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Information on EC 2.4.1.68 - glycoprotein 6-alpha-L-fucosyltransferase and Organism(s) Azorhizobium caulinodans and UniProt Accession Q43966

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase
IUBMB Comments
This enzyme catalyses a reaction similar to that of EC 2.4.1.214, glycoprotein 3-alpha-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage rather than an alpha1,3-linkage.
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This record set is specific for:
Azorhizobium caulinodans
UNIPROT: Q43966
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Word Map
  • 2.4.1.68
  • fucosylation
  • n-glycans
  • glcnac
  • antibody-dependent
  • alpha1,6-fucosylation
  • innermost
  • biantennary
  • fcgammariiia
  • alpha1,3-fucosyltransferase
  • non-fucosylated
  • emphysema-like
  • core-fucosylated
  • medicine
  • alpha1,2
  • synthesis
The taxonomic range for the selected organisms is: Azorhizobium caulinodans
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
alpha1,6-fucosyltransferase, fucosyltransferase 8, alpha1-6fuct, alpha-1,6-fucosyltransferase, alpha1,6fuct, 6fuct, alpha(1,6)ft, alpha6fuct, alpha(1,6)fucosyltransferase, nodz fucosyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
fucosyltransferase, guanosine diphosphofucose-glycoprotein
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GDP-fucose glycoprotein fucosyltransferase
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GDP-fucose-glycoprotein fucosyltransferase
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GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1-6fucosyltransferase
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GDP-L-fucose-glycoprotein fucosyltransferase
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GDPfucose glycoprotein fucosyltransferase
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glycoprotein fucosyltransferase
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guanosine diphosphofucose-glycoprotein fucosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein]
show the reaction diagram
alpha-2- and alpha-6-fucosyltransferases, from eukaryotic and prokaryotic origin, are grouped into a superfamily due to structural features and consensus peptide motifs in the catalytic domain
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase
This enzyme catalyses a reaction similar to that of EC 2.4.1.214, glycoprotein 3-alpha-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage rather than an alpha1,3-linkage.
CAS REGISTRY NUMBER
COMMENTARY hide
9033-08-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene nodZ
SwissProt
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Breton, C.; Oriol, R.; Imberty, A.
Conserved structural features in eukaryotic and prokaryotic fucosyltransferases
Glycobiology
8
87-94
1998
Azorhizobium caulinodans (Q43966), Bradyrhizobium japonicum (Q45271), Homo sapiens (Q9BYC5), Sus scrofa (P79282)
Manually annotated by BRENDA team