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Reference on EC 2.4.1.87 - N-acetyllactosaminide 3-alpha-galactosyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Basu, M.; Basu, S.
Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow
J. Biol. Chem.
248
1700-1706
1973
Oryctolagus cuniculus
Manually annotated by BRENDA team
Blake, D.A.; Goldstein, I.J.
An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1-3)-N-acetyllactosamine)
J. Biol. Chem.
256
5387-5393
1981
Mus musculus
Manually annotated by BRENDA team
Van den Eijnden, D.H.; Blanken, W.M.; Winterwerp, H.; Schiphorst, W.E.C.M.
Identification and characterization of an UDP-Gal: N-acetyllactosaminide alpha-1,3-D-galactosyltransferase in calf thymus
Eur. J. Biochem.
134
523-530
1983
Bos taurus
Manually annotated by BRENDA team
Elices, M.J.; Goldstein, I.J.
Glycosyltransferase activities of Ehrlich ascites tumor cells: detection, isolation, and characterization using oligosaccharide-Synsorb beads
Arch. Biochem. Biophys.
254
329-341
1987
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Blanken, W.M.; van den Eijnden, D.H.
Biosynthesis of terminal Gal alpha (1-3)Gal beta 1-4)GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha(1-3)galactosyltransferase from calf thymus
J. Biol. Chem.
260
12927-12934
1985
Bos taurus
Manually annotated by BRENDA team
Beyer, T.A.; Sadler, J.E.; Rearick, J.I.; Paulson, J.C.; Hill, R.L.
Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships
Adv. Enzymol. Relat. Areas Mol. Biol.
52
23-175
1981
Bos taurus
Manually annotated by BRENDA team
Elices, M.J.; Goldstein, I.J.
Biosynthesis of bi-, tri-, and tetraantennary oligosaccharides containing alpha-D-galactosyl residues at their nonreducing termini. Branch specificity of the Ehrlich tumor cell alpha(1,3)-galactosyltransferase
J. Biol. Chem.
264
1375-1380
1989
Mus musculus
Manually annotated by BRENDA team
Joziasse, D.H.; Shaper, N.L.; Kim, D.; van den Eijnden, D.H.; Shaper, J.H.
Murine alpha 1,3-galactosyltransferase. A single gene locus specifies four isoforms of the enzyme by alternative splicing
J. Biol. Chem.
267
5534-5541
1992
Mus musculus (P23336)
Manually annotated by BRENDA team
Joziasse, D.H.; Shaper, J.H.; van den Eijnden, D.H.; van Tunen, A.J.; Shaper, N.L.
Bovine alpha 1,3-galactosyltransferase: isolation and characterization of a cDNA clone. Identification of homologous sequences in human genomic DNA
J. Biol. Chem.
264
14290-14297
1989
Bos taurus
Manually annotated by BRENDA team
Elices, M.J.; Blake, D.A.; Goldstein, I.J.
Purification and characterization of a UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase from Ehrlich ascites tumor cells
J. Biol. Chem.
261
6064-6072
1986
Mus musculus
Manually annotated by BRENDA team
Van Halbeek, H.; Vliegenthart, J.F.G.
alpha-D-Galactosyltransferase activity in calf thymus. A high-resolution 1H-NMR study
Biochem. Biophys. Res. Commun.
110
124-131
1983
Bos taurus
Manually annotated by BRENDA team
Van den Eijnden, D.H.; Winterwerp, H.; Smeeman, P.; Schiphorst, W.E.C.M.
Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1-3 and beta 1-6 N-acetylglucosaminyltransferase activity
J. Biol. Chem.
258
3435-3437
1983
Rattus norvegicus
Manually annotated by BRENDA team
Henion, T.R.; Macher, B.A.; Anaraki, F.; Galili, U.
Defining the minimal size of catalytically active primate alpha 1,3 galactosyltransferase: structure-function studies on the recombinant truncated enzyme
Glycobiology
4
193-201
1994
Callithrix jacchus, no activity in african green monkey
Manually annotated by BRENDA team
Seppo, A.; Penttila, L.; Niemela, R.; Maaheimo, H.; Renkonen, O.; Keane, A.
Enzymic synthesis of octadecameric saccharides of multiply branched blood group I-type, carrying four distal alpha1,3-galactose or beta1,3-GlcNAc residues
Biochemistry
34
4655-4661
1995
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Meldgaard, P.; Holmes, E.H.; Bennett, E.P.; Clausen, H.; Zeuthen, J.; Wolf, H.O.T.F.
Blood group ABO-related glycosylation of urothelial cell lines: immunocytological, enzymic, and genetic characterization
Cancer Res.
54
2440-2447
1994
Homo sapiens
Manually annotated by BRENDA team
Imberty, A.; Monier, C.; Bettler, E.; Morera, S.; Freemont, P.; Sippl, M.; Flockner, H.; Ruger, W.; Breton, C.
Fold recognition study of alpha3-galactosyltransferase and molecular modeling of the nucleotide sugar-binding domain
Glycobiology
9
713-722
1999
Sus scrofa (P50127), Sus scrofa
Manually annotated by BRENDA team
Stults, C.L.M.; Macher, B.A.; Bhatti, R.; Srivastava, O.P.; Hindsgaul, O.
Characterization of the substrate specificity of alpha1,3-galactosyltransferase utilizing modified N-acetyllactosamine disaccharides
Glycobiology
9
661-668
1999
Mus musculus
Manually annotated by BRENDA team
Mercier, D.; Charreau, B.; Wierinckx, A.; Keijser, R.; Adriaensens, L.; Van den Berg, R.; Joziasse, D.H.
Regulation of alpha1,3galactosyltransferase expression in pig endothelial cells: Implications for xenotransplantation
Eur. J. Biochem.
269
1464-1473
2002
Sus scrofa (AF415202), Sus scrofa
Manually annotated by BRENDA team
Zhang, Y.; Swaminathan, G.J.; Deshpande, A.; Boix, E.; Natesh, R.; Xie, Z.; Acharya, K.R.; Brew, K.
Roles of individual enzyme-substrate interactions by alpha-1,3-galactosyltransferase in catalysis and specificity
Biochemistry
42
13512-13521
2003
Bos taurus (P14769)
Manually annotated by BRENDA team
Taylor, S.G.; McKenzie, I.F.; Sandrin, M.S.
Characterization of the rat alpha(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galalpha(1,3)Gal by two separate glycosylation pathways
Glycobiology
13
327-337
2003
Rattus norvegicus
Manually annotated by BRENDA team
Zhang, Y.; Deshpande, A.; Xie, Z.; Natesh, R.; Acharya, K.R.; Brew, K.
Roles of active site tryptophans in substrate binding and catalysis by alpha-1,3 galactosyltransferase
Glycobiology
14
1295-1302
2004
Bos taurus
Manually annotated by BRENDA team
Deriy, L.; Ogawa, H.; Gao, G.P.; Galili, U.
In vivo targeting of vaccinating tumor cells to antigen-presenting cells by a gene therapy method with adenovirus containing the alpha1,3galactosyltransferase gene
Cancer Gene Ther.
12
528-539
2005
Mus musculus
Manually annotated by BRENDA team
Hellrung, D.J.; Kisselev, S.; Link, C.J.
Co-expression of alpha(1,3)galactosyltransferase and Bacillus thuringiensis PIPLC enhances hyperacute rejection of tumor cells
Cancer Immunol. Immunother.
56
25-34
2007
Mus musculus
Manually annotated by BRENDA team
Milland, J.; Christiansen, D.; Lazarus, B.D.; Taylor, S.G.; Xing, P.X.; Sandrin, M.S.
The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene
J. Immunol.
176
2448-2454
2006
Mus musculus
Manually annotated by BRENDA team
Jamaluddin, H.; Tumbale, P.; Withers, S.G.; Acharya, K.R.; Brew, K.
Conformational changes induced by binding UDP-2F-galactose to alpha-1,3galactosyltransferase - implications for catalysis
J. Mol. Biol.
369
1270-1281
2007
Bos taurus (P14769)
Manually annotated by BRENDA team
Koike, C.; Uddin, M.; Wildman, D.E.; Gray, E.A.; Trucco, M.; Starzl, T.E.; Goodman, M.
Functionally important glycosyltransferase gain and loss during catarrhine primate emergence
Proc. Natl. Acad. Sci. USA
104
559-564
2007
Alouatta caraya (A1YGR5), Loris tardigradus (A1YGR6), Lemur catta (Q8HYB2)
Manually annotated by BRENDA team
Tumbale, P.; Jamaluddin, H.; Thiyagarajan, N.; Brew, K.; Acharya, K.R.
Structural basis of UDP-galactose binding by alpha-1,3-galactosyltransferase (alpha3GT): role of negative charge on aspartic acid 316 in structure and activity
Biochemistry
47
8711-8718
2008
Bos taurus, Bos taurus (P14769)
Manually annotated by BRENDA team
Molina, P.; Knegtel, R.M.; Macher, B.A.
Site-directed mutagenesis of glutamate 317 of bovine alpha -1,3Galactosyltransferase and its effect on enzyme activity: Implications for reaction mechanism
Biochim. Biophys. Acta
1770
1266-1273
2007
Bos taurus (P14769), Bos taurus
Manually annotated by BRENDA team
Saethre, M.; Schneider, M.K.; Lambris, J.D.; Magotti, P.; Haraldsen, G.; Seebach, J.D.; Mollnes, T.E.
Cytokine secretion depends on Galalpha (1,3)Gal expression in a pig-to-human whole blood model
J. Immunol.
180
6346-6353
2008
Sus scrofa
Manually annotated by BRENDA team
Jamaluddin, H.; Tumbale, P.; Ferns, T.A.; Thiyagarajan, N.; Brew, K.; Acharya, K.R.
Crystal structure of alpha-1,3-galactosyltransferase (alpha3GT) in a complex with p-nitrophenyl-beta-galactoside (pNPbetaGal)
Biochem. Biophys. Res. Commun.
385
601-604
2009
Bos taurus (P14769)
Manually annotated by BRENDA team
Pasek, M.; Ramakrishnan, B.; Boeggeman, E.; Manzoni, M.; Waybright, T.; Qasba, P.
Bioconjugation and detection of lactosamine moiety using l, 3-galactosyltransferase mutants that transfer C2-modified galactose with a chemical handle
Bioconjug. Chem.
20
608-618
2009
Bos taurus (P14769), Bos taurus
Manually annotated by BRENDA team
Tumbale, P.; Jamaluddin, H.; Thiyagarajan, N.; Acharya, K.R.; Brew, K.
Screening a limited structure-based library identifies UDP-GalNAc-specific mutants of alpha-1,3-galactosyltransferase
Glycobiology
18
1036-1043
2008
Bos taurus (P14769), Bos taurus
Manually annotated by BRENDA team
Shoemaker, G.; Soya, N.; Palcic, M.; Klassen, J.
Temperature-dependent cooperativity in donor-acceptor substrate binding to the human blood group glycosyltransferases
Glycobiology
18
587-592
2008
Homo sapiens
Manually annotated by BRENDA team
Han, W.; Cai, L.; Wu, B.; Li, L.; Xiao, Z.; Cheng, J.; Wang, P.G.
The wciN gene encodes an alpha-1,3-galactosyltransferase involved in the biosynthesis of the capsule repeating unit of Streptococcus pneumoniae serotype 6B
Biochemistry
51
5804-5810
2012
Streptococcus pneumoniae
Manually annotated by BRENDA team
Ohashi, T.; Fujiyama, K.; Takegawa, K.
Identification of novel alpha1,3-galactosyltransferase and elimination of alpha-galactose-containing glycans by disruption of multiple alpha-galactosyltransferase genes in Schizosaccharomyces pombe
J. Biol. Chem.
287
38866-38875
2012
Schizosaccharomyces pombe, Schizosaccharomyces pombe ARC039
Manually annotated by BRENDA team
Gomez, H.; Lluch, J.; Masgrau, L.
Substrate-assisted and nucleophilically assisted catalysis in bovine alpha1,3-galactosyltransferase. Mechanistic implications for retaining glycosyltransferases
J. Am. Chem. Soc.
135
7053-7063
2013
Bos taurus
Manually annotated by BRENDA team
Ardevol, A.; Rovira, C.
Reaction mechanisms in carbohydrate-active enzymes: glycoside hydrolases and glycosyltransferases. Insights from ab initio quantum mechanics/molecular mechanics dynamic simulations
J. Am. Chem. Soc.
137
7528-7547
2015
Micrococcus luteus, Bos taurus (P14769)
Manually annotated by BRENDA team
Galili, U.
Significance of the evolutionary alpha1,3-galactosyltransferase (GGTA1) gene inactivation in preventing extinction of apes and old world monkeys
J. Mol. Evol.
80
1-9
2014
Chlorocebus sabaeus, Erythrocebus patas, Gorilla gorilla, Macaca mulatta, Platyrrhini, Pan troglodytes, Pongo pygmaeus, Saimiri sp., Pongo abelii, Hominoidea, Metatheria, Ateles sp., Cercopithecoidea, Lemuridae, Eutheria, Homo sapiens (Q4G0N0), Callithrix jacchus (Q8SQ20)
Manually annotated by BRENDA team
Park, H.; Kim, Y.; Kim, K.; Kim, Y.; Yang, Y.; Jin, J.; Kim, Y.; Kim, B.; Shim, H.; Kim, Y.
Comparative n-linked glycan analysis of wild-type and alpha1,3-galactosyltransferase gene knock-out pig fibroblasts using mass spectrometry approaches
Mol. Cells
38
65-74
2015
Sus scrofa
Manually annotated by BRENDA team
Gao, H.; Zhao, C.; Xiang, X.; Li, Y.; Zhao, Y.; Li, Z.; Pan, D.; Dai, Y.; Hara, H.; Cooper, D.K.; Cai, Z.; Mou, L.
Production of alpha1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning
J. Reprod. Dev.
63
17-26
2017
Sus scrofa (P50127)
Manually annotated by BRENDA team
Chen, C.; Liu, B.; Xu, Y.; Utkina, N.; Zhou, D.; Danilov, L.; Torgov, V.; Veselovsky, V.; Feng, L.
Biochemical characterization of the novel alpha-1, 3-galactosyltransferase WclR from Escherichia coli O3
Carbohydr. Res.
430
36-43
2016
Escherichia coli (B5T072), Escherichia coli O3 (B5T072)
Manually annotated by BRENDA team
Hahn, A.; Drake, C.; Denmeade, S.; Zakharia, Y.; Maughan, B.; Kennedy, E.; Link, C.J.; Vahanian, N.; Hammers, H.; Agarwal, N.
A Phase I study of alpha-1,3-galactosyltransferase-expressing allogeneic renal cell carcinoma immunotherapy in patients with refractory metastatic renal cell carcinoma
Oncologist
25
121-e213
2020
Homo sapiens
Manually annotated by BRENDA team
Wang, Q.; Zhang, X.; Wang, B.; Bai, G.; Pan, D.; Yang, P.; Tao, K.; Li, X.; Dou, K.
Immortalization of porcine hepatocytes with a alpha-1,3-galactosyltransferase knockout background
Xenotransplantation
27
e12550
2020
Sus scrofa
Manually annotated by BRENDA team