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Disease on EC 2.4.1.212 - hyaluronan synthase

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DISEASE
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Acute Lung Injury
Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Adenocarcinoma
Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.
Proteoglycans and WT1 as markers for distinguishing adenocarcinoma, epithelioid mesothelioma, and benign mesothelium.
Adrenocortical Carcinoma
Differential Expression Profiles of Cell-to-Matrix-Related Molecules in Adrenal Cortical Tumors: Diagnostic and Prognostic Implications.
Aortic Aneurysm, Abdominal
HAS-1 genetic polymorphism in sporadic abdominal aortic aneurysm.
Arthritis
Early inflammatory arthritis in the rabbit: the influence of intraarticular and systemic corticosteroids on mRNA levels in connective tissues of the knee.
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.
Arthritis, Rheumatoid
Differential stimulation of three forms of hyaluronan synthase by TGF-beta, IL-1beta, and TNF-alpha.
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.
Asthma
Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease.
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Astrocytoma
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas.
Brain Ischemia
Translational event mediates differential production of tumor necrosis factor-alpha in hyaluronan-stimulated microglia and macrophages.
Brain Neoplasms
Role of HYAL1 expression in primary breast cancer in the formation of brain metastases.
Breast Neoplasms
ABC transporters do not contribute to extracellular translocation of hyaluronan in human breast cancer in vitro.
Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.
Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance.
Excessive hyaluronan production promotes acquisition of cancer stem cell signatures through the coordinated regulation of Twist and the transforming growth factor ? (TGF-?)-Snail signaling axis.
Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGF?-induced EMT in breast cancer.
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).
Hyaluronan synthase 2 (HAS2) regulates cell phenotype and invadopodia formation in luminal-like breast cancer cells.
Hyaluronan synthase 2 is an adverse prognostic marker in androgen receptor-negative breast cancer.
Hyaluronan synthase 2 overexpression is correlated with the tumorigenesis and metastasis of human breast cancer.
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells.
In Vitro Effects of HAS-2 Gene Silencing on the Proliferation and Apoptosis of the MCF-7 Human Breast Cancer Cell Line.
Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer.
Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.
Role of HYAL1 expression in primary breast cancer in the formation of brain metastases.
Silencing of HAS2-AS1 mediates PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and invasion in glioma.
Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells.
The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer.
The Secreted Protein C10orf118 Is a New Regulator of Hyaluronan Synthesis Involved in Tumour-Stroma Cross-Talk.
Carcinogenesis
Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.
HAS3 underexpression as an indicator of poor prognosis in patients with urothelial carcinoma of the upper urinary tract and urinary bladder.
Hyaluronan synthase 2 overexpression is correlated with the tumorigenesis and metastasis of human breast cancer.
Long noncoding RNA HAS2-AS1 accelerates non-small cell lung cancer chemotherapy resistance by targeting LSD1/EphB3 pathway.
Methods for measuring Class I membrane-bound hyaluronan synthase activity.
Studies of carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts.
Carcinoma
CD44 exon variant 6 epitope and hyaluronate synthase are expressed on HT29 human colorectal carcinoma cells in a SCID mouse model of metastasis formation.
Correlation between hyaluronic acid,hyaluronic Acid synthase and human renal clear cell carcinoma.
Differential Expression Profiles of Cell-to-Matrix-Related Molecules in Adrenal Cortical Tumors: Diagnostic and Prognostic Implications.
Expression cloning and molecular characterization of HAS protein, a eukaryotic hyaluronan synthase.
Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.
Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells.
Hyaluronan content in experimental carcinoma is not correlated to interstitial fluid pressure.
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion.
Hyaluronan Synthase and Hyaluronidase Expression in Serous Ovarian Carcinoma is Related to Anatomic Site and Chemotherapy Exposure.
Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells.
Hyaluronan synthase expression in ovarian cancer.
Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival.
Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling.
MicroRNA-125a suppresses cell migration, invasion, and regulates hyaluronic acid synthase 1 expression by targeting signal transducers and activators of transcription 3 in renal cell carcinoma cells.
Role of hyaluronan synthase 2 to promote CD44-dependent oral cavity squamous cell carcinoma progression.
Silencing of HAS2-AS1 mediates PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and invasion in glioma.
[Differential expression of hyaluronic acid synthase family in human bladder transitional cell carcinoma and its clinical significance].
Carcinoma, Non-Small-Cell Lung
Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling.
Carcinoma, Renal Cell
MicroRNA-125a suppresses cell migration, invasion, and regulates hyaluronic acid synthase 1 expression by targeting signal transducers and activators of transcription 3 in renal cell carcinoma cells.
Carcinoma, Squamous Cell
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
Role of hyaluronan synthase 2 to promote CD44-dependent oral cavity squamous cell carcinoma progression.
Carcinoma, Transitional Cell
[Differential expression of hyaluronic acid synthase family in human bladder transitional cell carcinoma and its clinical significance].
Cardiomegaly
Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat.
Cardiomyopathies
Hyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: a report from the children's oncology group.
Chondrosarcoma
Evidence for rapid metabolic turnover of hyaluronate synthetase in Swarm rat chondrosarcoma chondrocytes.
Colitis
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease.
Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model.
Colonic Neoplasms
Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.
Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Colorectal Neoplasms
CD44 exon variant 6 epitope and hyaluronate synthase are expressed on HT29 human colorectal carcinoma cells in a SCID mouse model of metastasis formation.
Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling.
COVID-19
Dysregulation of Pulmonary Responses in Severe COVID-19.
Cryptococcosis
Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection.
Cystitis, Interstitial
Uronate peaks and urinary hyaluronic acid levels correlate with interstitial cystitis severity.
Down Syndrome
New Insights into Pathobiology of Down Syndrome: Hyaluronan Synthase-2 Overexpression is Regulated by Collagen VI alpha-2 Chain.
Endometrial Neoplasms
Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer.
Role of hyaluronan and hyaluronan synthase in endometrial cancer.
Endometriosis
Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis.
Endotoxemia
Changes in DNA integrity and gene expression in ovarian follicular cells of lipopolysaccharide-treated female mice.
Familial Primary Pulmonary Hypertension
Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension.
Fatty Liver
Hyaluronan histochemistry-A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma.
Fibrosarcoma
bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells.
Inhibition of hyaluronate synthesis.
Glaucoma
Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration.
Glaucoma, Open-Angle
Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration.
Glioma
Characterization of hyaluronan synthase from a human glioma cell line.
Interfering with hyaluronic acid metabolism suppresses glioma cell proliferation by regulating autophagy.
Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity.
Graves Ophthalmopathy
Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy.
Expression of hyaluronan synthase messenger ribonucleic acids and their induction by interleukin-1beta in human orbital fibroblasts: potential insight into the molecular pathogenesis of thyroid-associated ophthalmopathy.
Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients.
Heart Septal Defects, Ventricular
A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect.
hyaluronan synthase deficiency
Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice.
Hypertension
Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension.
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Infections
Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection.
Induction of hyaluronan production by oncogenic KSHV and the contribution to viral pathogenesis in AIDS patients.
Mycobacteria exploit host hyaluronan for efficient extracellular replication.
Inflammatory Bowel Diseases
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease.
Influenza, Human
Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis.
Keloid
Altered expression of hyaluronan synthase and hyaluronidase mRNA may affect hyaluronic acid distribution in keloid disease compared with normal skin.
Inhibition of Hyaluronan Synthase 2 Reduces the Abnormal Migration Rate of Keloid Keratinocytes.
Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-?1.
Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes.
Lichen Sclerosus et Atrophicus
UVA and UVB decrease the expression of CD44 and hyaluronate in mouse epidermis, which is counteracted by topical retinoids.
Lipoblastoma
PLAG1 fusion oncogenes in lipoblastoma.
Liver Cirrhosis
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.
Lung Injury
Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Lung Neoplasms
Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway.
Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice.
Role of the extracellular matrix in variations of invasive pathways in lung cancers.
Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling.
Lymphoma, B-Cell
Importance of the GDF9 signaling pathway on cumulus cell expansion and oocyte competency in sheep.
Marfan Syndrome
Cell-free synthesis of hyaluronic acid in Marfan syndrome.
Melanoma
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells.
Altered expression of versican and hyaluronan in melanocytic tumors of dogs.
Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma.
Effect of a hyaluronan synthase suppressor, 4-methylumbelliferone, on B16F-10 melanoma cell adhesion and locomotion.
Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion.
Increased synthesis of hyaluronate enhances motility of human melanoma cells.
Mesothelioma
Hyaluronan production increases the malignant properties of mesothelioma cells.
Proteoglycans and WT1 as markers for distinguishing adenocarcinoma, epithelioid mesothelioma, and benign mesothelium.
Mesothelioma, Malignant
Expression of hyaluronan synthases and hyaluronan in malignant mesothelioma cells.
Hyaluronan synthase expression in pleural malignant mesotheliomas.
Mouth Neoplasms
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion.
Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer.
Mucinoses
Hereditary cutaneous mucinosis in shar pei dogs is associated with increased hyaluronan synthase-2 mRNA transcription by cultured dermal fibroblasts.
Reticular erythematous mucinosis syndrome with an infiltration of factor XIIIa+ and hyaluronan synthase 2+ dermal dendrocytes.
Multiple Myeloma
Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert pre-Mrna splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes.
Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients.
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia.
Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma.
Myopia
Increased Hyaluronan Synthase-2 mRNA Transcripts and Hyaluronan Accumulation Accompany Choroidal Thickening during the Recovery from Induced Myopia.
Nasal Polyps
Effect of Prostaglandin D2 on mRNA Expression of Three Isoforms of Hyaluronic Acid Synthase in Nasal Polyp Fibroblasts.
Neoplasm Metastasis
4-methylumbelliferone leads to growth arrest and apoptosis in canine mammary tumor cells.
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells.
CD44 exon variant 6 epitope and hyaluronate synthase are expressed on HT29 human colorectal carcinoma cells in a SCID mouse model of metastasis formation.
Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice.
HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells.
Hyaluronan synthase 2 overexpression is correlated with the tumorigenesis and metastasis of human breast cancer.
Melanoma cells block PEDF production in fibroblasts to induce the tumor-promoting phenotype of cancer-associated fibroblasts.
Methods for measuring Class I membrane-bound hyaluronan synthase activity.
Neoplasms
4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression.
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits the tumor invasion associated with N-cadherin decreasement.
A silk fibroin based hepatocarcinoma model and the assessment of the drug response in hyaluronan-binding protein 1 overexpressed HepG2 cells.
A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse.
Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression.
Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer.
Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.
Age-Related Changes in Pericellular Hyaluronan Organization Leads to Impaired Dermal Fibroblast to Myofibroblast Differentiation.
Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert pre-Mrna splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes.
Altered hyaluronan biosynthesis in cancer progression.
Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs.
CD44 attenuates metastatic invasion during breast cancer progression.
CD44-expressing undifferentiated carcinoma with rhabdoid features of the pancreas: Molecular analysis of aggressive invasion and metastasis.
Differential Expression Profiles of Cell-to-Matrix-Related Molecules in Adrenal Cortical Tumors: Diagnostic and Prognostic Implications.
Dissecting the role of hyaluronan synthases in the tumor microenvironment.
Early inflammatory arthritis in the rabbit: the influence of intraarticular and systemic corticosteroids on mRNA levels in connective tissues of the knee.
Effect of cytokines on hyaluronan synthase activity and response to oxidative stress by fibroblasts.
Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer.
Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer.
Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.
Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice.
Expression of the interleukin-4 receptor alpha in human conjunctival epithelial cells.
Fibroblast growth factor 17 and bone morphogenetic protein 15 enhance cumulus expansion and improve quality of in vitro-produced embryos in cattle.
GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.
Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration.
High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome.
Hyaluronan production enhances shedding of plasma membrane-derived microvesicles.
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).
Hyaluronan synthase 2 is an adverse prognostic marker in androgen receptor-negative breast cancer.
Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer.
Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells.
Hyaluronan synthase expression in ovarian cancer.
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells.
Hyaluronan-coated extracellular vesicles--a novel link between hyaluronan and cancer.
Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling.
Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis.
Identification of potential markers of oocyte competence expressed in bovine cumulus cells matured with follicle-stimulating hormone and/or phorbol myristate acetate in vitro.
Importance of the GDF9 signaling pathway on cumulus cell expansion and oocyte competency in sheep.
Increased mesangial cell hyaluronan expression in lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta.
Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis.
Inflammatory factor profiles one hour following vocal fold injury.
Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer.
Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast cancer.
Inhibition of HAS2 induction enhances the radiosensitivity of cancer cells via persistent DNA damage.
Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice.
Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer.
Melanoma cells block PEDF production in fibroblasts to induce the tumor-promoting phenotype of cancer-associated fibroblasts.
Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance.
Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion.
Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.
PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models.
PKC? facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft model.
Proinflammatory cytokines differentially regulate hyaluronan synthase isoforms in fetal and adult fibroblasts.
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations.
Regulation of hyaluronan synthase gene expression in human periodontal ligament cells by tumour necrosis factor-alpha, interleukin-1beta and interferon-gamma.
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element binding protein and retinoid acid receptor signaling.
Reversible meiotic arrest of bovine oocytes by EGFR inhibition and follicular hemisections.
Role of the extracellular matrix in variations of invasive pathways in lung cancers.
Stimulation of hyaluronan synthesis by tumor necrosis factor-alpha is mediated by the p50/p65 NF-kappa B complex in MRC-5 myofibroblasts.
The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, ?-defensin 2 and tumor necrosis factor-? genes.
The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep.
The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44.
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Transforming Growth Factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, Hyaluronan Synthase-2 and synthesis of Hyaluronan in Malignant Osteosarcoma cells.
Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes.
Variations in contents of hyaluronan in the peritumoral micro-environment of human chondrosarcoma.
Versican expression level in cumulus cells is associated with human oocyte developmental competence.
Neuroblastoma
Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3-induced mitophagy.
Neurofibrosarcoma
Hyaluronan expression as a significant prognostic factor in patients with malignant peripheral nerve sheath tumors.
Obesity
Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion.
Oligodendroglioma
Effect of hyaluronidase treatment of intact cells on hyaluronate synthetase activity.
Solubilization and partial purification of hyaluronate synthetase from oligodendroglioma cells.
Subcellular localization of hyaluronate synthetase in oligodendroglioma cells.
Osteoarthritis
Amelioration of osteoarthritis by intra-articular hyaluronan synthase 2 gene therapy.
Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage.
Differential stimulation of three forms of hyaluronan synthase by TGF-beta, IL-1beta, and TNF-alpha.
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.
Inhibition of glycolysis by targeting lactate dehydrogenase A facilitates hyaluronan synthase 2 synthesis in synovial fibroblasts of temporomandibular joint osteoarthritis.
Inhibitors of hyaluronan export from hops prevent osteoarthritic reactions.
Pirfenidone reduces subchondral bone loss and fibrosis after murine knee cartilage injury.
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Osteogenesis Imperfecta
Synthesis of hyaluronic acid and collagen in skin fibroblasts cultured from patients with osteogenesis imperfecta.
Osteosarcoma
Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity.
HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells.
Overexpression of KIAA1199, a novel strong hyaluronidase, is a poor prognostic factor in patients with osteosarcoma.
Silencing of HAS2-AS1 mediates PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and invasion in glioma.
Transforming Growth Factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, Hyaluronan Synthase-2 and synthesis of Hyaluronan in Malignant Osteosarcoma cells.
Ovarian Neoplasms
Hyaluronan synthase expression in ovarian cancer.
PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models.
Pancreatic Neoplasms
4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells.
Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.
Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL).
Pneumonia
Treatment with the hyaluronic acid synthesis inhibitor 4-methylumbelliferone suppresses SEB-induced lung inflammation.
Premature Birth
Cervical hyaluronan biology in pregnancy, parturition and preterm birth.
Prostatic Neoplasms
Concurrent expression of hyaluronan biosynthetic and processing enzymes promotes growth and vascularization of prostate tumors in mice.
Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.
Pulmonary Arterial Hypertension
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Pulmonary Disease, Chronic Obstructive
ADORA2B and Hyaluronan Modulate Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease.
Alterations in plasma hyaluronic acid in patients with clinically stable COPD versus (non)smoking controls.
COPD Exacerbations Are Associated With Proinflammatory Degradation of Hyaluronic Acid.
Pulmonary Fibrosis
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis.
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.
Rheumatic Fever
Antibodies against proteins of streptococcal hyaluronate synthase bind to human fibroblasts and are present in patients with rheumatic fever.
Molecular characterization of a locus required for hyaluronic acid capsule production in group A streptococci.
Sarcoma, Avian
Studies of carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts.
Scleromyxedema
Hyaluronic acid synthetase activity in lichen myxedematosus skin.
sphingomyelin phosphodiesterase deficiency
Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of hyaluronan Synthase 2 through decreased ceramide production and activation of Akt.
Squamous Cell Carcinoma of Head and Neck
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion.
Role of hyaluronan synthase 2 to promote CD44-dependent oral cavity squamous cell carcinoma progression.
Silencing of HAS2-AS1 mediates PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and invasion in glioma.
Stroke
Use of suppression subtractive hybridization for differential gene expression in stroke: discovery of CD44 gene expression and localization in permanent focal stroke in rats.
Thyroiditis
[Endocrine orbitopathy - the topic still alive].
Tuberculosis
c-Maf-dependent growth of Mycobacterium tuberculosis in a CD14(hi) subpopulation of monocyte-derived macrophages.
Mycobacteria exploit host hyaluronan for efficient extracellular replication.
Urinary Bladder Neoplasms
Involvement of glycogen debranching enzyme in bladder cancer.
Orphan nuclear receptor HNF4G promotes bladder cancer growth and invasion through the regulation of the hyaluronan synthase 2 gene.
Varicose Veins
Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins.
Vascular System Injuries
Role for Hyaluronan Synthase 3 in the Response to Vascular Injury.
Ventilator-Induced Lung Injury
The role of hyaluronan synthase 3 in ventilator-induced lung injury.
Virus Diseases
Chitin synthesis in chlorovirus CVK2-infected chlorella cells.
Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis.
Waldenstrom Macroglobulinemia
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia.
Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia.
Wiskott-Aldrich Syndrome
Differentially up-regulated genes in proliferating porcine neonatal pancreas cells caused by epidermal growth factor.