurocutaneous Syndromes
A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation.
Newcastle Disease
alpha 2,3-Sialylation of terminal GalNAc beta 1-3Gal determinants by ST3Gal II reveals the multifunctionality of the enzyme. The resulting Neu5Ac alpha 2-3GalNAc linkage is resistant to sialidases from Newcastle disease virus and Streptococcus pneumoniae.
Obesity
Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.
The glycosyltransferase ST3GAL2 modulates virus proliferation and the inflammation response in porcine reproductive and respiratory syndrome virus infection.
Osteoarthritis
MiR-193b modulates osteoarthritis progression through targeting ST3GAL4 via sialylation of CD44 and NF-?B pathway.
Osteosarcoma
Weighted gene correlation network analysis identifies the critical long non-coding RNAs participate in the progression of osteosarcoma.
Ovarian Neoplasms
5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells.
Altered mRNA expressions of sialyltransferases in ovarian cancers.
Correlation between Heterogeneous Expression of Sialyltransferases and MUC16 in Ovarian Tumor Tissues.
Different enzyme activities of sialyltransferases in gynecological cancer cell lines.
Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-?1-induced EMT and confers paclitaxel resistance in ovarian cancer.
The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features.
Porcine Reproductive and Respiratory Syndrome
The glycosyltransferase ST3GAL2 modulates virus proliferation and the inflammation response in porcine reproductive and respiratory syndrome virus infection.
Pre-Eclampsia
Soluble angiotensin IV receptor levels in preeclampsia: is there a variation?
Pregnancy, Ectopic
Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy.
Prostatic Neoplasms
Androgen-regulated transcriptional control of sialyltransferases in prostate cancer cells.
Expression of gangliosides, GD1a and sialyl paragloboside, is regulated by NF-?B-dependent transcriptional control of ?2,3-sialyltransferase I, II and VI in human castration-resistant prostate cancer cells.
The expression and functional analysis of the sialyl-T antigen in prostate cancer.
Seizures
Congenital Disorders of Ganglioside Biosynthesis.
Differential expression of mRNAs for sialyltransferase isoenzymes induced in the hippocampus of mouse following kindled seizures.
Enhanced Susceptibility to Chemoconvulsant-Induced Seizures in Ganglioside GM3 Synthase Knockout Mice.
Spastic Paraplegia, Hereditary
Congenital Disorders of Ganglioside Biosynthesis.
Gangliosides of the Vertebrate Nervous System.
Stomach Neoplasms
Altered mRNA expressions of sialyltransferases in human gastric cancer tissues.
Analysis of the Effect of Increased ?2,3-Sialylation on RTK Activation in MKN45 Gastric Cancer Spheroids Treated with Crizotinib.
Diagnostic utility of glycosyltransferase mRNA expression in gastric cancer.
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
Thrombocytopenia
Immune cells surveil aberrantly sialylated O-glycans on megakaryocytes to regulate platelet count.
Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.
Thrombosis
Overexpression of ST3Gal-I promotes migration and invasion of HCCLM3 in vitro and poor prognosis in human hepatocellular carcinoma.
Urinary Bladder Neoplasms
Development of Monoclonal Antibodies against CMP-N-Acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3Gal-I) Recombinant Protein Expressed in E. coli.
Downregulation of ST3GAL5 is associated with muscle invasion, high grade and a poor prognosis in patients with bladder cancer.
Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1.
Uterine Cervical Neoplasms
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Different enzyme activities of sialyltransferases in gynecological cancer cell lines.
Expression analysis of ST3GAL4 transcripts in cervical cancer cells.
Promoter Polymorphisms of ST3GAL4 and ST6GAL1 Genes and Associations with Risk of Premalignant and Malignant Lesions of the Cervix.
Virus Diseases
Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase.
The glycosyltransferase ST3GAL2 modulates virus proliferation and the inflammation response in porcine reproductive and respiratory syndrome virus infection.