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UDPgalactose + GlcNAcbeta-S-p-NP
UDP + Galbeta1-4 GlcNAcbeta-S-p-NP
-
-
-
?
UDPgalactose + GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-3Manbeta1-O(CH2)8COOCH2-mNP
UDP + Galbeta1-4 GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-3Manbeta1-O(CH2)8COOCH2-mNP
-
-
-
?
UDPgalactose + glucose
lactose + UDP
enzyme has no lactose synthase activity in presence of alpha-lactalbumin
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
7% of the activity with GlcNAcbeta-S-pNP
-
-
?
UDP-alpha-D-galactose + 4-methylumbelliferyl-beta-D-xylopyranoside
?
-
-
-
?
UDP-alpha-D-galactose + asialo-agalacto-transferrin
?
-
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
UDP-alpha-D-galactose + N-acetylgalactosamine
?
-
-
-
-
?
UDP-galactose + 4-methylumbelliferyl beta-D-xylopyranoside
UDP + ?
-
-
-
-
?
UDP-galactose + 4-nitrophenyl beta-D-xylopyranoside
UDP + beta-D-galactopyranosyl-1,4-xylopyranosyl-1-O-4-nitrophenol
-
-
-
-
?
UDP-galactose + benzyl 2-(acetylamino)-2-deoxy-beta-D-glucopyranoside
UDP + benzyl 2-(acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-beta-D-glucopyranoside
pH 7.0
-
-
?
UDP-galactose + chitotriose
?
GlcNAcbeta1,4-GlcNAcbeta1,4-GlcNAc
-
-
?
UDP-galactose + Glc-NAcbeta1-3Galbeta-O-naphthalenemethanol
?
-
-
-
?
UDP-galactose + GlcNAcbeta1,2-Manalpha1,3-Manbeta-OR
?
an N-linked biantennary oligosaccharide chain, one antenna is attached to the 3-hydroxyl-(1,2-1,3-arm) group of mannose, which is beta-1,4-linked to an N-linked chitobiose, attached to the aspargine residue of a protein
-
-
?
UDP-galactose + GlcNAcbeta1,2-Manalpha1,6 (GlcNAcbeta1,2-Manalpha1,3)Man
?
-
-
-
?
UDP-galactose + GlcNAcbeta1,2-Manalpha1,6-Manbeta-OR
?
an N-linked biantennary oligosaccharide chain, one antenna is attached to the 3-hydroxyl-(1,2-1,6-arm) group of mannose, which is beta-1,4-linked to an N-linked chitobiose, attached to the aspargine residue of a protein
-
-
?
UDP-galactose + GlcNAcbeta1,4-Manalpha1,3-Manbeta-OR
?
an N-linked biantennary oligosaccharide chain, one antenna is attached to the 3-hydroxyl-(1,4-1,3-arm) group of mannose, which is beta-1,4-linked to an N-linked chitobiose, attached to the aspargine residue of a protein
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosamine
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminyl-1,4-N-acetyl-beta-D-glucosamine
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,4-N-acetyl-beta-D-glucosamine
-
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1-4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
for the binding of GlcNAc in the monosaccharide binding site of beta4Gal-T1, there is a hydrophobic N-acetyl group-binding pocket formed by residues Arg359, Phe360, and Ile363 from the ?-helix region in the closed conformation of the long loop, the sugar donor specificity of beta4Gal-T1 toward galactose is determined by the Tyr residue at position 289 in the binding pocket. The two proteins beta4Gal-T1 and alpha-lactalbukin crystallize together as a complex only in the presence of either donor substrate or acceptor Glc or GlcNAc to form lactose synthase. The specificity of the sugar donor is generally determined by a few residues in the sugar-nucleotide binding pocket. The conformational change in beta4Gal-T1 also creates the binding site for a mammary gland-specific protein, alpha-lactalbumin, which changes the acceptor specificity of the enzyme toward glucose to synthesize lactose during lactation
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
UDP-galactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDP-galactose + TTTVTP-(GlcNAcbeta1-6[Galbeta1-3]GalNAcalpha1-)TG
UDP + TTTVTP-(Galbeta-1-4GlcNAcbeta1-6[Galbeta1-3]GalNAcalpha1-)TG
pH 7.0, 0.2 mM, 2% activity in A549 cells, 14% activity in H292 cells relative to benzyl 2-(acetylamino)-2-deoxy-beta-D-glucopyranoside
-
-
?
UDP-glucose + 4-methylumbelliferyl beta-D-xylopyranoside
UDP + 4-O-beta-D-galactosyl-beta-D-glucose
-
1.5% activity with UDO-glucose compared to UDP-galactose
-
-
?
UDP-glucuronic acid + 4-methylumbelliferyl beta-D-xylopyranoside
UDP + ?
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + 4-methylumbelliferyl beta-D-xylopyranoside
?
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + 4-methylumbelliferyl beta-D-xylopyranoside
UDP + ?
-
-
-
-
?
UDP-xylose + 4-methylumbelliferyl beta-D-xylopyranoside
UDP + ?
-
-
-
-
?
UDPgalactose + agalacto-poly-N-acetyllactosamine
?
-
-
-
-
?
UDPgalactose + alpha1-acid glycoprotein
?
-
-
-
-
?
UDPgalactose + asialo agalacto alpha1 acid glycoprotein
?
-
-
-
-
?
UDPgalactose + degalactosylated fetuin
UDP + fetuin containing beta-1,4-galactose linkages
UDPgalactose + glucose
lactose + UDP
UDPgalactose + lacto-N-triaosylceramide
?
-
-
-
-
?
UDPgalactose + lacto-N-triose II
?
-
-
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
?
UDPgalactose + ovalbumin
?
-
-
-
-
?
UDPgalactose + UDPglucose
UDP + lactose
-
-
-
?
additional information
?
-
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
-
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
the enzyme effectively galactosylates the GlcNAcbeta1,6Man arm of the highly branched N-glycans that are characteristic of glioma, overview
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
the enzyme transfers galactose from UDP-galactose to N-acetylglucosamine residues of the branched N-linked oligosaccharide chains of glycoproteins
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
catalytic cycle: Mn2+ binds first before UDP-Gal, two flexible loops, a long and a short loop, change their conformation from open to closed
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
residue Y285 alone is responsible for determination of enzyme substrate specificity, overview, active site structure, overview
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
UDP-Gal-Mn2+ substrate binding structure, overview
-
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
100% activity with UDP-galactose
-
-
?
UDPgalactose + degalactosylated fetuin
UDP + fetuin containing beta-1,4-galactose linkages
-
-
-
?
UDPgalactose + degalactosylated fetuin
UDP + fetuin containing beta-1,4-galactose linkages
-
-
-
-
?
UDPgalactose + glucose
lactose + UDP
-
in presence of alpha-lactalbumin
-
?
UDPgalactose + glucose
lactose + UDP
-
in presence of alpha-lactalbumin
-
?
UDPgalactose + glucose
lactose + UDP
-
in presence of alpha-lactalbumin
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
?
UDPgalactose + N-acetylglucosamine
UDP + N-acetyllactosamine
-
-
-
-
?
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
?
-
the enzyme may be involved in the synthesis of poly-N-acetyllactosamine, lacto-N-neotetraose and probably lacto-N-neotetraosylceramide in addition to the formation of the Galbeta1-4GlcNAc group of glycoprotein sugar chains and lactose
-
-
?
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
?
-
main enzyme responsible for the transfer of galactose residues from UDPgalactose into terminal N-acetylglucosamine residues of complex-type oligosaccharides in newly synthesized glycoproteins in the Golgi apparatus. Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId, a severe neurologic disease characterized by a hydrocephalus, myopathy and blood-clotting defects
-
-
?
additional information
?
-
-
enzyme activity might be involved in apoptotic pathway in hepatocarcinoma cells
-
-
?
additional information
?
-
-
decreasing the expression of GalT V in glioma cells promotes apoptosis, inhibits the invasion and migration and the ability of tumor formation in vivo, and reduces the activation of AKT, the enzyme functions as a glioma growth activator, overview, contribution of GalT V in the activation of AKT and MAPK kinase, contribution of serum or EGF in the transcription regulation of the GalT V gene, overview
-
-
?
additional information
?
-
-
downregulation of the enzyme inhibits CDK11(p58)-mediated apoptosis induced by cycloheximide, while ectopically expressed beta1,4-GT 1 increases CDK11p58-mediated apoptosis
-
-
?
additional information
?
-
-
the cell surface enzyme promotes apoptosis by inhibiting the epidermal growth factor receptor pathway via inhibition of the autophosphorylation of epidermal growth factor receptor especially at Try 1068, mechanism, overview
-
-
?
additional information
?
-
-
tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis, relationships between tumor beta-1,4-GT-IV overexpression and clinicopathologic characteristics, overview
-
-
?
additional information
?
-
-
beta-1,4-GTs are a family of glycosyltransferases responsible for biosynthesizing N-acetyllactosamine by the transfer of a galactose from UDP-galactose to the terminal N-acetylgluosamine of acceptor sugars in glycoproteins or glycolipids with a beta-1,4-linkage
-
-
?
additional information
?
-
complex penta-antennary N-glycan structure, detailed substrate binding structure analysis of the wild-type and mutant M340H enzymes, overview
-
-
?
additional information
?
-
-
substrate specificity of wild-type and mutant Y289L enzymes, overview
-
-
?
additional information
?
-
-
beta 1,4GalT V galactosylates the beta1,6-GlcNAc branch of N-glycans at the cell surface and of secreted glycoproteins, and functions as a positive regulator in glioma development, overview. As2O3-induced gioma cell apoptosis mechanism involves beta 1,4GalT V inhibition, overview
-
-
?
additional information
?
-
-
beta-1,4-galactosylransferase participates in the synthesis of Galbeta1-4-GlcNac disaccharide unit of glycoconjugates, overview
-
-
?
additional information
?
-
-
the specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis, overview
-
-
?
additional information
?
-
-
beta4Gal-T1 participates in the synthesis of Galbeta1-4-GlcNac disaccharide unit of glycoconjugates
-
-
?
additional information
?
-
-
UDP-mannose and UDP-N-acetyl galactosamine are no substrates for soluble beta1,4-GalT7
-
-
?
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0.16 - 0.27
4-methylumbelliferyl beta-D-xylopyranoside
0.35 - 1.06
4-methylumbelliferyl-beta-D-xylopyranoside
0.85 - 1.27
4-nitrophenyl beta-D-xylopyranoside
0.17
agalacto-poly-N-acetyllactosamine
-
-
-
0.2
alpha1-Acid glycoprotein
-
-
-
0.064
asialo-agalacto-transferrin
-
recombinant enzyme
-
0.01
Glc-NAcbeta1-3Galbeta-O-naphthalenemethanol
-
0.6
GlcNAcbeta1,2-Manalpha1,3-Manbeta-OR
-
1.23
GlcNAcbeta1,2-Manalpha1,6 (GlcNAcbeta1,2-Manalpha1,3)Man
-
0.06
GlcNAcbeta1,2-Manalpha1,6-Manbeta-OR
-
0.71
GlcNAcbeta1,4-Manalpha1,3-Manbeta-OR
-
0.83
lacto-N-triaosylceramide
-
-
0.19
lacto-N-triose II
-
-
0.01
N-acetyl-beta-D-glucosamine
-
1.59
N-acetyl-beta-D-glucosaminyl-1,4-N-acetyl-beta-D-glucosamine
-
850
N-acetylgalactosamine
-
-
0.0039 - 10
N-acetylglucosamine
0.22 - 0.4
UDP-alpha-D-galactose
0.23 - 0.31
UDP-galactose
0.28
UDP-glucose
-
purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
4
UDP-glucuronic acid
-
Km above 4 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
10
UDP-N-acetyl-alpha-D-glucosamine
-
Km above 10 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.16
UDP-xylose
-
purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.019 - 0.21
UDPgalactose
additional information
additional information
-
0.16
4-methylumbelliferyl beta-D-xylopyranoside
-
purified beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.27
4-methylumbelliferyl beta-D-xylopyranoside
-
purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.35
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme H195R, at pH 7.0 and 37°C
0.35
4-methylumbelliferyl-beta-D-xylopyranoside
recombinant wild type enzyme, at pH 7.0 and 37°C
0.44
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R226A, at pH 7.0 and 37°C
0.46
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R226K, at pH 7.0 and 37°C
0.54
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R270K, at pH 7.0 and 37°C
0.55
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme H195Q, at pH 7.0 and 37°C
0.59
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme Y199F, at pH 7.0 and 37°C
0.6
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R270A, at pH 7.0 and 37°C
0.64
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme H195A, at pH 7.0 and 37°C
1.06
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme Y196F, at pH 7.0 and 37°C
0.85
4-nitrophenyl beta-D-xylopyranoside
-
purified beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
1.27
4-nitrophenyl beta-D-xylopyranoside
-
purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
1
D-glucose
-
recombinant enzyme
1.1
D-glucose
-
recombinant N-deglycosylated enzyme
0.0039
N-acetylglucosamine
-
-
2.3
N-acetylglucosamine
-
-
2.5
N-acetylglucosamine
-
recombinant enzyme
2.8
N-acetylglucosamine
-
-
3.3
N-acetylglucosamine
-
-
3.6
N-acetylglucosamine
-
recombinant enzyme
8.3
N-acetylglucosamine
-
recombinant N-deglycosylated enzyme
10
N-acetylglucosamine
-
recombinant enzyme
0.22
UDP-alpha-D-galactose
recombinant wild type enzyme, at pH 7.0 and 37°C
0.27
UDP-alpha-D-galactose
mutant enzyme R270A, at pH 7.0 and 37°C
0.29
UDP-alpha-D-galactose
mutant enzyme R226K, at pH 7.0 and 37°C
0.32
UDP-alpha-D-galactose
mutant enzyme H195R, at pH 7.0 and 37°C
0.32
UDP-alpha-D-galactose
mutant enzyme Y199F, at pH 7.0 and 37°C
0.33
UDP-alpha-D-galactose
mutant enzyme H195Q, at pH 7.0 and 37°C
0.34
UDP-alpha-D-galactose
mutant enzyme R226A, at pH 7.0 and 37°C
0.34
UDP-alpha-D-galactose
mutant enzyme Y196F, at pH 7.0 and 37°C
0.37
UDP-alpha-D-galactose
mutant enzyme R270K, at pH 7.0 and 37°C
0.4
UDP-alpha-D-galactose
mutant enzyme H195A, at pH 7.0 and 37°C
0.23
UDP-galactose
-
purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.31
UDP-galactose
-
purified beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.019
UDPgalactose
-
-
0.025
UDPgalactose
-
recombinant enzyme
0.028
UDPgalactose
-
recombinant enzyme
0.091
UDPgalactose
-
recombinant enzyme
0.143
UDPgalactose
-
recombinant N-deglycosylated enzyme
0.2
UDPgalactose
-
reaction with glucose, wild-type enzyme and N-deglycosylated recombinant enzyme
0.21
UDPgalactose
-
reaction with glucose, recombinant enzyme
additional information
additional information
-
effects of cationic polypeptides
-
additional information
additional information
-
Km-value for ovalbumin for the N-deglycosylated recombinant enzyme is 6 mg/ml, and 15 mg/ml for th recombinant enzyme
-
additional information
additional information
kinetics, implications of the oligosaccharide structures on the kinetic parameters, overview
-
additional information
additional information
-
kinetics, mutant enzyme, overview
-
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1.13
4-methylumbelliferyl beta-D-xylopyranoside
-
purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.5 - 1.93
4-methylumbelliferyl-beta-D-xylopyranoside
1.52
4-nitrophenyl beta-D-xylopyranoside
-
purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
2.47
GlcNAcbeta1,2-Manalpha1,3-Manbeta-OR
-
1.74
GlcNAcbeta1,2-Manalpha1,6 (GlcNAcbeta1,2-Manalpha1,3)Man
-
1.9
GlcNAcbeta1,2-Manalpha1,6-Manbeta-OR
-
3.35
GlcNAcbeta1,4-Manalpha1,3-Manbeta-OR
-
3.6
N-acetyl-beta-D-glucosamine
-
4.82
N-acetyl-beta-D-glucosaminyl-1,4-N-acetyl-beta-D-glucosamine
-
0.5 - 1.93
UDP-alpha-D-galactose
1.14
UDP-galactose
-
Km above 0.003 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.02
UDP-glucose
-
purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.003
UDP-glucuronic acid
-
Km above 0.003 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.003
UDP-N-acetyl-alpha-D-glucosamine
-
Km above 0.003 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.01
UDP-xylose
-
purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.5
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme Y196F, at pH 7.0 and 37°C
0.77
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R270A, at pH 7.0 and 37°C
0.82
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R270K, at pH 7.0 and 37°C
0.89
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R226A, at pH 7.0 and 37°C
1.2
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme Y199F, at pH 7.0 and 37°C
1.35
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R226K, at pH 7.0 and 37°C
1.49
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme H195R, at pH 7.0 and 37°C
1.51
4-methylumbelliferyl-beta-D-xylopyranoside
recombinant wild type enzyme, at pH 7.0 and 37°C
1.62
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme H195Q, at pH 7.0 and 37°C
1.93
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme H195A, at pH 7.0 and 37°C
3.3
chitotriose
-
0.5
UDP-alpha-D-galactose
mutant enzyme Y196F, at pH 7.0 and 37°C
0.77
UDP-alpha-D-galactose
mutant enzyme R270A, at pH 7.0 and 37°C
0.82
UDP-alpha-D-galactose
mutant enzyme R270K, at pH 7.0 and 37°C
0.89
UDP-alpha-D-galactose
mutant enzyme R226A, at pH 7.0 and 37°C
1.2
UDP-alpha-D-galactose
mutant enzyme Y199F, at pH 7.0 and 37°C
1.35
UDP-alpha-D-galactose
mutant enzyme R226K, at pH 7.0 and 37°C
1.49
UDP-alpha-D-galactose
mutant enzyme H195R, at pH 7.0 and 37°C
1.51
UDP-alpha-D-galactose
recombinant wild type enzyme, at pH 7.0 and 37°C
1.62
UDP-alpha-D-galactose
mutant enzyme H195Q, at pH 7.0 and 37°C
1.93
UDP-alpha-D-galactose
mutant enzyme H195A, at pH 7.0 and 37°C
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H195A
the mutant shows reduced activity compared to the wild type enzyme
H195Q
the mutant shows reduced activity compared to the wild type enzyme
H195R
the mutant shows reduced activity compared to the wild type enzyme
M340H
site-directed mutagenesis, substrate binding structure in comparison to the wild-type enzyme, overview
M344H
-
in the presence of Mg2+ the mutant exhibits 25% of the catalytic activity compared to the wild type enzyme in the presence of Mn2+. Although the mutant has higher Km in the presence of Mg2+ for the substrates compared to the wild type enzyme in the presence of Mn2+, the catalytic efficiency with respect to donor and acceptor has decreased by an order of about 13 and 6, respectively. The turnover number of the mutant is only reduced to 60%
R226A
the mutant shows reduced activity compared to the wild type enzyme
R226K
the mutant shows reduced activity compared to the wild type enzyme
R228K
-
the mutation enhances the glucosyltransferase activity of beta4GalNAc-T1, which is low for the wild-type enzyme, by steric alterations, overview
R228LK
-
the mutation enhances glucosyltransferase activity
R270A
the mutant shows reduced activity compared to the wild type enzyme
R270K
the mutant shows reduced activity compared to the wild type enzyme
W312C/P401C
-
site-directed mutagenesis, the mutations facilitate invitro folding of the recombinantly expressed enzyme
W312C/P401C/M340H
-
site-directed mutagenesis, substrate binding structure in comparison to the wild-type enzyme, overview
Y196F
the mutant shows reduced activity compared to the wild type enzyme
Y199F
the mutant shows reduced activity compared to the wild type enzyme
Y268G
-
site-directed mutagenesis, the mutant enzyme is less active compared to the wild-type enzyme
Y268G/Y294G
-
site-directed mutagenesis, the mutant enzyme is less active compared to the wild-type enzyme
Y285I
-
site-directed mutagenesis, the mutation converts the betaGALT1 enzyme into an equally efficient beta4GalNAc-T1, EC 2.4.1.90
Y285L
-
site-directed mutagenesis, the mutation converts the betaGALT1enzyme into an equally efficient beta4GalNAc-T1, EC 2.4.1.90
Y289I
-
the mutation makes the enzyme equally as efficient as Gal- or GalNAc-transferase
Y289L/C342T
-
site-directed mutagenesis, the mutant is able to transfer GalNAc from the sugar donor UDP-GalNAc to the acceptor, GlcNAc, with efficiency as good as that of galactose from UDP-Gal, in contrast to the wild-type enzyme, mutant substrate specificity with different donor substrate and oligosaccharides as acceptor substrates, mass spectrometry product analysis, overview, the C342T mutation does not alter enzyme activity, but increases the enzyme stability at room temperature
Y289N
-
the mutation makes the enzyme equally as efficient as Gal- or GalNAc-transferase
Y294G
-
site-directed mutagenesis, the mutant enzyme is less active compared to the wild-type enzyme
Y289L
-
mutation of the beta4GalNAc-T1 converts the enzyme to a beta-1,4-galactosyltransferase-1, beta4Gal-T1. Substituting Tyr289 for Leu removes this restriction and the Tyr289Leu mutant can now transfer GalNAc or other Gal C2-analogues from their respective UDPderivatives, not normally substrates of the enzyme, to the acceptor GlcNAc with the same efficiency with which the wild-type enzyme transfers Gal from UDP-Gal, phenotype, overview
Y289L
-
the mutation makes the enzyme equally as efficient as Gal- or GalNAc-transferase
additional information
-
autophosphorylation of epidermal growth factor receptor, EGFR, and phosphorylation of protein kinase B, PKB/Akt, and extracellular signalregulated protein kinase1/2,ERK1/2, which are downstream molecules of EGFR, are reduced in cell surface beta1,4GT1-overexpressing SMMC-7721 cells, phenotype, overview, knockdown of beta1,4GT1 by siRNA increases the autophosphorylation of EGFR at Tyr1068
additional information
-
RNAi-mediated knockdown of beta1,4-GT 1 inhibits CDK11(p58)-mediated apoptosis induced by cycloheximide, while ectopically expressed beta1,4-GT 1 increases CDK11p58-mediated apoptosis, enzyme knockout also inhibits the release of cytochrome c from mitochondria and caspase-3 processing, mechanism of beta1,4-GT 1 in CHX-induced apoptosis of CDK11p58-overexpressing cells, overview
additional information
-
beta 1,4GalT V antisense constructs interfere with beta 1,4GalT V leading to promotion of As2O3-induced glioma cell apoptosis, while overexpression of beta 1,4GalT V inhibits it, overview
additional information
-
introduction of human betaGalT into suspension cultured tobacco cells results in the production of recombinant proteins with galactose-extended glycans and decreased contents of beta(1,2)-xylose and alpha(1,3)-fucose
additional information
-
expression vectors bearing the luminal domains of beta4GalT-II and glucuronyltransferase show in GST-pulldown assays that the Golgi luminal domains are sufficient for the complex to form
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Watzele, G.; Berger, E.G.
Near identity of HeLa cell galactosyltransferase with the human placental enzyme
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Homo sapiens
brenda
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266
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Homo sapiens
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Homo sapiens
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1978
Homo sapiens
brenda
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1978
Homo sapiens
brenda
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Homo sapiens
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1974
Homo sapiens, Rattus norvegicus
brenda
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Homo sapiens
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Homo sapiens
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1998
Homo sapiens (O43286)
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2002
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Bos taurus, Homo sapiens
-
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309
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280
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Homo sapiens
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30
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Bos taurus, Homo sapiens
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327
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Homo sapiens
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18
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Homo sapiens
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11
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Homo sapiens
brenda
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281
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Homo sapiens
brenda
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48
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Homo sapiens
brenda
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Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety
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353
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Homo sapiens (P15291)
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Structural snapshots of beta-1,4-galactosyltransferase-I along the kinetic pathway
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357
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Bos taurus, Homo sapiens
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365
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Homo sapiens
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Cell surface beta 1, 4-galactosyltransferase 1 promotes apoptosis by inhibiting epidermal growth factor receptor pathway
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291
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Homo sapiens
brenda
Rhee, S.W.; Starr, T.; Forsten-Williams, K.; Storrie, B.
The steady-state distribution of glycosyltransferases between the Golgi apparatus and the endoplasmic reticulum is approximately 90:10
Traffic
6
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2005
Homo sapiens
brenda
Fujiyama, K.; Furukawa, A.; Katsura, A.; Misaki, R.; Omasa, T.; Seki, T.
Production of mouse monoclonal antibody with galactose-extended sugar chain by suspension cultured tobacco BY2 cells expressing human beta(1,4)-galactosyltransferase
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358
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2007
Homo sapiens
brenda
Chang, K.H.; Lee, J.M.; Hwang-Bo, J.; Yoo, K.H.; Sohn, B.H.; Yang, J.M.; Chung, I.S.
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Homo sapiens
brenda
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Homo sapiens
brenda
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Drosophila melanogaster, Homo sapiens
brenda
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Homo sapiens
brenda
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Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis
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304
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2007
Homo sapiens
brenda
Daligault, F.; Rahuel-Clermont, S.; Gulberti, S.; Cung, M.T.; Branlant, G.; Netter, P.; Magdalou, J.; Lattard, V.
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Homo sapiens
brenda
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Bos taurus, Homo sapiens (O60909)
brenda
Lee, P.L.; Kohler, J.J.; Pfeffer, S.R.
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Glycobiology
19
655-664
2009
Homo sapiens
brenda
Brown, J.R.; Yang, F.; Sinha, A.; Ramakrishnan, B.; Tor, Y.; Qasba, P.K.; Esko, J.D.
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Homo sapiens (P15291)
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Wei, Y.; Zhou, F.; Ge, Y.; Chen, H.; Cui, C.; Li, Q.; Liu, D.; Yang, Z.; Wu, G.; Sun, S.; Gu, J.; Jiang, J.
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396
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2010
Homo sapiens
brenda
Choi, H.J.; Chung, T.W.; Kim, C.H.; Jeong, H.S.; Joo, M.; Youn, B.; Ha, K.T.
Estrogen induced beta-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells
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426
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Homo sapiens
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Homo sapiens
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Peanne, R.; Legrand, D.; Duvet, S.; Mir, A.M.; Matthijs, G.; Rohrer, J.; Foulquier, F.
Differential effects of lobe A and lobe B of the Conserved Oligomeric Golgi complex on the stability of (beta)1,4-galactosyltransferase 1 and (alpha)2,6-sialyltransferase 1
Glycobiology
21
864-876
2011
Homo sapiens
brenda
Zhu, F.; Shen, F.; Fan, Y.; Xie, Y.; Xia, Y.; Kong, Y.
Osteopontin increases the expression of beta1, 4-galactosyltransferase-I and promotes adhesion in human RL95-2 cells
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Homo sapiens, Mus musculus
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Wang, Y.; Xu, D.; Tao, R.; Wang, H.; Wang, Q.; Shen, A.
beta1,4-Galactosyltransferase-I contributes to the inflammatory processes in synovial tissue of patients with rheumatoid arthritis
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59
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Homo sapiens
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Liu, W.; Cui, Z.; Wang, Y.; Zhu, X.; Fan, J.; Bao, G.; Qiu, J.; Xu, D.
Elevated expression of beta 1,4-galactosyltransferase-I in cartilage and synovial tissue of patients with osteoarthritis
Inflammation
35
647-655
2012
Homo sapiens
brenda
Kouno, T.; Kizuka, Y.; Nakagawa, N.; Yoshihara, T.; Asano, M.; Oka, S.
Specific enzyme complex of beta-1,4-galactosyltransferase-II and glucuronyltransferase-P facilitates biosynthesis of N-linked human natural killer-1 (HNK-1) carbohydrate
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286
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2011
Homo sapiens
brenda
Tang, W.; Weng, S.; Zhang, S.; Wu, W.; Dong, L.; Shen, X.; Zhang, S.; Gu, J.; Xue, R.
Direct interaction between surface beta1,4-galactosyltransferase 1 and epidermal growth factor receptor (EGFR) inhibits EGFR activation in hepatocellular carcinoma
Biochem. Biophys. Res. Commun.
434
449-454
2013
Homo sapiens
brenda
Jiang, J.; Kanabar, V.; Padilla, B.; Man, F.; Pitchford, S.C.; Page, C.P.; Wagner, G.K.
Uncharged nucleoside inhibitors of beta-1,4-galactosyltransferase with activity in cells
Chem. Commun. (Camb.)
52
3955-3958
2016
Homo sapiens
brenda
Tsutsui, Y.; Ramakrishnan, B.; Qasba, P.K.
Crystal structures of beta-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding
J. Biol. Chem.
288
31963-31970
2013
Homo sapiens (Q9UBV7)
brenda
Saliba, M.; Ramalanjaona, N.; Gulberti, S.; Bertin-Jung, I.; Thomas, A.; Dahbi, S.; Lopin-Bon, C.; Jacquinet, J.C.; Breton, C.; Ouzzine, M.; Fournel-Gigleux, S.
Probing the acceptor active site organization of the human recombinant beta1,4-galactosyltransferase 7 and design of xyloside-based inhibitors
J. Biol. Chem.
290
7658-7670
2015
Homo sapiens (Q9UBV7)
brenda
Hesselink, T.; Rouwendal, G.J.; Henquet, M.G.; Florack, D.E.; Helsper, J.P.; Bosch, D.
Expression of natural human beta1,4-GalT1 variants and of non-mammalian homologues in plants leads to differences in galactosylation of N-glycans
Transgenic Res.
23
717-728
2014
Danio rerio (C1KH59), Homo sapiens (P15291), Gallus gallus (Q92074)
brenda