Information on EC 2.4.2.1 - purine-nucleoside phosphorylase

Word Map on EC 2.4.2.1
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.4.2.1
-
RECOMMENDED NAME
GeneOntology No.
purine-nucleoside phosphorylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
purine deoxyribonucleoside + phosphate = purine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
(2)
-
-
-
purine ribonucleoside + phosphate = purine + alpha-D-ribose 1-phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pentosyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
adenine and adenosine salvage I
-
-
adenine and adenosine salvage III
-
-
adenine and adenosine salvage V
-
-
adenosine nucleotides degradation II
-
-
arsenate detoxification I (glutaredoxin)
-
-
fluoroacetate and fluorothreonine biosynthesis
-
-
guanine and guanosine salvage
-
-
guanosine nucleotides degradation III
-
-
nucleoside and nucleotide degradation (archaea)
-
-
purine deoxyribonucleosides degradation I
-
-
purine deoxyribonucleosides degradation II
-
-
purine ribonucleosides degradation
-
-
salinosporamide A biosynthesis
-
-
urate biosynthesis/inosine 5'-phosphate degradation
-
-
xanthine and xanthosine salvage
-
-
purine metabolism
-
-
Purine metabolism
-
-
Pyrimidine metabolism
-
-
Nicotinate and nicotinamide metabolism
-
-
Metabolic pathways
-
-
Biosynthesis of secondary metabolites
-
-
SYSTEMATIC NAME
IUBMB Comments
purine-nucleoside:phosphate ribosyltransferase
Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9030-21-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
KY3106
-
-
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
Arthrobacter nucleogenes
KY3168
-
-
Manually annotated by BRENDA team
Arthrobacter nucleogenes KY3168
KY3168
-
-
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
strain Alk36
UniProt
Manually annotated by BRENDA team
strain Alk36
UniProt
Manually annotated by BRENDA team
Bacterium cadaveris
Bacterium cadaveris KY3402
KY3402
-
-
Manually annotated by BRENDA team
KY3491
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
KY3074
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
ATCC 954
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Leucisus rusticus
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
KY 3760
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
KY4057
-
-
Manually annotated by BRENDA team
KY4057
-
-
Manually annotated by BRENDA team
gene salT
UniProt
Manually annotated by BRENDA team
salmon
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain ME49
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
KY4208
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the salT-deficient mutant strain shows reduced salinosporamide A and salinosporamide B synthesis
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,6-dihydropurine riboside + phosphate
alpha-D-ribose 1-phosphate + 1,6-dihydropurine
show the reaction diagram
-
-
-
-
?
1-methylguanosine + phosphate
alpha-D-ribose 1-phosphate + 1-methylguanine
show the reaction diagram
-
-
-
-
?
1-methylinosine + phosphate
alpha-D-ribose 1-phosphate + 1-methylhypoxanthine
show the reaction diagram
-
-
-
-
?
2',3'-dideoxyinosine + phosphate
alpha-D-2,3-dideoxyribose 1-phosphate + hypoxanthine
show the reaction diagram
2',3'-dideoxyinosine + phosphate
hypoxanthine + 2,3-dideoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
2',3'-dideoxyinosine + phosphate
hypoxanthine + alpha-D-2,3-dideoxyribose 1-phosphate
show the reaction diagram
-
-
-
-
?
2'-amino-2'-deoxyadenosine + phosphate
adenine + 2-deoxy-2-imino-alpha-D-ribose 1-phosphate
show the reaction diagram
2'-amino-2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-2-imino-alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
2'-deoxy-2'-fluoroadenosine + phosphate
adenine + 2-deoxy-2-fluoro-alpha-D-arabinofuranose 1-phosphate
show the reaction diagram
-
-
-
-
?
2'-deoxy-6-methylpurine nucleoside + phosphate
?
show the reaction diagram
13.2% of the activity with inosine
-
-
?
2'-deoxyadenosine + phosphate
2-deoxy-alpha-D-ribose 1-phosphate + adenine
show the reaction diagram
-
10% of the activity with inosine
-
-
?
2'-deoxyadenosine + phosphate
adenine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
2'-deoxyguanosine + phosphate
guanine + alpha-D-2-deoxyribose 1-phosphate
show the reaction diagram
-
-
-
-
?
2'-deoxyinosine + phosphate
2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
show the reaction diagram
-
-
-
-
?
2'-deoxyinosine + phosphate
alpha-D-2-deoxyribose 1-phosphate + hypoxanthine
show the reaction diagram
2'-deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
2,6-diamino-8-azapurine + alpha-D-ribose 1-phosphate
N8-ribosyl-2,6-diamino-8-azapurine + N7-ribosyl-2,6-diamino-8-azapurine + phosphate
show the reaction diagram
-
-
-
-
?
2,6-dihydropurine nucleoside + phosphate
alpha-D-ribose 1-phosphate + 2,6-dihydropurine
show the reaction diagram
-
-
-
-
2-amino-6-mercapto-7-methylpurine ribonucleoside + alpha-D-ribose 1-phosphate
?
show the reaction diagram
2-amino-6-mercapto-7-methylpurine ribonucleoside + phosphate
alpha-D-ribose 1-phosphate + 2-amino-6-mercapto-7-methylpurine
show the reaction diagram
2-amino-6-mercapto-7-methylpurine ribonucleoside + phosphate
alpha-D-ribose 1-phosphate + ?
show the reaction diagram
-
-
-
-
?
2-chloroadenosine + phosphate
2-chloroadenine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
2-diamonopurine ribonucleoside + phosphate
2-diamonopurine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
2-fluoro-2'-deoxyadenosine + phosphate
2-fluoroadenine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
2-fluoro-2'-deoxyadenosine + phosphate
2-fluoroadenine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
no substrate for wild-type, substrate of double mutant E201Q/N243D
-
-
?
2-fluoro-2'-deoxyadenosine + phosphate
?
show the reaction diagram
-
a toxic prodrug
-
-
?
2-fluoroadenosine + phosphate
2-fluoroadenine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
3-(beta-D-ribofuranosyl)adenine + alpha-D-ribose 1-phosphate
?
show the reaction diagram
3-(beta-D-ribofuranosyl)hyopxanthine + alpha-D-ribose 1-phosphate
?
show the reaction diagram
3-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate
?
show the reaction diagram
-
-
-
-
?
3-deazainosine + phosphate
alpha-D-ribose 1-phosphate + 3-deazahypoxanthine
show the reaction diagram
5'-chloro-5'-deoxy-adenosine + phosphate
5-chloro-5-deoxy-D-ribose 1-phosphate + adenine
show the reaction diagram
-
-
-
-
5'-deoxy-5'-fluoroadenosine + phosphate
5-deoxy-5-fluoro-D-ribose-1-phosphate + adenine
show the reaction diagram
-
5'-deoxy-5'-fluoroadenosine + phosphate i.e. 5'-FDA
5-deoxy-5-fluoro-D-ribose-1-phosphate i.e. 5-FDRP
-
?
5'-deoxy-5'-iodo-2-fluoroadenosine + phosphate
2-fluoroadenine + 5-deoxy-5-iodo-alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
5'-deoxy-5'-methylthioadenosine + phosphate
5'-deoxy-5'-methylthioadenine + alpha-D-ribose 1-phosphate
show the reaction diagram
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-deoxy-5-methylthio-alpha-D-ribose 1-phosphate
show the reaction diagram
-
40% activity compared to adenosine
-
-
?
5'-methylthioinosine + phosphate
5'-methylthiohypoxanthine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
r
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
show the reaction diagram
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-D-ribose 1-phosphate
show the reaction diagram
5-aza-7-deazaguanine + phosphate
?
show the reaction diagram
-
-
-
-
r
6-(2-thienyl)-9-(beta-D-ribofuranosyl)purine + phosphate
6-(2-thienyl)purine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
6-cyclopropyl-9-(beta-D-ribofuranosyl)purine + phosphate
6-cyclopropylpurine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
6-ethyl-9-(beta-D-ribofuranosyl)purine + phosphate
6-ethylpurine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
6-mercaptoguanosine + phosphate
alpha-D-ribose 1-phosphate + 6-mercaptoguanine
show the reaction diagram
-
-
-
-
?
6-mercaptopurine riboside + phosphate
alpha-D-ribose 1-phosphate + 6-mercaptopurine
show the reaction diagram
6-phenyl-9-(beta-D-ribofuranosyl)purine + phosphate
6-phenylpurine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
6-thioxanthine + alpha-D-ribose 1-phosphate
6-thioxanthosine + phosphate
show the reaction diagram
7,8-dimethylguanosine + phosphate
7,8-dimethylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
7-(beta-D-ribofuranosyl)guanine + alpha-D-ribose 1-phosphate
?
show the reaction diagram
7-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate
?
show the reaction diagram
7-butylguanosine + phosphate
7-butylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
7-ethylguanosine + phosphate
7-ethylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
7-isobutylguanosine + phosphate
7-isobutylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
7-isopropylguanosine + phosphate
7-isopropylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
7-methyl-6-thio-guanosine + phosphate
7-methyl-6-thioguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
7-methyl-8-aminoguanosine + phosphate
7-methyl-8-aminoguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
7-methyladenosine + phosphate
7-methyladenine + alpha-D-ribose 1-phosphate
show the reaction diagram
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
7-methylinosine + phosphate
7-methylhypoxanthine + alpha-D-ribose 1-phosphate
show the reaction diagram
7-N-methyl-6-thiopurine riboside + phosphate
?
show the reaction diagram
-
-
-
-
?
7-prolylguanosine + phosphate
7-prolylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
8-aminoguanine + alpha-D-ribose 1-phosphate
8-aminoguanosine + phosphate
show the reaction diagram
8-azaguanine + alpha-D-ribose 1-phosphate
8-azaguanosine + phosphate
show the reaction diagram
8-azaguanine + alpha-D-ribose 1-phosphate
N9-beta-D-ribosyl-8-azaguanine + phosphate
show the reaction diagram
-
-
-
-
?
8-azahypoxanthine + alpha-D-ribose 1-phosphate
8-azainosine + phosphate
show the reaction diagram
-
-
-
?
8-methylguanosine + phosphate
8-methylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
9-(2-deoxy-2-fluoro-alpha-D-arabinofuranosyl)adenine + phosphate
adenine + 2-deoxy-2-fluoro-alpha-D-arabinofuranose 1-phosphate
show the reaction diagram
-
-
-
-
?
9-(6-deoxy-5-C-methyl-beta-D-ribo-hexofuranosyl)-6-methylpurine + phosphate
?
show the reaction diagram
-
-
-
-
r
9-(6-deoxy-beta-D-allofuranosyl)-6-methylpurine + phosphate
?
show the reaction diagram
-
-
-
-
r
9-(beta-D-ribofuranosyl)-6-methylpurine + phosphate
?
show the reaction diagram
-
-
-
-
r
9-beta-D-(2-deoxyribofuranosyl)-6-methylthiopurine + phosphate
6-methylthiopurine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
9-beta-D-ribofuranosyl-6-methylthiopurine + phosphate
6-methylthiopurine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
9-[2-deoxy-beta-D-ribofuranosyl]-6-methylpurine + phosphate
?
show the reaction diagram
9-[6-deoxy-alpha-L-talofuranosyl]-2-F-adenine + phosphate
?
show the reaction diagram
-
-
-
-
?
9-[6-deoxy-alpha-L-talofuranosyl]-6-methylpurine + phosphate
?
show the reaction diagram
-
-
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-2-fluoro-adenine + phosphate
?
show the reaction diagram
9-[6-deoxy-beta-L-talofuranosyl]-6-methylpurine + phosphate
?
show the reaction diagram
9-[alpha-L-lyxofuranosyl]-2-F-adenine + phosphate
?
show the reaction diagram
-
-
-
-
?
9-[beta-D-arabinofuranosyl]-2-fluoro-adenine + phosphate
?
show the reaction diagram
-
a toxic prodrug
-
-
?
9-[beta-D-arabinofuranosyl]-2-fluoroadenine + phosphate
?
show the reaction diagram
-
-
-
-
r
9-[beta-L-lyxofuranosyl]-2-fluoro-adenine + phosphate
?
show the reaction diagram
adenine + deoxyribose 1-phosphate
deoxyadenosine + phosphate
show the reaction diagram
adenine arabinoside + phosphate
alpha-D-arabinose 1-phosphate + adenine
show the reaction diagram
-
49% of the activity with adenosine
-
-
-
adenosine + arsenate
adenine + alpha-D-ribose 1-arsenate
show the reaction diagram
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
show the reaction diagram
adenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
show the reaction diagram
activity with mutant enzyme N239D, wild-type and mutant enzyme Y191L show no activity
-
-
?
arabinofuranosyladenine + phosphate
?
show the reaction diagram
4.3% of the activity with inosine
-
-
?
cytokinin + phosphate
? + alpha-D-ribose 1-phosphate
show the reaction diagram
-
the enzyme prefers cytokinin to unsubstituted aminopurines
-
-
r
deoxyadenosine + phosphate
alpha-D-ribose 1-phosphate + adenine
show the reaction diagram
deoxyguanosine + phosphate
guanine + alpha-D-deoxyribose 1-phosphate
show the reaction diagram
deoxyinosine + phosphate
hypoxanthine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
deoxyinosine + phosphate
hypoxanthine + alpha-D-deoxyribose 1-phosphate
show the reaction diagram
dihydrozeatin riboside + phosphate
dihydrozeatin + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
r
guanine + alpha-D-ribose 1-phosphate
guanosine + phosphate
show the reaction diagram
-
-
-
-
?
guanine + ribose 1-phosphate
guanosine + phosphate
show the reaction diagram
-
-
-
r
guanosine + arsenate
guanine + alpha-D-ribose 1-arsenate
show the reaction diagram
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
show the reaction diagram
hypoxanthine + alpha-D-deoxyribose 1-phosphate
deoxyinosine + phosphate
show the reaction diagram
-
-
-
-
r
hypoxanthine + alpha-D-ribose 1-phosphate
inosine + phosphate
show the reaction diagram
-
-
-
-
r
inosine + arsenate
hypoxanthine + ribose 1-arsenate
show the reaction diagram
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
show the reaction diagram
isopentenyladenosine + phosphate
isopentenyladenine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
r
methylthioinosine + phosphate
methylthiohypoxanthine + alpha-D-ribose 1-phosphate
show the reaction diagram
more '
?
show the reaction diagram
-
catalysis involves protonation of the purine base at position N7 by residue Asp204, which is triggered by Arg217
-
-
-
nicotinamide riboside + phosphate
nicotinamide + alpha-D-ribose 1-phosphate
show the reaction diagram
p-nitrophenyl beta-D-ribofuranoside + phosphate
?
show the reaction diagram
-
-
-
-
?
purine deoxyribonucleoside + phosphate
purine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
purine ribonucleoside + phosphate
purine + alpha-D-ribose 1-phosphate
show the reaction diagram
purine riboside + phosphate
alpha-D-ribose 1-phosphate + purine
show the reaction diagram
-
-
-
-
?
ribavirin + phosphate
1,2,4-triazole-3-carboxamide + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
ribavirin + phosphate
alpha-D-ribose 1-phosphate + 1,2,4-triazole-3-carboxamide
show the reaction diagram
-
22% of the activity with inosine. Phosphorolysis reaches an equilibrium when 15% of ribavirin is phosphorolyzed
-
-
r
trans-zeatin riboside + phosphate
trans-zeatin + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
r
uridine + phosphate
?
show the reaction diagram
-
-
-
-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
?
xanthosine + arsenate
xanthine + alpha-D-ribose 1-arsenate
show the reaction diagram
xanthosine + phosphate
alpha-D-ribose 1-phosphate + xanthine
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
2-fluoro-2'-deoxyadenosine + phosphate
?
show the reaction diagram
-
a toxic prodrug
-
-
?
5'-deoxy-5'-methylthioadenosine + phosphate
5'-deoxy-5'-methylthioadenine + alpha-D-ribose 1-phosphate
show the reaction diagram
9-[2-deoxy-beta-D-ribofuranosyl]-6-methylpurine + phosphate
?
show the reaction diagram
-
a toxic prodrug
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-2-fluoro-adenine + phosphate
?
show the reaction diagram
-
a toxic prodrug, substrate of enzyme mutant M64V, the drug product has anti-tumor activity
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-6-methylpurine + phosphate
?
show the reaction diagram
-
a toxic prodrug, substrate of enzyme mutant M64V, the drug product has anti-tumor activity
-
-
?
9-[beta-D-arabinofuranosyl]-2-fluoro-adenine + phosphate
?
show the reaction diagram
-
a toxic prodrug
-
-
?
9-[beta-L-lyxofuranosyl]-2-fluoro-adenine + phosphate
?
show the reaction diagram
-
a toxic prodrug, substrate of enzyme mutant M64V, the drug product has anti-tumor activity
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
show the reaction diagram
purine deoxyribonucleoside + phosphate
purine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
purine ribonucleoside + phosphate
purine + alpha-D-ribose 1-phosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranozyl)ethylphosphonic acid
-
with (hypoxanthine-9-yl)methyl aglycone, i.e. Yokomatsu compound
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranyl)ethylphosphonic acid with (hypoxanthine-9-yl)methyl aglycone
(3R,4R)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol
-
-
(3S)-3-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chlorophenyl)propanoic acid
-
IC50: 0.000036 mM
(3S,4R)-4-(guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylcarbonylphosphonic acid
-
competitive. For enzyme from cancer cell lines, Ki values are around 10 to 24 nM
(3S,4S)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol
-
-
(S)-3-(guanin-9-yl)pyrrolidin-N-ylcarbonylphosphonic acid
-
competitive. For enzyme from cancer cell lines, Ki values widely vary from 16 to 100 nM
1',9-methyl-immucillin-H
-
1,6-Dihydropurine riboside
-
-
1-((2-pyrrolidine-1-yl)ethyl)uracil
inhibits both enzymic activity and growth of Plasmodium falciparum
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine
-
-
1-methylguanine
1-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]guanidine
-
0.1 mM , 79.5% inhibition
1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]guanidine
-
0.1 mM , 70.6% inhibition
2'-deoxy-immucillin-G
-
2'-deoxy-immucillin-H
2,6-diamino-7-(5-mercapto-3,3-dimethylpentyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
IC50: 0.00005 mM
2,6-diamino-7-(cyclohexylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
IC50: 0.0066 mM
2,8-diamino-1,7-dihydro-6H-purine-6-thione
-
IC50: 0.00849 mM
2,8-diamino-1,9-dihydro-6H-purin-6-one
-
IC50: 0.002299 mM
2,8-diamino-3-(2-thienylmethyl)-3,9-dihydro-6H-purin-6-one
-
IC50: 0.001758 mM
2,8-diamino-9-(1,3-thiazol-4-ylmethyl)-1,9-dihydro-6H-purin-6-one
-
IC50: 0.001043 mM
2,8-diamino-9-(2-furylmethyl)-1,9-dihydro-6H-purin-6-one
-
IC50: 0.000092 mM; IC50: 0.00271 mM
2,8-diamino-9-(2-thienylmethyl)-1,9-dihydro-6H-purin-6-one
-
IC50: 0.000497 mM
2,8-diamino-9-(4-fluorobenzyl)-1,9-dihydro-6H-purin-6-one
-
IC50: 0.00417 mM
2,8-diamino-9-(pyridin-2-ylmethyl)-1,9-dihydro-6H-purin-6-one
-
IC50: 0.001971 mM
2,8-diamino-9-[(4-methyl-2-thienyl)methyl]-1,9-dihydro-6H-purin-6-one
-
IC50: 0.000362 mM
2,8-diamino-9-[4-(1H-imidazol-1-yl)benzyl]-1,9-dihydro-6H-purin-6-one
-
IC50: 0.000852 mM
2,8-diamino-9-[[1-(heptyloxy)-2-hydroxyethoxy]methyl]-1,9-dihydro-6H-purin-6-one
-
IC50: 0.00152 mM
2-(3,4-dichlorophenyl)-5-thioxo-5,6-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3,7(2H,4H)-dione
-
IC50: 0.00703 mM
2-amino-1,5-dihydro-7-[[(2S)-2-(aminomethyl)-1-pyrrolidinyl]-methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
IC50: 600 nM
2-amino-1,5-dihydro-7-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
acetic acid salt, IC50: 4.0 nM
2-amino-1,5-dihydro-7-[[[2-(hydroxy)ethyl]amino]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
IC50: 20 nM
2-amino-6-chloro-7-deazapurine 2'-deoxyriboside
-
-
2-amino-6-mercapto-7-methylpurine ribonucleoside
-
in absence of phosphate the enzyme catalyzes a slow hydrolysis, which is accompanied by inactivation of the enzyme
2-Amino-6-methylthiopurine
-
-