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Information on EC 2.4.1.37 - fucosylgalactoside 3-alpha-galactosyltransferase and Organism(s) Rattus norvegicus and UniProt Accession Q8CFC4

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.37 fucosylgalactoside 3-alpha-galactosyltransferase
IUBMB Comments
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q8CFC4
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
b transferase, b glycosyltransferase, blood group b galactosyltransferase, alpha(1-3)galactosyltransferase, blood group b glycosyltransferase, histo-blood group abo system transferase, blood group b glycosyltransferase gtb, glycosyltransferases b, blood group b alpha-(1,3)-galactosyltransferase, abo(h) blood group b glycosyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
histo-blood group B enzyme
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blood-group substance B-dependent galactosyltransferase
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glycoprotein-fucosylgalactoside alpha-galactosyltransferase
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histo-blood group B transferase
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histo-blood substance B-dependent galactosyltransferase
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UDP-galactose:O-alpha-L-fucosyl(1-2)D-galactose alpha-D-galactosyltransferase
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UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase
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[blood group substance] alpha-galactosyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
CAS REGISTRY NUMBER
COMMENTARY hide
37257-33-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-D-galactose + 2'-fucosyllactose
UDP + D-galactosyl-(1-3)-2'-fucosyllactose
show the reaction diagram
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-
-
?
UDP-D-galactose + H type 3-Sp-biotin
UDP + ?
show the reaction diagram
preferred substrates
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-
?
UDP-N-acetyl-D-galactosamine + 2'-fucosyllactose
UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->4)-beta-D-glucose
show the reaction diagram
low A-type activity
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-
?
UDP-N-acetyl-D-galactosamine + H type 3-Sp-biotin
UDP + ?
show the reaction diagram
low A-type activity
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
B-type gene Abo2
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
B-type enzyme expression in the surface epithelium
Manually annotated by BRENDA team
B-type enzyme expression
Manually annotated by BRENDA team
B-type enzyme expression in the surface epithelium
Manually annotated by BRENDA team
B-type enzyme expression
Manually annotated by BRENDA team
B-type enzyme expression
Manually annotated by BRENDA team
additional information
no B-type enzyme expression in small intestine, striated muscle, heart, liver, lung, skin, uterus, testis, lymph node, or brain
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
BGAT2_RAT
334
1
39079
Swiss-Prot
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
monomorphic B-type gene Abo2, DNA and amino acid sequence determination and analysis, located on chromosome 3q11-q12, functional expression in CHO cells expressing the H precursor
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Turcot, A.L.; Blancher, A.; Le Moullac-Vaidye, B.; Despiau, S.; Rocher, J.; Roubinet, F.; Szpirer, C.; Le Pendu, J.
Cloning of a rat gene encoding the histo-blood group B enzyme: rats have more than one Abo gene
Glycobiology
13
919-928
2003
Rattus norvegicus (Q8CFC4)
Manually annotated by BRENDA team