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Information on EC 2.4.1.34 - 1,3-beta-glucan synthase and Organism(s) Schizosaccharomyces pombe and UniProt Accession O74475
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EC Tree
2.4.1.34 1,3-beta-glucan synthaseSpecify your search results
Word Map
- 2.4.1.34
- candida
-
echinocandins
- albicans
- caspofungin
-
cytokinesis
- micafungin
- amphotericin
- candidiasis
- rho1
- anidulafungin
-
powdery
-
plasmodesmata
- mildew
- pneumocandins
- microspore
- papulacandins
-
calcofluor
- symplastic
-
candidemia
-
aculeacin
-
echinocandin-resistant
- agriculture
- analysis
- medicine
The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
callose synthase, fks1p, beta-1,3-glucan synthase, 1,3-beta-glucan synthase, 1,3-beta-d-glucan synthase, beta-glucan synthase, bgs1p, (1,3)-beta-d-glucan synthase, bgs4p, glucan synthase-like, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(1,3)-beta-glucan (callose) synthase
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1,3-beta-D-glucan synthase
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1,3-beta-D-glucan synthetase
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1,3-beta-D-glucan-UDP glucosyltransferase
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1,3-beta-glucan-uridine diphosphoglucosyltransferase
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beta-1,3-glucan synthase
beta-1,3-glucan synthetase
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callose synthase
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callose synthetase
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GS-II
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paramylon synthetase
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UDP-glucose-1,3-beta-glucan glucosyltransferase
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UDP-glucose-beta-glucan glucosyltransferase
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UDP-glucose:(1,3)beta-glucan synthase
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UDPglucose-1,3-beta-D-glucan glucosyltransferase
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uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase
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beta-1,3-glucan synthase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:(1->3)-beta-D-glucan 3-beta-D-glucosyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
9037-30-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDPglucose + (1,3-beta-D-glucosyl)n
UDP + (1,3-beta-D-glucosyl)n+1
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?
additional information
?
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involved in a late process of secondary or general septum synthesis, necessary to preserve cell integrity when cell wall synthesis or repair is needed
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?
additional information
?
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involved in a late process of secondary or general septum synthesis, necessary to preserve cell integrity when cell wall synthesis or repair is needed
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?
additional information
?
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bgs2p synthesizes linear beta-1,3-glucans, which remain unorganized and alkali-soluble untilcovalent linkages are set up between beta-1,3-glucans and other cell wall components involving beta-1,3-glucanosyltransferase activity, overview, bgs2p localizes to the spore periphery and is essential for maturation of the ascospore wall
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?
additional information
?
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linear (1,3)beta-D-glucan is the polysaccharide that specifically interacts with the fluorochrome Calcofluor white in fission yeast, the (1,3)beta-D-glucan synthase subunit Bgs1p is responsible for the fission yeast primary septum formation, Bgs1p is essential for vegetative cells and needed for correct septation and cell separation
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
involved in a late process of secondary or general septum synthesis, necessary to preserve cell integrity when cell wall synthesis or repair is needed
-
-
?
additional information
?
-
-
involved in a late process of secondary or general septum synthesis, necessary to preserve cell integrity when cell wall synthesis or repair is needed
-
-
?
additional information
?
-
-
bgs2p synthesizes linear beta-1,3-glucans, which remain unorganized and alkali-soluble untilcovalent linkages are set up between beta-1,3-glucans and other cell wall components involving beta-1,3-glucanosyltransferase activity, overview, bgs2p localizes to the spore periphery and is essential for maturation of the ascospore wall
-
-
?
additional information
?
-
-
linear (1,3)beta-D-glucan is the polysaccharide that specifically interacts with the fluorochrome Calcofluor white in fission yeast, the (1,3)beta-D-glucan synthase subunit Bgs1p is responsible for the fission yeast primary septum formation, Bgs1p is essential for vegetative cells and needed for correct septation and cell separation
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-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
caspofungin
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IC50: 0.3 microgram/ml, pH 7.5, temperature not specified
enfumafungin
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IC50: 40 microgram/ml, pH 7.5, temperature not specified
papulacandin
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IC50: 0.02 microgram/ml, pH 7.5, temperature not specified
pneumocandin
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IC50: 120 microgram/ml, pH 7.5, temperature not specified
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
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bgs2p localizes to the spore periphery and is essential for maturation of the ascospore wall
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
gene deletion strain, no viable spores, bgs4+ shut-off produces cell lysis at growing poles and mainly at the septum prior to cytokinesis
additional information
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gene deletion strain, no viable spores, bgs4+ shut-off produces cell lysis at growing poles and mainly at the septum prior to cytokinesis
additional information
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in the absence of Bgs1p abnormal septa are formed, but the cells cannot separate and eventually die, mutant phenotype, overview
additional information
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null bgs2 diploid mutants form four spore-like compartments inside each ascus, in which the electron-lucent layer is thinner and darker than in the wild-type, and the spores are unviable
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liu, J.; Wang, H.; McCollum, D.; Balasubramanian, M.K.
Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe
Genetics
153
1193-1203
1999
Schizosaccharomyces pombe
Cortes, J.C.; Carnero, E.; Ishiguro, J.; Sanchez, Y.; Duran, A.; Ribas, J.C.
The novel fission yeast (1,3)beta-D-glucan synthase catalytic subunit Bgs4p is essential during both cytokinesis and polarized growth
J. Cell Sci.
118
157-174
2005
Schizosaccharomyces pombe (O74475), Schizosaccharomyces pombe
Cortes, J.C.; Konomi, M.; Martins, I.M.; Munoz, J.; Moreno, M.B.; Osumi, M.; Duran, A.; Ribas, J.C.
The (1,3)beta-D-glucan synthase subunit Bgs1p is responsible for the fission yeast primary septum formation
Mol. Microbiol.
65
201-217
2007
Schizosaccharomyces pombe
de Medina-Redondo, M.; Arnaiz-Pita, Y.; Fontaine, T.; Del Rey, F.; Latge, J.P.; Vazquez de Aldana, C.R.
The beta-1,3-glucanosyltransferase gas4p is essential for ascospore wall maturation and spore viability in Schizosaccharomyces pombe
Mol. Microbiol.
68
1283-1299
2008
Schizosaccharomyces pombe
Martins, I.M.; Cortes, J.C.; Munoz, J.; Moreno, M.B.; Ramos, M.; Clemente-Ramos, J.A.; Duran, A.; Ribas, J.C.
Differential activities of three families of specific beta(1,3)glucan synthase inhibitors in wild-type and resistant strains of fission yeast
J. Biol. Chem.
286
3484-3496
2011
Schizosaccharomyces pombe
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