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The taxonomic range for the selected organisms is: Leishmania tarentolae
The enzyme appears in selected viruses and cellular organisms
Synonyms
hprt, hgprt, hypoxanthine-guanine phosphoribosyltransferase, hprt1, hypoxanthine phosphoribosyltransferase, hypoxanthine-guanine phosphoribosyl transferase, hypoxanthine phosphoribosyl transferase, hypoxanthine guanine phosphoribosyltransferase, hgprtase, guanine phosphoribosyltransferase,
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6-hydroxypurine phosphoribosyltransferase
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6-mercaptopurine phosphoribosyltransferase
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GMP pyrophosphorylase
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guanine phosphoribosyltransferase
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guanine-hypoxanthine phosphoribosyltransferase
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guanosine 5'-phosphate pyrophosphorylase
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guanosine phosphoribosyltransferase
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guanylate pyrophosphorylase
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guanylic pyrophosphorylase
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hypoxanthine-guanine phosphoribosyltransferase
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IMP pyrophosphorylase
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IMP-GMP pyrophosphorylase
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inosinate pyrophosphorylase
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inosine 5'-phosphate pyrophosphorylase
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inosinic acid pyrophosphorylase
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inosinic pyrophosphorylase
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phosphoribosyltransferase, 6-mercaptopurine
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phosphoribosyltransferase, hypoxanthine
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purine-6-thiol phosphoribosyltransferase
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transphosphoribosidase
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pentosyl group transfer
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IMP:diphosphate phospho-D-ribosyltransferase
Guanine and purine-6-thiol can replace hypoxanthine.
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guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
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hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
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additional information
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additional information
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salvage incorporation of exogenous purine nucleotides, no de novo synthesis
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additional information
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salvage incorporation of exogenous purine nucleotides, no de novo synthesis
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additional information
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enzyme is essential for salvaging exogenous purine bases
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additional information
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enzyme is essential for salvaging exogenous purine bases
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additional information
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additional information
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salvage incorporation of exogenous purine nucleotides, no de novo synthesis
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additional information
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salvage incorporation of exogenous purine nucleotides, no de novo synthesis
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additional information
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enzyme is essential for salvaging exogenous purine bases
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additional information
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enzyme is essential for salvaging exogenous purine bases
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0.127 - 0.138
5-phosphoribosyl 1-diphosphate
0.0028
guanine
recombinant enzyme, with 5-phospho-alpha-D-ribose 1-diphosphate
0.0044
hypoxanthine
recombinant enzyme, with 5-phospho-alpha-D-ribose 1-diphosphate
0.127
5-phosphoribosyl 1-diphosphate
recombinant enzyme, with guanine
0.138
5-phosphoribosyl 1-diphosphate
recombinant enzyme, with hypoxanthine
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additional information
recombinant enzyme, pI: 8.2
additional information
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recombinant enzyme, pI: 8.2
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gene hgprt
SwissProt
brenda
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Q9NJI5_LEITA
210
0
23397
TrEMBL
other Location (Reliability: 5)
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23000
2 * 23000, recombinant enzyme, SDS-PAGE
50000
recombinant enzyme, gel filtration
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dimer
2 * 23000, recombinant enzyme, SDS-PAGE
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recombinant enzyme, 7 mg/ml, hanging-drop vapour-diffusion method, TMD buffer, pH 7.5, + equal volume of reservoir solution: 18°C or 4°C, pH 5.6 , 19% isopropanol, 19% polyethylene glycol 4000, 5% glycerol, or 17% polyethylene glycol 4000, 5% glycerol
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recombinant from Escherichia coli
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DNA and amino acid sequence determination and analysis, functional expression in Escherichia coli BL21(DE3)
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medicine
potential target for antiparasitic chemotherapy
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Monzani, P.S.; Alfonzo, J.D.; Simpson, L.; Oliva, G.; Thiemann, O.H.
Cloning, characterization and preliminary crystallographic analysis of Leishmania hypoxanthine-guanine phosphoribosyltransferase
Biochim. Biophys. Acta
1598
3-9
2002
Leishmania tarentolae (Q9NJI5), Leishmania tarentolae
brenda
2.4.2.8 hypoxanthine phosphoribosyltransferase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
