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IUBMB CommentsThe enzyme isolated from the anaerobic bacterium Bacteroides thetaiotaomicron is involved in the degradation of host-derived N-glycans.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
bt1033,
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4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine:phosphate alpha-D-mannosyltransferase
The enzyme isolated from the anaerobic bacterium Bacteroides thetaiotaomicron is involved in the degradation of host-derived N-glycans.
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4-O-beta-D-mannosyl-N-acetyl-D-glucosamine + phosphate
N-acetyl-D-glucosamine + alpha-D-mannose 1-phosphate
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r
4-O-beta-N-acetyl-D-glucosaminyl-N-acetyl-D-glucosamine + alpha-D-mannose 1-phosphate
beta-N-acetyl-D-glucosaminyl-(1->4)-beta-N-acetyl-D-glucosaminyl-(1->4)-D-mannose + phosphate
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beta-N-acetyl-D-glucosaminyl-(1->4)-beta-N-acetyl-D-glucosaminyl-(1->4)-D-mannose + phosphate
4-O-beta-N-acetyl-D-glucosaminyl-N-acetyl-D-glucosamine + alpha-D-mannose 1-phosphate
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r
N-acetyl-D-glucosamine + alpha-D-mannose 1-phosphate
4-O-beta-D-mannosyl-N-acetyl-D-glucosamine + phosphate
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r
additional information
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additional information
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very low activity with D-glucose or D-mannose as acceptor and alpha-D-mannose 1-phosphate as donor
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additional information
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very low activity with D-glucose or D-mannose as acceptor and alpha-D-mannose 1-phosphate as donor
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4-O-beta-D-mannosyl-N-acetyl-D-glucosamine + phosphate
N-acetyl-D-glucosamine + alpha-D-mannose 1-phosphate
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r
N-acetyl-D-glucosamine + alpha-D-mannose 1-phosphate
4-O-beta-D-mannosyl-N-acetyl-D-glucosamine + phosphate
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r
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2.7
4-O-beta-N-acetyl-D-glucosaminyl-N-acetyl-D-glucosamine
pH 5.5, 30°C
2.6
alpha-D-mannose 1-phosphate
pH 5.5, 30°C
3.8
N-acetyl-D-glucosamine
pH 5.5, 30°C
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22
4-O-beta-N-acetyl-D-glucosaminyl-N-acetyl-D-glucosamine
pH 5.5, 30°C
25
alpha-D-mannose 1-phosphate
pH 5.5, 30°C
37
N-acetyl-D-glucosamine
pH 5.5, 30°C
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5.5
phosphorolytic reaction
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UniProt
brenda
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UniProt
brenda
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brenda
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Q8A8X4_BACTN
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
546
0
60933
TrEMBL
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35000
4 * 35000, SDS-PAGE, 4 * 37823, amino acid sequence
37823
4 * 35000, SDS-PAGE, 4 * 37823, amino acid sequence
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homotetramer
4 * 35000, SDS-PAGE, 4 * 37823, amino acid sequence
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4.5 - 10.5
4°C, 24 h stable
725534
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expressed in Escherichia coli DH5alpha
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Nihira, T.; Suzuki, E.; Kitaoka, M.; Nishimoto, M.; Ohtsubo, K.; Nakai, H.
Discovery of beta-1,4-D-mannosyl-N-acetyl-D-glucosamine phosphorylase involved in the metabolism of N-glycans
J. Biol. Chem.
288
27366-27374
2013
Bacteroides thetaiotaomicron (Q8A8X4), Bacteroides thetaiotaomicron (Q8A8Y4), Bacteroides thetaiotaomicron VPI-5482 (Q8A8X4), Bacteroides thetaiotaomicron VPI-5482 (Q8A8Y4), Bacteroides thetaiotaomicron VPI-5482
brenda