Information on EC 2.4.2.45 - decaprenyl-phosphate phosphoribosyltransferase

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The expected taxonomic range for this enzyme is: Corynebacterineae

EC NUMBER
COMMENTARY
2.4.2.45
-
RECOMMENDED NAME
GeneOntology No.
decaprenyl-phosphate phosphoribosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate = trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
show the reaction diagram
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-
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PATHWAY
KEGG Link
MetaCyc Link
mycolyl-arabinogalactan-peptidoglycan complex biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate:diphosphate phospho-alpha-D-ribosyltransferase
Requires Mg2+. Isolated from Mycobacterium tuberculosis. Has some activity with other polyprenyl phosphates.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase
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5-phospho-alpha-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase
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5-phospho-alpha-D-ribose-1-diphosphate: decaprenyl-phosphate
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5-phospho-alpha-D-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase
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DPPR synthase
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Rv3806
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
no activity in Azorhizobium caulinodans
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-
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
physiological function
-
the enzyme is essential for the growth of Mycobacterium tuberculosis
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate
trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
show the reaction diagram
-
-
-
-
?
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate
trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
show the reaction diagram
-
-
-
-
?
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
SUBUNITS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
?
-
x * 30000, SDS-PAGE; x * 33000, estimated from amino acid sequence
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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expressed in Escherichia coli ER2566 cells
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ENGINEERING
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
D77E
-
15% activity compared to the wild type enzyme
E195A
-
17% activity compared to the wild type enzyme
F59A
-
94% activity compared to the wild type enzyme
F62A
-
72% activity compared to the wild type enzyme
H84L
-
15% activity compared to the wild type enzyme
N29A
-
18% activity compared to the wild type enzyme
N73Q
-
15% activity compared to the wild type enzyme
R201A
-
1% activity compared to the wild type enzyme
R22L
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10% activity compared to the wild type enzyme
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
medicine
-
the enzyme is a good target for the development of tuberculosis drugs