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Synonyms
pnp, purine nucleoside phosphorylase, pnpase, pfpnp, purine-nucleoside phosphorylase, adenosine phosphorylase, hspnp, hppnp, tvpnp, inosine phosphorylase,
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adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
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-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
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-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
?
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 1% of the activity with inosine, isoform of 702 amino acids, 15% of the activity with inosine
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-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 17% of the activity with inosine, isoform of 702 amino acids, 18% of the activity with inosine
-
-
?
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 23% of the activity with inosine, isoform of 702 amino acids, 31% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
reaction with adenosine-specific phosphorylase, no activity with inosine-guanosine phosphorylase
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
additional information
?
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two purine nucleoside phosphorylases: 1. inosine-guanosine phosphorylase, 2. adenosine-specific phosphorylase
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-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
reaction with adenosine-specific phosphorylase, no activity with inosine-guanosine phosphorylase
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 1% of the activity with inosine, isoform of 702 amino acids, 48% of the activity with inosine
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
reaction with ionosine-guanosine phosphorylase, very low activity with the adenosine-specific phosphorylase
-
-
?
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
reaction with inosine-guanosine phosphorylase, no activity with the adenosine-specific phosphorylase
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
reaction with inosine-guanosine phosphorylase, no activity with the adenosine-specific phosphorylase
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 87% of the activity with inosine, isoform of 702 amino acids, 46% of the activity with inosine
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
reaction with ionosine-guanosine phosphorylase, no activity with the adenosine-specific phosphorylase
-
-
?
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Parks, R.E.; Agarwal, R.P.
Purine nucleoside phosphorylase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
7
483-514
1972
Klebsiella aerogenes, Aeromonas hydrophila, Brevibacillus brevis, Bacillus cereus, Bacillus subtilis, Bacillus licheniformis, Bacterium cadaveris, Bos taurus, Canis lupus familiaris, Gallus gallus, Columba livia, Clavibacter michiganensis subsp. sepedonicus, Oryctolagus cuniculus, Escherichia coli, Equus caballus, Pectobacterium carotovorum, Felis catus, Homo sapiens, Lactobacillus leichmannii, Leucisus rusticus, Macaca mulatta, Micrococcus luteus, Papio hamadryas, Proteus vulgaris, Shewanella putrefaciens, Rattus norvegicus, salmon, Salmonella enterica subsp. enterica serovar Enteritidis, Sus scrofa
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brenda
Jensen, K.J.
Two purine nucleoside phosphorylases in Bacillus subtilis. Purification and some properties of the adenosine-specific phosphorylase
Biochim. Biophys. Acta
525
346-356
1978
Bacillus subtilis
brenda
Bzowska, A.; Kulikowska, E.; Shugar, D.
Purine nucleoside phosphorylases: properties, functions, and clinical aspects
Pharmacol. Ther.
88
349-425
2000
Acholeplasma laidlawii, Klebsiella aerogenes, Geobacillus stearothermophilus, Bacillus cereus, Cellulomonas sp., Pectobacterium carotovorum, Fasciola hepatica, Klebsiella sp., Micrococcus luteus, Mus musculus, Plasmodium falciparum, Plasmodium lophurae, Proteus vulgaris, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Saccharolobus solfataricus, Trypanosoma brucei, Trypanosoma cruzi, Homo sapiens (P00491), Homo sapiens, Escherichia coli (P0ABP8), Bacillus subtilis (P46354), Bos taurus (P55859), Saccharomyces cerevisiae (Q05788)
brenda
Martins, N.H.; Meza, A.N.; Santos, C.R.; de Giuseppe, P.O.; Murakami, M.T.
Molecular cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of a purine nucleoside phosphorylase from Bacillus subtilis strain 168
Acta Crystallogr. Sect. F
67
618-622
2011
Bacillus subtilis (O34925), Bacillus subtilis, Bacillus subtilis 168 (O34925)
brenda
Xie, X.; Xia, J.; He, K.; Lu, L.; Xu, Q.; Chen, N.
Low-molecular-mass purine nucleoside phosphorylase: characterization and application in enzymatic synthesis of nucleoside antiviral drugs
Biotechnol. Lett.
33
1107-1112
2011
Bacillus subtilis, Bacillus subtilis 168, Escherichia coli, Pseudoalteromonas sp.
brenda