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GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
-
-
?
GDP-beta-L-fucose + 2-nitrophenyl beta-D-galactopyranoside
GDP + 2-nitrophenyl alpha-L-fucosyl-(1->2)-beta-D-galactopyranoside
-
-
-
-
?
GDP-beta-L-fucose + beta-D-galactose
?
-
-
-
-
?
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine
-
i.e. N-acetyllactosamine, reaction of EC 2.4.1.344
-
-
?
GDP-beta-L-fucose + Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc-beta-O-PA8
?
-
-
-
-
?
GDP-beta-L-fucose + lactose-N-biose I
?
-
-
-
-
?
GDP-beta-L-fucose + lactosylceramide
?
-
-
-
-
?
GDP-beta-L-fucose + phenyl 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside
GDP + phenyl L-fucosyl-alpha (1->2)-D-Gal-beta-(1->3)-alpha-D-GalNAc
-
-
-
-
?
GDP-beta-L-fucose + phenyl beta-D-thiogalactopyranoside
GDP + phenyl L-fucosyl-alpha-(1->2)-beta-D-thiogalactopyranoside
-
-
-
-
?
GDP-fucose + asialofetuin
GDP + asialofetuin
-
-
-
-
?
GDP-fucose + Galbeta-O-Bn
GDP + L-Fucalpha(1-2)Galbeta-O-Bn
-
-
-
-
?
GDP-L-fucose + 6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
GDP + L-Fucalpha(1-2)6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
-
-
-
-
?
GDP-L-fucose + agalacto-asialofetuin
GDP + alpha-L-fucosyl-1,2-agalacto-asialofetuin
-
-
-
-
?
GDP-L-fucose + asialo alpha1 acid glycoprotein
GDP + alpha-L-fucosyl-1,2-asialo alpha1 acid glycoprotein
-
-
-
-
?
GDP-L-fucose + asialofetuin
GDP + alpha-L-fucosyl-1,2-asialofetuin
-
-
-
-
?
GDP-L-fucose + beta-D-galactose-beta-O-2-(2-carbomethoxyethylthio)ethyl
?
-
-
-
-
?
GDP-L-fucose + beta-D-galactosyl-R
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
GDP-L-fucose + bovine IgG diantennary glycopeptide
GDP + ?
-
-
-
-
?
GDP-L-fucose + D-fucose
GDP + alpha-L-fucosyl-1,2-D-fucose
-
-
-
-
?
GDP-L-fucose + D-galactose
GDP + alpha-L-fucosyl-1,2-D-galactose
GDP-L-fucose + di-N-acetylchitobiose
GDP + ?
-
-
-
-
?
GDP-L-fucose + fetuin
GDP + alpha-L-fucosyl-1,2-fetuin
-
-
-
-
?
GDP-L-fucose + fetuin triantennary asialoglycopeptide
GDP + ?
-
-
-
-
?
GDP-L-fucose + Galbeta(1-3)GalNAc
GDP + L-Fucalpha(1-2)Galbeta(1-3)GalNAc
-
-
-
-
?
GDP-L-fucose + Galbeta(1-3)GlcNAcbeta-O-allyl/acrylamide copolymer
GDP + ?
-
-
-
-
?
GDP-L-fucose + Galbeta(1-3)GlcNAcbeta-O-benzyl
GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta-O-benzyl
-
-
-
-
?
GDP-L-fucose + Galbeta(1-4)Glc-beta-O-2-(2-carbomethoxyethylthio)ethyl
GDP + L-Fucalpha(1-2)Galbeta(1-4)Glc-beta-O-2-(2-carbomethoxyethylthio)ethyl
-
-
-
-
?
GDP-L-fucose + Galbeta(1-4)GlcNAc-beta-O-2-(2-carbomethoxyethylthio)ethyl
GDP + L-Fucalpha(1-2)Galbeta(1-4)Glc-beta-O-2-(2-carbomethoxyethylthio)ethyl
-
-
-
-
?
GDP-L-fucose + Galbeta(1-4)GlcNAcbeta-O-benzyl
GDP + L-Fucalpha(1-2)Galbeta(1-4)GlcNAcbeta-O-benzyl
-
-
-
-
?
GDP-L-fucose + Galbeta(1-6)GalNAc
GDP + L-Fucalpha(1-2)Galbeta(1-6)GalNAc
-
-
-
-
?
GDP-L-fucose + Galbeta-O-benzyl
GDP + L-Fucalpha(1-2)Galbeta-O-benzyl
-
-
-
-
?
GDP-L-fucose + GM1 ganglioside
GDP + ?
-
-
-
-
?
GDP-L-fucose + lacto-N-biose 1
GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAc
GDP-L-fucose + lacto-N-neotetraose
GDP + lacto-N-fucopentaose IV
-
-
-
-
?
GDP-L-fucose + lacto-N-tetraose
GDP + lacto-N-fucopentaose I
-
-
-
-
?
GDP-L-fucose + lactose
GDP + fucosyllactose
GDP-L-fucose + N-acetylallolactosamine
GDP + ?
-
-
-
-
?
GDP-L-fucose + N-acetyllactosamine
GDP + alpha-L-fucosyl-1,2-N-acetyllactosamine
-
-
-
-
?
GDP-L-fucose + p-nitrophenyl beta-D-fucoside
GDP + alpha-L-fucosyl-1,2-nitrophenyl beta-D-fucoside
-
-
-
-
?
GDP-L-fucose + phenyl-beta-D-galactoside
?
-
-
-
-
?
GDP-L-fucose + phenyl-beta-D-galactoside
GDP + phenyl 2-O-(alpha-L-fucopyranosyl)-beta-D-galactopyranoside
additional information
?
-
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
-
i.e. lacto-N-biose I
-
-
?
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
-
i.e. lacto-N-biose I, reaction of EC 2.4.1.69
82% of the activity with phenyl beta-D-galactopyranoside
-
?
GDP-L-fucose + beta-D-galactosyl-R
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
-
349720, 489348, 489349, 489350, 489351, 489352, 489358, 489359, 489360, 489361, 489365 -
-
?
GDP-L-fucose + beta-D-galactosyl-R
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
the enzyme transfers fucose equally well to Galbeta(1-3)GlcNAc type and Galbeta(1-4)GlcNAc type substrates. Galbeta1-3GalNAc structures are less efficient acceptors
-
-
?
GDP-L-fucose + beta-D-galactosyl-R
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
acceptor specificity, overview. C6-sulfation of terminal Gal in the LacNAc unit increases acceptor efficiency, C-6 sialylation abolishes acceptor ability, C6-sulfation of GlcNAc in LacNAc type 2 decreases by 80% the acceptor ability, whereas LacNAc type 1 is unaffected, the C-4 hydroxyl rather than the C-6 hydroxyl group of the GlcNAc moiety in LacNAc type 1 is essential for activity, the acrylamide copolymer of Galbeta(1-3)GlcNAcbeta-O-Al is the best acceptor among the acrylamide copolymers, Lewis x does not serve as an acceptor
-
-
?
GDP-L-fucose + beta-D-galactosyl-R
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
detailed characterization of specificity
-
-
?
GDP-L-fucose + beta-D-galactosyl-R
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
the acid form of the enzyme is probably involved in glycoprotein synthesis in vivo
-
-
?
GDP-L-fucose + beta-D-galactosyl-R
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
fucosyltransferase 1 may contribute to pathological prostatic growth
-
-
?
GDP-L-fucose + beta-D-galactosyl-R
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
enzyme is involved in expression of blood group H, Lewis b from Lewis a and Globo H
-
-
?
GDP-L-fucose + D-galactose
GDP + alpha-L-fucosyl-1,2-D-galactose
-
-
-
-
?
GDP-L-fucose + D-galactose
GDP + alpha-L-fucosyl-1,2-D-galactose
-
-
-
?
GDP-L-fucose + D-galactose
GDP + alpha-L-fucosyl-1,2-D-galactose
-
-
-
-
?
GDP-L-fucose + lacto-N-biose 1
GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAc
-
-
-
-
?
GDP-L-fucose + lacto-N-biose 1
GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAc
-
i.e. Gal(1-3)GlcNAc
-
-
?
GDP-L-fucose + lactose
GDP + fucosyllactose
-
-
-
?
GDP-L-fucose + lactose
GDP + fucosyllactose
-
-
-
-
?
GDP-L-fucose + lactose
GDP + fucosyllactose
-
-
2'-fucosyllactose
?
GDP-L-fucose + phenyl-beta-D-galactoside
GDP + phenyl 2-O-(alpha-L-fucopyranosyl)-beta-D-galactopyranoside
-
-
-
-
?
GDP-L-fucose + phenyl-beta-D-galactoside
GDP + phenyl 2-O-(alpha-L-fucopyranosyl)-beta-D-galactopyranoside
-
-
-
?
GDP-L-fucose + phenyl-beta-D-galactoside
GDP + phenyl 2-O-(alpha-L-fucopyranosyl)-beta-D-galactopyranoside
-
-
-
-
?
additional information
?
-
transfection of the mouse Fut1 and Fut2, and human FUT1 genes into human ovarian carcinoma-derived RMG-1 cells results in 2030fold increases in cellular alpha1,2-fucosyltransferase activity, and in alteration of the glycolipid composition, including not only fucosylated products, but also precursor glycolipids
-
-
?
additional information
?
-
-
transfection of the mouse Fut1 and Fut2, and human FUT1 genes into human ovarian carcinoma-derived RMG-1 cells results in 2030fold increases in cellular alpha1,2-fucosyltransferase activity, and in alteration of the glycolipid composition, including not only fucosylated products, but also precursor glycolipids
-
-
?
additional information
?
-
-
secretor-type alpha1-2 fucosyltransferase shows significant lower affinity than the H-gene encoded enzyme for phenyl-beta-D-galactopyranoside and GDP-L-fucose as well as for type 1 oligosaccharide acceptors, Galbeta1-4GlcNAc. Type 1 acceptors, Galbeta1-3GlcNAc, and type 3 acceptors, Galbeta1-3GalNAc, are preferentially used by the secretor-type enzyme as compared with the H enzyme
-
-
?
additional information
?
-
-
enzyme favors certain glycoproteins containing polylactosamine units
-
-
?
additional information
?
-
-
alpha-galactosidase and alpha-1,2-fucosyltransferase can inhibit the expression of Gal-alpha-1,3-Gal synergistically, leading to stronger resistance of xenograft against cytolysis mediated by natural antibodies and complements
-
-
?
additional information
?
-
-
FUT1 is able to efficiently alpha(1,2)-fucosylate the O-linked glycans of PSGL-1 but not the sLex structures that bind too the P-selectin
-
-
?
additional information
?
-
-
the enzyme reduces terminal alpha(2,3)-sialylation in transfected cells and transgenic animals
-
-
?
additional information
?
-
-
FUT2 directs alpha2-fucosylation on type 1 chains on both N- and O-linked glycan structures
-
-
?
additional information
?
-
-
FUT2 regulates the expression of a carbohydrate on the gastrointestinal epitheliumstrong association is observed between the nonsense mutation 428G--A in the FUT2 gene and a slow disease progression of HIV-1 infection
-
-
?
additional information
?
-
-
FutC substrates are generated by both FutA and FutB, and their heptad repeat number correlates to Lewis y O-antigen polymer sizes
-
-
?
additional information
?
-
-
human secretor FUT2 gene, which codes for an alph(1,2)-fucosyltransferase synthesizing the H-type 1 antigen in saliva and mucosa, is associated with susceptibility to norovirus infections. the FUT2 nonsecretor (se428se428) genotype is associated with resistance to nosocomial and sporadic outbreaks with norovirus
-
-
?
additional information
?
-
-
enzyme accepts both precursors of type 1 and type 2 H epitopes, catalyzing reactions of EC 2.4.1.69 and EC 2.4.1.344. The enzyme does not display alpha-(1,3)-fucosyltransferase activity or alpha-(1, 4)-fucosyl transferase activity
-
-
?
additional information
?
-
-
the enzyme transfers fucose equally well to type I (Galbeta-(1->3)-GIcNAc) and type 2 (Galbeta-(1->4)-GIcNAc) substrates, reaction of EC 2.4.1.344, but type 3 (Galbeta-(1->3)-GalNAc) structures are less efficient acceptors
-
-
?
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Adenocarcinoma
?2,3-sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues.
Adenocarcinoma
Elevated expression of H type GDP-L-fucose:beta-D-galactoside alpha-2-L-fucosyltransferase is associated with human colon adenocarcinoma progression.
Adenocarcinoma
Enzyme activities in human breast tumor cells and sera.
Adenocarcinoma of Lung
Clinical significance and biological function of fucosyltransferase 2 in lung adenocarcinoma.
Adenoma
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Adenoma
Elevated expression of H type GDP-L-fucose:beta-D-galactoside alpha-2-L-fucosyltransferase is associated with human colon adenocarcinoma progression.
Arthritis, Rheumatoid
Fucosyltransferase 1 mediates angiogenesis in rheumatoid arthritis.
Arthritis, Rheumatoid
Fucosyltransferase 1 mediates angiogenesis, cell adhesion and rheumatoid arthritis synovial tissue fibroblast proliferation.
Arthritis, Rheumatoid
Production of soluble human alpha3-fucosyltransferase (FucT VII) by membrane targeting and in vivo proteolysis.
Breast Neoplasms
Alterations in serum glycosyltransferases and 5'-nucleotidase in breast cancer patients.
Breast Neoplasms
Analysis of breast cancer-associated glycosphingolipids using electrospray ionization-linear ion trap quadrupole mass spectrometry.
Breast Neoplasms
Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells.
Breast Neoplasms
Immunohistochemical expression of blood group substances and related carbohydrate antigens in breast carcinoma.
Breast Neoplasms
Increased fucosylation has a pivotal role in multidrug resistance of breast cancer cells through miR-224-3p targeting FUT4.
Breast Neoplasms
MicroRNA-106b targets FUT6 to promote cell migration, invasion, and proliferation in human breast cancer.
Breast Neoplasms
[Study on relationship of fucosyltransferase gene types in breast cancer with metastasis and prognosis]
Caliciviridae Infections
A homozygous nonsense mutation (428G-->A) in the human secretor (FUT2) gene provides resistance to symptomatic norovirus (GGII) infections.
Caliciviridae Infections
Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection.
Caliciviridae Infections
Mendelian resistance to human norovirus infections.
Caliciviridae Infections
Norwalk virus RNA is infectious in Mammalian cells.
Caliciviridae Infections
Susceptibility to winter vomiting disease: a sweet matter.
Carcinogenesis
Elevation of alpha2-->6 sialyltransferase and alpha1-->2 fucosyltransferase activities in human choriocarcinoma.
Carcinogenesis
Potential tumor markers for human gastric cancer: an elevation of glycan:sulfotransferases and a concomitant loss of alpha1,2-fucosyltransferase activities.
Carcinoma
alpha1,2Fucosyltransferase increases resistance to apoptosis of rat colon carcinoma cells.
Carcinoma
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Carcinoma
Altered mRNA expression of glycosyltransferases in human gastric carcinomas.
Carcinoma
Beta-1,3-galactosyltransferase and alpha-1,2-fucosyltransferase involved in the biosynthesis of type-1-chain carbohydrate antigens in human colon adenocarcinoma cell lines.
Carcinoma
Biosynthesis in vitro of SA-Lex and SA-diLex by alpha 1-3 fucosyltransferases from colon carcinoma cells and embryonic brain tissues.
Carcinoma
Biosynthesis of the sialyl-Lex determinant carried by type 2 chain glycosphingolipids (IV3NeuAcIII3FucnLc4, VI3NeuAcV3FucnLc6, and VI3NeuAcIII3V3Fuc2nLc6) in human lung carcinoma PC9 cells.
Carcinoma
Biosynthetic pathways for the Leb and Y glycolipids in the gastric carcinoma cell line KATO III as analyzed by a novel assay.
Carcinoma
C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells.
Carcinoma
Correlation between glycoconjugate expression and fucosyltransferase activity in human colorectal carcinoma.
Carcinoma
Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells due to increased expression of integrin alpha5beta1 with the Lewis Y-structure on transfection of the alpha1,2-fucosyltransferase gene.
Carcinoma
Fucosyltransferase activity in metastasizing and nonmetastasizing rat mammary carcinomas.
Carcinoma
Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue.
Carcinoma
Increase of rat colon carcinoma cells tumorigenicity by alpha(1-2) fucosyltransferase gene transfection.
Carcinoma
Increased tumorigenicity of rat colon carcinoma cells after alpha1,2-fucosyltransferase FTA anti-sense cDNA transfection.
Carcinoma
Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity.
Carcinoma
Role for alpha1,2-fucosyltransferase and histo-blood group antigen H type 2 in resistance of rat colon carcinoma cells to 5-fluorouracil.
Carcinoma
Serum fucosylation changes in oral cancer and oral precancerous conditions: alpha-L-fucosidase as a marker.
Carcinoma
Simultaneous determination of six tumor markers in patients with prostatic carcinoma and bladder tumors.
Carcinoma
The binding characteristics and utilization of Aleuria aurantia, Lens culinaris and few other lectins in the elucidation of fucosyltransferase activities resembling cloned FT VI and apparently unique to colon cancer cells.
Carcinoma
Upregulation of Fucosyltransferase 3, 8 and protein O-Fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs).
Carcinoma
[alpha1,2-fucosyltransferase gene transfection influences on biological behavior of ovarian carcinoma-derived RMG-I cells]
Carcinoma, Bronchogenic
Serum sialyltransferase and fucosyltransferase activities in patients with bronchial carcinoma.
Carcinoma, Embryonal
Coordinate expression of X and Y haptens during murine embryogenesis.
Carcinoma, Embryonal
Developmentally regulated expression of cell surface carbohydrates during mouse embryogenesis.
Carcinoma, Embryonal
Molecular cloning and expression of a mouse alpha-1,3 fucosyltransferase gene that shows homology with the human alpha-1,3 fucosyltransferase IV gene.
Carcinoma, Embryonal
Purification and properties of N-acetylglucosaminide alpha 1----3-fucosyltransferase from embryonal carcinoma cells.
Carcinoma, Hepatocellular
Altered plasma and tissue fucosyltransferase activities in hepatocellular carcinoma.
Carcinoma, Hepatocellular
An amino acid region at the N-terminus of rat hepatoma alpha1-->2 fucosyltransferase modulates enzyme activity and interaction with lipids: strong preference for glycosphingolipids containing terminal Galbeta1-->3GalNAc-structures.
Carcinoma, Hepatocellular
Comparative study on fucosylation of chicken liver and virus-induced hepatoma Mc-29.
Carcinoma, Hepatocellular
Distribution of glycosyltransferases among Golgi apparatus subfractions from liver and hepatomas of the rat.
Carcinoma, Hepatocellular
Downregulation of microRNA-15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2-induced Globo H expression.
Carcinoma, Hepatocellular
Enzymatic basis of sugar structures of alpha-fetoprotein in hepatoma and hepatoblastoma cell lines: correlation with activities of alpha 1-6 fucosyltransferase and N-acetylglucosaminyltransferases III and V.
Carcinoma, Hepatocellular
Enzymic synthesis of a new type of fucose-containing glycolipid with fucosyltransferase of rat ascites hepatoma cell, AH 7974F.
Carcinoma, Hepatocellular
Gene expression of alpha1-6 fucosyltransferase in human hepatoma tissues: a possible implication for increased fucosylation of alpha-fetoprotein.
Carcinoma, Hepatocellular
Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Glycosyltransferases and glycosidases in Morris hepatomas.
Carcinoma, Hepatocellular
Multiple forms of chicken liver and hepatoma Mc-29 microsomal and plasma-membrane sialyl and fucosyltransferases.
Carcinoma, Hepatocellular
Overexpression of alpha1-6 fucosyltransferase in hepatoma cells suppresses intrahepatic metastasis after splenic injection in athymic mice.
Carcinoma, Hepatocellular
Plasma fucosyltransferase activity in patients with hepatocellular carcinoma, with special reference to correlation with fucosylated species of alpha-fetoprotein.
Carcinoma, Hepatocellular
The alpha1-6-fucosyltransferase gene and its biological significance.
Carcinoma, Hepatocellular
The chemical carcinogen-induced enzyme, GDP-fucose: GM1 alpha 1----2 fucosyltransferase in rat liver and hepatoma: modulation by and association with phospholipids.
Carcinoma, Hepatocellular
The enzymatic basis for the conversion of nonfucosylated to fucosylated alpha-fetoprotein by acyclic retinoid treatment in human hepatoma cells: activation of alpha1-6 fucosyltransferase.
Carcinoma, Ovarian Epithelial
Core fucosylation of copper transporter 1 plays a crucial role in cisplatin-resistance of epithelial ovarian cancer by regulating drug uptake.
Carcinoma, Squamous Cell
Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth.
Cardiovascular Diseases
Are serum concentrations of vitamin B-12 causally related to cardiometabolic risk factors and disease? A Mendelian randomization study.
Cholangitis, Sclerosing
A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis.
Cholangitis, Sclerosing
Fucosyltransferase 2: A Genetic Risk Factor for Primary Sclerosing Cholangitis and Crohn's Disease-A Comprehensive Review.
Cholangitis, Sclerosing
Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.
Choriocarcinoma
Elevation of alpha2-->6 sialyltransferase and alpha1-->2 fucosyltransferase activities in human choriocarcinoma.
Colitis
Altered immune system glycosylation causes colitis in alpha1,2-fucosyltransferase transgenic mice.
Colitis, Ulcerative
Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China.
Colonic Neoplasms
Beta-1,3-galactosyltransferase and alpha-1,2-fucosyltransferase involved in the biosynthesis of type-1-chain carbohydrate antigens in human colon adenocarcinoma cell lines.
Colonic Neoplasms
Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1.
Colonic Neoplasms
Elevated expression of H type GDP-L-fucose:beta-D-galactoside alpha-2-L-fucosyltransferase is associated with human colon adenocarcinoma progression.
Colonic Neoplasms
Expression of H type 1 antigen of ABO histo-blood group in normal colon and aberrant expressions of H type 2 and H type 3/4 antigens in colon cancer.
Colonic Neoplasms
Increased sialyl Lewis A expression and fucosyltransferase activity with acquisition of a high metastatic capacity in a colon cancer cell line.
Colonic Neoplasms
The binding characteristics and utilization of Aleuria aurantia, Lens culinaris and few other lectins in the elucidation of fucosyltransferase activities resembling cloned FT VI and apparently unique to colon cancer cells.
Colonic Neoplasms
Transcriptional regulation of fucosyltransferase 1 gene expression in colon cancer cells.
Colonic Neoplasms
[Fucosyltransferase producing sialyl Le(a) and sialyl Le(x) carbohydrate antigen in gastrointestinal cancer]
Colorectal Neoplasms
Altered mRNA expression of specific molecular species of fucosyl- and sialyl-transferases in human colorectal cancer tissues.
Colorectal Neoplasms
Correlation between glycoconjugate expression and fucosyltransferase activity in human colorectal carcinoma.
Colorectal Neoplasms
Fucosylated TGF-? receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells.
Colorectal Neoplasms
Involvement of carbohydrate antigen sialyl Lewis(x) in colorectal cancer metastasis.
Colorectal Neoplasms
miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.
Colorectal Neoplasms
Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells.
Colorectal Neoplasms
Tumor-related expression of alpha1,2fucosylated antigens on colorectal carcinoma cells and its suppression by cell-mediated priming using sugar acceptors for alpha1,2fucosyltransferase.
Communicable Diseases
Fucosyltransferase Gene Polymorphisms and Lewisb-Negative Status Are Frequent in Swedish Newborns, With Implications for Infectious Disease Susceptibility and Personalized Medicine.
COVID-19
Genetic Polymorphisms in the Host and COVID-19 Infection.
Crohn Disease
Association of FUT2 and ABO with Crohn's disease in Koreans.
Crohn Disease
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
Crohn Disease
Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.
Cystic Fibrosis
Genetic Polymorphisms in the Host and COVID-19 Infection.
Dermatitis, Atopic
Fucosyltransferase VII-positive, skin-homing T cells in the blood and skin lesions of atopic dermatitis patients.
Diabetes Mellitus, Type 2
Are serum concentrations of vitamin B-12 causally related to cardiometabolic risk factors and disease? A Mendelian randomization study.
Digestive System Diseases
Variations in human liver fucosyltransferase activities in hepatobiliary diseases.
Endometrial Neoplasms
[Abnormal expression of carbohydrate chain and its mechanism in endometrial cancer]
Enterocolitis, Necrotizing
A Study on Fucosyltransferase 2 Gene Polymorphism and Secretion Status Related to Neonatal Necrotizing Enterocolitis.
Esophageal Squamous Cell Carcinoma
Upregulation of Fucosyltransferase 3, 8 and protein O-Fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs).
Exostoses
[Primary study on glycan structure in pathopoiesis mechanism of recurrent respiratory papillomatosis]
Fatty Liver
Intestinal ?1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice.
Fetal Growth Retardation
Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation.
Gastroenteritis
Clinical significance of the fucosyltransferase 2 (FUT2) secretor status in children hospitalized with acute gastroenteritis in Taiwan.
Gastroenteritis
Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection.
Gastrointestinal Neoplasms
[Fucosyltransferase producing sialyl Le(a) and sialyl Le(x) carbohydrate antigen in gastrointestinal cancer]
Hemochromatosis
Genetic Variants Influencing Biomarkers of Nutrition Are Not Associated with Cognitive Capability in Middle-Aged and Older Adults.
Hepatitis
The alpha1-6-fucosyltransferase gene and its biological significance.
Hepatitis B
Downregulation of microRNA-15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2-induced Globo H expression.
Hepatoblastoma
Enzymatic basis of sugar structures of alpha-fetoprotein in hepatoma and hepatoblastoma cell lines: correlation with activities of alpha 1-6 fucosyltransferase and N-acetylglucosaminyltransferases III and V.
Herpes Simplex
Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLex in virus-infected cells.
Herpes Simplex
Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genes.
Herpes Simplex
Inhibition of protein deacetylation augments herpes simplex virus type 1-activated transcription of host fucosyltransferase genes associated with virus-induced sLex expression.
Herpes Simplex
NF?B-mediated activation of the cellular FUT3, 5 and 6 gene cluster by herpes simplex virus type 1.
Hidradenitis Suppurativa
A new nonsense mutation in the POGLUT1 gene in two sisters with Dowling-Degos disease.
HIV Infections
Decrease of Lewis frequency in HIV-infected patients: possible competition of fucosylated antigens with HIV for binding to DC-SIGN.
Infections
A nonsense mutation (428G-->A) in the fucosyltransferase FUT2 gene affects the progression of HIV-1 infection.
Infections
Effects of child and maternal Histo Blood Group Antigen status on symptomatic and asymptomatic enteric infections in early childhood.
Infections
Epithelial glycosylation in gut homeostasis and inflammation.
Infections
Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.
Infections
Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection.
Infections
Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G->A) and vitamin B-12 in Europe and West Africa.
Infections
Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genes.
Infections
Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
Infections
Mendelian resistance to human norovirus infections.
Infections
New Insight into the Molecular Mechanism of the FUT2 Regulating Escherichia coli F18 Resistance in Weaned Piglets.
Infections
Norwalk virus RNA is infectious in Mammalian cells.
Infections
Sensitivity to human serum of gammaretroviruses produced from pig endothelial cells transduced with glycosyltransferase genes.
Infections
Susceptibility to winter vomiting disease: a sweet matter.
Infections
Translational Approach to Induce and Evaluate Verocytotoxic E. coli O138 Based Disease in Piglets.
Infections
Use of flow cytometry to monitor infection and recombinant human alpha-1,3/4 fucosyltransferase production in baculovirus infected Sf9 cell cultures.
Infections
Virus-induced appearance of the selectin ligand sLeX in herpes simplex virus type 1-infected T-cells: involvement of host and viral factors.
Infections
Virus-induced transcriptional activation of host FUT genes associated with neo-expression of Ley in cytomegalovirus-infected and sialyl-Lex in varicella-zoster virus-infected diploid human cells.
Inflammatory Bowel Diseases
Association of Fucosyltransferase 2 Gene Polymorphisms with Inflammatory Bowel Disease in Patients from Southeast China.
Inflammatory Bowel Diseases
Association of Fucosyltransferase 2 Gene Variant with Inflammatory Bowel Diseases: A Meta-Analysis.
Influenza, Human
Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4
Intestinal Neoplasms
[Glycosyltransferase genes for synthesis of Lewis antigens]
Leukemia
Glycosyltransferase activities in leukemic cells from patients and human leukemic cell lines.
Leukemia
Guanosine diphosphate-L-fucose plasma: N-acetylglucosaminide fucosyltransferase as in index of bone marrow hyperplasia after chemotherapy.
Leukemia
Sensitivity to human serum of gammaretroviruses produced from pig endothelial cells transduced with glycosyltransferase genes.
Leukemia
Significance of altered alpha-2-L-fucosyltransferase levels in serum of leukemic patients.
Leukemia
Variation of levels of plasma guanosine diphosphate L-fucose:beta-D-galactosyl alpha-2-L-fucosyltransferase in acute adult leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Electrofocusing patterns of fucosyltransferase activity in plasma of patients with chronic granulocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Plasma fucosyltransferase as an indicator of imminent blastic crisis.
Leukemia, Myeloid, Acute
Guanosine diphosphate-L-fucose plasma: N-acetylglucosaminide fucosyltransferase as in index of bone marrow hyperplasia after chemotherapy.
Leukemia, T-Cell
Human T-cell leukemia virus-1 encoded Tax protein transactivates alpha 1-->3 fucosyltransferase Fuc-T VII, which synthesizes sialyl Lewis X, a selectin ligand expressed on adult T-cell leukemia cells.
Leukemia-Lymphoma, Adult T-Cell
Human T-cell leukemia virus-1 encoded Tax protein transactivates alpha 1-->3 fucosyltransferase Fuc-T VII, which synthesizes sialyl Lewis X, a selectin ligand expressed on adult T-cell leukemia cells.
Leukemia-Lymphoma, Adult T-Cell
Suppression of sialyl Lewis X expression and E-selectin-mediated cell adhesion in cultured human lymphoid cells by transfection of antisense cDNA of an alpha1-->3 fucosyltransferase (Fuc-T VII).
Leukemia-Lymphoma, Adult T-Cell
Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element.
Liver Neoplasms
mRNA expression of three glycosyltransferases in human hepatoma tissues.
Lung Diseases
Serum sialyltransferase and fucosyltransferase activities in patients with bronchial carcinoma.
Lung Neoplasms
An integromic signature for lung cancer early detection.
Lung Neoplasms
Clinical significance and biological function of fucosyltransferase 2 in lung adenocarcinoma.
Lung Neoplasms
Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer.
Lung Neoplasms
Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
Lymphoma
Guanosine diphosphate-L-fucose plasma: N-acetylglucosaminide fucosyltransferase as in index of bone marrow hyperplasia after chemotherapy.
Lymphoma, Non-Hodgkin
Guanosine diphosphate-L-fucose plasma: N-acetylglucosaminide fucosyltransferase as in index of bone marrow hyperplasia after chemotherapy.
Melanoma
Enzymatic basis for a lectin-resistant phenotype: increase in a fucosyltransferase in mouse melanoma cells.
Melanoma
Reduction of metastatic properties of BL6 melanoma cells expressing terminal fucose(alpha)1-2-galactose after alpha1,2-fucosyltransferase cDNA transfection.
Melanoma
Selectin ligands on human melanoma cells.
Melanoma
The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells.
Melanoma, Experimental
Enzymic properties of an N-acetylglucosaminide 3-alpha-L-fucosyltransferase of a wheat-germ agglutinin-resistant melanoma clone.
Multiple Myeloma
Serum sialyltransferase and fucosyltransferase activities in patients with multiple myeloma.
Neoplasm Metastasis
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Neoplasm Metastasis
Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
Neoplasm Metastasis
Increased sialyl Lewis A expression and fucosyltransferase activity with acquisition of a high metastatic capacity in a colon cancer cell line.
Neoplasm Metastasis
Involvement of carbohydrate antigen sialyl Lewis(x) in colorectal cancer metastasis.
Neoplasm Metastasis
Overexpression of alpha1-6 fucosyltransferase in hepatoma cells suppresses intrahepatic metastasis after splenic injection in athymic mice.
Neoplasm Metastasis
True significance of N-acetylglucosaminyltransferases GnT-III, V and ?1,6 fucosyltransferase in epithelial-mesenchymal transition and cancer.
Neoplasm Metastasis
[Study on relationship of fucosyltransferase gene types in breast cancer with metastasis and prognosis]
Neoplasms
A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis.
Neoplasms
A High-Throughput Glycosyltransferase Inhibition Assay for Identifying Molecules Targeting Fucosylation in Cancer Cell-Surface Modification.
Neoplasms
alpha(1,3)Fucosyltransferase expression in E-selectin-mediated binding of gastrointestinal tumor cells.
Neoplasms
Alteration of liver glycopatterns during cirrhosis and tumor progression induced by HBV.
Neoplasms
Alterations in glycosyltransferase activity in human colon cancer.
Neoplasms
Alterations in serum glycosyltransferases and 5'-nucleotidase in breast cancer patients.
Neoplasms
Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.
Neoplasms
Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells.
Neoplasms
Carcinoma-related alterations of glycosyltransferases in human tissues.
Neoplasms
Cell surface fucosylation does not affect development of colon tumors in mice with germline Smad3 mutation.
Neoplasms
Comprehensive N-glycan profiles of hepatocellular carcinoma reveal association of fucosylation with tumor progression and regulation of FUT8 by microRNAs.
Neoplasms
Decrease of human serum fucosyltransferase as an indicator of successful tumor therapy.
Neoplasms
Development of fluorescent probes for the detection of fucosylated N-glycans using an Aspergillus oryzae lectin.
Neoplasms
Elevated expression of H type GDP-L-fucose:beta-D-galactoside alpha-2-L-fucosyltransferase is associated with human colon adenocarcinoma progression.
Neoplasms
Enzyme activities in human breast tumor cells and sera.
Neoplasms
Evaluation of serum fucosyltransferases in malignancy.
Neoplasms
Evaluation of two plasma fucosyltransferases as marker enzymes in non-Hodgkin's lymphoma.
Neoplasms
Expression of alpha1-6 fucosyltransferase in rat tissues and human cancer cell lines.
Neoplasms
Expression of L-selectin ligands by transformed endothelial cells enhances T cell-mediated rejection.
Neoplasms
Fentanyl Promotes Breast Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Upregulating ?1, 6-Fucosylation via Wnt/?-Catenin Signaling Pathway.
Neoplasms
Fucosylated TGF-? receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells.
Neoplasms
Fucosyltransferase 2 induced epithelial-mesenchymal transition via TGF-?/Smad signaling pathway in lung adenocarcinaoma.
Neoplasms
Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines.
Neoplasms
Fucosyltransferase activity in metastasizing and nonmetastasizing rat mammary carcinomas.
Neoplasms
Fucosyltransferase of the peritoneum contributed to the adhesion of cancer cells to the mesothelium.
Neoplasms
FUT family mediates the multidrug resistance of human hepatocellular carcinoma via the PI3K/Akt signaling pathway.
Neoplasms
Genome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity.
Neoplasms
Glycosyltransferase levels in tumors metastatic to liver and in uninvolved liver tissue.
Neoplasms
Human serum fucosyltransferase and tumor therapy.
Neoplasms
Immunohistochemical expression of blood group substances and related carbohydrate antigens in breast carcinoma.
Neoplasms
Knockdown of fucosyltransferase III disrupts the adhesion of circulating cancer cells to E-selectin without affecting hematopoietic cell adhesion.
Neoplasms
miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.
Neoplasms
Monoclonal antibody (G10) to a common antigen of human squamous cell carcinoma: binding of the antibody to the H type 2 blood group determinant.
Neoplasms
Overexpression of ?2,3sialyl T-antigen in breast cancer determined by miniaturized glycosyltransferase assays and confirmed using tissue microarray immunohistochemical analysis.
Neoplasms
Peritoneal colonization by human pancreatic cancer cells is inhibited by antisense FUT3 sequence.
Neoplasms
Potential tumor markers for human gastric cancer: an elevation of glycan:sulfotransferases and a concomitant loss of alpha1,2-fucosyltransferase activities.
Neoplasms
Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity.
Neoplasms
Screening of enzymatic synthesis and expression of Lewis determinants in human colorectal carcinoma.
Neoplasms
Serum levels of glycosyltransferases and related glycoproteins as indicators of cancer: biological and clinical implications.
Neoplasms
Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).
Neoplasms
The binding characteristics and utilization of Aleuria aurantia, Lens culinaris and few other lectins in the elucidation of fucosyltransferase activities resembling cloned FT VI and apparently unique to colon cancer cells.
Neoplasms
The use of con A Sepharose as an affinity adsorbent in a simple assay of serum sialyl and fucosyltransferase and its application in tumour diagnosis.
Neoplasms
Transgene expression of alpha(1,2)-fucosyltransferase-I (FUT1) in tumor cells selectively inhibits sialyl-Lewis x expression and binding to E-selectin without affecting synthesis of sialyl-Lewis a or binding to P-selectin.
Neoplasms
True significance of N-acetylglucosaminyltransferases GnT-III, V and ?1,6 fucosyltransferase in epithelial-mesenchymal transition and cancer.
Neoplasms
Tumor-related expression of alpha1,2fucosylated antigens on colorectal carcinoma cells and its suppression by cell-mediated priming using sugar acceptors for alpha1,2fucosyltransferase.
Neoplasms
[Elevation of serum fucosyltransferase activities in malignant diseases--a sensitive tumor marker?]
Neuroblastoma
Dorsal root ganglia neuron-specific promoter activity of the rabbit beta-galactoside alpha1,2-fucosyltransferase gene.
Obesity
Intestinal ?1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice.
Ovarian Neoplasms
miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11.
Ovarian Neoplasms
[Impact of alpha1,2-Fucosyl Transferase Gene Transfection on Cancer-related Gene Expression Profile of Human Ovarian Cancer Cell Line RMG-1.]
Ovarian Neoplasms
[Inhibitory effect of anti-Lewis y antibody on alpha1,2-fucosyltransferase gene transfected human ovarian cancer cells in vitro.]
Pancreatic Neoplasms
Restoration of alpha(1,2) fucosyltransferase activity decreases adhesive and metastatic properties of human pancreatic cancer cells.
Pancreatitis, Chronic
ABO blood type B and fucosyltransferase 2 non-secretor status as genetic risk factors for chronic pancreatitis.
Pancreatitis, Chronic
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
Pancreatitis, Chronic
Genetic susceptibility factors for alcohol-induced chronic pancreatitis.
Prostatic Neoplasms
Lack of selectin-dependent adhesion in prostate cancer cells expressing sialyl Le(x).
Prostatic Neoplasms
Overexpression of ? (1,6) fucosyltransferase associated with aggressive prostate cancer.
Prostatic Neoplasms
Overexpression of ? (1,6) fucosyltransferase in the development of castration-resistant prostate cancer cells.
Pulmonary Emphysema
Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling.
Pulmonary Fibrosis
Regulation of the IGF1 signaling pathway is involved in idiopathic pulmonary fibrosis induced by alveolar epithelial cell senescence and core fucosylation.
Small Cell Lung Carcinoma
Biosynthesis of the sialyl-Lex determinant carried by type 2 chain glycosphingolipids (IV3NeuAcIII3FucnLc4, VI3NeuAcV3FucnLc6, and VI3NeuAcIII3V3Fuc2nLc6) in human lung carcinoma PC9 cells.
Stomach Neoplasms
Gene expression of alpha1-6 fucosyltransferase in human hepatoma tissues: a possible implication for increased fucosylation of alpha-fetoprotein.
Stomach Neoplasms
Potential tumor markers for human gastric cancer: an elevation of glycan:sulfotransferases and a concomitant loss of alpha1,2-fucosyltransferase activities.
Stomach Neoplasms
Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells.
Stomach Neoplasms
Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population.
Stomach Neoplasms
[Fucosyltransferase producing sialyl Le(a) and sialyl Le(x) carbohydrate antigen in gastrointestinal cancer]
Teratocarcinoma
A fucosyltransferase in teratocarcinoma stem cells. Decreased activity accompanying differentiation to parietal endoderm cells.
Tuberculosis
Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.
type 1 galactoside alpha-(1,2)-fucosyltransferase deficiency
An Alu-mediated large deletion of the FUT2 gene in individuals with the ABO-Bombay phenotype.
Urinary Bladder Neoplasms
Major differences in glycosylation and Fucosyltransferase expression in low-grade versus high-grade bladder cancer cell lines.
Urinary Bladder Neoplasms
Simultaneous determination of six tumor markers in patients with prostatic carcinoma and bladder tumors.
Virus Diseases
Blood group type A secretors are associated with a higher risk of COVID-19 cardiovascular disease complications.
Virus Diseases
Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4
Virus Diseases
Susceptibility to winter vomiting disease: a sweet matter.
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Scudder, P.R.; Chantler, E.N.
Glycosyltransferases of the human cervical epithelium. I. Characterization of a beta-galactoside alpha-2-L-fucosyltransferase and the identification of a beta-N-acetylglucosaminide alpha-3-L-fucosyltransferase
Biochim. Biophys. Acta
660
128-135
1981
Homo sapiens
brenda
Kyprianou, P.; Betteridge, A.; Donald, A.S.R.; Watkins, W.M.
Purification of the blood group H gene associated alpha-2-L-fucosyltransferase from human plasma
Glycoconjugate J.
7
573-588
1990
Homo sapiens
brenda
Chester, M.A.; Yates, A.D.; Watkins, W.M.
Phenyl beta-D-galactosylpyranoside as an acceptor substrate for the blood-group H gene-associated guanosine diphosphate L-fucose:beta-D-galactosyl alpha-2-L-fucosyltransferase
Eur. J. Biochem.
69
583-592
1976
Homo sapiens
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brenda
Sarnesto, A.; Koehlin, T.; Thurin, J.; Blaszczyk-Thurin, M.
Purification of Hgene-encoded beta-galactoside alpha 1->2 fucosyltransferase from human serum
J. Biol. Chem.
265
15067-15075
1990
Homo sapiens
brenda
Sarnesto, A.; Koehlin, T.; Hindsgaul, O.; Thurin, J.; Blaszczyk-Thurin, M.
Purification of the secretor-type beta-galactoside alpha 1->2-fucosyltransferase from human serum
J. Biol. Chem.
267
2737-2744
1992
Homo sapiens
brenda
Pacuszka, T.; Koscielak, J.
alpha 1->2 Fucosyltransferase of human bone marrow
FEBS Lett.
41
348-351
1974
Homo sapiens
brenda
Chou, T.H.; Murphy, C.; Kessel, D.
Selective inhibition of a plasma fucosyltransferase by N-ethylmaleimide
Biochem. Biophys. Res. Commun.
74
1001-1006
1977
Homo sapiens
brenda
Prieto, P.A.; Larsen, R.D.; Cho, M.; Rivera, H.N.; Shilatifard, A.; Lowe, J.B.; Cummings, R.D.; Smith, D.F.
Expression of human H-type alpha1,2-fucosyltransferase encoding for blood group H(O) antigen in Chinese hamster ovary cells. Evidence for preferential fucosylation and truncation of polylactosamine sequences
J. Biol. Chem.
272
2089-2097
1997
Homo sapiens
brenda
Domino, S.E.; Hiraiwa, N.; Lowe, J.B.
Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha-(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells
Biochem. J.
327
105-115
1997
Homo sapiens, Mus musculus
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brenda
Masutani, H.; Kimura, H.
Purification and characterization of secretory-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase from human gastric mucosa
J. Biochem.
118
541-545
1995
Homo sapiens
brenda
Marker, P.C.; Stephan, J.P.; Lee, J.; Bald, L.; Mather, J.P.; Cunha, G.R.
Fucosyltransferase1 and H-type complex carbohydrates modulate epithelial cell proliferation during prostatic branching morphogenesis
Dev. Biol.
233
95-108
2001
Homo sapiens, Rattus norvegicus
brenda
Chandrasekaran, E.V.; Chawda, R.; Locke, R.D.; Piskorz, C.F.; Matta, K.L.
Biosynthesis of the carbohydrate antigenic determinants, Globo H, blood group H, and Lewis b: a role for prostate cancer cell alpha1,2-L-fucosyltransferase
Glycobiology
12
153-162
2002
Homo sapiens
brenda
Koda, Y.; Soejima, M.; Kimura, H.
Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUT1) during differentiation of the human erythroid lineage
Eur. J. Biochem.
256
379-387
1998
Homo sapiens
brenda
Chandrasekaran, E.V.; Jain, R.K.; Larsen, R.D.; Wlasichuk, K.; Matta, K.L.
Characterization of the specificities of human blood group H gene-specified alpha1,2-L-fucosyltransferase toward sulfated/sialylated/fucosylated acceptors: evidence for an inverse relationship between alpha1,2-L-fucosylation of Gal and alpha1,6-L-fucosylation of asparagine-linked GlcNAc
Biochemistry
35
8914-8924
1996
Homo sapiens
brenda
Yan, J.L.; Yu, L.Y.; Guo, L.H.
Human alpha galactosidase and alpha 1,2 fucosyltransferase concordantly inhibit xenoreactivity of NIH 3T3 cells with human serum
Acta Pharmacol. Sin.
24
878-884
2003
Homo sapiens
brenda
Mathieu, S.; Prorok, M.; Benoliel, A.M.; Uch, R.; Langlet, C.; Bongrand, P.; Gerolami, R.; El-Battari, A.
Transgene expression of alpha(1,2)-fucosyltransferase-I (FUT1) in tumor cells selectively inhibits sialyl-lewis x expression and binding to E-selectin without affecting synthesis of sialyl-Lewis a or binding to P-selectin
Am. J. Pathol.
164
371-383
2004
Homo sapiens
brenda
Serpa, J.; Mendes, N.; Reis, C.A.; Santos Silva, L.F.; Almeida, R.; Le Pendu, J.; David, L.
Two new FUT2 (fucosyltransferase 2 gene) missense polymorphisms, 739G-->A and 839T-->C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal
Biochem. J.
383
469-474
2004
Homo sapiens
brenda
Iwamori, M.; Tanaka, K.; Kubushiro, K.; Lin, B.; Kiguchi, K.; Ishiwata, I.; Tsukazaki, K.; Nozawa, S.
Alterations in the glycolipid composition and cellular properties of ovarian carcinoma-derived RMG-1 cells on transfection of the alpha1,2-fucosyltransferase gene
Cancer Sci.
96
26-30
2005
Homo sapiens (P19526), Homo sapiens, Mus musculus (P97327), Mus musculus (Q9JL27), Mus musculus
brenda
Sepp, A.; Skacel, P.; Lindstedt, T.; Lechler, R.I.
Expression of alpha(1,3)galactose and other type 2 oligosaccharide structures in a porcine endothelial cell line transfected with human alpha(1,2)-fucosyltransferase cDNA
J. Biol. Chem.
272
23104-23110
1997
Homo sapiens
brenda
Kindberg, E.; Hejdeman, B.; Bratt, G.; Wahren, B.; Lindblom, B.; Hinkula, J.; Svensson, L.
A nonsense mutation (428G-->A) in the fucosyltransferase FUT2 gene affects the progression of HIV-1 infection
AIDS
20
685-689
2006
Homo sapiens
brenda
Park, K.U.; Song, J.; Han, K.S.; Kim, J.Q.
The fusion allele of the FUT2 (secretor type alpha(1,2)-fucosyltransferase) gene at a high frequency and a new se385 allele in a Korean population
Ann. Hematol.
84
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2005
Homo sapiens
brenda
Holgersson, J.; Loefling, J.
Glycosyltransferases involved in type 1 chain and Lewis antigen biosynthesis exhibit glycan and core chain specificity
Glycobiology
16
584-593
2006
Homo sapiens
brenda
Chandrasekaran, E.V.; Xue, J.; Piskorz, C.; Locke, R.D.; Toth, K.; Slocum, H.K.; Matta, K.L.
Potential tumor markers for human gastric cancer: an elevation of glycan:sulfotransferases and a concomitant loss of alpha1,2-fucosyltransferase activities
J. Cancer Res. Clin. Oncol.
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2007
Homo sapiens
brenda
Thorven, M.; Grahn, A.; Hedlund, K.O.; Johansson, H.; Wahlfrid, C.; Larson, G.; Svensson, L.
A homozygous nonsense mutation (428G-->A) in the human secretor (FUT2) gene provides resistance to symptomatic norovirus (GGII) infections
J. Virol.
79
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2005
Homo sapiens
brenda
Nilsson, C.; Skoglund, A.; Moran, A.P.; Annuk, H.; Engstrand, L.; Normark, S.
An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection
Proc. Natl. Acad. Sci. USA
103
2863-2868
2006
Homo sapiens
brenda
Meng, D.; Newburg, D.S.; Young, C.; Baker, A.; Tonkonogy, S.L.; Sartor, R.B.; Walker, W.A.; Nanthakumar, N.N.
Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling
Am. J. Physiol. Gastrointest. Liver Physiol.
293
G780-G787
2007
Homo sapiens
brenda
Soejima, M.; Koda, Y.
Distinct single nucleotide polymorphism pattern at the FUT2 promoter among human populations
Ann. Hematol.
87
19-25
2008
Homo sapiens
brenda
Mathieu, S.; Gerolami, R.; Luis, J.; Carmona, S.; Kol, O.; Crescence, L.; Garcia, S.; Borentain, P.; El-Battari, A.
Introducing alpha(1,2)-linked fucose into hepatocarcinoma cells inhibits vasculogenesis and tumor growth
Int. J. Cancer
121
1680-1689
2007
Homo sapiens
brenda
Moehler, T.M.; Sauer, S.; Witzel, M.; Andrulis, M.; Garcia-Vallejo, J.J.; Grobholz, R.; Willhauck-Fleckenstein, M.; Greiner, A.; Goldschmidt, H.; Schwartz-Albiez, R.
Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis
J. Cell. Physiol.
215
27-36
2008
Homo sapiens
brenda
Yip, S.P.; Lai, S.K.; Wong, M.L.
Systematic sequence analysis of the human fucosyltransferase 2 (FUT2) gene identifies novel sequence variations and alleles
Transfusion
47
1369-1380
2007
Homo sapiens (Q10981), Homo sapiens
brenda
Silva, L.M.; Carvalho, A.S.; Guillon, P.; Seixas, S.; Azevedo, M.; Almeida, R.; Ruvoen-Clouet, N.; Reis, C.A.; Le Pendu, J.; Rocha, J.; David, L.
Infection-associated FUT2 (Fucosyltransferase 2) genetic variation and impact on functionality assessed by in vivo studies
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2010
Homo sapiens
brenda
Abrantes, J.; Posada, D.; Guillon, P.; Esteves, P.J.; Le Pendu, J.
Widespread gene conversion of alpha-2-fucosyltransferase genes in mammals
J. Mol. Evol.
69
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2009
Bos taurus (A4IFH1), Bos taurus (Q28113), Bos taurus (Q9TTY3), Chlorocebus sabaeus, Chlorocebus sabaeus (O77711), Chlorocebus sabaeus (O77712), Gorilla gorilla (O77486), Gorilla gorilla (Q9TUD4), Homo sapiens (P19526), Homo sapiens (Q10981), Homo sapiens (Q5XLR8), Homo sapiens, Hylobates agilis (Q6LA46), Hylobates lar (Q9TTC7), Macaca fascicularis (Q9N266), Monodelphis domestica, Mus musculus (O09160), Mus musculus (P97353), Oryctolagus cuniculus (Q10979), Oryctolagus cuniculus (Q10983), Oryctolagus cuniculus (Q29505), Oryctolagus cuniculus, Pan troglodytes (O77485), Pan troglodytes (Q9TUD6), Pongo pygmaeus (O77487), Pongo pygmaeus (Q6LA45), Rattus norvegicus (Q10980), Rattus norvegicus (Q10984), Rattus norvegicus (Q9WUE6), Sus scrofa (Q10982), Sus scrofa (Q29043), Xenopus tropicalis
brenda
Hazra, A.; Kraft, P.; Selhub, J.; Giovannucci, E.L.; Thomas, G.; Hoover, R.N.; Chanock, S.J.; Hunter, D.J.
Common variants of FUT2 are associated with plasma vitamin B12 levels
Nat. Genet.
40
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2008
Homo sapiens (Q10981)
brenda
Carlsson, B.; Kindberg, E.; Buesa, J.; Rydell, G.E.; Lidon, M.F.; Montava, R.; Abu Mallouh, R.; Grahn, A.; Rodriguez-Diaz, J.; Bellido, J.; Arnedo, A.; Larson, G.; Svensson, L.
The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection
PLoS ONE
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e5593
2009
Homo sapiens (Q10981)
brenda
Tao, S.; He, Y.; Ying, Y.; Hong, X.; Xu, X.; Zhu, F.; Lv, H.; Yan, L.
C35T mutation could slightly decrease the activity of human alpha-(1,2)-fucosyltransferase
Transfus. Clin. Biol.
19
5-10
2012
Homo sapiens
brenda
Zeyland, J.; Wozniak, A.; Gawronska, B.; Juzwa, W.; Jura, J.; Nowak, A.; S?omski, R.; Smorag, Z.; Szalata, M.; Mazurek, U.; Lipinski, D.
Double transgenic pigs with combined expression of human alpha1,2-fucosyltransferase and alpha-galactosidase designed to avoid hyperacute xenograft rejection
Arch. Immunol. Ther. Exp.
62
411-422
2014
Homo sapiens (P19526)
brenda
Isozaki, T.; Ruth, J.H.; Amin, M.A.; Campbell, P.L.; Tsou, P.S.; Ha, C.M.; Haines, G.K.; Edhayan, G.; Koch, A.E.
Fucosyltransferase 1 mediates angiogenesis, cell adhesion and rheumatoid arthritis synovial tissue fibroblast proliferation
Arthritis Res. Ther.
16
R28
2014
Homo sapiens (P19526)
brenda
Gao, N.; Liu, J.; Liu, D.; Hao, Y.; Yan, L.; Ma, Y.; Zhuang, H.; Hu, Z.; Gao, J.; Yang, Z.; Shi, H.; Lin, B.
c-Jun transcriptionally regulates alpha 1, 2-fucosyltransferase 1 (FUT1) in ovarian cancer
Biochimie
107 Pt B
286-292
2014
Homo sapiens (P19526)
brenda
Che, Y.; Ren, X.; Xu, L.; Ding, X.; Zhang, X.; Sun, X.
Critical involvement of the alpha(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia
Oncol. Rep.
35
3025-3033
2016
Homo sapiens (P19526)
brenda
Dicioccio, R.A.; Barlow, J.J.; Matta, K.L.
Modified procedure for detection of GDP-L-fucose:galactoside 2-fucosyltransferase
Clin. Chim. Acta
108
41-48
1980
Homo sapiens
brenda
Kyprianou, P.; Betteridge, A.; Donald, A.S.; Watkins, W.M.
Purification of the blood group H gene associated alpha-2-L-fucosyltransferase from human plasma
Glycoconj. J.
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573-588
1990
Homo sapiens
brenda