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UDPgalactose + GlcNAcbeta-S-p-NP
UDP + Galbeta1-4 GlcNAcbeta-S-p-NP
-
-
-
?
UDPgalactose + GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-3Manbeta1-O(CH2)8COOCH2-mNP
UDP + Galbeta1-4 GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-3Manbeta1-O(CH2)8COOCH2-mNP
-
-
-
?
UDPgalactose + glucose
lactose + UDP
enzyme has no lactose synthase activity in presence of alpha-lactalbumin
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
7% of the activity with GlcNAcbeta-S-pNP
-
-
?
UDP-alpha-D-galactose + asialo-agalacto-transferrin
?
-
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-D-galactosamine
?
-
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
UDP-alpha-D-galactose + ovalbumin
UDP + ?
-
-
-
-
?
UDP-alpha-D-glucose + N-acetyl-alpha-D-glucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDP-galactose + GlcNAcbeta(1,2)Manalpha(1,6)(GlcNAcbeta(1,2)Manalpha(1,3))Manbeta(1,4)GlcNAcbeta(1,4)GlcNAc-PA
UDP + Galbeta1,4-GlcNAcbeta(1,2)Manalpha(1,6)(GlcNAcbeta(1,2)Manalpha(1,3))Manbeta(1,4)GlcNAcbeta(1,4)GlcNAc-PA
-
-
-
-
?
UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
UDP-galactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDP-galactose + ovalbumin
UDP + ?
-
-
-
-
?
UDPgalactose + agalacto-poly-N-acetyllactosamine
?
-
-
-
-
?
UDPgalactose + alpha1-acid glycoprotein
?
-
-
-
-
?
UDPgalactose + asialo agalacto alpha1 acid glycoprotein
?
-
-
-
-
?
UDPgalactose + degalactosylated fetuin
UDP + fetuin containing beta-1,4-galactose linkages
UDPgalactose + glucose
lactose + UDP
UDPgalactose + lacto-N-triaosylceramide
?
-
-
-
-
?
UDPgalactose + lacto-N-triose II
?
-
-
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
?
UDPgalactose + ovalbumin
?
-
-
-
-
?
UDPgalactose + UDPglucose
UDP + lactose
-
-
-
?
additional information
?
-
UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
-
-
-
?
UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
-
synthesis of Galbeta1,4GlcNAc groups in N-linked sugar chains of glycoproteins involved in many physiological functions, e.g. sperm-egg interactions, cell migration, and embryonic development, enzyme expression is highly increased during cycloheximide-induced cell apoptosis in liver carcinoma
-
-
?
UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
-
enzyme is highly specific for UDP-galactose as donor substrate
-
-
?
UDPgalactose + degalactosylated fetuin
UDP + fetuin containing beta-1,4-galactose linkages
-
-
-
?
UDPgalactose + degalactosylated fetuin
UDP + fetuin containing beta-1,4-galactose linkages
-
-
-
-
?
UDPgalactose + glucose
lactose + UDP
-
in presence of alpha-lactalbumin
-
?
UDPgalactose + glucose
lactose + UDP
-
in presence of alpha-lactalbumin
-
?
UDPgalactose + glucose
lactose + UDP
-
in presence of alpha-lactalbumin
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
?
-
the enzyme may be involved in the synthesis of poly-N-acetyllactosamine, lacto-N-neotetraose and probably lacto-N-neotetraosylceramide in addition to the formation of the Galbeta1-4GlcNAc group of glycoprotein sugar chains and lactose
-
-
?
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
?
-
main enzyme responsible for the transfer of galactose residues from UDPgalactose into terminal N-acetylglucosamine residues of complex-type oligosaccharides in newly synthesized glycoproteins in the Golgi apparatus. Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId, a severe neurologic disease characterized by a hydrocephalus, myopathy and blood-clotting defects
-
-
?
additional information
?
-
-
the enzyme utilizes different glycoproteins and glycolipids as substrates, patients with rheumatoid arthritis have a higher content of an acidic isoform compared to healthy individuals, the isoform is not associated with inflammation per se but specifically with rheumatoid arthritis
-
-
?
additional information
?
-
-
analysis of cell surface sugar chains in the cancer cell lines, overview
-
-
?
additional information
?
-
-
UDP-glucose and UDP-N-acetylgalactosamine are poor substrates, the latter due to Tyr286 which is a sterical hindrance and traps hydrolyzed GalNAc in the oxocarbenium-ion-like state, enzyme interacts with alpha-lactalbumin to form the lactose synthase enzyme complex
-
-
?
additional information
?
-
-
tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis, relationships between tumor beta-1,4-GT-IV overexpression and clinicopathologic characteristics, overview
-
-
?
additional information
?
-
-
beta-1,4-GTs are a family of glycosyltransferases responsible for biosynthesizing N-acetyllactosamine by the transfer of a galactose from UDP-galactose to the terminal N-acetylgluosamine of acceptor sugars in glycoproteins or glycolipids with a beta-1,4-linkage
-
-
?
additional information
?
-
-
substrate specificity of wild-type and mutant Y289L enzymes, overview
-
-
?
additional information
?
-
beta1,4-galactosyltransferase II is one of the enzymes transferring galactose to the terminal N-acetylglucosamine of complex-type N-glycans. Beta1,4GalT II might serve as a target gene of p53 transcription factor during adriamycin-induced HeLa cell apoptosis, mechanisms of its expression regulation, overview
-
-
?
additional information
?
-
-
no activity with 5-(indol-4-yl)-UDP-alpha-D-galactose
-
-
-
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UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
UDP-galactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
?
additional information
?
-
UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
-
-
-
?
UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
-
synthesis of Galbeta1,4GlcNAc groups in N-linked sugar chains of glycoproteins involved in many physiological functions, e.g. sperm-egg interactions, cell migration, and embryonic development, enzyme expression is highly increased during cycloheximide-induced cell apoptosis in liver carcinoma
-
-
?
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
?
-
the enzyme may be involved in the synthesis of poly-N-acetyllactosamine, lacto-N-neotetraose and probably lacto-N-neotetraosylceramide in addition to the formation of the Galbeta1-4GlcNAc group of glycoprotein sugar chains and lactose
-
-
?
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
?
-
main enzyme responsible for the transfer of galactose residues from UDPgalactose into terminal N-acetylglucosamine residues of complex-type oligosaccharides in newly synthesized glycoproteins in the Golgi apparatus. Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId, a severe neurologic disease characterized by a hydrocephalus, myopathy and blood-clotting defects
-
-
?
additional information
?
-
-
the enzyme utilizes different glycoproteins and glycolipids as substrates, patients with rheumatoid arthritis have a higher content of an acidic isoform compared to healthy individuals, the isoform is not associated with inflammation per se but specifically with rheumatoid arthritis
-
-
?
additional information
?
-
-
tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis, relationships between tumor beta-1,4-GT-IV overexpression and clinicopathologic characteristics, overview
-
-
?
additional information
?
-
beta1,4-galactosyltransferase II is one of the enzymes transferring galactose to the terminal N-acetylglucosamine of complex-type N-glycans. Beta1,4GalT II might serve as a target gene of p53 transcription factor during adriamycin-induced HeLa cell apoptosis, mechanisms of its expression regulation, overview
-
-
?
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1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1-methyl-1H-indol-4-yl)pyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indazol-4-yl)pyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-4-yl)pyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-5-yl)pyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-6-yl)pyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)pyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(isoquinolin-4-yl)pyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(pyridin-3-yl)pyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(pyridin-4-yl)pyrimidine-2,4(1H,3H)-dione
-
-
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-3-(1H-indol-3-yl)propanoic acid
-
-
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-4-methylpentanoic acid
-
-
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-6-aminohexanoic acid
-
-
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)acetic acid
-
-
5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophene-2-carbaldehyde
-
-
alpha-lactalbumin
-
inhibits reaction with UDPgalactose and N-acetylglucosamine
-
alpha1-Acid glycoprotein
-
above 1.4 mM with respect to acceptor sites
-
D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol
-
potent inhibitor
N-acetylglucosamine
-
above 10 mM
p-hydroxymercuribenzoate
-
-
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Adenocarcinoma
Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.
Arthritis, Rheumatoid
beta1,4-Galactosyltransferase-I contributes to the inflammatory processes in synovial tissue of patients with rheumatoid arthritis.
Asthma
Genome-wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.
Astrocytoma
Over-expression of beta-1,4-galactosyltransferase I, II, and V in human astrocytoma.
Astrocytoma
Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line.
Atherosclerosis
Platelet derived growth factor recruits lactosylceramide to induce cell proliferation in UDP Gal:GlcCer: beta1 --> 4Galactosyltransferase (GalT-V) mutant Chinese hamster ovary cells.
Biliary Tract Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Breast Neoplasms
?1,4-Galactosyltransferase V Modulates Breast Cancer Stem Cells through Wnt/?-catenin Signaling Pathway.
Breast Neoplasms
Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.
Carcinogenesis
beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization.
Carcinoma
Expression of galactosyltransferase in prostatic tumors.
Carcinoma
Increase in beta-1,4-galactosyltransferase activity during PC12 cell differentiation induced by forskolin and 2-chloroadenosine.
Carcinoma
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Carcinoma, Ehrlich Tumor
Ehrlich ascites tumor cell UDP-Gal:N-acetyl-D-glucosamine beta(1,4)-galactosyltransferase. Purification, characterization, and topography of the acceptor-binding site.
Carcinoma, Embryonal
Cell surface and Golgi pools of beta-1,4-galactosyltransferase are differentially regulated during embryonal carcinoma cell differentiation.
Carcinoma, Embryonal
Characterization of a murine beta 1-4 galactosyltransferase expressed in COS-1 cells.
Carcinoma, Embryonal
Dominant negative mutation in cell surface beta 1,4-galactosyltransferase inhibits cell-cell and cell-matrix interactions.
Carcinoma, Embryonal
Effects of overexpression of beta 1,4-galactosyltransferase on glycoprotein biosynthesis in F9 embryonal carcinoma cells.
Carcinoma, Embryonal
Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase.
Carcinoma, Hepatocellular
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Colonic Neoplasms
Characterization of monoclonal antibodies to serum galactosyltransferase.
Colonic Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Colorectal Neoplasms
Lactosylceramide synthase ?-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer.
Colorectal Neoplasms
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis.
Connective Tissue Diseases
Determination of beta4-galactosyltransferase-7 activity using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Ehlers-Danlos Syndrome
Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family.
Esophageal Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Gastrointestinal Neoplasms
Characterization of monoclonal antibodies to serum galactosyltransferase.
Glioblastoma
B4GALT3 promotes cell proliferation and invasion in glioblastoma.
Glioblastoma
Over-expression of beta-1,4-galactosyltransferase I, II, and V in human astrocytoma.
Glioma
Beta1,4-galactosyltransferase V A growth regulator in glioma.
Glioma
Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma.
Glioma
beta1,4-Galactosyltransferase V regulates self-renewal of glioma-initiating cell.
Glioma
Down-regulation of beta1,4-galactosyltransferase V is a critical part of etoposide-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells.
Glioma
Down-regulation of the expression of beta1,4-galactosyltransferase V promotes integrin beta1 maturation.
Glomerulonephritis, IGA
Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in Beta-1,4-galactosyltransferase-deficient mice.
Herpes Zoster
Aggregation of beta-1,4-galactosyltransferase on mouse sperm induces the acrosome reaction.
Herpes Zoster
Binding of caput epididymal mouse sperm to the zona pellucida.
Herpes Zoster
Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling.
Herpes Zoster
Characterization of a novel ZP3-independent sperm-binding ligand that facilitates sperm adhesion to the egg coat.
Herpes Zoster
Egg cortical granule N-acetylglucosaminidase is required for the mouse zona block to polyspermy.
Herpes Zoster
Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions.
Herpes Zoster
Plasma membrane association, purification, and partial characterization of mouse sperm beta 1,4-galactosyltransferase.
Herpes Zoster
Porcine sperm surface beta1,4galactosyltransferase binds to the zona pellucida but is not necessary or sufficient to mediate sperm-zona pellucida binding.
Herpes Zoster
Receptor function of mouse sperm surface galactosyltransferase during fertilization.
Herpes Zoster
Sperm from a variety of mammalian species express beta1,4-galactosyltransferase on their surface.
Herpes Zoster
Sperm from beta1,4-galactosyltransferase I-null mice exhibit precocious capacitation.
Herpes Zoster
Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida.
Herpes Zoster
Sperm-egg binding requires a multiplicity of receptor-ligand interactions: new insights into the nature of gamete receptors derived from reproductive tract secretions.
Herpes Zoster
Spermatozoa from a marsupial, the brushtail possum, contain beta1,4-galactosyltransferase.
Herpes Zoster
The receptor function of galactosyltransferase during mammalian fertilization.
Infections
Beta-(1 --> 4)-galactosyltransferase activity in native and engineered insect cells measured with time-resolved europium fluorescence.
Insulin Resistance
Downregulation of ?1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation.
Leukemia
B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.
Liver Diseases
Characterization of monoclonal antibodies to serum galactosyltransferase.
Lung Neoplasms
Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator.
Lung Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Lymphatic Metastasis
?-1,4-Galactosyltransferase III suppresses ?1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer.
Mastocytoma
Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase.
Melanoma
Functionally distinct laminin receptors mediate cell adhesion and spreading: the requirement for surface galactosyltransferase in cell spreading.
Melanoma
The level of cell surface beta1,4-galactosyltransferase I influences the invasive potential of murine melanoma cells.
Melanoma, Experimental
Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.
Neoplasm Metastasis
?-1,4-Galactosyltransferase III suppresses ?1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer.
Neoplasm Metastasis
Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
Neoplasm Metastasis
Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma.
Neoplasm Metastasis
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis.
Neoplasms
?-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via ?1-Integrin and Predicts Poor Prognosis in Neuroblastoma.
Neoplasms
?1,4-Galactosyltransferase V Modulates Breast Cancer Stem Cells through Wnt/?-catenin Signaling Pathway.
Neoplasms
B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.
Neoplasms
Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer.
Neoplasms
Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin.
Neoplasms
Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
Neoplasms
Ehrlich ascites tumor cell UDP-Gal:N-acetyl-D-glucosamine beta(1,4)-galactosyltransferase. Purification, characterization, and topography of the acceptor-binding site.
Neoplasms
Estrogen induced ?-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells.
Neoplasms
Expression of galactosyltransferase in prostatic tumors.
Neoplasms
Gene-linked shift in ganglioside distribution influences growth and vascularity in a mouse astrocytoma.
Neoplasms
Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.
Neoplasms
Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma.
Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Neoplasms
Platelet derived growth factor recruits lactosylceramide to induce cell proliferation in UDP Gal:GlcCer: beta1 --> 4Galactosyltransferase (GalT-V) mutant Chinese hamster ovary cells.
Neoplasms
The Immunological Regulation Roles of Porcine ?-1, 4 Galactosyltransferase V (B4GALT5) in PRRSV Infection.
Neoplasms
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis.
Neoplasms
Tumor necrosis factor-alpha up-regulates the expression of beta1,4-galactosyltransferase I in primary human endothelial cells by mRNA stabilization.
Neoplasms
Up-regulation of lactosylceramide synthase in MDR1 overexpressing human liver tumour cells.
Neoplasms
Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model.
Neuroblastoma
Long noncoding RNA differentiation antagonizing nonprotein coding RNA promotes the proliferation, invasion and migration of neuroblastoma cells via targeting ?-1, 4-galactosyltransferase III by sponging miR-338-3p.
Neuroblastoma
Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases.
Ovarian Neoplasms
Integrated bioinformatic analysis identifies UBE2Q1 as a potential prognostic marker for high grade serous ovarian cancer.
Pancreatic Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Pneumonia
Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.
Prostatic Hyperplasia
Expression of galactosyltransferase in prostatic tumors.
Rotavirus Infections
Detection of an unusual G8P[8] rotavirus in a Rotarix-vaccinated child with acute gastroenteritis using Nanopore MinION sequencing: A case report.
Sarcoma, Avian
D-galactosyltransferase and its endogenous substrates in chick embryo fibroblasts transformed by Rous sarcoma virus.
Spinal Cord Injuries
Altered beta-1,4-galactosyltransferase I expression during early inflammation after spinal cord contusion injury.
Stomach Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Urinary Bladder Neoplasms
Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer.
Uterine Cervical Neoplasms
B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.
Uterine Cervical Neoplasms
Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development.
Vesicular Stomatitis
Calsenilin and CALP interact with the cytoplasmic tail of UDP-Gal:GA2/GM2/GD2 beta-1,3-galactosyltransferase.
Whooping Cough
Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling.
Whooping Cough
Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFbeta signal transduction mechanisms.
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0.163
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1-methyl-1H-indol-4-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
-
pH and temperature not specified in the publication
1
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indazol-4-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
0.207
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-4-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
-
pH and temperature not specified in the publication
1
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-5-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
0.25
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-6-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
-
pH and temperature not specified in the publication
1
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
1
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(isoquinolin-4-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
1
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(pyridin-3-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
1
1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(pyridin-4-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
0.284 - 1
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-3-(1H-indol-3-yl)propanoic acid
1
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-4-methylpentanoic acid
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
1
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-6-aminohexanoic acid
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
1
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)acetic acid
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
1
5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophene-2-carbaldehyde
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
0.284
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-3-(1H-indol-3-yl)propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
1
2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-3-(1H-indol-3-yl)propanoic acid
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
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Watzele, G.; Berger, E.G.
Near identity of HeLa cell galactosyltransferase with the human placental enzyme
Nucleic Acids Res.
18
7174
1990
Homo sapiens
brenda
Amano, J.; Straehl, P.; Berger, E.G.; Kochibe, N.; Kobata, A.
Structures of mucin-type sugar chains of the galactosyltransferase purified from human milk. Occurrence of the ABO and Lewis blood group determinants
J. Biol. Chem.
266
11461-11477
1991
Homo sapiens
brenda
Mengle-Gaw, L.; McCoy-Haman, M.F.; Tiemeier, D.C.
Genomic structure and expression of human beta-1,4-galactosyltransferase
Biochem. Biophys. Res. Commun.
176
1269-1276
1991
Homo sapiens
brenda
Krezdorn, C.H.; Watzele, G.; Kleene, R.B.; Ivanov, S.X.; Berger, E.G.
Purification and characterization of recombinant human beta 1-4 galactosyltransferase expressed in Saccharomyces cerevisiae
Eur. J. Biochem.
212
113-120
1993
Homo sapiens
brenda
Berger, E.G.; Kozdrowski, I.; Weiser, M.M.; van den Eijnden, D.H.; Schiphorst, W.E.C.M.
Human serum galactosyltransferase: distinction, separation and product identification of two galactosyltransferase activities
Eur. J. Biochem.
90
213-222
1978
Homo sapiens
brenda
Rao, G.J.S.; Chyatte, D.; Nadler, H.L.
Enhancement of UDPgalactose: glycoprotein galactosyltransferase in cultured human skin fibroblasts by cationic polypeptides
Biochim. Biophys. Acta
541
435-443
1978
Homo sapiens
brenda
Bella, A.; Whitehead, J.S.; Kim, Y.S.
Human plasma uridine diphosphate galactose-glycoprotein galactosyltransfertase. Purification, properties and kinetics of the enzyme-catalysed reaction
Biochem. J.
167
621-628
1977
Homo sapiens
brenda
Nelson, J.D.; Jato-Rodriguez, J.J.; Mookerjea, S.
The occurrence and properties of soluble UDP-galactose:glycoprotein galactosyltransferase in human amniotic fluid
Can. J. Biochem.
52
42-50
1974
Homo sapiens, Rattus norvegicus
brenda
Kitchen, B.J.; Andrews, P.
Kinetic studies on the effect of uridine diphosphate galactose and manganous ions on the reaction between lactose synthetase A protein from human milk and p-hydroxymercuribenzoate
Biochem. J.
143
587-590
1974
Homo sapiens
brenda
Nakazawa, K.; Furukawa, K.; Narimatsu, H.; Kobata, A.
Kinetic study of human beta-1,4-galactosyltransferase expressed in E. coli
J. Biochem.
113
747-753
1993
Homo sapiens
brenda
Sato, T.; Furukawa, K.; Bakker, H.; Van den Eijnden, D.H.; Van Die, I.
Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal: GlcNAc beta-1,4-galactosyltransferase
Proc. Natl. Acad. Sci. USA
95
472-477
1998
Homo sapiens (O43286), Homo sapiens
brenda
Hansske, B.; Thiel, C.; Lubke, T.; Hasilik, M.; Honing, S.; Peters, V.; Heidemann, P.H.; Hoffmann, G.F.; Berger, E.G.; Von Figura, K.; Korner, C.
Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId
J. Clin. Invest.
109
725-733
2002
Homo sapiens
brenda
Herrmann, G.F.; Elling, L.; Krezdorn, C.H.; Kleene, R.; Berger, E.G.; Wandrey, C.
Use of transformed whole yeast cells expressing beta-1,4-galactosyltransferase for the synthesis of N-acetyllactosamine
Bioorg. Med. Chem. Lett.
5
673-676
1995
Bos taurus, Homo sapiens
-
brenda
Elling, L.; Zervosen, A.; Gallego, R.G.; Nieder, V.; Malissard, M.; Berger, E.G.; Vliegenthart, J.F.G.; Kamerling, J.P.
UDP-N-acetyl-alpha-D-glucosamine as acceptor substrate of beta-1,4-galactosyltransferase. Enzymatic synthesis of UDP-N-acetyllactosamine
Glycoconjugate J.
16
327-336
1999
Homo sapiens
brenda
Malissard, M.; Borsig, L.; Di Marco, S.; Gruetter, M.G.; Kragl, U.; Wandrey, C.; Berger, E.G.
Recombinant soluble beta-1,4-galactosyltransferases expressed in Saccharomyces cerevisiae. Purification, characterization and comparison with human enzyme
Eur. J. Biochem.
239
340-348
1996
Homo sapiens
brenda
Takamatsu, S.; Inoue, N.; Katsumata, T.; Nakamura, K.; Fujibayashi, Y.; Takeuchi, M.
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures
Biochemistry
44
6343-6349
2005
Homo sapiens
brenda
Ramakrishnan, B.; Boeggeman, E.; Ramasamy, V.; Qasba, P.K.
Structure and catalytic cycle of beta-1,4-galactosyltransferase
Curr. Opin. Struct. Biol.
14
593-600
2004
Bos taurus, Homo sapiens
brenda
Alavi, A.; Axford, J.S.; Pool, A.J.
Serum galactosyltransferase isoform changes in rheumatoid arthritis
J. Rheumatol.
31
1513-1520
2004
Homo sapiens
brenda
Zhang, S.; Cai, M.; Zhang, S.W.; Hu, Y.; Gu, J.X.
Involvement of beta 1,4 galactosyltransferase I and Gal beta1-4GlcNAc groups in human hepatocarcinoma cell apoptosis
Mol. Cell. Biochem.
243
81-86
2003
Homo sapiens
brenda
Boeggeman, E.; Ramakrishnan, B.; Kilgore, C.; Khidekel, N.; Hsieh-Wilson, L.C.; Simpson, J.T.; Qasba, P.K.
Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method
Bioconjug. Chem.
18
806-814
2007
Homo sapiens
brenda
Chen, W.S.; Chang, H.Y.; Li, C.P.; Liu, J.M.; Huang, T.S.
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis
Clin. Cancer Res.
11
8615-8622
2005
Homo sapiens
brenda
Rhee, S.W.; Starr, T.; Forsten-Williams, K.; Storrie, B.
The steady-state distribution of glycosyltransferases between the Golgi apparatus and the endoplasmic reticulum is approximately 90:10
Traffic
6
978-990
2005
Homo sapiens
brenda
Zhou, J.; Wei, Y.; Liu, D.; Ge, X.; Zhou, F.; Yun, X.; Jiang, J.; Gu, J.
Identification of beta 1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis
J. Biochem.
143
547-554
2008
Homo sapiens (O60909)
brenda
Choi, H.J.; Chung, T.W.; Kim, C.H.; Jeong, H.S.; Joo, M.; Youn, B.; Ha, K.T.
Estrogen induced beta-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells
Biochem. Biophys. Res. Commun.
426
620-625
2012
Homo sapiens
brenda
Chang, H.H.; Chen, C.H.; Chou, C.H.; Liao, Y.F.; Huang, M.J.; Chen, Y.H.; Wang, W.J.; Huang, J.; Hung, J.S.; Ho, W.L.; Jeng, Y.M.; Che, M.I.; Lee, H.; Lu, M.Y.; Yang, Y.L.; Jou, S.T.; Lin, D.T.; Lin, K.H.; Hsu, W.M.; Huang, M.C.
beta-1,4-Galactosyltransferase III enhances invasive phenotypes via beta1-integrin and predicts poor prognosis in neuroblastoma
Clin. Cancer Res.
19
1705-1716
2013
Homo sapiens (P15291), Homo sapiens
brenda
Chatterjee, S.B.; Hou, J.; Bandaru, V.V.R.; Pezhouh, M.K.; Syed Rifat Mannan, A.A.; Sharma, R.
Lactosylceramide synthase beta-1,4-GalT-V A novel target for the diagnosis and therapy of human colorectal cancer
Biochem. Biophys. Res. Commun.
508
380-386
2019
Homo sapiens
brenda
Jiang, J.; Kanabar, V.; Padilla, B.; Man, F.; Pitchford, S.C.; Page, C.P.; Wagner, G.K.
Uncharged nucleoside inhibitors of beta-1,4-galactosyltransferase with activity in cells
Chem. Commun. (Camb.)
52
3955-3958
2016
Homo sapiens
brenda
Cui, C.; Chen, X.; Liu, Y.; Cao, B.; Xing, Y.; Liu, C.; Yang, F.; Li, Y.; Yang, T.; Hua, L.; Tian, M.; Wei, Y.; Gong, Y.; Jiang, J.
beta1,4-Galactosyltransferase V activates Notch1 signaling in glioma stem-like cells and promotes their transdifferentiation into endothelial cells
J. Biol. Chem.
293
2219-2230
2018
Homo sapiens
brenda
Morokuma, D.; Xu, J.; Hino, M.; Mon, H.; Merzaban, J.S.; Takahashi, M.; Kusakabe, T.; Lee, J.M.
Expression and Characterization of human beta-1,4-galactosyltransferase 1 (beta4GalT1) using silkworm-baculovirus expression system
Mol. Biotechnol.
59
151-158
2017
Homo sapiens
brenda
Harrus, D.; Khoder-Agha, F.; Peltoniemi, M.; Hassinen, A.; Ruddock, L.; Kellokumpu, S.; Glumoff, T.
The dimeric structure of wild-type human glycosyltransferase B4GalT1
PLoS ONE
13
e0205571
2018
Homo sapiens
brenda