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CMP-9-acetamidoneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-9-acetamidoneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
less effective than CMP-N-acetylneuraminate
-
-
?
CMP-9-aminoacetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-9-aminoacetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-9-aminoacetylneuraminate can replace CMP-N-acetylneuraminate only with asialofetuin as acceptor
-
-
?
CMP-9-azido-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-9-azido-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-9-azido-N-acetylneuraminate can replace CMP-N-acetylneuraminate with asialofetuin or antifreeze glycoprotein as acceptor
-
-
?
CMP-9-benzamidoneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-9-benzamidoneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
less effective than CMP-N-acetylneuraminate
-
-
?
CMP-9-hexanoylamidoneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-9-hexanoylamidoneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
less effective than CMP-N-acetylneuraminate
-
-
?
CMP-9-O-acetyl-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-9-O-acetyl-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + N-acetyllactosamin-butyl
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + recombinant alpha-1-antitrypsin
CMP + ?
-
in addition to the expected alpha-2,6-sialylation of galactose, a second disialyl galactose motif Neu5Ac-alpha2,3(Neu5Ac-alpha2,6)Gal is produced by the enzyme activity
-
-
?
CMP-N-acetylneuraminate + antifreeze glycoprotein
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
CMP-N-acetylneuraminate + asialo-milk glycopeptide
CMP + milk glycopeptide
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-polysialoglycoprotein
CMP + alpha-sialosyl-(2-6)-asialo-polysialoglycoprotein
-
from egg, Sia residue is alpha-2,6-linked to the proximal GalNAc residue in asialo-polysialoglycoprotein, acceptor carbohydrate unit: Galbeta(1-3)GalNAcalpha(1-O)-Ser/Thr, but not GalNAc1 to O-Ser/Thr
-
?
CMP-N-acetylneuraminate + erythrocyte hemagglutination inhibitor
?
-
-
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)GalNAc-R
CMP + Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
CMP-N-acetylneuraminate + GalNAc-R
CMP + NeuAcalpha(2-6)GalNAc-R
CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
-
-
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
CMP-N-acetylneuraminate + GTTPSPVPT[GalNAc]TSTTSAP
CMP + GTTPSPVPT[Neu5Acalpha(2-6)GalNAc]TSTTSAP
hexadecaglycopeptide acceptor, corresponding to the MUC5AC tandem repeat sequence substituted by a GalNAc residue on Thr-9, hST6GalNAc-I
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
poor acceptor
-
?
CMP-N-acetylneuraminate + native fetuin
?
CMP-N-acetylneuraminate + native polysialoglycoprotein
?
-
from egg, almost identical amount of Neu5Ac is incorporated into native and asialo-polysialoglycoprotein acceptor, acceptor carbohydrate unit: Galbeta(1-3)GalNAcalpha(1-O)-Ser/Thr, but not GalNAc1 to O-Ser/Thr
-
-
?
CMP-N-acetylneuraminate + NeuAcalpha(2-3)Galbeta(1-3)GalNAc-R
CMP + NeuAcalpha(2-3)Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
CMP-N-acetylneuraminate + p-nitrophenyl-beta-D-galactoside
CMP + alpha-sialosyl-(2-6)-p-nitrophenyl-beta-D-galactoside
-
-
-
?
CMP-N-acetylneuraminate + protein MUC1-MFP6
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
CMP-N-acetylneuraminate + VPSTPPTPSPSTPPTPSPSCCHPR-GalNAc
CMP + ?
-
-
-
?
CMP-N-glycolylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-glycolylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
CMP-Neu5Ac + asialofetuin
CMP + ?
-
-
-
-
?
CMP-Neu5Ac + fetuin
CMP + ?
-
isoform ST6GalNAc-I, 84% of reactivity with asialofetuin, isoform ST6GalNAc-II, 88% of reactivity with asialofetuin
-
-
?
CMP-Neu5Ac + HIV 120gp (17-mer)
CMP + ?
-
isoform ST6GalNAc-I, 34% of reactivity with asialofetuin, isoform ST6GalNAc-II, 38% of reactivity with asialofetuin
-
-
?
CMP-Neu5Ac + HIV 120gp (21-mer)
CMP + ?
-
isoform ST6GalNAc-I, 62% of reactivity with asialofetuin, isoform ST6GalNAc-II, 58% of reactivity with asialofetuin
-
-
?
CMP-sialic acid-PEG4-biotin + desialyated bovine serum albumin
?
-
bacterially produced ST6 is active and capable of catalyzing the transfer of sialic acid onto a desialylated O-glycoprotein, bovine submaxillary mucin
-
-
?
cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin
CMP + ?
-
CMP-Neu9NSydCl
-
-
?
cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + butyl beta-N-acetyllactosaminide
CMP + ?
-
CMP-Neu9NSydCl
-
-
?
cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin
CMP + ?
-
CMP-Neu9Az
-
-
?
cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + N-acetyllactosamin-butyl
CMP + ?
-
CMP-Neu9Az
-
-
?
additional information
?
-
CMP-9-O-acetyl-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-9-O-acetyl-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
poor donor, 10% as effective as CMP-N-acetylneuraminate
-
-
?
CMP-9-O-acetyl-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-9-O-acetyl-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
poor donor, 10% as effective as CMP-N-acetylneuraminate
-
-
?
CMP-N-acetylneuraminate + antifreeze glycoprotein
?
-
-
-
-
?
CMP-N-acetylneuraminate + antifreeze glycoprotein
?
-
-
-
-
?
CMP-N-acetylneuraminate + antifreeze glycoprotein
?
-
from antarctic fish
-
-
r
CMP-N-acetylneuraminate + antifreeze glycoprotein
?
-
antifreeze glycoprotein 8, best acceptor
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
formation of Galbeta(1-3)(NeuAcalpha(2-6))GalNAc
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
ST6GalNAc-II
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
STM, i.e. hST6GalNAc-II, more effective than native fetuin
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
formation of Galbeta(1-3)(NeuAcalpha(2-6))GalNAc
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
formation of Galbeta(1-3)(NeuAcalpha(2-6))GalNAc
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
good substrate
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
formation of Galbeta(1-3)(NeuAcalpha(2-6))GalNAc
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)GalNAc-R
CMP + Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
-
R: protein, formation of TF Sia6Core-1, Galbeta(1-3)(NeuAcalpha(2,6))GalNAc-R, or of TF DiSiaCore-1, NeuAcalpha(2-3)Galbeta(1-3)(NeuAcalpha(2,6))GalNAc-R, by the sialyltransferase ST6GalNAc-II
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)GalNAc-R
CMP + Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
-
R: p-nitrophenol
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)GalNAc-R
CMP + Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
-
R: p-nitrophenol
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)GalNAc-R
CMP + Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
-
R: protein, but not p-nitrophenol
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)GalNAc-R
CMP + Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
-
R: protein, but not p-nitrophenol
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)GalNAc-R
CMP + Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
-
R: protein, but not p-nitrophenol
-
-
?
CMP-N-acetylneuraminate + GalNAc-R
CMP + NeuAcalpha(2-6)GalNAc-R
-
formation of the TF-related blood group antigen sialosyl-Tn, NeuAcalpha(2-6)GalNAc-R, by the sialyltransferase ST6GalNAc-I
-
?
CMP-N-acetylneuraminate + GalNAc-R
CMP + NeuAcalpha(2-6)GalNAc-R
-
R: protein
-
?
CMP-N-acetylneuraminate + GalNAc-R
CMP + NeuAcalpha(2-6)GalNAc-R
-
R: protein, but not p-nitrophenol
-
?
CMP-N-acetylneuraminate + GalNAc-R
CMP + NeuAcalpha(2-6)GalNAc-R
-
R: protein
-
?
CMP-N-acetylneuraminate + GalNAc-R
CMP + NeuAcalpha(2-6)GalNAc-R
-
R: protein, but not p-nitrophenol
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
one of the last steps of the biosynthesis of oligosaccharides of glycoproteins
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
the relative preference of enzyme for a monosaccharide versus a substituted GalNAc may play a role in regulation of chain length during mucin synthesis
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
STM catalyzes the synthesis of O-glycans, SIATL1 gene encoding STM is widely expressed in normal human tissues, as well as in normal breast and prostate epithelial cells, but significantly down-regulated or absent in corresponding tumor cell lines
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ST6GalNAc-II expression is significantly increased in colorectal carcinomas in cases with metastases to lymph nodes along the vascular trunk, involved in biosynthesis of the TF glycotype
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
hST6GalNAc-I catalyzes the key step in the biosynthesis of Sialyl-Tn antigen, Neu5Acalpha(2-6)GalNAcalpha1-O-Ser/Thr
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ST6GalNAc-I is responsible for the synthesis of Sialyl-Tn antigen, Neu5Acalpha(2-6)GalNAc, synthesis of Sialyl-Tn structures in mucin O-glycosylation stops further processing and elongation of the carbohydrate chain
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
required for synthesis of polySia side chains in trout egg polysialoglycoproteins, developmental expression pattern of enzyme in cortical vesicles during oogenesis, activity increases during oogenesis
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
pathway of biosynthesis of glycans present in mucins
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
involved in the sialylation of submaxillary gland mucin in vivo
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
the relative preference of enzyme for a monosaccharide versus a substituted GalNAc may play a role in regulation of chain length during mucin synthesis
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
last step in the synthesis of ovine submaxillary mucin, catalyzes the chain-terminating process in oligosaccharide synthesis of glycoproteins, may well be involved in the process of secretion
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
pathway of biosynthesis of glycans present in mucins
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
involved in the biosynthesis of oligosaccharide sequences of glycoproteins
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
one of the last steps of the biosynthesis of oligosaccharides of glycoproteins
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
the relative preference of enzyme for a monosaccharide versus a substituted GalNAc may play a role in regulation of chain length during mucin synthesis
-
-
?
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
involved in biosynthesis of O-linked oligosaccharide chains of glycoproteins
-
-
?
CMP-N-acetylneuraminate + native fetuin
?
STM, i.e. hST6GalNAc-II, 83% as effective as asialo-fetuin
-
-
?
CMP-N-acetylneuraminate + native fetuin
?
-
-
-
-
?
CMP-N-acetylneuraminate + NeuAcalpha(2-3)Galbeta(1-3)GalNAc-R
CMP + NeuAcalpha(2-3)Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
-
R: protein, formation of TF Sia6Core-1, Galbeta(1-3)(NeuAcalpha(2,6))GalNAc-R, or of TF DiSiaCore-1, NeuAcalpha(2-3)Galbeta(1-3)(NeuAcalpha(2,6))GalNAc-R, by the sialyltransferase ST6GalNAc-II
-
?
CMP-N-acetylneuraminate + NeuAcalpha(2-3)Galbeta(1-3)GalNAc-R
CMP + NeuAcalpha(2-3)Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
-
R: protein, also p-nitrophenol, but with very low activity possibly due to another factor present in the fraction
-
?
CMP-N-acetylneuraminate + NeuAcalpha(2-3)Galbeta(1-3)GalNAc-R
CMP + NeuAcalpha(2-3)Galbeta(1-3)(NeuAcalpha(2-6))GalNAc-R
-
R: protein, also p-nitrophenol, but with very low activity possibly due to another factor present in the fraction
-
?
CMP-N-acetylneuraminate + protein MUC1-MFP6
?
-
recombinant protein substrate expressed in MDA-MB-231 breast cancer cells, glycoprofiling, overview
-
-
?
CMP-N-acetylneuraminate + protein MUC1-MFP6
?
-
recombinant protein substrate, glycoprofiling, overview
-
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
preference of enzyme for a monosaccharide versus a disaccharide acceptor
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-N-glycolylneuraminate has the same efficiency as CMP-N-acetylneuraminate, CMP-9-O-acetyl-N-acetylneuraminate has much lower efficiency than CMP-N-acetylneuraminate
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-N-glycolylneuraminate can replace CMP-N-acetylneuraminate
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
antifreeze glycoprotein
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
-
-
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
acceptor substrate specificity
-
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
hST6GalNAc-I transfers a sialic acid residue in alpha2,6-linkage to GalNAc-O-Ser/Thr, substrate specificity of hST6GalNAc-I and -II
-
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-orosomucoid
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
asialo-fetuin
-
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ST6GalNAc-II demands an acceptor with a protein backbone
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
Galbeta(1-3)GalNAc-O-Ser/Thr or Neu5Acalpha(2-3)Galbeta(1-3)GalNAc-O-Ser/Thr acceptor specificity
-
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
native fetuin
-
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
native and asialo-polysialoglycoprotein, acceptor carbohydrate unit: Galbeta(1-3)GalNAcalpha(1-O)-Ser/Thr, but not GalNAc1 to O-Ser/Thr
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-N-glycolylneuraminate can replace CMP-N-acetylneuraminate
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
preference of enzyme for a monosaccharide versus a disaccharide acceptor
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
mucin-type acceptors
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
erythrocyte hemagglutination inhibitor, milk glycopeptide
-
ir
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-N-glycolylneuraminate can replace CMP-N-acetylneuraminate
-
ir
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
ir
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
bovine submaxillary asialo-mucin
-
ir
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
specific for alpha-N-acetylgalactosamine attached through alpha-glycosidic linkage to threonine or serine in polypeptide chain
-
ir
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
porcine submaxillary asialo-mucin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
porcine submaxillary asialo-mucin
-
ir
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
native submaxillary mucin, less effective than asialo-mucin
-
ir
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
native fetuin
-
ir
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
ir
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
absolute requirement for protein as the aglycon
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
-
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
acceptor substrate specificity
-
r
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
preference of enzyme for a monosaccharide versus a disaccharide acceptor
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-N-glycolylneuraminate has the same efficiency as CMP-N-acetylneuraminate, CMP-9-O-acetyl-N-acetylneuraminate has much lower efficiency than CMP-N-acetylneuraminate
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
antifreeze glycoprotein is the best substrate
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
sialyl-2,3-antifreeze glycoprotein, better than native form
-
r
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
antifreeze glycoprotein from antarctic fish
-
r
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-N-glycolylneuraminate can replace CMP-N-acetylneuraminate
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
R: H or a beta-galactoside
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
asialo-fetuin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
transfers sialic acid to the core region of O-linked glycans
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
specific for alpha-N-acetylgalactosamine attached through alpha-glycosidic linkage to threonine or serine in polypeptide chain
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
porcine submaxillary asialo-mucin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
porcine submaxillary asialo-mucin
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-9-acetamidoneuraminate, CMP-9-benzamidoneuraminate and CMP-9-hexanoylamidoneuraminate are less effective, CMP-9-azido-N-acetylneuraminate can replace CMP-N-acetylneuraminate with asialofetuin or antifreeze glycoprotein as acceptor, CMP-9-aminoacetylneuraminate only with asialofetuin as acceptor
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
antifreeze glycoprotein
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
antifreeze glycoprotein
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
antifreeze glycoprotein
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
-
r
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
absolute requirement for protein as the aglycon
-
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
linkage formed is NeuAc(2-6)GalNAcalpha(1-)O-Thr/Ser
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
ovine submaxillary asialo-mucin
formation of NeuAcalpha(2-6)GalNAc
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
bovine submaxillary asialo-mucin
linkage formed is NeuAc(2-6)GalNAcalpha(1-)O-Thr/Ser
ir
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
porcine submaxillary asialo-mucin
-
-
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
porcine submaxillary asialo-mucin
linkage formed is NeuAc(2-6)GalNAcalpha(1-)O-Thr/Ser
ir
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
ovine submaxillary asialo-mucin
-
-
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
ovine submaxillary asialo-mucin
formation of NeuAcalpha(2-6)GalNAc
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
ovine submaxillary asialo-mucin is the most effective acceptor
linkage formed is NeuAc(2-6)GalNAcalpha(1-)O-Thr/Ser
ir
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
porcine submaxillary asialo-mucin
-
-
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser
linkage formed is NeuAc(2-6)GalNAcalpha(1-)O-Thr/Ser
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
ovine and porcine submaxillary asialo-mucin are good acceptors
linkage formed is NeuAc(2-6)GalNAcalpha(1-)O-Thr/Ser
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
ovine submaxillary asialo-mucin
formation of NeuAcalpha(2-6)GalNAc
?
CMP-N-glycolylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-glycolylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-N-glycolylneuraminate can replace CMP-N-acetylneuraminate with the same efficiency
-
-
?
CMP-N-glycolylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-glycolylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
-
-
-
?
CMP-N-glycolylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-glycolylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
-
-
-
?
CMP-N-glycolylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + R-(2,6-alpha-N-glycolylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
CMP-N-glycolylneuraminate can replace CMP-N-acetylneuraminate with the same efficiency
-
-
?
additional information
?
-
-
no acceptor: lactose
-
-
?
additional information
?
-
STM contains 2 catalytic domains, the L-sialylmotif, aa 148-194, and S-sialylmotif, aa 303-324, no acceptors: asialo-BSM, alpha1 acid glycoprotein, glycosphingolipids
-
-
?
additional information
?
-
-
STM contains 2 catalytic domains, the L-sialylmotif, aa 148-194, and S-sialylmotif, aa 303-324, no acceptors: asialo-BSM, alpha1 acid glycoprotein, glycosphingolipids
-
-
?
additional information
?
-
-
no acceptor: TF-PAA, i.e. Galbeta(1-3)GalNAc conjugated to poly[N-(2-hydroxyethyl)acrylamide]
-
-
?
additional information
?
-
-
enzyme transfers sialic acid to O-linked oligosaccharide of glycoprotein, isoform ST6GalNAc-I prefers sialyl Tn antigen, i.e. Neu5Acalpha2-6GalNAc-O-Ser/Thr, isoform ST6GalNAc-II prefers T antigen as substrate
-
-
?
additional information
?
-
-
the enzyme participates in the core O-glycan biosynthesis, overview
-
-
?
additional information
?
-
-
the enzyme transfers a sialic acid residue in alpha-2,6-linkage to the GalNAcalpha1-O-Ser/Thr structure
-
-
?
additional information
?
-
-
human ST6Gal-I demonstrates acceptor specificity towards various terminal LacNAc (type 2) structures including several glycoproteins containing these terminal structures. Significant activities towards GalNAcbeta1-4GlcNAc, i.e.LacDiNAc and GlcNAcbeta1-4GlcNAcbeta1-4GlcNAc, i.e. chitotriose structures are found and less activities with fucosides Fucalpha1-2Galbeta1-4GlcNAc. The enzyme also accepts chitobiose structures as (GlcNAcbeta1-2Manalpha)2,3-Manbeta1-4GlcNAcbeta1-4GlcNAcbeta1-Gly-L-Glu-L-Asn. In addition, hST6Gal-I sialylates sulfated lactose and H-type 2 glycans
-
-
?
additional information
?
-
-
sialylation of Gal-deficient asialo-immunoglobulin A1 myeloma protein by the enzyme generates sialylated immunoglobulin A1 that mimics the Gal-deficient immunoglobulin A1 glycoforms in patients with IgA nephropathy, characterized by alpha2,6-sialylated galactose-deficient N-acetylgalactosamine. The enzyme adds three to six N-acetylneuraminic acid residues to synthetic hinge region peptides with three to seven N-acetylgalactosamine residues, with at least one N-acetylgalactosamine remaining without N-acetylneuraminic acid
-
-
?
additional information
?
-
the enzyme can sialylate GalNAc of galactose-deficient immunoglobulin A1
-
-
?
additional information
?
-
-
the enzyme can sialylate GalNAc of galactose-deficient immunoglobulin A1
-
-
?
additional information
?
-
-
no activity with cytidine-5'-yl-5-(3-[4-Chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5-dideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate (CMP-Neu5SydCl)
-
-
-
additional information
?
-
-
no acceptor: beta-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenol
-
-
?
additional information
?
-
-
no acceptor: beta-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenol
-
-
?
additional information
?
-
-
no acceptors: asialo-collacalia mucoid, asialo-proteose peptone, asialo-prothrombin, asialo-thyroglobulin, asialo-transferrin, asialo-chondromucoprotein fractions from cartilage, human blood group substance A or B, various sugars
-
-
?
additional information
?
-
-
no acceptor: lactose
-
-
?
additional information
?
-
-
no acceptor: lactose
-
-
?
additional information
?
-
-
no acceptor: N-acetyl-D-galactosaminyl-p-nitrophenol
-
-
?
additional information
?
-
-
very poor acceptor: ovine submaxillary asialo-mucin
-
-
?
additional information
?
-
-
no acceptor: beta-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenol
-
-
?
additional information
?
-
-
no donor: CMP-9-amino-acetylneuraminate
-
-
?
additional information
?
-
-
no acceptor: human asialo-transferrin
-
-
?
additional information
?
-
-
no acceptor: lactose
-
-
?
additional information
?
-
-
no acceptor: N-acetyl-D-galactosaminyl-p-nitrophenol
-
-
?
additional information
?
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no acceptors: glycoproteins with Asn-linked oligosaccharides, glycosides, mono- and oligosaccharides
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Sadler, J.E.; Rearick, J.I.; Hill, R.L.
Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands
J. Biol. Chem.
254
5934-5941
1979
Sus scrofa
brenda
Sherblom, A.P.; Bourassa, C.R.
Specificity of submaxillary gland sialyltransferases
Biochim. Biophys. Acta
761
94-102
1983
Bos taurus, Ovis aries, Rattus norvegicus, Sus scrofa
brenda
Beyer, T.A.; Rearick, J.I.; Paulson, J.C.; Prieels, J.P.; Sadler, J.E.; Hill, R.L.
Biosynthesis of mammalian glycoproteins. Glycosylation pathways in the synthesis of the nonreducing terminal sequences
J. Biol. Chem.
254
12531-12541
1979
Sus scrofa
brenda
Bergh, M.L.E.; van den Eijnden, D.H.
Aglycon specificity of fetal calf liver and ovine and porcine submaxillary gland alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase
Eur. J. Biochem.
136
113-118
1983
Ovis aries, Sus scrofa
brenda
Higa, H.H.; Paulson, J.C.
Sialylation of glycoprotein oligosaccharides with N-acetyl-, N-glycolyl-, and N-O-diacetylneuraminic acids
J. Biol. Chem.
260
8838-8849
1985
Bos taurus, Sus scrofa
brenda
Bauvois, B.; Cacan, R.; Fournet, B.; Caen, J.; Montreuil, J.; Verbert, A.
Discrimination between activity of (alpha 2-3)-sialyltransferase and (alpha 2-6)-sialyltransferase in human platelets using p-nitrophenyl-beta-D-galactoside as acceptor
Eur. J. Biochem.
121
567-572
1982
Homo sapiens
brenda
Sadler, J.E.; Rearick, J.I.; Paulson, J.C.; Hill, R.L.
Purification to homogeneity of a beta-galactoside alpha2 leads to 3 sialyltransferase and partial purification of an alpha-N-acetylgalactosaminide alpha2 leads to 6 sialyltransferase from porcine submaxillary glands
J. Biol. Chem.
254
4434-4443
1979
Sus scrofa
brenda
Gasnier, F.; Baubichon-Cortay, H.; Louisot, P.; Gateau-Roesch, O.
Sialylation processes in mitochondria: evidence for two distinct sialyltransferases located in the outer membrane
J. Biochem.
110
702-707
1991
Mus musculus, Mus musculus OF1
brenda
Bergh, M.L.E.; Koppen, P.L.; Van den Eijnden, D.H.
Specificity of ovine submaxillary-gland sialyltransferases. Application of high-pressure liquid chromatography in the identification of sialo-oligosaccharide products
Biochem. J.
201
411-415
1982
Ovis aries
brenda
Gross, H.J.; Rose, U.; Krause, J.M.; Paulson, J.C.; Schmid, K.; Feeney, R.E.; Brossmer, R.
Transfer of synthetic sialic acid analogues to N- and O-linked glycoprotein glycans using four different mammalian sialyltransferases
Biochemistry
28
7386-7392
1989
Sus scrofa
brenda
Carlson, D.M.; McGuire, E.J.; Jourdian, G.W.; Roseman, S.
The sialic acids. XVI. Isolation of a mucin sialyltransferase from sheep submaxillary gland
J. Biol. Chem.
248
5763-5773
1973
Ovis aries
brenda
Kitazume, S.; Kitajima, K.; Inoue, S.; Inoue, Y.; Troy, F.A.2nd.
Developmental expression of trout egg polysialoglycoproteins and the prerequisite alpha2,6-, and alpha2,8-sialyl and alpha2,8-polysialyltransferase activities required for their synthesis during oogenesis
J. Biol. Chem.
269
10330-10340
1994
Oncorhynchus mykiss
brenda
Schneider, F.; Kemmner, W.; Haensch, W.; Franke, G.; Gretschel, S.; Karsten, U.; Schlag, P.M.
Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-sialyltransferase is related to poor patient survival in human colorectal carcinomas
Cancer Res.
61
4605-4611
2001
Homo sapiens
brenda
Sotiropoulou, G.; Kono, M.; Anisowicz, A.; Stenman, G.; Tsuji, S.; Sager, R.
Identification and functional characterization of a human GalNAc alpha2,6-sialyltransferase with altered expression in breast cancer
Mol. Med.
8
42-55
2002
Homo sapiens (Q9UJ37), Homo sapiens
brenda
Julien, S.; Krzewinski-Recchi, M.A.; Harduin-Lepers, A.; Gouyer, V.; Huet, G.; Le Bourhis, X.; Delannoy, P.
Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac:GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA
Glycoconjugate J.
18
883-893
2001
Homo sapiens (Q9NSC7)
-
brenda
Marcos, N.T.; Cruz, A.; Silva, F.; Almeida, R.; David, L.; Mandel, U.; Clausen, H.; von Mensdorff-Pouilly, S.; Reis, C.A.
Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines
J. Histochem. Cytochem.
51
761-771
2003
Homo sapiens
brenda
Marcos, N.T.; Pinho, S.; Grandela, C.; Cruz, A.; Samyn-Petit, B.; Harduin-Lepers, A.; Almeida, R.; Silva, F.; Morais, V.; Costa, J.; Kihlberg, J.; Clausen, H.; Reis, C.A.
Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen
Cancer Res.
64
7050-7057
2004
Homo sapiens
brenda
Julien, S.; Adriaenssens, E.; Ottenberg, K.; Furlan, A.; Courtand, G.; Vercoutter-Edouart, A.S.; Hanisch, F.G.; Delannoy, P.; Le Bourhis, X.
ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity
Glycobiology
16
54-64
2006
Homo sapiens
brenda
Blixt, O.; Allin, K.; Bohorov, O.; Liu, X.; Andersson-Sand, H.; Hoffmann, J.; Razi, N.
Glycan microarrays for screening sialyltransferase specificities
Glycoconj. J.
25
59-68
2008
Homo sapiens
brenda
Cao, Y.; Merling, A.; Karsten, U.; Goletz, S.; Punzel, M.; Kraft, R.; Butschak, G.; Schwartz-Albiez, R.
Expression of CD175 (Tn), CD175s (sialosyl-Tn) and CD176 (Thomsen-Friedenreich antigen) on malignant human hematopoietic cells
Int. J. Cancer
123
89-99
2008
Homo sapiens
brenda
Suzuki, H.; Moldoveanu, Z.; Hall, S.; Brown, R.; Vu, H.L.; Novak, L.; Julian, B.A.; Tomana, M.; Wyatt, R.J.; Edberg, J.C.; Alarcon, G.S.; Kimberly, R.P.; Tomino, Y.; Mestecky, J.; Novak, J.
IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1
J. Clin. Invest.
118
629-639
2008
Homo sapiens
brenda
Skretas, G.; Carroll, S.; DeFrees, S.; Schwartz, M.F.; Johnson, K.F.; Georgiou, G.
Expression of active human sialyltransferase ST6GalNAcI in Escherichia coli
Microb. Cell Fact.
8
50
2009
Gallus gallus, Homo sapiens
brenda
Stuchlova Horynova, M.; Vrablikova, A.; Stewart, T.J.; Takahashi, K.; Czernekova, L.; Yamada, K.; Suzuki, H.; Julian, B.A.; Renfrow, M.B.; Novak, J.; Raska, M.
N-acetylgalactosaminide alpha2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy
Nephrol. Dial. Transplant.
30
234-238
2015
Homo sapiens (A0A024R8M1), Homo sapiens
brenda
Takahashi, K.; Raska, M.; Horynova, M.; Hall, S.; Poulsen, K.; Kilian, M.; Hiki, Y.; Yuzawa, Y.; Moldoveanu, Z.; Julian, B.; Renfrow, M.; Novak, J.
Enzymatic sialylation of IgA1 O-glycans: Implications for studies of IgA nephropathy
PLoS ONE
9
e99026
2014
Homo sapiens
brenda
Chinoy, Z.S.; Bodineau, C.; Favre, C.; Moremen, K.W.; Duran, R.V.; Friscourt, F.
Selective engineering of linkage-specific alpha2,6-N-linked sialoproteins using sydnone-modified sialic acid bioorthogonal reporters
Angew. Chem. Int. Ed. Engl.
58
4281-4285
2019
Homo sapiens
brenda
Pallister, E.G.; Choo, M.S.F.; Tai, J.N.; Leong, D.S.Z.; Tang, W.Q.; Ng, S.K.; Huang, K.; Marchesi, A.; Both, P.; Gray, C.; Rudd, P.M.; Flitsch, S.L.; Nguyen-Khuong, T.
Exploiting the disialyl galactose activity of alpha2,6-sialyltransferase from Photobacterium damselae to generate a highly sialylated recombinant alpha-1-antitrypsin
Biochemistry
59
3123-3128
2020
Photobacterium damselae
brenda