Information on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.4.2.19
-
RECOMMENDED NAME
GeneOntology No.
nicotinate-nucleotide diphosphorylase (carboxylating)
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
-
NAD biosynthesis I (from aspartate)
-
Nicotinate and nicotinamide metabolism
-
nicotine biosynthesis
-
superpathway of nicotine biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
nicotinate-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes [3].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
general stress protein 70
-
-
-
-
GSP70
-
-
-
-
Hp-QAPRTase
-
-
hQPRTase
Q15274
human QPRTase
NAD pyrophosphorylase
-
-
-
-
NadC
-
-
-
-
NadC
Q9X1X8
-
nicotinate mononucleotide pyrophosphorylase (carboxylating) (EC 2.4.2.19)
-
-
-
-
nicotinate-nucleotide pyrophosphorylase (carboxylating)
-
-
-
-
nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase (decarboxylating)
-
-
-
-
pyrophosphorylase, nicotinate mononucleotide (carboxylating)
-
-
-
-
QAPRTase
-
-
-
-
QAPRTase
-
-
QAPRTase
Burkholderia sp. PsJN
-
-
-
QAPRTase
P43619
-
QAPRTase
-
-
QAPRTase
Q9X1X8
-
QPRTase
-
-
QPRTase
Q15274
-
QPRTase
-
-
-
-
QPT1
Q0WX55
-
QPT2
Q0WX54
-
quinolate phosphoribosyltransferase
-
-
quinolinate phosphoribosyl transferase
P43619
-
quinolinate phosphoribosyltransferase
-
-
-
-
quinolinate phosphoribosyltransferase
-
-
quinolinate phosphoribosyltransferase
Q15274
-
quinolinate phosphoribosyltransferase
-
-
quinolinate phosphoribosyltransferase
-
-
quinolinate phosphoribosyltransferase (decarboxylating)
-
-
-
-
quinolinate phosphoribosyltransferase 1
Q0WX55
-
quinolinate phosphoribosyltransferase 2
Q0WX54
-
quinolinate phosphoribosyltransferase [decarboxylating]
-
-
-
-
quinolinic acid phosphoribosyltransferase
-
-
-
-
quinolinic phosphoribosyltransferase
-
-
-
-
TM1645
Q9X1X8
-
type II quinolic acid phosphoribosyltransferase
Q9X1X8
-
type II quinolinic acid phosphoribosyltransferase
-
-
CAS REGISTRY NUMBER
COMMENTARY
37277-74-0
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
DOB1 and other phthalate-degrading strains have two dissimilar genes for this enzyme, while non-phthalate-degrading strains have only a single gene
-
-
Manually annotated by BRENDA team
strain PsJN
-
-
Manually annotated by BRENDA team
Burkholderia sp. PsJN
strain PsJN
-
-
Manually annotated by BRENDA team
nov. subsp. quinolinicus
-
-
Manually annotated by BRENDA team
subsp. quinolinicus
-
-
Manually annotated by BRENDA team
strain MSB8, gene TM1645
SwissProt
Manually annotated by BRENDA team
i.e. Vigna radiata
-
-
Manually annotated by BRENDA team
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
NAD+
-
0.1 mM, 75% inhibition
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
glycerol
-
glycerol markedly activates enzyme activity at pH 6.1 and pH 6.5, inhibition above pH 7.0, inhibition is strongest at pH 9.0
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.00004
-
5-phospho-alpha-D-ribose 1-diphosphate
-
mutant E214A
5436
0.000049
-
5-phospho-alpha-D-ribose 1-diphosphate
-
mutant E214D
5436
0.000064
-
5-phospho-alpha-D-ribose 1-diphosphate
-
mutant R118A, at 25C
5436
0.0007
-
5-phospho-alpha-D-ribose 1-diphosphate
-
mutant K284A
5436
0.00073
-
5-phospho-alpha-D-ribose 1-diphosphate
-
mutant K185A, at 25C
5436
0.035
-
5-phospho-alpha-D-ribose 1-diphosphate
-
mutant R152A, at 25C
5436
1.8
-
5-phospho-alpha-D-ribose 1-diphosphate
-
mutant H188A, at 25C
5436
3.9
-
5-phospho-alpha-D-ribose 1-diphosphate
-
mutant E214Q
5436
12
-
5-phospho-alpha-D-ribose 1-diphosphate
-
mutant D235A
5436
18
-
5-phospho-alpha-D-ribose 1-diphosphate
-
wild-type
5436
18
-
5-phospho-alpha-D-ribose 1-diphosphate
-
wild-type, at 25C
5436
0.32
-
nicotinic acid
-
mutant K185A, at 25C
14511
0.0011
-
Quinolinic acid
-
mutant K185A, at 25C
16108
0.0015
-
Quinolinic acid
-
mutant R118A, at 25C
16108
0.0019
-
Quinolinic acid
-
mutant E214A; mutant E214D
16108
0.023
-
Quinolinic acid
-
mutant K284A
16108
0.1
-
Quinolinic acid
-
mutant R152A, at 25C
16108
12
-
Quinolinic acid
-
mutant E214Q
16108
16
-
Quinolinic acid
-
mutant H188A, at 25C
16108
37
-
Quinolinic acid
-
wild-type
16108
37
-
Quinolinic acid
-
wild-type, at 25C
16108
52
-
Quinolinic acid
-
mutant D235A
16108
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
PDB
SCOP
CATH
ORGANISM
Burkholderia pseudomallei (strain 1710b)
Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Helicobacter pylori (strain ATCC 700392 / 26695)
Helicobacter pylori (strain ATCC 700392 / 26695)
Helicobacter pylori (strain ATCC 700392 / 26695)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)