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1,6-dihydropurine riboside + phosphate
alpha-D-ribose 1-phosphate + 1,6-dihydropurine
-
-
-
-
?
1,N2-ethenoguanine + alpha-D-ribose 1-phosphate
1,N2-ethenoguanosine + phosphate
-
-
-
r
1,N6-etheno-isoguanine + alpha-D-ribose 1-phosphate
1,N6-etheno-isoguanosine + phosphate
isoguanine is 2-hydroxy-6-aminopurine and showing a solvent-induced keto-enol tautomerism
-
-
r
1,N6-ethenoadenine + alpha-D-ribose 1-phosphate
1,N6-ethenoadenine N7-riboside + phosphate
-
-
-
r
1,N6-ethenoadenine + alpha-D-ribose 1-phosphate
1,N6-ethenoadenine N9-riboside + phosphate
-
-
-
r
1,N6-ethenoadenosine + phosphate
1,N6-ethenoadenine + beta-D-ribose 1-phosphate
i.e. 3-beta-D-ribosylimidazo[2,l-i]purine
-
-
r
1-methyladenosine + phosphate
1-methyladenine + alpha-D-ribose 1-phosphate
-
-
-
r
1-methylguanosine + phosphate
1-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
r
1-methylguanosine + phosphate
alpha-D-ribose 1-phosphate + 1-methylguanine
-
-
-
-
?
1-methylinosine + phosphate
alpha-D-ribose 1-phosphate + 1-methylhypoxanthine
-
-
-
-
?
2',3'-dideoxyinosine + phosphate
alpha-D-2,3-dideoxyribose 1-phosphate + hypoxanthine
2',3'-dideoxyinosine + phosphate
hypoxanthine + 2,3-dideoxy-alpha-D-ribose 1-phosphate
-
-
-
?
2',3'-dideoxyinosine + phosphate
hypoxanthine + alpha-D-2,3-dideoxyribose 1-phosphate
-
-
-
-
?
2'-amino-2'-deoxyadenosine + phosphate
adenine + 2-deoxy-2-imino-alpha-D-ribose 1-phosphate
2'-amino-2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-2-imino-alpha-D-ribose 1-phosphate
-
-
-
?
2'-deoxy-2'-fluoroadenosine + phosphate
adenine + 2-deoxy-2-fluoro-alpha-D-arabinofuranose 1-phosphate
-
-
-
?
2'-deoxy-6-methylpurine nucleoside + phosphate
?
2'-deoxyadenosine + phosphate
2-deoxy-alpha-D-ribose 1-phosphate + adenine
-
10% of the activity with inosine
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
2'-deoxyguanosine + phosphate
guanine + alpha-D-2-deoxyribose 1-phosphate
-
-
-
-
?
2'-deoxyinosine + phosphate
2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
-
-
-
-
?
2'-deoxyinosine + phosphate
alpha-D-2-deoxyribose 1-phosphate + hypoxanthine
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N7-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N8-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N8-ribosyl-2,6-diamino-8-azapurine + N7-ribosyl-2,6-diamino-8-azapurine + phosphate
-
-
-
-
?
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N9-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diaminopurine + alpha-D-ribose 1-phosphate
2,6-diaminopurine ribonucleoside + phosphate
-
-
-
r
2,6-diaminopurine nucleoside + phosphate
alpha-D-ribose 1-phosphate + 2,6-diaminopurine
-
-
-
?
2,6-diaminopurine ribonucleoside + phosphate
2,6-diaminopurine + alpha-D-ribose 1-phosphate
-
-
-
-
?
2-amino-6-chloropurine + alpha-D-ribose 1-phosphate
2-amino-6-chloropurine ribonucleoside + phosphate
-
-
-
r
2-amino-6-mercapto-7-methylpurine ribonucleoside + alpha-D-ribose 1-phosphate
?
2-amino-6-mercapto-7-methylpurine ribonucleoside + phosphate
alpha-D-ribose 1-phosphate + 2-amino-6-mercapto-7-methylpurine
2-amino-6-mercapto-7-methylpurine ribonucleoside + phosphate
alpha-D-ribose 1-phosphate + ?
-
-
-
-
?
2-chloroadenosine + phosphate
2-chloroadenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
2-fluoro-2-deoxyadenosine + phosphate
?
-
a toxic prodrug
-
-
?
2-fluoro-2-deoxyadenosine + phosphate
adenine + 2-fluoro-2-deoxy-alpha-D-ribose 1-phosphate
2-fluoroadenosine + phosphate
2-fluoroadenine + alpha-D-ribose 1-phosphate
-
-
-
?
3-(beta-D-ribofuranosyl)adenine + alpha-D-ribose 1-phosphate
?
3-(beta-D-ribofuranosyl)hyopxanthine + alpha-D-ribose 1-phosphate
?
3-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate
?
-
-
-
-
?
3-deazainosine + phosphate
alpha-D-ribose 1-phosphate + 3-deazahypoxanthine
5'-chloro-5'-deoxy-adenosine + phosphate
5-chloro-5-deoxy-D-ribose 1-phosphate + adenine
-
-
-
?
5'-deoxy-5'-fluoroadenosine + phosphate
5-deoxy-5-fluoro-D-ribose-1-phosphate + adenine
-
5'-deoxy-5'-fluoroadenosine + phosphate i.e. 5'-FDA
5-deoxy-5-fluoro-D-ribose-1-phosphate i.e. 5-FDRP
-
?
5'-deoxy-5'-iodo-2-fluoroadenosine + phosphate
2-fluoroadenine + 5-deoxy-5-iodo-alpha-D-ribose 1-phosphate
-
-
-
-
?
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-deoxy-5-methylthio-alpha-D-ribose 1-phosphate
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-alpha-D-ribose 1-phosphate
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
5-aza-7-deazaguanine + phosphate
?
-
-
-
-
r
6-(2-thienyl)-9-(beta-D-ribofuranosyl)purine + phosphate
6-(2-thienyl)purine + alpha-D-ribose 1-phosphate
-
-
-
-
?
6-cyclopropyl-9-(beta-D-ribofuranosyl)purine + phosphate
6-cyclopropylpurine + alpha-D-ribose 1-phosphate
-
-
-
-
?
6-ethyl-9-(beta-D-ribofuranosyl)purine + phosphate
6-ethylpurine + alpha-D-ribose 1-phosphate
-
-
-
-
?
6-mercaptoguanosine + phosphate
alpha-D-ribose 1-phosphate + 6-mercaptoguanine
-
-
-
-
?
6-mercaptopurine riboside + phosphate
alpha-D-ribose 1-phosphate + 6-mercaptopurine
6-mercaptopurine-2'-deoxyriboside + phosphate
6-mercaptopurine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
6-phenyl-9-(beta-D-ribofuranosyl)purine + phosphate
6-phenylpurine + alpha-D-ribose 1-phosphate
-
-
-
-
?
6-thioguanine + alpha-D-ribose 1-phosphate
6-thioguanine ribonucleoside + phosphate
-
-
-
r
6-thioxanthine + alpha-D-ribose 1-phosphate
6-thioxanthosine + phosphate
7,8-dimethylguanosine + phosphate
7,8-dimethylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-(beta-D-ribofuranosyl)guanine + alpha-D-ribose 1-phosphate
?
7-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate
?
7-butylguanosine + phosphate
7-butylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-ethylguanosine + phosphate
7-ethylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-isobutylguanosine + phosphate
7-isobutylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-isopropylguanosine + phosphate
7-isopropylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methyl-6-thio-guanosine + phosphate
7-methyl-6-thioguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methyl-6-thioguanosine + phosphate
7-methyl-6-thioguanine + alpha-D-ribose 1-phosphate
-
-
-
r
7-methyl-8-aminoguanosine + phosphate
7-methyl-8-aminoguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methyladenosine + phosphate
7-methyladenine + alpha-D-ribose 1-phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
7-methylguanosine + phosphate
-
-
-
r
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
7-methylinosine + phosphate
7-methylhypoxanthine + alpha-D-ribose 1-phosphate
7-N-methyl-6-thiopurine riboside + phosphate
?
-
-
-
-
?
7-prolylguanosine + phosphate
7-prolylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
8-aminoguanine + alpha-D-ribose 1-phosphate
8-aminoguanosine + phosphate
8-azaadenine + alpha-D-ribose 1-phosphate
8-azaadenosine + phosphate
-
-
-
r
8-azaguanine + alpha-D-ribose 1-phosphate
8-azaguanine N7-D-riboside + phosphate
-
-
-
r
8-azaguanine + alpha-D-ribose 1-phosphate
8-azaguanosine + phosphate
8-azaguanine + alpha-D-ribose 1-phosphate
N9-beta-D-ribosyl-8-azaguanine + phosphate
-
-
-
-
?
8-azaguanosine + phosphate
8-azaguanine + alpha-D-ribose 1-phosphate
8-azahypoxanthine + alpha-D-ribose 1-phosphate
8-azainosine + phosphate
-
-
?
8-methylguanosine + phosphate
8-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
9-(2-deoxy-2-fluoro-alpha-D-arabinofuranosyl)adenine + phosphate
adenine + 2-deoxy-2-fluoro-alpha-D-arabinofuranose 1-phosphate
-
-
-
?
9-(6-deoxy-5-C-methyl-beta-D-ribo-hexofuranosyl)-6-methylpurine + phosphate
?
-
-
-
-
r
9-(6-deoxy-beta-D-allofuranosyl)-6-methylpurine + phosphate
?
-
-
-
-
r
9-(beta-D-ribofuranosyl)-6-methylpurine + phosphate
?
-
-
-
-
r
9-beta-D-(2-deoxyribofuranosyl)-6-methylthiopurine + phosphate
6-methylthiopurine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
9-beta-D-arabinosyl-2-fluoroadenine + phosphate
2-fluoroadenine + beta-D-arabinose 1-phosphate
i.e. fludarabine
-
-
r
9-beta-D-ribofuranosyl-6-methylthiopurine + phosphate
6-methylthiopurine + alpha-D-ribose 1-phosphate
-
-
-
?
9-[2-deoxy-beta-D-ribofuranosyl]-6-methylpurine + phosphate
?
9-[6-deoxy-alpha-L-talofuranosyl]-2-F-adenine + phosphate
?
-
-
-
-
?
9-[6-deoxy-alpha-L-talofuranosyl]-6-methylpurine + phosphate
?
-
-
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-2-fluoro-adenine + phosphate
?
9-[6-deoxy-beta-L-talofuranosyl]-6-methylpurine + phosphate
?
9-[alpha-L-lyxofuranosyl]-2-F-adenine + phosphate
?
-
-
-
-
?
9-[beta-D-arabinofuranosyl]-2-fluoro-adenine + phosphate
?
-
a toxic prodrug
-
-
?
9-[beta-D-arabinofuranosyl]-2-fluoroadenine + phosphate
?
-
-
-
-
r
9-[beta-L-lyxofuranosyl]-2-fluoro-adenine + phosphate
?
adenine + alpha-D-ribose 1-phosphate
adenosine + phosphate
-
-
-
r
adenine + deoxyribose 1-phosphate
deoxyadenosine + phosphate
adenine arabinoside + phosphate
alpha-D-arabinose 1-phosphate + adenine
-
49% of the activity with adenosine
-
-
?
adenosine + arsenate
adenine + alpha-D-ribose 1-arsenate
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
adenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
activity with mutant enzyme N239D, wild-type and mutant enzyme Y191L show no activity
-
-
?
arabinofuranosyladenine + phosphate
?
4.3% of the activity with inosine
-
-
?
cytokinin + phosphate
? + alpha-D-ribose 1-phosphate
-
the enzyme prefers cytokinin to unsubstituted aminopurines
-
-
r
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
dihydrozeatin riboside + phosphate
dihydrozeatin + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanine + alpha-D-ribose 1-phosphate
guanosine + phosphate
guanine + ribose 1-phosphate
guanosine + phosphate
-
-
-
r
guanosine + arsenate
guanine + alpha-D-ribose 1-arsenate
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
deoxyinosine + phosphate
-
-
-
-
r
hypoxanthine + alpha-D-ribose 1-phosphate
inosine + phosphate
-
-
-
-
r
inosine + arsenate
hypoxanthine + ribose 1-arsenate
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
isopentenyladenosine + phosphate
isopentenyladenine + alpha-D-ribose 1-phosphate
-
-
-
-
r
methylthioinosine + phosphate
methylthiohypoxanthine + alpha-D-ribose 1-phosphate
N2,3-etheno-O6-methylguanine + alpha-D-ribose 1-phosphate
N2,3-etheno-O6-methylguanosine + phosphate
-
-
-
r
N2,3-ethenoguanine + alpha-D-ribose 1-phosphate
N2,3-ethenoguanosine + phosphate
-
-
-
r
N7-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N8-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N9-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
nicotinamide riboside + phosphate
nicotinamide + alpha-D-ribose 1-phosphate
O6-methyl-N2,3-ethenoguanine + alpha-D-ribose 1-phosphate
O6-methyl-N2,3-ethenoguanosine + phosphate
-
-
-
r
p-nitrophenyl beta-D-ribofuranoside + phosphate
?
-
-
-
-
?
purine deoxyribonucleoside + phosphate
purine + 2-deoxy-alpha-D-ribose 1-phosphate
purine ribonucleoside + phosphate
purine + alpha-D-ribose 1-phosphate
purine riboside + phosphate
alpha-D-ribose 1-phosphate + purine
-
-
-
-
?
ribavirin + phosphate
1,2,4-triazole-3-carboxamide + alpha-D-ribose 1-phosphate
-
-
-
-
?
ribavirin + phosphate
alpha-D-ribose 1-phosphate + 1,2,4-triazole-3-carboxamide
-
22% of the activity with inosine. Phosphorolysis reaches an equilibrium when 15% of ribavirin is phosphorolyzed
-
-
r
trans-zeatin riboside + phosphate
trans-zeatin + alpha-D-ribose 1-phosphate
-
-
-
-
r
uridine + phosphate
?
-
-
-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
-
-
-
?
xanthosine + arsenate
xanthine + alpha-D-ribose 1-arsenate
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
xanthosine + phosphate
xanthine + alpha-D-ribose 1-phosphate
additional information
?
-
2',3'-dideoxyinosine + phosphate
alpha-D-2,3-dideoxyribose 1-phosphate + hypoxanthine
-
22% of the activity with inosine
-
-
?
2',3'-dideoxyinosine + phosphate
alpha-D-2,3-dideoxyribose 1-phosphate + hypoxanthine
-
12% of the activity with inosine
-
-
?
2'-amino-2'-deoxyadenosine + phosphate
adenine + 2-deoxy-2-imino-alpha-D-ribose 1-phosphate
-
-
-
?
2'-amino-2'-deoxyadenosine + phosphate
adenine + 2-deoxy-2-imino-alpha-D-ribose 1-phosphate
-
-
-
?
2'-deoxy-6-methylpurine nucleoside + phosphate
?
13.2% of the activity with inosine
-
-
?
2'-deoxy-6-methylpurine nucleoside + phosphate
?
13.2% of the activity with inosine
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 1% of the activity with inosine, isoform of 702 amino acids, 15% of the activity with inosine
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 1% of the activity with inosine, isoform of 702 amino acids, 15% of the activity with inosine
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
-
12% of the activity with inosine
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
54.7% of the activity with 2'-deoxyinosine
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
13.4% of the activity with inosine
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
-
37% activity compared to adenosine
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
moderate activity
-
-
r
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 17% of the activity with inosine, isoform of 702 amino acids, 18% of the activity with inosine
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 17% of the activity with inosine, isoform of 702 amino acids, 18% of the activity with inosine
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
20% of the activity with inosine
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
83.2% of the activity with 2'-deoxyinosine
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
3.7% of the activity with inosine
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
3.7% of the activity with inosine
-
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
22.5% phosphorolysis of substrate within 30 min
-
?
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
22.5% phosphorolysis of substrate within 30 min
-
?
2'-deoxyinosine + phosphate
alpha-D-2-deoxyribose 1-phosphate + hypoxanthine
-
-
-
?
2'-deoxyinosine + phosphate
alpha-D-2-deoxyribose 1-phosphate + hypoxanthine
-
-
-
-
?
2'-deoxyinosine + phosphate
alpha-D-2-deoxyribose 1-phosphate + hypoxanthine
-
-
-
-
?
2'-deoxyinosine + phosphate
alpha-D-2-deoxyribose 1-phosphate + hypoxanthine
-
-
-
-
?
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 23% of the activity with inosine, isoform of 702 amino acids, 31% of the activity with inosine
-
-
?
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
22% of the activity with inosine
-
-
?
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
40.5% phosphorolysis of substrate within 30 min
-
?
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
40.5% phosphorolysis of substrate within 30 min
-
?
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N7-D-ribosyl-2,6-diamino-8-azapurine + phosphate
enzyme PNP mutant D204N and mutant N243D
-
-
r
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N7-D-ribosyl-2,6-diamino-8-azapurine + phosphate
PNP mutant D204N
-
-
r
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N7-D-ribosyl-2,6-diamino-8-azapurine + phosphate
enzyme PNP mutant D204N
-
-
r
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N8-D-ribosyl-2,6-diamino-8-azapurine + phosphate
-
-
-
r
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N8-D-ribosyl-2,6-diamino-8-azapurine + phosphate
wild-type enzyme PNP
-
-
r
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N8-D-ribosyl-2,6-diamino-8-azapurine + phosphate
wild-type enzyme PNP
-
-
r
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N9-D-ribosyl-2,6-diamino-8-azapurine + phosphate
enzyme PNP mutant N243D
-
-
r
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N9-D-ribosyl-2,6-diamino-8-azapurine + phosphate
PNP mutant D204N
-
-
r
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N9-D-ribosyl-2,6-diamino-8-azapurine + phosphate
enzyme PNP mutant D204N
-
-
r
2-amino-6-mercapto-7-methylpurine ribonucleoside + alpha-D-ribose 1-phosphate
?
-
-
-
-
?
2-amino-6-mercapto-7-methylpurine ribonucleoside + alpha-D-ribose 1-phosphate
?
-
-
-
?
2-amino-6-mercapto-7-methylpurine ribonucleoside + alpha-D-ribose 1-phosphate
?
-
-
-
?
2-amino-6-mercapto-7-methylpurine ribonucleoside + phosphate
alpha-D-ribose 1-phosphate + 2-amino-6-mercapto-7-methylpurine
-
-
-
?
2-amino-6-mercapto-7-methylpurine ribonucleoside + phosphate
alpha-D-ribose 1-phosphate + 2-amino-6-mercapto-7-methylpurine
-
-
-
-
?
2-amino-6-mercapto-7-methylpurine ribonucleoside + phosphate
alpha-D-ribose 1-phosphate + 2-amino-6-mercapto-7-methylpurine
-
-
-
-
?
2-amino-6-mercapto-7-methylpurine ribonucleoside + phosphate
alpha-D-ribose 1-phosphate + 2-amino-6-mercapto-7-methylpurine
-
-
-
-
?
2-fluoro-2-deoxyadenosine + phosphate
adenine + 2-fluoro-2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
2-fluoro-2-deoxyadenosine + phosphate
adenine + 2-fluoro-2-deoxy-alpha-D-ribose 1-phosphate
-
no substrate for wild-type, substrate of double mutant E201Q/N243D
-
-
?
2-fluoro-2-deoxyadenosine + phosphate
adenine + 2-fluoro-2-deoxy-alpha-D-ribose 1-phosphate
-
-
the product 2-fluoroadenine is highly cytotoxic for Trichomonas vaginalis
-
?
3-(beta-D-ribofuranosyl)adenine + alpha-D-ribose 1-phosphate
?
-
-
-
-
?
3-(beta-D-ribofuranosyl)adenine + alpha-D-ribose 1-phosphate
?
-
-
-
?
3-(beta-D-ribofuranosyl)adenine + alpha-D-ribose 1-phosphate
?
-
-
-
-
?
3-(beta-D-ribofuranosyl)adenine + alpha-D-ribose 1-phosphate
?
-
-
-
?
3-(beta-D-ribofuranosyl)hyopxanthine + alpha-D-ribose 1-phosphate
?
-
-
-
?
3-(beta-D-ribofuranosyl)hyopxanthine + alpha-D-ribose 1-phosphate
?
-
-
-
-
?
3-(beta-D-ribofuranosyl)hyopxanthine + alpha-D-ribose 1-phosphate
?
-
-
-
?
3-deazainosine + phosphate
alpha-D-ribose 1-phosphate + 3-deazahypoxanthine
-
-
-
-
?
3-deazainosine + phosphate
alpha-D-ribose 1-phosphate + 3-deazahypoxanthine
-
-
-
-
?
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-deoxy-5-methylthio-alpha-D-ribose 1-phosphate
-
-
-
?
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-deoxy-5-methylthio-alpha-D-ribose 1-phosphate
-
-
-
?
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-deoxy-5-methylthio-alpha-D-ribose 1-phosphate
-
40% activity compared to adenosine
-
-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-alpha-D-ribose 1-phosphate
-
-
-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-alpha-D-ribose 1-phosphate
-
-
-
?
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
-
-
-
?
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
-
-
-
?
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
-
-
-
r
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
-
-
-
r
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
ver low activity
-
-
?
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
very low activity
-
-
?
6-mercaptopurine riboside + phosphate
alpha-D-ribose 1-phosphate + 6-mercaptopurine
-
-
-
-
?
6-mercaptopurine riboside + phosphate
alpha-D-ribose 1-phosphate + 6-mercaptopurine
-
14% of the activity with inosine
-
-
?
6-thioxanthine + alpha-D-ribose 1-phosphate
6-thioxanthosine + phosphate
-
-
-
?
6-thioxanthine + alpha-D-ribose 1-phosphate
6-thioxanthosine + phosphate
-
-
-
-
?
7-(beta-D-ribofuranosyl)guanine + alpha-D-ribose 1-phosphate
?
-
-
-
?
7-(beta-D-ribofuranosyl)guanine + alpha-D-ribose 1-phosphate
?
-
-
-
?
7-(beta-D-ribofuranosyl)guanine + alpha-D-ribose 1-phosphate
?
-
-
-
?
7-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate
?
-
-
-
?
7-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate
?
-
-
-
?
7-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate
?
-
-
-
?
7-methyladenosine + phosphate
7-methyladenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methyladenosine + phosphate
7-methyladenine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methyladenosine + phosphate
7-methyladenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methyladenosine + phosphate
7-methyladenine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methyladenosine + phosphate
7-methyladenine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
r
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
low activity
-
-
r
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
r
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
r
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methylinosine + phosphate
7-methylhypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methylinosine + phosphate
7-methylhypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methylinosine + phosphate
7-methylhypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methylinosine + phosphate
7-methylhypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
7-methylinosine + phosphate
7-methylhypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methylinosine + phosphate
7-methylhypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
7-methylinosine + phosphate
7-methylhypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
8-aminoguanine + alpha-D-ribose 1-phosphate
8-aminoguanosine + phosphate
-
-
-
-
?
8-aminoguanine + alpha-D-ribose 1-phosphate
8-aminoguanosine + phosphate
-
-
-
?
8-aminoguanine + alpha-D-ribose 1-phosphate
8-aminoguanosine + phosphate
-
-
-
?
8-aminoguanine + alpha-D-ribose 1-phosphate
8-aminoguanosine + phosphate
-
-
-
?
8-aminoguanine + alpha-D-ribose 1-phosphate
8-aminoguanosine + phosphate
-
-
-
?
8-azaguanine + alpha-D-ribose 1-phosphate
8-azaguanosine + phosphate
-
-
-
-
?
8-azaguanine + alpha-D-ribose 1-phosphate
8-azaguanosine + phosphate
-
-
-
-
r
8-azaguanine + alpha-D-ribose 1-phosphate
8-azaguanosine + phosphate
-
-
-
?
8-azaguanine + alpha-D-ribose 1-phosphate
8-azaguanosine + phosphate
-
-
-
r
8-azaguanine + alpha-D-ribose 1-phosphate
8-azaguanosine + phosphate
-
-
-
r
8-azaguanosine + phosphate
8-azaguanine + alpha-D-ribose 1-phosphate
-
-
-
r
8-azaguanosine + phosphate
8-azaguanine + alpha-D-ribose 1-phosphate
-
-
-
r
9-[2-deoxy-beta-D-ribofuranosyl]-6-methylpurine + phosphate
?
-
-
-
-
r
9-[2-deoxy-beta-D-ribofuranosyl]-6-methylpurine + phosphate
?
-
a toxic prodrug
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-2-fluoro-adenine + phosphate
?
-
a toxic prodrug, substrate of enzyme mutant M64V, the drug product has anti-tumor activity
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-2-fluoro-adenine + phosphate
?
-
a toxic prodrug, substrate of enzyme mutant M64V
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-6-methylpurine + phosphate
?
-
a toxic prodrug, substrate of enzyme mutant M64V, the drug product has anti-tumor activity
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-6-methylpurine + phosphate
?
-
a toxic prodrug, substrate of enzyme mutant M64V, liberation of methylpurine
-
-
?
9-[beta-L-lyxofuranosyl]-2-fluoro-adenine + phosphate
?
-
a toxic prodrug, substrate of enzyme mutant M64V, the drug product has anti-tumor activity
-
-
?
9-[beta-L-lyxofuranosyl]-2-fluoro-adenine + phosphate
?
-
a toxic prodrug, substrate of enzyme mutant M64V
-
-
?
adenine + deoxyribose 1-phosphate
deoxyadenosine + phosphate
-
-
-
-
r
adenine + deoxyribose 1-phosphate
deoxyadenosine + phosphate
-
-
-
r
adenine + deoxyribose 1-phosphate
deoxyadenosine + phosphate
-
-
-
r
adenine + deoxyribose 1-phosphate
deoxyadenosine + phosphate
-
-
-
-
?
adenine + deoxyribose 1-phosphate
deoxyadenosine + phosphate
-
-
-
-
r
adenine + deoxyribose 1-phosphate
deoxyadenosine + phosphate
-
-
-
r
adenine + deoxyribose 1-phosphate
deoxyadenosine + phosphate
-
-
-
-
?
adenosine + arsenate
adenine + alpha-D-ribose 1-arsenate
-
-
-
-
?
adenosine + arsenate
adenine + alpha-D-ribose 1-arsenate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
low activity
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
reaction with adenosine-specific phosphorylase, no activity with inosine-guanosine phosphorylase
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 1% of the activity with inosine, isoform of 702 amino acids, 48% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 1% of the activity with inosine, isoform of 702 amino acids, 48% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
no activity
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
no activity
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
no activity
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
61% of the activity with deoxyguanosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
41% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
59.9% of the activity with 2'-deoxyinosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
no activity
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
160% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
activity with OUNOII, no activity with PUNPI
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
160% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
no activity
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
very low activity
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
low activity
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
low activity
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
low activity
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
very low activity
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
best substrate
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
best substrate
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
wild-type enzyme and mutant enzyme K244Q show no activity with adenosine, mutant enzyme N243D and N243D/K244Q are active with adenosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
48% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
48% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
15.4% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
45% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
15.4% of the activity with inosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
78% of the activity with deoxyguanosine
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
100% activity
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
exclusive substrate for the hexameric enzyme
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
exclusive substrate for the hexameric enzyme
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
in the reverse reaction the catalytic activity with adenine is higher than that with either hypoxanthine or guanine
-
-
r
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
-
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
reaction with adenosine-specific phosphorylase, no activity with inosine-guanosine phosphorylase
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
112.9% of the activity with inosine
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
112.9% of the activity with inosine
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
61% of the activity with deoxyguanosine
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
2'-deoxyadenosine, 160% of the activity with inosine
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
2'-deoxyadenosine, 65% of the activity with adenosine. 3'-deoxyadenosine, 8% of the activity with adenosine
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
2'-deoxyadenosine, 65% of the activity with adenosine. 3'-deoxyadenosine, 8% of the activity with adenosine
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
2'-deoxyadenosine, 57% of the activity with inosine. 3'-deoxyadenosine, 7% of the activity with inosine
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
78% of the activity with deoxyguanosine
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
-
?
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
reaction with ionosine-guanosine phosphorylase, very low activity with the adenosine-specific phosphorylase
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
11% of the activity with inosine
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyguanosine, 469% of the activity with inosine
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
85% of the activity with inosine
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyguanosine, 469% of the activity with inosine
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
85% of the activity with inosine
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyguanosine, 41% of the activity with inosine. 3'-deoxyguanosine, 16% of the activity with inosine
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyguanosine, 41% of the activity with inosine. 3'-deoxyguanosine, 16% of the activity with inosine
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
14% of the activity with inosine
-
-
?
deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
-
19% of the activity with inosine
-
-
?
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
reaction with inosine-guanosine phosphorylase, no activity with the adenosine-specific phosphorylase
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyinosine and 5'-deoxyinosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
88% of the activity with deoxyguanosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyinosine, 87% of the activity with inosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
as active as inosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyinosine, 691% of the activity with inosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyinosine, 691% of the activity with inosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
as active as inosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyinosine, 43% of the activity with adenosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
2'-deoxyinosine, 43% of the activity with adenosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
136% of the activity with inosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
136% of the activity with inosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
?
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
?
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
88% of the activity with deoxyguanosine
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
-
r
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
-
-
-
?
guanine + alpha-D-ribose 1-phosphate
guanosine + phosphate
-
-
-
r
guanine + alpha-D-ribose 1-phosphate
guanosine + phosphate
-
-
-
-
?
guanine + alpha-D-ribose 1-phosphate
guanosine + phosphate
-
-
-
r
guanine + alpha-D-ribose 1-phosphate
guanosine + phosphate
-
-
-
r
guanosine + arsenate
guanine + alpha-D-ribose 1-arsenate
-
-
-
-
?
guanosine + arsenate
guanine + alpha-D-ribose 1-arsenate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
no activity
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
moderate activity
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
moderate activity
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
reaction with inosine-guanosine phosphorylase, no activity with the adenosine-specific phosphorylase
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 87% of the activity with inosine, isoform of 702 amino acids, 46% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
isoform of 816 amino acids, 87% of the activity with inosine, isoform of 702 amino acids, 46% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
47.4% of the reaction with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
47.4% of the reaction with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
48% of the activity with deoxyguanosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
no activity with mutant enzyme N239D
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
58.7% of the activity with 2'-deoxyinosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
66% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
21% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
53% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
84% of the activity with guanosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
53% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
84% of the activity with guanosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
Halalkalibacterium halodurans
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
Halalkalibacterium halodurans Alk36
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
insight into catalytically relevant correlated motions in human purine nucleoside phosphorylase
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
2'-deoxyinosine, 27% of the activity with inosine. 3'-deoxyinosine, 10% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
2'-deoxyinosine, 27% of the activity with inosine. 3'-deoxyinosine, 10% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
2.3% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
55.8% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
56% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
55.8% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
absolute specificity for inosine and guanosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
16% of the activity with inosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
81% of the activity with deoxyguanosine
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
8.7% phosphorolysis of substrate within 30 min
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
exclusive substrate for the trimeric enzyme
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
8.7% phosphorolysis of substrate within 30 min
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
exclusive substrate for the trimeric enzyme
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
r
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + arsenate
hypoxanthine + ribose 1-arsenate
-
ribosyl group is nearly dissociated from the base prior to attack of the arsenate
-
?
inosine + arsenate
hypoxanthine + ribose 1-arsenate
-
-
-
-
?
inosine + arsenate
hypoxanthine + ribose 1-arsenate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
no activity
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
best substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
best substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
reaction with ionosine-guanosine phosphorylase, no activity with the adenosine-specific phosphorylase
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
the equilibrium is reached when approximately 14% of inosine is phosphorylated
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
the equilibrium is reached when approximately 14% of inosine is phosphorylated
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
highest activity
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
46% of the activity with deoxyguanosine
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
83% of the activity with 2'-deoxyinosine
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
reaction reaches an equilibrium when 21% of the inosine is phosphorolyzed
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
Halalkalibacterium halodurans
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
Halalkalibacterium halodurans Alk36
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
best substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
best substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
best substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
mechanism
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
complete conversion
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
34% of the activity with adenosine
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
equilibrium when 65% of inosine has been phosphorylated
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
34% of the activity with adenosine
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
equilibrium when 65% of inosine has been phosphorylated
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
preferred substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
preferred substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
preferred substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
preferred substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
preferred substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
preferred substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
preferred substrate
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
complete conversion
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
absolute specificity for inosine and guanosine
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
82% of the activity with deoxyguanosine
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
19.1% phosphorolysis of substrate within 30 min
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
19.1% phosphorolysis of substrate within 30 min
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
r
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
r
methylthioinosine + phosphate
methylthiohypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
?
methylthioinosine + phosphate
methylthiohypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
methylthioinosine + phosphate
methylthiohypoxanthine + alpha-D-ribose 1-phosphate
-
-
-
-
?
N7-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
the N7-riboside of 8-azaDaPur seems to be quite rapidly and specifically phosphorolysed by calf PNP. The mutation at Asn243 markedly accelerates this process
-
-
r
N7-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
enzyme PNP mutant D204N
-
-
r
N7-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
-
-
-
r
N8-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
wild-type enzyme PNP
-
-
r
N8-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
wild-type enzyme PNP
-
-
r
N9-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
enzyme PNP mutant N243D
-
-
r
N9-D-ribosyl-2,6-diamino-8-azapurine + phosphate
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
enzyme PNP mutant D204N
-
-
r
nicotinamide riboside + phosphate
nicotinamide + alpha-D-ribose 1-phosphate
-
-
-
?
nicotinamide riboside + phosphate
nicotinamide + alpha-D-ribose 1-phosphate
-
-
-
?
nicotinamide riboside + phosphate
nicotinamide + alpha-D-ribose 1-phosphate
-
-
-
r
nicotinamide riboside + phosphate
nicotinamide + alpha-D-ribose 1-phosphate
-
-
-
?
nicotinamide riboside + phosphate
nicotinamide + alpha-D-ribose 1-phosphate
-
-
-
r
purine deoxyribonucleoside + phosphate
purine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
purine deoxyribonucleoside + phosphate
purine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
purine deoxyribonucleoside + phosphate
purine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
purine ribonucleoside + phosphate
purine + alpha-D-ribose 1-phosphate
-
-
-
?
purine ribonucleoside + phosphate
purine + alpha-D-ribose 1-phosphate
-
-
-
-
?
purine ribonucleoside + phosphate
purine + alpha-D-ribose 1-phosphate
-
-
-
-
?
purine ribonucleoside + phosphate
purine + alpha-D-ribose 1-phosphate
-
-
-
r
xanthosine + arsenate
xanthine + alpha-D-ribose 1-arsenate
-
-
-
?
xanthosine + arsenate
xanthine + alpha-D-ribose 1-arsenate
-
-
-
-
?
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
-
-
-
-
?
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
-
-
-
r
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
-
43.5% of the activity with inosine
-
-
?
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
-
43.5% of the activity with inosine
-
-
?
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
-
-
-
-
?
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
no activity with mutant enzymes Y191L and N239D
-
-
?
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
-
26% of the activity with inosine
-
-
?
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
-
-
-
-
?
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
-
-
-
-
r
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
-
reaction only at high concentrations
-
-
?
xanthosine + phosphate
xanthine + alpha-D-ribose 1-phosphate
-
-
-
r
xanthosine + phosphate
xanthine + alpha-D-ribose 1-phosphate
-
-
-
r
additional information
?
-
the enzyme cannot accept 6-chloropurines
-
-
?
additional information
?
-
-
the enzyme cannot accept 6-chloropurines
-
-
?
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
the enzyme cannot accept 6-chloropurines
-
-
?
additional information
?
-
substrate specificity, detailed overview, no activity with 2'-deoxyadenosine
-
-
-
additional information
?
-
-
substrate specificity, detailed overview, no activity with 2'-deoxyadenosine
-
-
-
additional information
?
-
substrate specificity, detailed overview, no activity with 2'-deoxyadenosine
-
-
-
additional information
?
-
no activity is detected for adenosine or 2'-deoxyadenosine
-
-
?
additional information
?
-
-
no activity is detected for adenosine or 2'-deoxyadenosine
-
-
?
additional information
?
-
-
two purine nucleoside phosphorylases: 1. inosine-guanosine phosphorylase, 2. adenosine-specific phosphorylase
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
key enzyme in purine salvage pathway
-
-
?
additional information
?
-
N7-D-ribosyl-2,6-diamino-8-azapurine is a good fluorogenic substrate for mammalian forms of PNP, while the N8-riboside is selective to the Escherichia coli enzyme. The altered specificity of the PNP mutants towards some of the purine analogues can be related to differences in binding modes of 8-azapurine bases in the PNP active site, including binding in the upside-down position (rotation by 180 degree when compared with standard binding mode). Ribosylation of 2,6-diamino-8-azapurine leads to at least three fluorescent ribosides. The N9-riboside is very highly fluorescent, but its fluorescence is generally similar, in terms of lambdamax and decay time, to that of the free base. By contrast, fluorescence of N7- and N8-ribosides is red-shifted by about 70 nm and thanks to this shift their cleavage via phosphorolysis (or hydrolysis) leads to a high fluorogenic effect at about 360 nm, which can be analytically useful
-
-
-
additional information
?
-
the trimeric PNP binds adenosine but it does not catalyze its phosphorolysis
-
-
-
additional information
?
-
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
catalysis involves protonation of the purine base at position N7 by residue Asp204, which is triggered by Arg217
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-
?
additional information
?
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-
catalysis involves protonation of the purine base at position N7 by residue Asp204, which is triggered by Arg217
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-
?
additional information
?
-
-
enzyme shows a high tolerance to the steric and hydrophobic environment at the 6-position of the synthesized purine ribonucleosides
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?
additional information
?
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no substrate: xanthosine, uridine, 2'-deoxythymidine, cytidine
-
-
?
additional information
?
-
-
no substrate: xanthosine, uridine, 2'-deoxythymidine, cytidine
-
-
?
additional information
?
-
etheno-derivatives of guanine, O6-methylguanine, and isoguanine are prepared and examined as potential substrates of purine-nucleoside phosphorylase in the reverse (synthetic) pathway. 1,N2-ethenoguanine and 1,N6-etheno-isoguanine are excellent substrates for purine-nucleoside phosphorylase (PNP) from Escherichia coli, while O6-methyl-N2,3-ethenoguanine exhibits moderate activity with this enzyme. The ribosylation reaction is fully reversible by the addition of a phosphate buffer up to a concentration of about 5 mM. The inability of the enzyme to ribosylate N2,3-ethenoguanine is not due to geometric hindrance, but rather should be ascribed to unfavorable energetic factors, in accordance with previous reports about the relative instability of the glycosidic bond in this compound. N2,3-etheno-O6-methylguanine is a poor substrate, it competitively competes with guanine in the ribosylation process, acting as quasi inhibitor of the Escherichia coli PNP. 6-Aminopurine ribosides, not possessing a mobile proton at the N1 position, do not react with trimeric forms of PNP
-
-
-
additional information
?
-
-
etheno-derivatives of guanine, O6-methylguanine, and isoguanine are prepared and examined as potential substrates of purine-nucleoside phosphorylase in the reverse (synthetic) pathway. 1,N2-ethenoguanine and 1,N6-etheno-isoguanine are excellent substrates for purine-nucleoside phosphorylase (PNP) from Escherichia coli, while O6-methyl-N2,3-ethenoguanine exhibits moderate activity with this enzyme. The ribosylation reaction is fully reversible by the addition of a phosphate buffer up to a concentration of about 5 mM. The inability of the enzyme to ribosylate N2,3-ethenoguanine is not due to geometric hindrance, but rather should be ascribed to unfavorable energetic factors, in accordance with previous reports about the relative instability of the glycosidic bond in this compound. N2,3-etheno-O6-methylguanine is a poor substrate, it competitively competes with guanine in the ribosylation process, acting as quasi inhibitor of the Escherichia coli PNP. 6-Aminopurine ribosides, not possessing a mobile proton at the N1 position, do not react with trimeric forms of PNP
-
-
-
additional information
?
-
hexameric PNPs accept as substrates many nucleoside analogues with various modifications in the purine ring, with an important exception of 7-deaza nucleosides. N7-Methylated guanosine, inosine and adenosine are unusual fluorescent substrates of both trimeric and hexameric PNPs
-
-
-
additional information
?
-
hexameric PNPs accept as substrates many nucleoside analogues with various modifications in the purine ring, with an important exception of 7-deaza nucleosides. N7-Methylated guanosine, inosine and adenosine are unusual fluorescent substrates of both trimeric and hexameric PNPs
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-
-
additional information
?
-
N1-methylated guanosine, inosine, and adenosine derivatives are selective substrates for hexameric PNP from Escherichia coli. Hexameric PNPs accept as substrates many nucleoside analogues with various modifications in the purine ring, with an important exception of 7-deaza nucleosides. N7-Methylated guanosine, inosine and adenosine are unusual fluorescent substrates of both trimeric and hexameric PNPs. Escherichia coli PNP converts pro-drugs, which are relative nontoxic purine nucleosides (for example 6-methyl purine 2'-deoxynucleoside or fludarabine), to their respective purine analogs (here, to 6-methylpurine and 2-fluoroadenine, respectively), which are very potent, toxic drugs. Enzymatic ribosylation of 8-azapurines, overview. Isoadenosine (3-beta-D-ribosyl-adenine), is, unlike the parent adenosine, a quite good substrate for mammalian and bacterial PNP. Ribosylation of tri-cyclic nucleobase analogues and phosphorolysis
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-
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additional information
?
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N1-methylated guanosine, inosine, and adenosine derivatives are selective substrates for hexameric PNP from Escherichia coli. Hexameric PNPs accept as substrates many nucleoside analogues with various modifications in the purine ring, with an important exception of 7-deaza nucleosides. N7-Methylated guanosine, inosine and adenosine are unusual fluorescent substrates of both trimeric and hexameric PNPs. Escherichia coli PNP converts pro-drugs, which are relative nontoxic purine nucleosides (for example 6-methyl purine 2'-deoxynucleoside or fludarabine), to their respective purine analogs (here, to 6-methylpurine and 2-fluoroadenine, respectively), which are very potent, toxic drugs. Enzymatic ribosylation of 8-azapurines, overview. Isoadenosine (3-beta-D-ribosyl-adenine), is, unlike the parent adenosine, a quite good substrate for mammalian and bacterial PNP. Ribosylation of tri-cyclic nucleobase analogues and phosphorolysis
-
-
-
additional information
?
-
N7-D-ribosyl-2,6-diamino-8-azapurine is a good fluorogenic substrate for mammalian forms of PNP, including human blood PNP, while the N8-riboside is selective to the Escherichia coli enzyme. Wild-type calf PNP gives N7- and N8-ribosides, while the calf enzyme N243D PNP mutant directs the ribosyl substitution at N9- and N7-positions. The Escherichia coli enzyme ribosylates adenine and 8-azaadenine. In both cases, the N9-ribosides are the only detectable ribosylation products for the wild-type enzyme, while the D204N mutant reacting with the latter substrate does produce the N8-riboside. The altered specificity of the PNP mutants towards some of the purine analogues can be related to differences in binding modes of 8-azapurine bases in the PNP active site, including binding in the upside-down position (rotation by 180 degree when compared with standard binding mode). Ribosylation of 2,6-diamino-8-azapurine leads to at least three fluorescent ribosides. The N9-riboside is very highly fluorescent, but its fluorescence is generally similar, in terms of lambdamax and decay time, to that of the free base. By contrast, fluorescence of N7- and N8-ribosides is red-shifted by about 70 nm and thanks to this shift their cleavage via phosphorolysis (or hydrolysis) leads to a high fluorogenic effect at about 360 nm, which can be analytically useful
-
-
-
additional information
?
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-
N7-D-ribosyl-2,6-diamino-8-azapurine is a good fluorogenic substrate for mammalian forms of PNP, including human blood PNP, while the N8-riboside is selective to the Escherichia coli enzyme. Wild-type calf PNP gives N7- and N8-ribosides, while the calf enzyme N243D PNP mutant directs the ribosyl substitution at N9- and N7-positions. The Escherichia coli enzyme ribosylates adenine and 8-azaadenine. In both cases, the N9-ribosides are the only detectable ribosylation products for the wild-type enzyme, while the D204N mutant reacting with the latter substrate does produce the N8-riboside. The altered specificity of the PNP mutants towards some of the purine analogues can be related to differences in binding modes of 8-azapurine bases in the PNP active site, including binding in the upside-down position (rotation by 180 degree when compared with standard binding mode). Ribosylation of 2,6-diamino-8-azapurine leads to at least three fluorescent ribosides. The N9-riboside is very highly fluorescent, but its fluorescence is generally similar, in terms of lambdamax and decay time, to that of the free base. By contrast, fluorescence of N7- and N8-ribosides is red-shifted by about 70 nm and thanks to this shift their cleavage via phosphorolysis (or hydrolysis) leads to a high fluorogenic effect at about 360 nm, which can be analytically useful
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
-
cellular function seems concerned primarily with nucleoside breakdown
-
-
?
additional information
?
-
-
children lacking PNP activity exhibit severe T cell immunodeficiency while maintaining normal or exaggerated B cell function. The PNP deficiency results in very low uric acid concentrations and high concentrations of the nucleoside substrate of PNP in plasma and urine
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-
?
additional information
?
-
in intact cells, the enzyme functions in the direction of phosphorolysis, leading to degradation of purine nucleosides via coupling with guanase and xanthine oxidase. PNP deficiency is a rare disorder associated with an autosomal recessive form of cellular, but not humoral, immunodeficiency, and comprises about 4% of all cases of severe combined immunodeficiency. Mutations identified in cases of PNP deficiency
-
-
?
additional information
?
-
-
in intact cells, the enzyme functions in the direction of phosphorolysis, leading to degradation of purine nucleosides via coupling with guanase and xanthine oxidase. PNP deficiency is a rare disorder associated with an autosomal recessive form of cellular, but not humoral, immunodeficiency, and comprises about 4% of all cases of severe combined immunodeficiency. Mutations identified in cases of PNP deficiency
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-
?
additional information
?
-
enzyme plays a key role in the purine salvage pathway. PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects on B-cell function
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-
?
additional information
?
-
-
enzyme plays a key role in the purine salvage pathway. PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects on B-cell function
-
-
?
additional information
?
-
N7-D-ribosyl-2,6-diamino-8-azapurine is a good fluorogenic substrate for mammalian forms of PNP, while the N8-riboside is selective to the Escherichia coli enzyme. Ribosylation of 2,6-diamino-8-azapurine leads to at least three fluorescent ribosides. The N9-riboside is very highly fluorescent, but its fluorescence is generally similar, in terms of lambdamax and decay time, to that of the free base. By contrast, fluorescence of N7- and N8-ribosides is red-shifted by about 70 nm and thanks to this shift their cleavage via phosphorolysis (or hydrolysis) leads to a high fluorogenic effect at about 360 nm, which can be analytically useful
-
-
-
additional information
?
-
-
N7-D-ribosyl-2,6-diamino-8-azapurine is a good fluorogenic substrate for mammalian forms of PNP, while the N8-riboside is selective to the Escherichia coli enzyme. Ribosylation of 2,6-diamino-8-azapurine leads to at least three fluorescent ribosides. The N9-riboside is very highly fluorescent, but its fluorescence is generally similar, in terms of lambdamax and decay time, to that of the free base. By contrast, fluorescence of N7- and N8-ribosides is red-shifted by about 70 nm and thanks to this shift their cleavage via phosphorolysis (or hydrolysis) leads to a high fluorogenic effect at about 360 nm, which can be analytically useful
-
-
-
additional information
?
-
nicotinamide riboside is a substrate of trimeric PNPs because it mimics 6-keto/N1H arrangement of 6-oxopurine nucleosides and 8-azaguanine. For trimeric PNP, the proton at the purine position N1 is required for catalysis. N7-Methylated guanosine, inosine and adenosine are unusual fluorescent substrates of both trimeric and hexameric PNPs. No activity with pro-drugs 6-methyl purine 2'-deoxynucleoside or fludarabine (9-beta-D-arabinosyl-2-fluoroadenine). Enzymatic ribosylation of 8-azapurines, overview. Isoadenosine (3-beta-D-ribosyl-adenine), is, unlike the parent adenosine, a quite good substrate for mammalian and bacterial PNP. Ribosylation of tri-cyclic nucleobase analogues and phosphorolysis
-
-
-
additional information
?
-
the nutraceutical nicotinamide riboside (NR), an efficacious biosynthetic precursor to NAD, is readily metabolized by the purine nucleoside phosphorylase (PNP). Access to the PNP-stable versions of NR is difficult because the glycosidic bond of NR is easily cleaved. Unlike NR, NRH, the reduced form of NR, offers sufficient chemical stability to allow the successful functionalisation of the ribosyl-moiety. A series of NRH and NR derived amino acid conjugates is generated in good to excellent yields and show that O5'-esterification prevents the PNP-catalyzed phosphorolysis of these NR prodrugs, overview. Enzyme PNP catalyzes the phosphorolysis of nicotinamide riboside chloride (NR-Cl) and glycine nicotinamide riboside conjugate (Gly-NR)
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-
-
additional information
?
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the recombinant enzyme does not metabolize adenosine to adenine or N6-etheno-adenosine to N6-etheno-adenine
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-
-
additional information
?
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no significant activity towards adenosine. Substrate binding structure analysis, active site structure comparisons, overview
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-
-
additional information
?
-
-
no significant activity towards adenosine. Substrate binding structure analysis, active site structure comparisons, overview
-
-
-
additional information
?
-
no significant activity towards adenosine. Substrate binding structure analysis, active site structure comparisons, overview
-
-
-
additional information
?
-
no significant activity towards adenosine. Substrate binding structure analysis, active site structure comparisons, overview
-
-
-
additional information
?
-
no significant activity towards adenosine. Substrate binding structure analysis, active site structure comparisons, overview
-
-
-
additional information
?
-
no significant activity towards adenosine. Substrate binding structure analysis, active site structure comparisons, overview
-
-
-
additional information
?
-
no significant activity towards adenosine. Substrate binding structure analysis, active site structure comparisons, overview
-
-
-
additional information
?
-
no significant activity towards adenosine. Substrate binding structure analysis, active site structure comparisons, overview
-
-
-
additional information
?
-
Leucisus rusticus
-
in fish skin the enzyme plays a key role in the deposition of guanine and hypoxanthine crystals
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?
additional information
?
-
-
enzyme is more specific to natural 6-oxopurine nucleosides and synthetic compounds, and does not catalyze the phosphorolysis of adenosine
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-
?
additional information
?
-
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
the complete hydrophobic pocket plays an important role in the catalytic function. A potential transition state structure is present in hydrogen bond between the carboxyl groups of Thr90 in the phosphate binding site
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-
?
additional information
?
-
-
the complete hydrophobic pocket plays an important role in the catalytic function. A potential transition state structure is present in hydrogen bond between the carboxyl groups of Thr90 in the phosphate binding site
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-
?
additional information
?
-
the complete hydrophobic pocket plays an important role in the catalytic function. A potential transition state structure is present in hydrogen bond between the carboxyl groups of Thr90 in the phosphate binding site
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?
additional information
?
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-
enzyme is able to reactivate scrambled RNaseA
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?
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
in cultured cells (CFs, GMCs, PGVSMCs), isolated perfused kidneys, and in vivo, N6-etheno-adenosine is converted to N6-etheno-adenine. This reaction is abolished by 8-aminoguanine. When kidneys are not inserted into the perfusion system, N6-etheno-ATP is not metabolized. The conversions are inhibited by the PNPase inhibitor forodesine
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additional information
?
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in cultured cells (CFs, GMCs, PGVSMCs), isolated perfused kidneys, and in vivo, N6-etheno-adenosine is converted to N6-etheno-adenine. This reaction is abolished by 8-aminoguanine. When kidneys are not inserted into the perfusion system, N6-etheno-ATP is not metabolized. The conversions are inhibited by the PNPase inhibitor forodesine
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-
additional information
?
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salmon
-
in fish skin the enzyme plays a key role in the deposition of guanine and hypoxanthine crystals
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?
additional information
?
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the enzyme is specific for adenine nucleosides which includes adenosine analogs modified in the aglycone, pentose or both moieties
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?
additional information
?
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no activity with inosine and guanosine
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?
additional information
?
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-
the enzyme has no detectable ribohydrolase activity
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?
additional information
?
-
no substrate: acyclovir, benzimidazole, 2,6-diaminopurine
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-
?
additional information
?
-
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no substrate: acyclovir, benzimidazole, 2,6-diaminopurine
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-
?
additional information
?
-
-
the hexamric PNP binds adenosine but it does not catalyze its phosphorolysis
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
thermophilic PNPs and PyNPs accept nucleosides with arabinose, C2'-fluororibose and C2'-fluoroarabinose as the sugar moiety. Substrate spectrum of thermostable nucleoside phosphorylases, overview
-
-
-
additional information
?
-
no substrate: acyclovir, benzimidazole, 2,6-diaminopurine
-
-
?
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(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranozyl)ethylphosphonic acid
-
with (hypoxanthine-9-yl)methyl aglycone, i.e. Yokomatsu compound
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone
(3R,4R)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol
-
-
(3S)-3-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chlorophenyl)propanoic acid
IC50: 0.000036 mM
(3S,4R)-4-(guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylcarbonylphosphonic acid
-
competitive. For enzyme from cancer cell lines, Ki values are around 10 to 24 nM
(3S,4S)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol
-
-
(S)-3-(guanin-9-yl)pyrrolidin-N-ylcarbonylphosphonic acid
-
competitive. For enzyme from cancer cell lines, Ki values widely vary from 16 to 100 nM
1,5-O-bis(N-benzyloxycarbonylglycyl)-2,3-O-isopropylidene beta-D-riboside
-
1,6-Dihydropurine riboside
-
-
1-((2-pyrrolidine-1-yl)ethyl)uracil
inhibits both enzymic activity and growth of Plasmodium falciparum
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine
-
-
1-[2,3-O-isopropylidene-D-ribofuranosyl]-1,4-dihydropyridine-3-carboxamide
-
1-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]guanidine
0.1 mM , 79.5% inhibition
1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]guanidine
0.1 mM , 70.6% inhibition
2,6-diamino-7-(5-mercapto-3,3-dimethylpentyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00005 mM
2,6-diamino-7-(cyclohexylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.0066 mM
2,8-diamino-1,7-dihydro-6H-purine-6-thione
IC50: 0.00849 mM
2,8-diamino-1,9-dihydro-6H-purin-6-one
IC50: 0.002299 mM
2,8-diamino-3-(2-thienylmethyl)-3,9-dihydro-6H-purin-6-one
IC50: 0.001758 mM
2,8-diamino-9-(1,3-thiazol-4-ylmethyl)-1,9-dihydro-6H-purin-6-one
IC50: 0.001043 mM
2,8-diamino-9-(2-furylmethyl)-1,9-dihydro-6H-purin-6-one
IC50: 0.000092 mM; IC50: 0.00271 mM
2,8-diamino-9-(2-thienylmethyl)-1,9-dihydro-6H-purin-6-one
IC50: 0.000497 mM
2,8-diamino-9-(4-fluorobenzyl)-1,9-dihydro-6H-purin-6-one
IC50: 0.00417 mM
2,8-diamino-9-(pyridin-2-ylmethyl)-1,9-dihydro-6H-purin-6-one
IC50: 0.001971 mM
2,8-diamino-9-[(4-methyl-2-thienyl)methyl]-1,9-dihydro-6H-purin-6-one
IC50: 0.000362 mM
2,8-diamino-9-[4-(1H-imidazol-1-yl)benzyl]-1,9-dihydro-6H-purin-6-one
IC50: 0.000852 mM
2,8-diamino-9-[[1-(heptyloxy)-2-hydroxyethoxy]methyl]-1,9-dihydro-6H-purin-6-one
IC50: 0.00152 mM
2-(3,4-dichlorophenyl)-5-thioxo-5,6-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3,7(2H,4H)-dione
IC50: 0.00703 mM
2-amino-1,5-dihydro-7-[[(2S)-2-(aminomethyl)-1-pyrrolidinyl]-methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 600 nM
2-amino-1,5-dihydro-7-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one
acetic acid salt, IC50: 4.0 nM
2-amino-1,5-dihydro-7-[[[2-(hydroxy)ethyl]amino]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 20 nM
2-amino-6-chloro-7-deazapurine 2'-deoxyriboside
-
2-amino-6-mercapto-7-methylpurine ribonucleoside
-
in absence of phosphate the enzyme catalyzes a slow hydrolysis, which is accompanied by inactivation of the enzyme
2-Amino-6-methylthiopurine
-
-
2-amino-6-oxo-9-[3-hydroxy-2-(phosphonomethoxy)propyl]-purine
-
2-amino-7-(1,2-dithian-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000018 mM
2-amino-7-(2,3,5-trichlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00024 mM
2-amino-7-(2-chlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00012 mM
2-amino-7-(2-furylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000083 mM
2-amino-7-(2-hydroxybenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00027 mM
2-amino-7-(2-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000021 mM
2-amino-7-(2-thienylmethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
IC50: 0.000674 mM
2-amino-7-(3,4-dichlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000017 mM
2-amino-7-(3-chlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00002 mM
2-amino-7-(3-fluorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000024 mM
2-amino-7-(3-hydroxybenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00007 mM
2-amino-7-(3-methoxybenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000082 mM
2-amino-7-(3-methylbenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000057mM
2-amino-7-(3-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000025 mM
2-amino-7-(4-chlorobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000025 mM
2-amino-7-(4-iodobenzyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000023 mM
2-amino-7-(biphenyl-4-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000546 mM
2-amino-7-(cycloheptylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00003 mM
2-amino-7-(cyclohexylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000047 mM
2-amino-7-(cyclopentylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000029 mM
2-amino-7-(piperidin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.001 mM
2-amino-7-(pyridin-2-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000025 mM
2-amino-7-(pyridin-4-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000064 mM
2-amino-7-(tetrahydro-2-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000011 mM
2-amino-7-(tetrahydrofuran-2-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00007 mM
2-amino-7-([[(2R,3S)-1,3,4-trihydroxybutan-2-yl]amino]methyl)-3,5-dihydro-4Hpyrrolo[3,2-d]pyrimidin-4-one
-
i.e. DATMe-immucillin-G
2-amino-7-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000051 mM
2-amino-7-cyclohex-1-en-1-yl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.0019 mM
2-amino-7-phenoxy-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000042 mM
2-amino-7-[(3-hydroxyphenyl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
1.82% inhibition at 0.2 mM
2-amino-7-[(3-methylcyclohexyl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000025 mM
2-amino-7-[(3-tert-butylcyclohexyl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000025 mM
2-amino-7-[(4-chloropyridin-3-yl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000135 mM
2-amino-7-[(pyridin-3-yl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
35.2% inhibition at 0.2 mM
2-amino-7-[([1,1'-biphenyl]-4-yl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
1.52% inhibition at 0.2 mM
2-amino-7-[3-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000124 mM; IC50: 0.000147 mM
2-amino-7-[3-(trifluoromethyl)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000036 mM
2-amino-7-[4-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2-amino-7-[4-(propan-2-yl)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
2-amino-7-[[(1,3-dihydroxypropan-2-yl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
i.e. SerMe-immucillin-G
2-amino-7-[[(1R,3S,5S,7S)-4-methyl-2-adamantyl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00009 mM
2-amino-7-[[(2-hydroxyethyl)(methyl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 60 nM
2-amino-7-[[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 620 nM
2-amino-7-[[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 600 nM
2-amino-7-[[(2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 2 nM
2-amino-7-[[3-(hydroxymethyl)piperidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.004 mM
2-amino-7-[[bis(2-hydroxyethyl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 5 nM
2-amino-7-[[ethyl(2-hydroxyethyl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 220 nM
2-amino-9-(2-thienylmethyl)-8-thioxo-1,7,8,9-tetrahydro-6H-purin-6-one
IC50: 0.002866 mM
2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine
2-chloro-6-(3-phenyl-1-propoxy)purine
-
2-chloroadenosine
-
inhibits ribosylation of adenine and N6-furfuryladenine
2-fluoro-2'-deoxyadenosine
-
the substrate releases highly cytotoxic 2-fluoroadenine. 2-Fluoro-2'-deoxyadenosine and 2-fluoroadenine exert strong inhibition of Trichomonas vaginalis growth with estimated IC50 values of 106 nM and 84 nM. 2-Fluoro-2'-deoxyadenosine might be useful as a potential chemotherapeutic agent against Trichomonas vaginalis
2-phenyl-5,7-dithioxo-1,2,4,5,6,7-hexahydro-3H-pyrazolo[4,3-d]pyrimidin-3-one
IC50: 0.02284 mM
3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
3-((2-pyrrolidine-1-yl)ethyl)uracil
inhibits both enzymic activity and growth of Plasmodium falciparum
3-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-phenylpropanoic acid
IC50: 0.000047 mM
3-(3-chlorophenyl)-3-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)propanenitrile
IC50: 0.000011 mM
3-(3-chlorophenyl)-3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)propanenitrile
IC50: 0.00001 mM
3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(pyridin-3-yl)propanenitrile
-
72.7% inhibition at 0.2 mM
3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-pyridin-3-ylpropanenitrile
IC50: 0.000039 mM
3-carbamoyl-1-[2,3-O-isopropylidene-D-ribofuranosyl]pyridin-1-ium
-
3-[(2R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-G
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-H
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-G
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
4-imino-7-methyl-1,2,3,4-tetrahydropyrazolo [1,5-a] [1,3,5] triazin-2-one
-
5'-chloro-5'-deoxy-8-aminoguanosine
5'-deoxy-5'-iodo-9-deazainosine
-
5'-deoxy-5'-iodoinosine
-
5'-methylthio-immucillin H
-
5'-methylthio-immucillin-H
5,5'-dithiobis(2-nitrobenzoic acid)
5-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,3-dimethylpentane-1-sulfonamide
IC50: 0.0001 mM
5-amino-3-(2-thienylmethyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
IC50: 0.001839 mM
6-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-4,4-dimethylhexanamide
IC50: 0.2 mM
6-(2,6-diamino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-4,4-dimethylhexanenitrile
IC50: 0.00026 mM
6-amino-2-chloro-7-deazapurine 2'-deoxyriboside
-
6-amino-5-bromopyrimidine-2,4(1H,3H)-dione
formation of eight hydrogen bonds with key residues in the active site E203, N245 and T244
6-amino-7-(2-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00016 mM
6-amino-7-phenylethinyl-7-deazapurine 2'-deoxyriboside
-
6-benzyloxy-2-chloropurine
-
6-chloro-7-deazapurine 2'-deoxyriboside
-
6-hydroxy-9-p-aminobenzylpurine
-
-
6-methylformycin A
strng inhibition
6-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
-
7-(3-thienylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000028 mM
7-(cyclopentylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000029 mM
7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00004 mM
7-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
7-ketopyrazolo[4,3-d]pyrimidine
-
inhibits phosphorolysis of 7-methylguanosine uncompetitively, inhibits synthesis of 8-azaguanosine competitively
7-[(2S,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
-
7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
i.e. forodesine
7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-6-carboxylic acid
-
-
7-[3-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.00019 mM
7-[[(1,3-dihydroxypropan-2-yl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
7-[[(3R,4R)-4-hydroxy-3-(hydroxymethyl)pyrrolidin-2-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
i.e. BCX-4208, mimics the charged ribosyl oxocarbenium ion formed during the transition state
7KPP
-
non-substrate inhibitor of both the phosphorolytic and reverse synthetic pathways, inhibits synthesis of 8-azaguanosine from 8-azaguanine competitively
8-amino-3-(2-thienylmethyl)guanine
-
8-amino-5'-deoxy-5'-chloroguanosine
8-amino-5'-deoxy-5'-iodoguanosine
-
8-aza-2,6-diamino-(S)-9-[2-(phosphonomethoxy)ethyl]-purine
-
8-aza-2,6-diaminopurine
-
noncompetitive
8-bromo-N(9)-acycloguanosine
-
-
8-Bromoadenosine
about 30% inhibition
8-dimethylaminoinosine
about 20% inhibition
8-methoxyinosine
-
about 20% inhibition
9-(1,3-dihydroxy-2-propoxymethyl)guanine
-
-
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine
9-(2-fluoro-3,4-dihydroxybutyl)-guanine
9-(2-hydroxyethoxymethyl)guanine
-
-
9-(2-phosphonylmethoxyethyl)-8-azaguanine
9-(3,4-dihydroxybutyl)guanine
and analogues
9-(3-pyridylmethyl)-9-deaza-guanosine
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine
9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine
9-(5,5-difluoro-5-phosphonopentyl)guanine
9-(5,5-difluoro-5-phosphopentyl)guanine
-
-
9-(5,5-difluorophosphonopentyl)guanine
-
9-(5-phosphonopentyl)guanine
-
alpha-D-ribose 1-phosphate
aminopterin
-
noncompetitive
apigenin
77.4% inhibition at 0.15 mM, reversible inhibition
baicalein
72% inhibition at 0.15 mM, reversible inhibition
chrysin
5,7-dihydroxyflavone, a natural flavone found in various plant extracts, including blue passionflower, honey and propolis, etc., 38.8% inhibition at 0.15 mM, reversible inhibition
cis-1,1-difluoro-2-(tetrahydro-3-piranozyl)ethylphosphonic acid
-
with (hypoxanthine-9-yl)methyl aglycone
cis-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethylpyrrolidin-3-ol
-
-
D,L-6-methyl 5,6,7,8-tetrahydropterin
-
competitive
erythro-9-(2-hydroxy-3-nonyl)adenine
-
competitive
forodesine hydrochloride
-
hypoxanthine arabinoside
-
-
L-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
N(1)-Methylformycin A
-
-
N(6)-methylformycin B
-
-
N2,3-etheno-O6-methylguanine
is a poor substrate, it competitively competes with guanine in the ribosylation process, acting as quasi inhibitor of the Escherichia coli PNP
N2,3-ethenoguanine
exhibits moderate, possibly competitive inhibition of Escherichia coli PNP
nicotinamide 5-O-glycyl-beta-D-riboside
-
nicotinamide 5-O-L-isoleucyl-beta-D-riboside
-
nicotinamide 5-O-L-leucyl-beta-D-riboside
-
nicotinamide 5-O-L-methionyl-beta-D-riboside
-
nicotinamide 5-O-L-tryptophanyl-beta-D-riboside
-
nicotinamide 5-O-L-tyrosinyl-beta-D-riboside
-
nicotinamide 5-O-L-valyl-beta-D-riboside
-
reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-isoleucyl)-2,3-O-isopropylidene beta-D-riboside
-
reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-leucyl)-2,3-O-isopropylidene beta-D-riboside
-
reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-methionyl)-2,3-O-isopropylidene beta-D-riboside
-
reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-tyrosinyl)-2,3-O-isopropylidene beta-D-riboside
-
reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-valyl)-2,3-O-isopropylidene beta-D-riboside
-
reduced nicotinamide 5-O-(N-tert-butyloxycarbonylglycyl)-2,3-O-isopropylidene beta-D-riboside
-
reduced nicotinamide 5-O-(N1,Nalpha-bis(tert-butyloxycarbonyl)-L-tryptophanyl)-2,3-O-isopropylidene beta-D-riboside
-
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone
-
multisubstrate analogue inhibitor
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone
-
multisubstrate analogue inhibitor
1',9-methyl-immucillin-H
-
-
1',9-methyl-immucillin-H
-
1-methylguanine
-
-
2'-deoxy-immucillin-H
-
2'-deoxy-immucillin-H
-
-
2-amino-7-(pyridin-2-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000015 mM
2-amino-7-(pyridin-2-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
2-amino-7-(pyridin-2-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
-
2-amino-7-[4-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
2-amino-7-[4-(benzyloxy)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
-
2-amino-7-[4-(propan-2-yl)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
1.8fold selectivity for Schistosoma enzyme over human enzyme
2-amino-7-[4-(propan-2-yl)benzyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
1.8fold selectivity for Schistosoma enzyme over human enzyme
2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine
-
2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine
-
binding of multisubstrate analogue inhibitor to trimeric PNPs is a one-step process
2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine
-
kinetics of binding of multisubstrate analogue inhibitor; kinetics of binding of the multisubstrate analogue inhibitor 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine with the trimeric purine nucleoside phosphorylase
3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
-
-
3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
-
competitive inhibition with regard to inosine
3-[(2R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
6.4fold selectivity for Schistosoma enzyme over human enzyme
3-[(2R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
-
6.4fold selectivity for Schistosoma enzyme over human enzyme
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-G
-
-
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-G
-
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-H
-
-
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-H
-
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
weak binding inhibitor
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
weak binding inhibitor
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
dissociation constant of 30 pM, an inhibitor release half-time of 64 min. Tight binding with 4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A is in part due to a 2.7 A ionic interaction between a PO4 oxygen and the N1' cation of the hydroxypyrrolidine. The interaction of the inhibitor with TvPNP is the tightest-binding enzymatic interaction known for an immucillin analogue of adenosine; tight binding inhibitor
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-G
-
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-G
-
-
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
-
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
-
5'-amido-immucillin-H
-
-
5'-carboxy-immucillin-H
-
-
5'-carboxy-immucillin-H
-
5'-chloro-5'-deoxy-8-aminoguanosine
-
-
5'-chloro-5'-deoxy-8-aminoguanosine
-
-
5'-deoxy-immucillin-H
-
5'-deoxy-immucillin-H
-
-
5'-fluoro-immucillin-H
-
-
5'-methylthio-immucillin-H
favors inhibition of Plasmodium falciparum purine nucleoside phosphorylase over human enzyme
5'-methylthio-immucillin-H
-
favours inhibition of Plasmodium falciparum purine nucleoside phosphorylase over human enzyme
5'-methylthio-immucillin-H
-
5'-methylthio-immucillin-H
-
-
5'-methylthio-immucillin-H
a potent and selective inhibitor of PfPNP. Imucillins are known inhibitors of PfPNP
5'-methylthio-immucillin-H
-
5'-thio-immucillin-H
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
6-methylformycin
-
-
7-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
IC50: 0.000035 mM
7-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
11% inhibition at 0.2 mM
7-Deazainosine
-
-
7-[[(1,3-dihydroxypropan-2-yl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
i.e. SerMe-immucillin-H. Kd-value 5.2 pM
7-[[(1,3-dihydroxypropan-2-yl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
i.e. SerMe-immucillin-H. Inhibitor is orally available with a long residence time on blood enzyme
8-amino-5'-deoxy-5'-chloroguanosine
-
-
8-amino-5'-deoxy-5'-chloroguanosine
-
-
8-Amino-9-benzylguanine
-
-
8-Amino-9-benzylguanine
-
8-Amino-9-benzylguanine
-
-
8-aminoguanosine
-
-
8-Bromoguanosine
about 30% inhibition
8-Bromoguanosine
-
about 25% inhibition
8-methylaminoinosine
about 30% inhibition
8-methylaminoinosine
-
about 25% inhibition
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine
-
multisubstrate analogue inhibitor
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine
-
multisubstrate analogue inhibitor
9-(2-fluoro-3,4-dihydroxybutyl)-guanine
-
-
9-(2-fluoro-3,4-dihydroxybutyl)-guanine
-
-
9-(2-phosphonylmethoxyethyl)-8-azaguanine
-
inhibits phosphorolytic and synthetic reaction, competitive
9-(2-phosphonylmethoxyethyl)-8-azaguanine
-
competitive versus 8-azaguanine and alpha-D-ribose 1-phosphate
9-(3-pyridylmethyl)-9-deaza-guanosine
i.e. peldesine or BCX34
9-(3-pyridylmethyl)-9-deaza-guanosine
i.e. peldesine or BCX34
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine
-
multisubstrate analogue inhibitor
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine
-
multisubstrate analogue inhibitor
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine
-
multisubstrate analogue inhibitor
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine
-
multisubstrate analogue inhibitor
9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine
-
9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine
-
multisubstrate analogue inhibitor. Upon titration of the recombinant enzyme, endothermic as well as exothermic signals are obtained. Part of the recombinant enzyme forms a complex with its product, hypoxanthine, although hypoxanthine was not present at any purification stage except for its natural occurrence in Escherichia coli cells. Binding of hypoxanthine is accompanied with a large negative change of the free enthalpy, and therefore the replacement of hypoxanthine by 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine yields a positive heat signal
9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine
-
-
9-(5,5-difluoro-5-phosphonopentyl)guanine
-
-
9-(5,5-difluoro-5-phosphonopentyl)guanine
-
i.e. Danzin compound
9-benzylguanine
-
9-benzylguanine
-
isothermal titration calorimetry study. At 25°C, the tighter 9-benzylguanine binding reaction goes from an enthalpically-driven reaction in the absence of phosphate to an entropically-driven reaction at 10 mM phosphate, and the enthalpically-driven nature of the binding reaction is restored at 75 mM phosphate. Bound phosphate affects the interactions of the side-chains with the ribose catalytic site. 9-Benzylguanine interacts with Phe159 from an adjacent subunit
9-deazaguanine
-
multisubstrate analogue inhibitor
9-deazaguanine
-
multisubstrate analogue inhibitor
acyclovir
-
-
acyclovir
ACV, an acyclic derivative of the PNP substrate guanosine, an acyclic analogue of 2'-deoxyguanosine, that is used as an antiviral drug for the treatment of some human viral infections. The ACV molecule occupies the nucleoside-binding pocket in the active-site cavity, where it adopts two conformations. Sulfate ions are located in both the nucleoside-binding and phosphate-binding pockets of the enzyme. Binding structure, overview
acyclovir
-
isothermal titration calorimetry study. At 25°C and with an increase in the phosphate concentration from 0 to 50 mM, acyclovir binding becomes more entropically-driven
acyclovir
about 40% inhibition
acyclovir
-
about 35% inhibition
adenosine
-
-
adenosine
binds to enzyme and behaves as a weak inhibitor of inosine phosphorolysis
adenosine
-
1 mM, about 20% inhibition
AgNO3
-
-
alpha-D-ribose 1-phosphate
-
-
alpha-D-ribose 1-phosphate
mixed inhibition of phosphorolysis of inosine
alpha-D-ribose 1-phosphate
-
mixed inhibition
alpha-D-ribose 1-phosphate
-
product inhibition
alpha-D-ribose 1-phosphate
-
-
alpha-D-ribose 1-phosphate
-
product inhibition
alpha-D-ribose 1-phosphate
-
-
CuSO4
-
slight
DADMe-immucillin-G
i.e. forodesine or BCX4945
DADMe-immucillin-G
i.e. forodesine or BCX4945
DADMe-immucillin-G
i.e. forodesine or BCX4945
DADMe-immucillin-H
i.e. ulodesine or BCX4208
DADMe-immucillin-H
i.e. ulodesine or BCX4208
DADMe-immucillin-H
i.e. ulodesine or BCX4208
DATMe-immucillin-H
-
deoxyimmucillin-H
-
DFPP-DG
-
folate
-
0.05-0.1 mM, slight competitive inhibitor
Formycin A
-
-
Formycin A
an analogue of adenosine
Formycin A
a potent inhibitor of hexameric PNPs. Inhibitor-enzyme interaction and kinetic analysis with wild-type and mutant PNPs, detailed overview. With the wild-type enzyme, in the P8.3 at 10°C a model of binding one molecule per enzyme hexamer gives the best fit and at 25°C all types of fits are comparable. The strongest association is observed in the phosphate buffer pH 7.0. On the other hand, results show that the presence of phosphate at pH 8.3 is responsible for a strong binding impairment (Kd increase). The behaviour of the Kapp calculated for the PNPY-FA complexes corresponds to the Kapp of the PNPWT-FA. Their values suggest stronger than in the PNPWT-FA complexes association in the P7 and P8.3 at 10°C and in H8.3, P7 and P8.3 at 25°C
Formycin A
an analogue of adenosine
formycin B
-
-
formycin B
-
inhibits phosphorolysis of 7-methylguanosine uncompetitively; weak, uncompetitive inhibitor. Formycin B forms a weakly fluorescent complex with the enzyme
formycin B
structural, 9-deaza-8-aza analogue of inosine
formycin B
structural, 9-deaza-8-aza analogue of inosine
formycin B
structural, 9-deaza-8-aza analogue of inosine
forodesine
-
a highly potent, orally active, rationally designed PNP inhibitor, that is active in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma; a highly potent, orally active, rationally designed PNP inhibitor, use for the management of some B-cell malignancies
ganciclovir
-
ganciclovir
-
isothermal titration calorimetry study. At 25°C and with an increase in the phosphate concentration from 0 to 50 mM, ganciclovir binding becomes more enthalpically-driven
guanine
-
-
guanine
inhibits phosphorolysis of xanthosine
guanine
competitive inhibition of hydrolysis of inosine
guanine
-
competitive versus phosphate and inosine
guanine
-
product inhibition
guanine
-
inhibits phosphorolysis of xanthosine
guanine
-
product inhibition
guanosine
-
strong competitive inhibitor with deoxyinosine as substrate
guanosine
inhibits phosphorolysis of xynthosine
guanosine
uncompetitive with alpha-D-1-ribose 1-phosphate as varied substrate
guanosine
-
uncompetitive inhibition of alpha-D-ribose 1-phosphate
guanosine
-
product inhibition
guanosine
-
inhibits phosphorolysis of xynthosine
HgCl2
-
-
hypoxanthine
-
-
hypoxanthine
inhibits phosphorolysis of xanthosine
hypoxanthine
-
inhibits phosphorolysis of xanthosine
hypoxanthine
-
product inhibition
immucillin-A
weak binding inhibitor
immucillin-A
weak binding inhibitor
immucillin-A
-
slow-onset tight binding inhibition, inhibitor release half-time of 17.2 min; slow-onset tightbinding inhibition with TvPNP, to give an equilibrium dissociation constant of 87 pM and an inhibitor release half-time of 17.2 min
immucillin-G
an analogue of guanosine
immucillin-G
dissociation constant of 42 pM
immucillin-G
an analogue of guanosine
immucillin-G
dissociation constant of 900 pM
immucillin-H
dissociation constant: 23 pM
immucillin-H
i.e. forodesine or BCX1777, an analogue of inosine
immucillin-H
dissociation constant: 56 pM
immucillin-H
i.e. forodesine or BCX1777, an analogue of inosine
immucillin-H
-
transition-state analogue inhibitor
immucillin-H
transition-state analogue inhibitor
Inosine
-
-
Inosine
-
strong competitive inhibitor with deoxyinosine as substrate
Inosine
-
inhibits ribosylation of hypoxanthine and guanine
L-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
L-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
-
N(6)-Methylformycin A
-
competitive with respect to inosine, 7-methylguanosine and 7-methyladenosine
N(7)-acycloguanosine
-
-
N(9)-acycloguanosine
-
-
N7-acycloguanosine
-
PCMB
-
adenosine-specific phosphorylase
PCMB
-
dithiothreitol restores activity
PCMB
-
no inhibition of PUNPII
PCMB
-
0.1 mM, 85% loss of activity within 15 min
phosphate
-
phosphate
-
uncompetitive versus guanine
phosphate
-
product inhibition
phosphate
-
high phosphate concentrations negatively affect the affinity of the enzyme for inosine
SerMe-immucillin-H
SerMe-ImmH, uses achiral dihydroxyaminoalcohol seramide as the ribocation mimic
SerMe-immucillin-H
SerMe-ImmH, uses achiral dihydroxyaminoalcohol seramide as the ribocation mimic
xanthine
poor inhibitor of phosphorolysis of guanosine
xanthine
-
poor inhibitor of phosphorolysis of guanosine
Xanthosine
poor inhibitor of phosphorolysis of guanosine
Xanthosine
-
poor inhibitor of phosphorolysis of guanosine
additional information
-
inhibition by 9-cycloaliphatic methyl and 9-saturated heterocyclic methyl-9-deazapurines
-
additional information
formycins are 9-deaza-8-aza-nucleosides and selective inhibitors of hexameric PNPs. 8-Aza-9-deazapurine derivatives as enzyme inhibitors, overview
-
additional information
formycins are 9-deaza-8-aza-nucleosides and selective inhibitors of hexameric PNPs. 8-Aza-9-deazapurine derivatives as enzyme inhibitors, overview
-
additional information
thermodynamics for binding the immucillins to the first subunit of human purine nucleoside phosphorylase. Titrations of purine nucleoside phosphorylase using isothermal calorimetry indicate that binding of a structurally rigid first-generation immucillin-H is driven by large negative enthalpy values with a substantial entropic penalty. The tightest-binding inhibitors have increased conformational flexibility. Despite their conformational freedom in solution, flexible inhibitors bind with high affinity because of reduced entropic penalties. Entropic penalties are proposed to arise from conformational freezing of the purine nucleoside phosphorylase-inhibitor complex with the entropy term dominated by protein dynamics. The conformationally flexible immucillins reduce the system entropic penalty. Disrupting the ribosyl 5'-hydroxyl interaction of transition state analogues with purine nucleoside phosphorylase causes favorable entropy of binding. Tight binding of the immucillins is characterized by large enthalpic contributions, emphasizing their similarity to the transition state
-
additional information
-
thermodynamics for binding the immucillins to the first subunit of human purine nucleoside phosphorylase. Titrations of purine nucleoside phosphorylase using isothermal calorimetry indicate that binding of a structurally rigid first-generation immucillin-H is driven by large negative enthalpy values with a substantial entropic penalty. The tightest-binding inhibitors have increased conformational flexibility. Despite their conformational freedom in solution, flexible inhibitors bind with high affinity because of reduced entropic penalties. Entropic penalties are proposed to arise from conformational freezing of the purine nucleoside phosphorylase-inhibitor complex with the entropy term dominated by protein dynamics. The conformationally flexible immucillins reduce the system entropic penalty. Disrupting the ribosyl 5'-hydroxyl interaction of transition state analogues with purine nucleoside phosphorylase causes favorable entropy of binding. Tight binding of the immucillins is characterized by large enthalpic contributions, emphasizing their similarity to the transition state
-
additional information
-
multisubstrate analogue inhibitors with 9-deazaguanine aglycone have better anti-leukaemic and anti-lymphoma activities compared to the guanine and hypoxanthine analogues, and applied in the concentration of 100 microM, cause a statistically significant decrease in the cell viability in all human leukemia and lymphoma cells used. No differences are observed between the effects on the growth of tumour cells sensible to the inhibition of purine nucleoside phosphorylase, such as human adult T-cell leukemia and lymphoma cells, and other investigated cells
-
additional information
-
the enzyme is not inhibited by extracts of Hedyotis diffusa, orange peel, Scutellaria baicalensis, Solanum nigrum, Rhizoma Chuanxiong, Prunella vulgaris, Dendranthema indicum, or Paclitaxel. The natural extract of Angelica sinensis exhibits 8.59% inhibition of enzyme activity
-
additional information
development, validation, and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase, overview. Evaluation of a set of 8-halo-, 8-amino-, 8-O-alkyl-substituted purine ribonucleosides synthesized on purpose as potential inhibitors against MtbPNP. The assayed 8-substituted ribonucleosides do not exert a significant inhibitory effect against the tested enzymes up to 1 mM. No or poor inhibition by formycin A (an inhibitor of hexameric PNP), 8-ethylaminoinosine, 8-methoxyinosine, and 8-ethoxyinosine
-
additional information
-
development, validation, and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase, overview. Evaluation of a set of 8-halo-, 8-amino-, 8-O-alkyl-substituted purine ribonucleosides synthesized on purpose as potential inhibitors against MtbPNP. The assayed 8-substituted ribonucleosides do not exert a significant inhibitory effect against the tested enzymes up to 1 mM. No or poor inhibition by formycin A (an inhibitor of hexameric PNP), 8-ethylaminoinosine, 8-methoxyinosine, and 8-ethoxyinosine
-
additional information
immucillins are potent slow-binding inhibitors, forming rapidly the enzyme/inhibitor collision complex that is characterized by nM enzyme/inhibitor affinity, followed by a slow conformational change leading a tight-binding enzyme/inhibitor complex. Immucilins, like ground-state analogue inhibitors, bind with the stoichiometry of three molecules per enzyme trimer. Another interesting class of PNP inhibitors comprises so-called bisubstrate analogs, represented by purine-alkylphosphonates and difluoromethylene phosphonates, which compete with both PNP substrates, nucleoside and phosphate, and therefore interact with PNP with inhibition constants markedly dependent on inorganic phosphate concentration. 8-aza-9-deazapurine derivatives as enzyme inhibitors, overview
-
additional information
the hydroxylation on position C4' of chrysin (-> apigenin) mildly decreases the binding affinities for PNP, whereas on the position C6 of chrysin (-> baicalein) it significantly increases binding affinities. The hydroxylation on position C4' and C6 greatly improves their PNP inhibitory effects. Results from molecular modeling reveal that there are two binding sites, i.e. active site (major) and tryptophan site (minor) on PNP, and the binding of these flavonoids might induce a serious conformational destabilization of PNP as a result of altering the microenvironment and morphology by flavonoids. Docking analysis of chrysin, baicalein or apigenin with PNP at 25°C, overview
-
additional information
-
the hydroxylation on position C4' of chrysin (-> apigenin) mildly decreases the binding affinities for PNP, whereas on the position C6 of chrysin (-> baicalein) it significantly increases binding affinities. The hydroxylation on position C4' and C6 greatly improves their PNP inhibitory effects. Results from molecular modeling reveal that there are two binding sites, i.e. active site (major) and tryptophan site (minor) on PNP, and the binding of these flavonoids might induce a serious conformational destabilization of PNP as a result of altering the microenvironment and morphology by flavonoids. Docking analysis of chrysin, baicalein or apigenin with PNP at 25°C, overview
-
additional information
-
development, validation, and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase, overview. Evaluation of a set of 8-halo-, 8-amino-, 8-O-alkyl-substituted purine ribonucleosides synthesized on purpose as potential inhibitors against MtbPNP. The assayed 8-substituted ribonucleosides do not exert a significant inhibitory effect against the tested enzymes up to 1 mM. No or poor inhibition by formycin A (an inhibitor of hexameric PNP), 8-bromoadenosine, 8-ethylaminoinosine, 8-dimethylaminoinosine, and 8-ethoxyinosine
-
additional information
-
the enzyme inhibitors 8-amino-5'-deoxy-5'-chloroguanosine and 8-amino-9-benzylguanine may have some antimalarial potential by limiting hypoxanthine production in the parasite-infected erythrocyte
-
additional information
pharmacophore-based virtual screening coupled to a consensual molecular docking approach is used to identify 59 potential PfPNP inhibitors that are predicted to be orally absorbed in a Caco-2 cell model. Superposition of the bioactive conformations of 5'-methylthioimmucillin-H (PDB ID 1Q1G) and DADMe-immucillin-G (PDB ID 3PHC). Inhibitor docking analysis, kinetics, and binding structures, overview. Molecular dynamics simulations
-
additional information
-
pharmacophore-based virtual screening coupled to a consensual molecular docking approach is used to identify 59 potential PfPNP inhibitors that are predicted to be orally absorbed in a Caco-2 cell model. Superposition of the bioactive conformations of 5'-methylthioimmucillin-H (PDB ID 1Q1G) and DADMe-immucillin-G (PDB ID 3PHC). Inhibitor docking analysis, kinetics, and binding structures, overview. Molecular dynamics simulations
-
additional information
insensitive to methylthio-immucillin-H
-
additional information
-
insensitive to methylthio-immucillin-H
-
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0.022
1-Methylguanosine
-
-
0.391 - 14.9
2',3'-dideoxyinosine
0.19
2'-deoxyadenosine
-
-
0.015 - 1.9
2'-deoxyguanosine
0.043 - 2.06
2'-deoxyinosine
0.035 - 0.2
2,6-diamino-8-azapurine
0.013
2-amino-6-mercapto-7-methylpurine
-
0.029 - 0.1425
2-amino-6-mercapto-7-methylpurine ribonucleoside
0.023 - 0.264
2-fluoro-2'-deoxyadenosine
0.012
2-fluoroadenosine
pH 7.4, 25°C
0.15 - 0.8
3-(beta-D-ribofuranosyl)adenine
0.22 - 0.26
3-(beta-D-ribofuranosyl)hypoxanthine
0.0106 - 0.0319
5'-methylthioadenosine
0.0088 - 0.06
5'-methylthioinosine
0.167
6-mercaptoguanosine
-
-
0.07
6-mercaptopurine riboside
-
-
0.065
7,8-dimethylguanosine
-
-
0.027 - 0.108
7-(beta-D-ribofuranosyl)guanine
0.64 - 1.52
7-(beta-D-ribofuranosyl)hypoxanthine
0.034
7-butylguanosine
-
-
0.013
7-ethylguanosine
-
-
0.069
7-isopropylguanine
-
-
0.358
7-methyl-6-thio-guanosine
-
pH 7.6
0.0147 - 39.3
7-methylguanosine
0.033 - 0.6
7-Methylinosine
0.012 - 0.08
7-N-methyl-6-thiopurine riboside
0.025
7-prolylguanosine
-
-
0.661
8-Azahypoxanthine
-
0.1
8-methylguanosine
-
-
0.126
9-beta-D-(2-deoxyribofuranosyl)-6-methylthiopurine
pH 7.4, 25°C
0.009
9-beta-D-ribofuranosyl-6-methylthiopurine
pH 7.4, 25°C
0.1 - 0.133
alpha-D-deoxyribose 1-phosphate
0.04 - 0.228
alpha-D-ribose 1-phosphate
0.02 - 0.35
deoxyguanosine
0.027 - 0.67
deoxyinosine
0.1
deoxyribose 1-phosphate
-
reaction with adenine
0.0033 - 45.6
hypoxanthine
0.09
isobutylguanosine
-
-
0.005 - 0.016
Methylthioinosine
0.05 - 0.08
N7-D-ribosyl-2,6-diamino-8-azapurine
0.007
N8-D-ribosyl-2,6-diamino-8-azapurine
pH 6.5, 25°C, recombinant wild-type enzyme
0.02
N9-D-ribosyl-2,6-diamino-8-azapurine
about, pH 6.5, 25°C, recombinant wild-type enzyme
0.62 - 1.48
nicotinamide riboside
0.09
p-nitrophenyl beta-D-ribofuranoside
0.5
ribose 1-phosphate
-
-
additional information
additional information
-
0.391
2',3'-dideoxyinosine
mutant Y88L, pH 7.0, 25°C
0.45
2',3'-dideoxyinosine
mutant Y88F, pH 7.0, 25°C
0.645
2',3'-dideoxyinosine
mutant Y88M, pH 7.0, 25°C
0.675
2',3'-dideoxyinosine
mutant Y88H, pH 7.0, 25°C
0.81
2',3'-dideoxyinosine
mutant Y88C, pH 7.0, 25°C
0.86
2',3'-dideoxyinosine
mutant Y88Q, pH 7.0, 25°C
0.98
2',3'-dideoxyinosine
mutant Y88W, pH 7.0, 25°C
1.03
2',3'-dideoxyinosine
wild-type, pH 7.0, 25°C
1.67
2',3'-dideoxyinosine
mutant Y88A, pH 7.0, 25°C
2.6
2',3'-dideoxyinosine
-
-
4.06
2',3'-dideoxyinosine
mutant Y88S, pH 7.0, 25°C
4.41
2',3'-dideoxyinosine
mutant Y88V, pH 7.0, 25°C
4.67
2',3'-dideoxyinosine
mutant Y88I, pH 7.0, 25°C
8.16
2',3'-dideoxyinosine
mutant Y88T, pH 7.0, 25°C
9.53
2',3'-dideoxyinosine
mutant Y88M, pH 7.0, 25°C
12.7
2',3'-dideoxyinosine
mutant Y88D, pH 7.0, 25°C
14.9
2',3'-dideoxyinosine
mutant Y88E, pH 7.0, 25°C
0.015
2'-deoxyguanosine
-
pH 7.0, 25°C
0.024
2'-deoxyguanosine
-
-
0.1
2'-deoxyguanosine
-
-
1.01
2'-deoxyguanosine
pH 7.0, 80°C
1.9
2'-deoxyguanosine
-
-
0.043
2'-deoxyinosine
-
-
0.062
2'-deoxyinosine
-
-
0.068
2'-deoxyinosine
-
pH 7.0, 25°C
0.079
2'-deoxyinosine
-
pH 7.4
0.091
2'-deoxyinosine
-
pH 7.4
2.06
2'-deoxyinosine
pH 7.0, 80°C
0.035
2,6-diamino-8-azapurine
-
mutant enzyme N243D, pH and temperature not specified in the publication
0.035
2,6-diamino-8-azapurine
pH 6.5, 25°C, recombinant mutant N243D
0.06
2,6-diamino-8-azapurine
pH 6.5, 25°C, recombinant wild-type enzyme
0.06
2,6-diamino-8-azapurine
-
wild type enzyme, pH and temperature not specified in the publication
0.2
2,6-diamino-8-azapurine
above, pH 6.5, 25°C, recombinant wild-type enzyme and mutant D204N
0.029
2-amino-6-mercapto-7-methylpurine ribonucleoside
-
-
0.1425
2-amino-6-mercapto-7-methylpurine ribonucleoside
-
pH 7.6
0.023
2-fluoro-2'-deoxyadenosine
pH 7.4, 25°C
0.264
2-fluoro-2'-deoxyadenosine
-
mutant E201Q/N243D
0.15
3-(beta-D-ribofuranosyl)adenine
-
-
0.15
3-(beta-D-ribofuranosyl)adenine
-
0.8
3-(beta-D-ribofuranosyl)adenine
-
-
0.8
3-(beta-D-ribofuranosyl)adenine
-
0.22
3-(beta-D-ribofuranosyl)hypoxanthine
-
-
0.22
3-(beta-D-ribofuranosyl)hypoxanthine
-
0.26
3-(beta-D-ribofuranosyl)hypoxanthine
-
-
0.26
3-(beta-D-ribofuranosyl)hypoxanthine
-
0.0106
5'-methylthioadenosine
pH 7.4
0.0319
5'-methylthioadenosine
pH 7.4
0.0088
5'-methylthioinosine
wild type enzyme, at pH 7.4, temperature not specified in the publication
0.011
5'-methylthioinosine
mutant enzyme V66I/Y160F, at pH 7.4, temperature not specified in the publication
0.011
5'-methylthioinosine
mutant enzyme V73I, at pH 7.4, temperature not specified in the publication
0.012
5'-methylthioinosine
mutant enzyme V66I, at pH 7.4, temperature not specified in the publication
0.015
5'-methylthioinosine
mutant enzyme V66I/V73I, at pH 7.4, temperature not specified in the publication
0.018
5'-methylthioinosine
mutant enzyme V66I/Y73I/Y160F, at pH 7.4, temperature not specified in the publication
0.044
5'-methylthioinosine
mutant enzyme Y160F, at pH 7.4, temperature not specified in the publication
0.06
5'-methylthioinosine
mutant enzyme V73I/Y160F, at pH 7.4, temperature not specified in the publication
0.027
7-(beta-D-ribofuranosyl)guanine
-
0.108
7-(beta-D-ribofuranosyl)guanine
-
0.64
7-(beta-D-ribofuranosyl)hypoxanthine
-
1.26
7-(beta-D-ribofuranosyl)hypoxanthine
-
1.52
7-(beta-D-ribofuranosyl)hypoxanthine
-
0.0147
7-methylguanosine
-
-
0.015
7-methylguanosine
-
-
0.015
7-methylguanosine
-
0.016
7-methylguanosine
-
0.0168
7-methylguanosine
pH 7.0, 25°C, recombinant enzyme
0.0168
7-methylguanosine
-
wild-type, pH not specified in the publication, temperature not specified in the publication
0.0264
7-methylguanosine
25°C, pH 7.0
0.05
7-methylguanosine
-
mutant F159W, pH not specified in the publication, temperature not specified in the publication
0.0544
7-methylguanosine
pH 7.0, 25°C
0.07
7-methylguanosine
-
mutant F200W, pH not specified in the publication, temperature not specified in the publication
0.6
7-methylguanosine
-
-
9.2
7-methylguanosine
-
presence of 50 mM phosphate, pH 7.0
12.5
7-methylguanosine
-
presence of 50 mM phosphate, pH 7.0
13
7-methylguanosine
-
presence of 100 mM phosphate, pH 7.0
13.9
7-methylguanosine
-
presence of 100 mM phosphate, pH 7.0
16.3
7-methylguanosine
-
presence of 100 mM phosphate, pH 7.0
39.3
7-methylguanosine
-
presence of 50 mM phosphate, pH 7.0
0.033
7-Methylinosine
-
pH 7.0, 25°C
0.169
7-Methylinosine
-
-
0.247
7-Methylinosine
-
-
0.012
7-N-methyl-6-thiopurine riboside
-
enzyme purified from mantle cell lymphoma, pH 7.5, temperature not specified in the publication
0.04
7-N-methyl-6-thiopurine riboside
-
enzyme purified from diffuse large B-cell lymphoma progressed from follicular lymphoma, pH 7.5, temperature not specified in the publication
0.06
7-N-methyl-6-thiopurine riboside
-
recombinant enzyme, pH 7.5, temperature not specified in the publication
0.08
7-N-methyl-6-thiopurine riboside
-
enzyme purified from peripheral blood mononuclear cell, pH 7.5, temperature not specified in the publication
0.09
8-Azaguanine
-
pH 5.9
0.09
8-Azaguanine
-
wild type enzyme, pH and temperature not specified in the publication
0.09
8-Azaguanine
about, pH 6.5, 25°C, recombinant wild-type enzyme
0.1
8-Azaguanine
-
Km above 0.1 mM, mutant enzyme N243D, pH and temperature not specified in the publication
0.1
8-Azaguanine
above, pH 6.5, 25°C, recombinant mutant N243D
0.2
8-Azaguanine
above, pH 6.5, 25°C, recombinant wild-type enzyme
0.34
adenine
-
-
0.0061
adenosine
-
-
0.0061
adenosine
-
25°C, pH 7.4
0.0103
adenosine
recombinant mutant N256D, pH 7.0, 25°C
0.028
adenosine
-
mutant enzyme N243D/K244Q, pH 6.0
0.042
adenosine
-
mutant enzyme N243D/K244Q, pH 7.0
0.045
adenosine
-
mutant enzyme N243D, pH 6.0 ot pH 7.0
0.046
adenosine
pH 7.4, 25°C
0.083
adenosine
-
wild type trimeric enzyme, at pH 8.0 and 70°C
0.097
adenosine
80°C, pH 7.0
0.097
adenosine
-
mutant hexameric enzyme N204D, at pH 8.0 and 70°C
0.262
adenosine
pH 7.1, 25°C, mutant enzyme N239D
0.578
adenosine
pH 7.0, 90°C
1.45
adenosine
pH 8.0, 50°C, recombinant enzyme
0.1
alpha-D-deoxyribose 1-phosphate
-
reaction with adenine
0.129
alpha-D-deoxyribose 1-phosphate
-
reaction with hypoxanthine
0.133
alpha-D-deoxyribose 1-phosphate
-
reaction with guanine
0.04
alpha-D-ribose 1-phosphate
-
reaction with adenine
0.041
alpha-D-ribose 1-phosphate
-
reaction with guanine
0.042
alpha-D-ribose 1-phosphate
-
reaction with hypoxanthine
0.059
alpha-D-ribose 1-phosphate
-
-
0.134
alpha-D-ribose 1-phosphate
-
-
0.2
alpha-D-ribose 1-phosphate
-
-
0.228
alpha-D-ribose 1-phosphate
-
reaction with guanine
0.63
arsenate
-
-
0.8
arsenate
-
reaction with inosine
0.02
deoxyguanosine
-
0.0443
deoxyguanosine
-
-
0.027
deoxyinosine
-
-
0.091
deoxyinosine
pH 7.4
0.259
deoxyinosine
pH 7.4
0.006
guanine
-
pH 7.0
0.006
guanine
recombinant erythrocyte enzyme
0.014
guanine
-
reaction with ribose 1-phosphate
0.017
guanine
-
reaction with deoxyribose 1-phosphate
0.0041
guanosine
-
-
0.0071
guanosine
-
wild type hexameric enzyme, at pH 8.0 and 70°C
0.0089
guanosine
-
pH 7.4
0.0094
guanosine
-
pH 7.4
0.012
guanosine
-
pH 7.0, 25°C
0.012
guanosine
recombinant erythrocyte enzyme
0.0193
guanosine
pH 7.0, 25°C
0.0341
guanosine
pH 7.4, 25°C, wild-type light PNP
0.0399
guanosine
pH 7.4, 25°C, wild-type heavy PNP
0.042
guanosine
-
wild-tpe, pH 7.4, 25°C
0.047
guanosine
-
mutant L22E/H104R, pH 7.4, 25°C
0.049
guanosine
-
pH 7.4, 25°C
0.0542
guanosine
pH 7.4, 25°C, mutant F159Y heavy PNP
0.0564
guanosine
pH 7.4, 25°C, mutant F159Y light PNP
0.059
guanosine
-
mutant E201Q/N243D
0.06
guanosine
-
25°C, pH 7.4
0.092
guanosine
-
native enzyme, at pH 7.4 and 25°C
0.155
guanosine
pH 7.1, 25°C, wild-type enzyme
0.206
guanosine
Halalkalibacterium halodurans
pH 7.5
0.249
guanosine
pH 7.1, 25°C, mutant enzyme Y191L
0.407
guanosine
-
mutant trimeric enzyme A196E/D238N, at pH 8.0 and 70°C
0.5
guanosine
recombinant wild-type enzyme, pH 7.0, 25°C
0.53
guanosine
pH 7.0, 80°C
0.69
guanosine
pH 7.0, 90°C
0.842
guanosine
recombinant mutant N256D, pH 7.0, 25°C
1.16
guanosine
pH 8.0, 50°C, recombinant enzyme
0.0033
hypoxanthine
-
-
0.01
hypoxanthine
-
mutant enzyme Y88F
0.013
hypoxanthine
-
mutant enzyme S33A
0.019
hypoxanthine
-
mutant enzyme H86A
0.02
hypoxanthine
-
with ribose 1-phosphate
0.02
hypoxanthine
-
mutant enzyme R84A and H257A
0.021
hypoxanthine
-
reaction with deoxyribose 1-phosphate
0.024
hypoxanthine
-
mutant enzyme T242A
0.025
hypoxanthine
-
mutant enzyme F159A
0.03
hypoxanthine
-
wild-type enzyme
0.03
hypoxanthine
recombinant erythrocyte enzyme
0.04
hypoxanthine
-
mutant enzyme K244A
0.18
hypoxanthine
-
mutant enzyme M219A
0.57
hypoxanthine
-
mutant enzyme F200A
1
hypoxanthine
-
mutant enzyme E201A
2.3
hypoxanthine
-
mutant enzyme N243A
0.00001
Inosine
mutant T90R/T156A, pH 7.6, 37°C
0.00002
Inosine
mutant T90R, pH 7.6, 37°C
0.00003
Inosine
mutant T156S, pH 7.6, 37°C
0.00004
Inosine
mutant V206I, pH 7.6, 37°C
0.00031
Inosine
-
isoform of 816 amino acids, pH 7.0, 37°C
0.00039
Inosine
wild-type, pH 7.6, 37°C
0.00045
Inosine
-
pH 7.0, 37°C
0.00085
Inosine
-
pH 7.0, 37°C
0.00092
Inosine
mutant T90S, pH 7.6, 37°C
0.00135
Inosine
mutant T156A, pH 7.6, 37°C
0.0025
Inosine
mutant enzyme Y160F, at pH 7.4, temperature not specified in the publication
0.0036
Inosine
mutant enzyme V73I/Y160F, at pH 7.4, temperature not specified in the publication
0.004
Inosine
pH 7.4, temperature not specified in the publication
0.004
Inosine
mutant enzyme V66I/Y73I/Y160F, at pH 7.4, temperature not specified in the publication
0.0047
Inosine
-
pH 7.5, 25°C
0.005
Inosine
pH 7.5, 25°C
0.0062
Inosine
mutant enzyme V66I/Y160F, at pH 7.4, temperature not specified in the publication
0.011
Inosine
-
pH 7.4, temperature not specified in the publication
0.011
Inosine
wild type enzyme, at pH 7.4, temperature not specified in the publication
0.012
Inosine
-
isoform of 702 amino acids, pH 7.0, 37°C
0.013
Inosine
mutant enzyme V73I, at pH 7.4, temperature not specified in the publication
0.0134
Inosine
pH 7.0, 25°C, recombinant enzyme
0.0134
Inosine
-
wild-type, pH not specified in the publication, temperature not specified in the publication
0.016
Inosine
-
pH 7.4, 25°C
0.016
Inosine
mutant enzyme V66I, at pH 7.4, temperature not specified in the publication
0.021
Inosine
recombinant wild-type enzyme, pH 7.0, 25°C
0.022
Inosine
-
mutant enzymes N243A and T242A
0.025
Inosine
-
25°C, pH 7.4
0.027
Inosine
-
mutant L22E/H104R, pH 7.4, 25°C
0.028
Inosine
mutant enzyme V66I/V73I, at pH 7.4, temperature not specified in the publication
0.03
Inosine
-
wild-tpe, pH 7.4, 25°C
0.032
Inosine
-
wild-type enzyme, pH 6.0
0.032
Inosine
wild-type, pH 7.5, 25°C
0.037
Inosine
-
mutant enzyme K244A
0.038
Inosine
pH 7.5, 25°C
0.038
Inosine
mutant V39T/N123L/R210Q, pH 7.5, 25°C
0.039
Inosine
mutant N123L/R210Q, pH 7.5, 25°C
0.04
Inosine
-
wild-type enzyme
0.04
Inosine
pH 7.5, 25°C
0.04
Inosine
-
pH 7.0, 25°C
0.04
Inosine
recombinant erythrocyte enzyme
0.048
Inosine
wild-type, pH 7.0, 25°C
0.058
Inosine
-
mutant enzyme Y88F
0.058
Inosine
-
wild-type enzyme, pH 7.0
0.06
Inosine
-
pH 7.5, 37°C
0.073
Inosine
mutant Y88F, pH 7.0, 25°C
0.074
Inosine
mutant Y88H, pH 7.0, 25°C
0.08
Inosine
mutant Y88A, pH 7.0, 25°C
0.0823
Inosine
-
mutant enzyme N243D/K244Q, pH 7.0
0.094
Inosine
mutant Y88L, pH 7.0, 25°C
0.096
Inosine
pH 7.4, 25°C
0.104
Inosine
mutant T90A/T156A, pH 7.6, 37°C
0.11
Inosine
-
enzyme from vegetative cells
0.11
Inosine
-
free enzyme, at pH 7.4, temperature not specified in the publication
0.13
Inosine
-
mutant enzyme R84A
0.137
Inosine
80°C, pH 7.0
0.14
Inosine
-
enzyme from spores
0.14
Inosine
-
mutant enzyme S33A
0.144
Inosine
recombinant mutant N256E, pH 7.0, 25°C
0.15
Inosine
pH 7.5, 37°C
0.164
Inosine
-
immobilized enzyme, at pH 7.4, temperature not specified in the publication
0.17
Inosine
mutant Y88C, pH 7.0, 25°C
0.2
Inosine
-
inosine-guanosine phosphorylase
0.21
Inosine
-
mutant enzyme H257A
0.22
Inosine
-
mutant enzyme E89A
0.222
Inosine
recombinant mutant N256D, pH 7.0, 25°C
0.231
Inosine
pH 7.1, 25°C, mutant enzyme Y191L
0.236
Inosine
Halalkalibacterium halodurans
pH 7.5
0.245
Inosine
-
mutant F159W, pH not specified in the publication, temperature not specified in the publication
0.28
Inosine
-
mutant enzyme H86A
0.31
Inosine
-
mutant enzyme F159A
0.318
Inosine
pH 7.0, 90°C
0.32
Inosine
25°C, pH 7.4
0.322
Inosine
80°C, pH 7.4
0.326
Inosine
-
mutant F200W, pH not specified in the publication, temperature not specified in the publication
0.345
Inosine
mutant Y88M, pH 7.0, 25°C
0.37
Inosine
mutant Y88R, pH 7.0, 25°C
0.39
Inosine
pH 7.6, 37°C
0.43
Inosine
mutant Y88S, pH 7.0, 25°C
0.484
Inosine
-
mutant enzyme N243D, pH 7.0
0.491
Inosine
-
pH 7.6, 37°C
0.5
Inosine
mutant Y88W, pH 7.0, 25°C
0.691
Inosine
-
mutant enzyme N243D, pH 6.0
0.729
Inosine
-
mutant enzyme N243D/K244Q, pH 6.0
0.75
Inosine
25°C, pH 7.4
0.79
Inosine
-
pH and temperature not specified in the publication
0.845
Inosine
mutant Y88M, pH 7.0, 25°C
0.855
Inosine
mutant Y88Q, pH 7.0, 25°C
0.963
Inosine
pH 7.1, 25°C, wild-type enzyme
1.2
Inosine
mutant Y88T, pH 7.0, 25°C
1.2
Inosine
mutant Y88V, pH 7.0, 25°C
1.35
Inosine
25°C, pH 7.4
1.42
Inosine
mutant Y88I, pH 7.0, 25°C
1.796
Inosine
-
pH 7.6, 37°C
2.08
Inosine
pH 7.0, 80°C
2.6
Inosine
mutant Y88D, pH 7.0, 25°C
4.86
Inosine
mutant Y88E, pH 7.0, 25°C
5.3
Inosine
pH 8.0, 50°C, recombinant enzyme
8
Inosine
-
mutant enzyme M219A
8.4
Inosine
-
mutant enzyme E201A
19
Inosine
-
mutant enzyme F200A
143.1
Inosine
mutant T90A, pH 7.6, 37°C
0.005
Methylthioinosine
-
pH 7.4
0.0108
Methylthioinosine
-
pH 7.4
0.012
Methylthioinosine
pH 7.5, 25°C
0.016
Methylthioinosine
-
pH 7.5, 25°C
0.05
N7-D-ribosyl-2,6-diamino-8-azapurine
about, pH 6.5, 25°C, recombinant mutant N243D
0.052
N7-D-ribosyl-2,6-diamino-8-azapurine
pH 6.5, 25°C, recombinant wild-type enzyme
0.08
N7-D-ribosyl-2,6-diamino-8-azapurine
about, pH 6.5, 25°C, recombinant wild-type enzyme
0.62
nicotinamide riboside
-
1.48
nicotinamide riboside
-
0.09
p-nitrophenyl beta-D-ribofuranoside
-
-
0.09
p-nitrophenyl beta-D-ribofuranoside
-
25°C, pH 7.4
0.0031 - 0.0056
phosphate
pH 7.0, 25°C, with 7-methylguanosine
0.013
phosphate
-
reaction with inosine
0.015
phosphate
-
reaction with guanosine
0.028
phosphate
-
reaction with inosine
0.0343
phosphate
25°C, pH 7.0, cosubstrate: 7-methylguanosine
0.05
phosphate
-
enzyme purified from peripheral blood mononuclear cell, pH 7.5, temperature not specified in the publication
0.1
phosphate
-
reaction with inosine
0.1
phosphate
-
recombinant enzyme, pH 7.5, temperature not specified in the publication
0.12
phosphate
-
reaction with inosine
0.126
phosphate
pH 7.0, 25°C, with guanosine
0.132
phosphate
25°C, pH 7.0, cosubstrate: inosine
0.135
phosphate
-
reaction with 7-methylinosine
0.15
phosphate
-
pH 7.5, 37°C
0.167
phosphate
-
reaction with 7-methylinosine
0.1868
phosphate
-
pH 7.6
0.22
phosphate
-
reaction with inosine, mutant enzyme T242A
0.37
phosphate
-
reaction with inosine
0.427
phosphate
-
cosubstrate 2-amino-6-mercapto-7-methylpurine ribonucleoside, pH 7.0, 25°C
0.427
phosphate
-
cosubstrate 7-methylinosine, pH 7.0, 25°C
0.583
phosphate
-
cosubstrate inosine, pH 7.0, 25°C
0.66
phosphate
pH 7.5, 37°C
1.131
phosphate
-
cosubstrate 2'-deoxyinosine, pH 7.0, 25°C
1.345
phosphate
-
cosubstrate guanosine, pH 7.0, 25°C
2.1
phosphate
-
mutant enzyme Y88F
2.349
phosphate
-
cosubstrate 2'-deoxyguanosine, pH 7.0, 25°C
2.5
phosphate
-
mutant enzymes H257A and F159A
2.7
phosphate
-
reaction with inosine, mutant enzyme K244A
3.5
phosphate
-
reaction with inosine, mutant enzyme N243A
3.6
phosphate
-
reaction with inosine, mutant enzyme S33A
3.9
phosphate
-
reaction with inosine, inosine-guanosine phosphorylase
4
phosphate
-
reaction with inosine, wild-type enzyme
4
phosphate
recombinant erythrocyte enzyme
4.3
phosphate
-
mutant enzyme M219A
4.5
phosphate
-
reaction with inosine, mutant enzyme F200A
4.5
phosphate
-
reaction with inosine, mutant enzyme R84A
5.1
phosphate
-
enzyme from vegetative cells
6.1
phosphate
-
reaction with inosine, mutant enzyme E201A
7.2
phosphate
-
enzyme from spores
9.2
phosphate
-
reaction with inosine, mutant enzyme H86A
13.1
phosphate
-
reaction with guanosine
91
phosphate
-
reaction with inosine, mutant enzyme E89A
0.085
uridine
pH 7.5, 25°C
0.28
xanthine
pH 6.0
0.051
Xanthosine
-
-
0.072
Xanthosine
pH 7.1, 25°C, wild-type enzyme
0.536
Xanthosine
recombinant mutant N256D, pH 7.0, 25°C
0.555
Xanthosine
recombinant wild-type enzyme, pH 7.0, 25°C
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
additional information
additional information
-
-
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
analysis of the thermodynamic activation parameters for the glycosidic bond cleavage step in native HsPNP using the previously reported reaction mechanism. The higher activation enthalpy for ADO compared to those of INO and GUO further predicts that the reaction rate with ADO is significantly more temperature sensitive than those of the 6-oxopurines
-
additional information
additional information
-
analysis of the thermodynamic activation parameters for the glycosidic bond cleavage step in native HsPNP using the previously reported reaction mechanism. The higher activation enthalpy for ADO compared to those of INO and GUO further predicts that the reaction rate with ADO is significantly more temperature sensitive than those of the 6-oxopurines
-
additional information
additional information
kinetic analysis, HpPNP has low affinity towards the natural substrate adenosine
-
additional information
additional information
kinetic analysis, kinetic isotope effeccts, quantum mechanical and molecular mechanical (QM/MM) molecular dynamics (MD) simulations, overview
-
additional information
additional information
steady-state kinetics and kinetic analysis
-
additional information
additional information
-
steady-state kinetics and kinetic analysis
-
additional information
additional information
steady-state Michaelis-Menten kinetics for the light- and heavy-isotope-labeled PNPs are measured for guanosine phosphorolysis, single-turnover pre-steady-state constants. Detailed isotope and kinetic analysis of wild-type an dmutant F159Y mutant enzymes, overview
-
additional information
additional information
-
steady-state Michaelis-Menten kinetics for the light- and heavy-isotope-labeled PNPs are measured for guanosine phosphorolysis, single-turnover pre-steady-state constants. Detailed isotope and kinetic analysis of wild-type an dmutant F159Y mutant enzymes, overview
-
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0.000001
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranozyl)ethylphosphonic acid
-
approximate value, with (hypoxanthine-9-yl)methyl aglycone, i.e. Yokomatsu compound
0.0000072 - 0.0000112
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone
0.00000182
(3R,4R)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol
-
overall dissociation constant
0.01
(3S,4R)-4-(guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylcarbonylphosphonic acid
-
recombinant enzyme, pH 7.5, temperature not specified in the publication
0.000000032
(3S,4S)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol
-
overall dissociation constant
0.02
(S)-3-(guanin-9-yl)pyrrolidin-N-ylcarbonylphosphonic acid
-
recombinant enzyme, pH 7.5, temperature not specified in the publication
0.05 - 0.6
1',9-methyl-immucillin-H
0.025
1,6-Dihydropurine riboside
-
-
0.027
1-((2-pyrrolidine-1-yl)ethyl)uracil
pH 7.5, 25°C
0.0021 - 0.0062
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine
0.0000019 - 0.000019
2'-deoxy-immucillin-H
0.000306
2-amino-1,5-dihydro-7-[[(2S)-2-(aminomethyl)-1-pyrrolidinyl]-methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one
37°C, pH 7.0
0.000002
2-amino-1,5-dihydro-7-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one
37°C, pH 7.0, acetic acid salt
0.0000102
2-amino-1,5-dihydro-7-[[[2-(hydroxy)ethyl]amino]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one
37°C, pH 7.0
0.0024
2-amino-6-chloro-7-deazapurine 2'-deoxyriboside
-
0.038
2-amino-6-methyl-5,6,7,8-tetrahydropteridin-4(1H)-one
-
-
0.3
2-Amino-6-methylthiopurine
-
-
0.0000000034
2-amino-7-([[(2R,3S)-1,3,4-trihydroxybutan-2-yl]amino]methyl)-3,5-dihydro-4Hpyrrolo[3,2-d]pyrimidin-4-one
-
-
0.0000000021
2-amino-7-[[(1,3-dihydroxypropan-2-yl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
-
0.0000306
2-amino-7-[[(2-hydroxyethyl)(methyl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
0.0003163
2-amino-7-[[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
0.0003061
2-amino-7-[[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
0.000001
2-amino-7-[[(2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
0.0000018
2-amino-7-[[3-(hydroxymethyl)piperidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
0.0000025
2-amino-7-[[bis(2-hydroxyethyl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
0.0001122
2-amino-7-[[ethyl(2-hydroxyethyl)amino]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
0.0014
2-chloro-6-(3-phenyl-1-propoxy)purine
-
0.006
3-((2-pyrrolidine-1-yl)ethyl)uracil
pH 7.5, 25°C
0.0000009 - 0.0015
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-G
0.0000005 - 0.0036
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-H
0.0000015
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
0.000018
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-G
-
-
0.0000000107 - 0.000018
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
0.00022 - 0.0089
5'-amido-immucillin-H
0.000012 - 0.000017
5'-carboxy-immucillin-H
0.0004 - 0.012
5'-chloro-5'-deoxy-8-aminoguanosine
0.00018
5'-deoxy-5'-iodo-9-deazainosine
-
0.018
5'-deoxy-5'-iodoinosine
-
0.0000000077 - 0.0000016
5'-deoxy-immucillin-H
0.000002 - 0.0000022
5'-fluoro-immucillin-H
0.0000018
5'-methylthio-immucillin H
pH 7.4, temperature not specified in the publication
0.00000027 - 0.0056
5'-methylthio-immucillin-H
0.000000093 - 0.05
5'-thio-immucillin-H
0.008
6-amino-2-chloro-7-deazapurine 2'-deoxyriboside
-
0.005
6-amino-7-phenylethinyl-7-deazapurine 2'-deoxyriboside
-
0.0006
6-benzyloxy-2-chloropurine
-
0.0023
6-chloro-7-deaza-purine 2'-deoxyriboside
-
0.203
6-hydroxy-9-p-aminobenzylpurine
-
-
0.073
6-Mercaptopurine
-
-
0.0003 - 0.0252
6-methylformycin A
0.13
6-methylthiopurine
-
-
0.2
7-Deazaguanine
pH 7.6, 25°C
0.06 - 0.33
7-Deazainosine
0.002 - 0.093
7-ketopyrazolo[4,3-d]pyrimidine
0.082
7-methylguanine
25°C, pH 7.0, with 7-methylguanosine as varied substrate
0.000000016
7-[[(3R,4R)-4-hydroxy-3-(hydroxymethyl)pyrrolidin-2-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
-
0.0033
8-amino-5'-deoxy-5'-iodoguanosine
-
0.0002 - 0.008
8-Amino-9-benzylguanine
0.0002
8-aminoguanine
-
-
0.007 - 0.017
8-aminoguanosine
0.195
8-aza-2,6-diaminopurine
-
-
0.0041
8-bromo-N(9)-acycloguanosine
-
-
0.024 - 0.027
9-(1,3-dihydroxy-2-propoxymethyl)guanine
0.0000075 - 0.0000076
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine
0.058 - 0.068
9-(2-hydroxyethoxymethyl)guanine
0.0000135
9-(3-pyridylmethyl)-9-deaza-guanosine
pH and temperature not specified in the publication
0.0000044 - 0.0000081
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine
0.0000053 - 0.0000057
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine
0.0000033 - 0.0069
9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine
0.000002
9-(5,5-difluoro-5-phosphonopentyl)guanine
-
approximate value
0.0000056 - 0.0000061
9-deazaguanine
0.0085 - 0.361
alpha-D-ribose 1-phosphate
0.063
cis-1,1-difluoro-2-(tetrahydro-3-piranozyl)ethylphosphonic acid
-
wild-type, pH not specified in the publication, temperature not specified in the publication
0.000000066
cis-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethylpyrrolidin-3-ol
-
overall dissociation constant
0.000000034 - 0.000000121
DADMe-immucillin-G
0.000000009 - 0.00000035
DADMe-immucillin-H
0.000000009
DATMe-immucillin-H
pH and temperature not specified in the publication
0.0000074 - 0.000682
deoxyimmucillin-H
0.0000044
DFPP-DG
pH and temperature not specified in the publication
0.19
erythro-9-(2-hydroxy-3-nonyl)adenine
-
-
0.0053 - 0.667
Formycin A
0.00039 - 0.705
formycin B
0.0016 - 0.05
hypoxanthine
0.000015
immucillin H
pH 7.4, temperature not specified in the publication
0.000000133 - 0.000346
immucillin-G
0.000000011 - 0.00045
immucillin-H
0.00000038
L-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
slow-onset binding constant
0.027
N(1)-Methylformycin A
-
pH 7
0.00027 - 0.0003
N(6)-methyl-formycin A
0.018
N(6)-methylformycin B
-
pH 7
0.005 - 0.097
N(7)-acycloguanosine
0.0022
N(7)-methylformycin A
pH 5.5
0.0034 - 0.014
N(9)-acycloguanosine
0.0075
N2,3-etheno-O6-methylguanine
pH 7.3, 25°C
0.038
N2,3-ethenoguanine
pH 7.3, 25°C
0.18
oxoformycin B
-
pH 7
0.000000005
SerMe-immucillin-H
pH and temperature not specified in the publication
additional information
additional information
-
0.0000072
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone
-
erythrocyte enzyme, pH 7.0, 25°C
0.0000112
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone
-
pH 7.0, 25°C
0.05
1',9-methyl-immucillin-H
Ki above 0.05 mM, pH 7.4, temperature not specified in the publication
0.6
1',9-methyl-immucillin-H
-
Ki above 0.6 mM, pH 7.4, temperature not specified in the publication
0.0021
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine
-
reaction with 7-methylguanosine
0.0062
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine
-
reaction with inosine
0.0000019
2'-deoxy-immucillin-H
-
pH 7.4, temperature not specified in the publication
0.000019
2'-deoxy-immucillin-H
pH 7.4, temperature not specified in the publication
0.0000009
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-G
-
pH 7.4, temperature not specified in the publication
0.0015
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-G
pH 7.4, temperature not specified in the publication
0.0000005
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-H
-
pH 7.4, temperature not specified in the publication
0.0036
4'-deaza-1'-aza-2'-deoxy-1',9-methyl-immucillin-H
pH 7.4, temperature not specified in the publication
0.0000015
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
0.0000015
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
25°C, pH 7.4
0.0000000107
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
25°C, pH 7.4, wild-type enzyme, measured in slow-onset tight-binding phase
0.000000011
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
overall dissociation constant
0.00000027
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
25°C, pH 7.4, mutant enzyme H257G, measured in slow-onset tight-binding phase
0.0000009
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
25°C, pH 7.4, mutant enzyme H257D, measured in slow-onset tight-binding phase
0.00000095
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
25°C, pH 7.4, mutant enzyme H257F, measured in slow-onset tight-binding phase
0.0000038
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
-
0.0000038
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
25°C, pH 7.4
0.000018
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
25°C, pH 7.4
0.00022
5'-amido-immucillin-H
-
pH 7.4, temperature not specified in the publication
0.0089
5'-amido-immucillin-H
pH 7.4, temperature not specified in the publication
0.000012
5'-carboxy-immucillin-H
pH 7.4, temperature not specified in the publication
0.000017
5'-carboxy-immucillin-H
-
pH 7.4, temperature not specified in the publication
0.0004
5'-chloro-5'-deoxy-8-aminoguanosine
-
-
0.012
5'-chloro-5'-deoxy-8-aminoguanosine
-
-
0.0000000077
5'-deoxy-immucillin-H
25°C, pH 7.4, mutant enzyme H257G
0.00000002
5'-deoxy-immucillin-H
25°C, pH 7.4, wild-type enzyme
0.000000054
5'-deoxy-immucillin-H
25°C, pH 7.4, mutant enzyme H257D
0.000000198
5'-deoxy-immucillin-H
25°C, pH 7.4, mutant enzyme H257F
0.0000011
5'-deoxy-immucillin-H
pH 7.4, temperature not specified in the publication
0.0000016
5'-deoxy-immucillin-H
-
pH 7.4, temperature not specified in the publication
0.000002
5'-fluoro-immucillin-H
pH 7.4, temperature not specified in the publication
0.0000022
5'-fluoro-immucillin-H
-
pH 7.4, temperature not specified in the publication
0.00000027
5'-methylthio-immucillin-H
-
pH 7.4, temperature not specified in the publication
0.0000027
5'-methylthio-immucillin-H
pH 7.4, equilibrium inhibition constant
0.0056
5'-methylthio-immucillin-H
pH 7.4, temperature not specified in the publication
0.000000093
5'-thio-immucillin-H
-
pH 7.4, temperature not specified in the publication
0.05
5'-thio-immucillin-H
Ki above 0.05 mM, pH 7.4, temperature not specified in the publication
0.0003
6-methylformycin A
pH and temperature not specified in the publication
0.005
6-methylformycin A
pH 6.0
0.0252
6-methylformycin A
pH 5.5
0.06
7-Deazainosine
-
-
0.002
7-ketopyrazolo[4,3-d]pyrimidine
-
pH 7.3, concentration of the substrate 8-azaguanosine is 0.005-0.05 mM
0.0028 - 0.0035
7-ketopyrazolo[4,3-d]pyrimidine
-
pH 6.5, concentration of the substrate 8-azaguanosine is 0.05-0.25 mM
0.0036
7-ketopyrazolo[4,3-d]pyrimidine
-
pH 7.9, concentration of the substrate 8-azaguanosine is 0.005-0.05 mM
0.0037
7-ketopyrazolo[4,3-d]pyrimidine
-
pH 8.2, concentration of the substrate 8-azaguanosine is 0.005-0.05 mM
0.0042
7-ketopyrazolo[4,3-d]pyrimidine
-
pH 8.2, concentration of the substrate 8-azaguanosine is 0.005-0.05 mM
0.038
7-ketopyrazolo[4,3-d]pyrimidine
-
pH 6.0, concentration of the substrate 7-methylguanosine is 0.032 mM
0.054
7-ketopyrazolo[4,3-d]pyrimidine
-
pH 7.0, concentration of the substrate 7-methylguanosine is 0.03 mM
0.073
7-ketopyrazolo[4,3-d]pyrimidine
-
pH 7.0, concentration of the substrate 7-methylguanosine is 0.122 mM
0.093
7-ketopyrazolo[4,3-d]pyrimidine
-
pH 8.0, concentration of the substrate 7-methylguanosine is 0.032 mM
0.0002
8-Amino-9-benzylguanine
-
-
0.0002
8-Amino-9-benzylguanine
-
0.008
8-Amino-9-benzylguanine
-
-
0.007
8-aminoguanosine
-
-
0.013
8-aminoguanosine
-
-
0.017
8-aminoguanosine
-
-
0.024
9-(1,3-dihydroxy-2-propoxymethyl)guanine
-
reaction with 7-methylguanosine
0.027
9-(1,3-dihydroxy-2-propoxymethyl)guanine
-
reaction with inosine
0.0000075
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine
-
pH 7.0, 25°C
0.0000076
9-(2'-benzyl-5',5'-difluoro-5'-phosphonopentyl)guanine
-
erythrocyte enzyme, pH 7.0, 25°C
0.058
9-(2-hydroxyethoxymethyl)guanine
-
reaction with 7-methylguanosine
0.068
9-(2-hydroxyethoxymethyl)guanine
-
reaction with inosine
0.0000044
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine
-
pH 7.0, 25°C
0.0000081
9-(5',5'-difluoro-5'-phosphonobutyl)-9-deazaguanine
-
erythrocyte enzyme, pH 7.0, 25°C
0.0000053
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine
-
erythrocyte enzyme, pH 7.0, 25°C
0.0000057
9-(5',5'-difluoro-5'-phosphonoheptyl)-9-deazaguanine
-
pH 7.0, 25°C
0.0000033
9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine
pH 7.0, 25°C, in the presence of 1 mM phosphate
0.0069
9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine
-
wild-type, pH not specified in the publication, temperature not specified in the publication
0.0000056
9-deazaguanine
-
erythrocyte enzyme, pH 7.0, 25°C
0.0000061
9-deazaguanine
-
pH 7.0, 25°C
0.028
acyclovir
-
pH 7.5, 37°C
0.049
adenosine
-
-
0.0085
alpha-D-ribose 1-phosphate
-
with guanosine as variable substrate
0.035
alpha-D-ribose 1-phosphate
-
with phosphate as variable substrate
0.32
alpha-D-ribose 1-phosphate
-
with phosphate as variable substrate and 0.2 mM guanosine
0.36
alpha-D-ribose 1-phosphate
-
with guanosine as variable substrate and 20 mM phosphate
0.361
alpha-D-ribose 1-phosphate
-
-
0.000000034
DADMe-immucillin-G
-
wild-tpe, pH 7.4, 25°C
0.000000121
DADMe-immucillin-G
-
mutant L22E/H104R, pH 7.4, 25°C
0.000000009
DADMe-immucillin-H
pH and temperature not specified in the publication
0.000000023
DADMe-immucillin-H
pH and temperature not specified in the publication
0.00000024
DADMe-immucillin-H
-
mutant L22E/H104R, pH 7.4, 25°C
0.00000035
DADMe-immucillin-H
-
wild-tpe, pH 7.4, 25°C
0.0000074
deoxyimmucillin-H
pH 7.4, equilibrium inhibition constant
0.00001
deoxyimmucillin-H
pH 7.4, equilibrium inhibition constant
0.00013
deoxyimmucillin-H
pH 7.4, inhibition constant during slow-onset phase
0.000682
deoxyimmucillin-H
pH 7.4, inhibition constant during slow-onset phase
0.0053
Formycin A
-
-
0.014
Formycin A
pH 7.0, 25°C
0.0685
Formycin A
-
mutant enzyme N243D/K244Q, with adenosine as substrate
0.114
Formycin A
-
mutant enzyme N243D/K244Q, with inosine as substrate
0.143
Formycin A
-
mutant enzyme N243D, with adenosine as substrate
0.667
Formycin A
-
wild-type enzyme, with inosine as substrate
0.00039
formycin B
-
-
0.005
formycin B
pH and temperature not specified in the publication
0.1
formycin B
-
inhibition of phosphorolysis of 7-methylguanosine
0.1
formycin B
-
phosphorolysis of 7-methylguanosine
0.1
formycin B
pH and temperature not specified in the publication
0.279
formycin B
-
wild-type enzyme, with inosine as substrate
0.339
formycin B
-
mutant enzyme N243D/K244Q, with inosine as substrate
0.67
formycin B
-
mutant enzyme N243D, with inosine as substrate
0.705
formycin B
-
mutant enzyme N243D/K244Q, with inosine as substrate
0.0025
guanine
pH 7.0, 25°C
0.0025
guanine
25°C, pH 7.0, with phosphate as varied substrate
0.0025
guanine
-
versus phosphate
0.0036
guanine
25°C, pH 7.0, with inosine as varied substrate
0.0036
guanine
-
versus inosine
0.004
guanine
-
inhibition of phosphorolysis of xanthosine
0.0065
guanine
-
with guanosine as variable substrate
0.012
guanine
-
with guanosine as variable substrate and 200 mM phosphate
0.0125
guanine
-
with guanosine as variable substrate and phosphate as fixed substrate
0.0145
guanine
-
with guanosine as variable substrate and 40 mM phosphate
0.025
guanine
-
with phosphate as variable substrate
0.065
guanine
-
with phosphate as variable substrate and 0.2 mM guanosine
0.01
guanosine
-
inhibition of phosphorolysis of xanthosine
0.01
guanosine
-
with guanine as variable substrate and ribose 1-phosphate as fixed substrate
0.0313
guanosine
-
with guanine as variable substrate and 0.4 mM ribose 1-phosphate
0.8
guanosine
25°C, pH 7.0, about, with alpha-D-ribose 1-phosphate as varied substrate
0.8
guanosine
-
versus alpha-D-ribose 1-phosphate
0.0016
hypoxanthine
pH 7.0, 25°C
0.007
hypoxanthine
-
inhibition of phosphorolysis of xanthosine
0.05
hypoxanthine
-
with guanosine as variable substrate and 200 mM phosphate
0.000001
immucillin-A
-
-
0.000001
immucillin-A
-
25°C, pH 7.4
0.000000133
immucillin-G
-
wild-tpe, pH 7.4, 25°C
0.000000175
immucillin-G
-
mutant L22E/H104R, pH 7.4, 25°C
0.0000009
immucillin-G
pH 7.4, equilibrium inhibition constant
0.00000189
immucillin-G
pH 7.4, equilibrium inhibition constant
0.000016
immucillin-G
-
-
0.000016
immucillin-G
-
25°C, pH 7.4
0.000346
immucillin-G
pH 7.4, inhibition constant during slow-onset phase
0.000000011
immucillin-H
25°C, pH 7.4, mutant enzyme H257G
0.0000000579
immucillin-H
25°C, pH 7.4, wild-type enzyme, measured in slow-onset tight-binding phase
0.000000058
immucillin-H
pH and temperature not specified in the publication
0.000000072
immucillin-H
-
0.000000086
immucillin-H
25°C, pH 7.4, mutant enzyme H257D
0.000000172
immucillin-H
25°C, pH 7.4, mutant enzyme H257F
0.00000037
immucillin-H
pH 7.4, temperature not specified in the publication
0.0000006
immucillin-H
pH 7.4, equilibrium inhibition constant
0.00000067
immucillin-H
-
mutant L22E/H104R, pH 7.4, 25°C
0.00000086
immucillin-H
-
pH 7.4, temperature not specified in the publication
0.000001
immucillin-H
-
wild-tpe, pH 7.4, 25°C
0.00000203
immucillin-H
pH 7.4, equilibrium inhibition constant
0.000012
immucillin-H
-
-
0.000012
immucillin-H
-
25°C, pH 7.4
0.000029
immucillin-H
pH 7.4, inhibition constant during slow-onset phase
0.00045
immucillin-H
pH 7.4, inhibition constant during slow-onset phase
0.00027
N(6)-methyl-formycin A
pH 8.0
0.0003
N(6)-methyl-formycin A
-
0.0003
N(6)-methyl-formycin A
-
pH 7
0.0003
N(6)-methyl-formycin A
pH 7
0.005
N(7)-acycloguanosine
-
0.097
N(7)-acycloguanosine
-
-
0.0034
N(9)-acycloguanosine
-
-
0.014
N(9)-acycloguanosine
-
2.5
phosphate
25°C, pH 7.0, with alpha-D-ribose 1-phosphate as varied substrate
4.4
phosphate
-
with ribose 1-phosphate as variable substrate and guanine as fixed substrate
4.7
phosphate
25°C, pH 7.0, with guanine as varied substrate
4.7
phosphate
-
versus guanine
26
phosphate
-
with guanine as variable substrate and ribose 1-phosphate as fixed substrate
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
additional information
additional information
-
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
inhibition kinetics
-
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.