Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
UDP-D-glucosamine + UDP-D-glucuronate
[beta-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + n UDP
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate
[beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
additional information
?
-
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
-
-
-
?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
-
-
-
-
?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
-
-
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
-
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
-
-
-
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]
-
-
-
?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate
[beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate
[beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
addition of monosaccharides to the linear heteropolysaccharide chain
-
-
?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate
[beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
addition of monosaccharides to the linear heteropolysaccharide chain, recombinant isozyme HAS2 prefers the production of a mixture of 8mers and 16mers
-
-
?
additional information
?
-
isozyme HAS1 requires higher cellular UDP-GlcNAc concentration than isozymes HAS2 and HAS3. HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. HAS works on the cytosolic pool of the UDPsugars
-
-
?
additional information
?
-
isozyme HAS1 requires higher cellular UDP-GlcNAc concentration than isozymes HAS2 and HAS3. HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. HAS works on the cytosolic pool of the UDPsugars
-
-
?
additional information
?
-
isozyme HAS1 requires higher cellular UDP-GlcNAc concentration than isozymes HAS2 and HAS3. HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. HAS works on the cytosolic pool of the UDPsugars
-
-
?
additional information
?
-
-
isozyme HAS1 requires higher cellular UDP-GlcNAc concentration than isozymes HAS2 and HAS3. HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. HAS works on the cytosolic pool of the UDPsugars
-
-
?
additional information
?
-
two glycosyltransferase activities in HAS that add glucuronic acid and N-acetylglucosamine into their alternating positions in the chain, using UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc) as substrates. Sufficient supply of both UDP-GlcUA and UDP-GlcNAc is important for hyaluronan synthesis
-
-
?
additional information
?
-
two glycosyltransferase activities in HAS that add glucuronic acid and N-acetylglucosamine into their alternating positions in the chain, using UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc) as substrates. Sufficient supply of both UDP-GlcUA and UDP-GlcNAc is important for hyaluronan synthesis
-
-
?
additional information
?
-
two glycosyltransferase activities in HAS that add glucuronic acid and N-acetylglucosamine into their alternating positions in the chain, using UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc) as substrates. Sufficient supply of both UDP-GlcUA and UDP-GlcNAc is important for hyaluronan synthesis
-
-
?
additional information
?
-
-
two glycosyltransferase activities in HAS that add glucuronic acid and N-acetylglucosamine into their alternating positions in the chain, using UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc) as substrates. Sufficient supply of both UDP-GlcUA and UDP-GlcNAc is important for hyaluronan synthesis
-
-
?
additional information
?
-
-
regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis
-
-
?
additional information
?
-
-
the isozymes form products of different size, HA synthesis modeling, active site and substrate binding site are located on the big cytoplasmic loop
-
-
?
additional information
?
-
-
HAS2, localized in the plasma membrane, uses cytoplasmic UDP-glucuronic acid and UDP-N-acetylglucosamine as substrates
-
-
?
additional information
?
-
isozyme HAS1 requires higher cellular UDP-GlcNAc concentration than isozymes HAS2 and HAS3. HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. HAS works on the cytosolic pool of the UDPsugars
-
-
?
additional information
?
-
isozyme HAS1 requires higher cellular UDP-GlcNAc concentration than isozymes HAS2 and HAS3. HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. HAS works on the cytosolic pool of the UDPsugars
-
-
?
additional information
?
-
isozyme HAS1 requires higher cellular UDP-GlcNAc concentration than isozymes HAS2 and HAS3. HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. HAS works on the cytosolic pool of the UDPsugars
-
-
?
additional information
?
-
-
isozyme HAS1 requires higher cellular UDP-GlcNAc concentration than isozymes HAS2 and HAS3. HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. HAS works on the cytosolic pool of the UDPsugars
-
-
?
additional information
?
-
two glycosyltransferase activities in HAS that add glucuronic acid and N-acetylglucosamine into their alternating positions in the chain, using UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc) as substrates. Sufficient supply of both UDP-GlcUA and UDP-GlcNAc is important for hyaluronan synthesis
-
-
?
additional information
?
-
two glycosyltransferase activities in HAS that add glucuronic acid and N-acetylglucosamine into their alternating positions in the chain, using UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc) as substrates. Sufficient supply of both UDP-GlcUA and UDP-GlcNAc is important for hyaluronan synthesis
-
-
?
additional information
?
-
two glycosyltransferase activities in HAS that add glucuronic acid and N-acetylglucosamine into their alternating positions in the chain, using UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc) as substrates. Sufficient supply of both UDP-GlcUA and UDP-GlcNAc is important for hyaluronan synthesis
-
-
?
additional information
?
-
-
two glycosyltransferase activities in HAS that add glucuronic acid and N-acetylglucosamine into their alternating positions in the chain, using UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc) as substrates. Sufficient supply of both UDP-GlcUA and UDP-GlcNAc is important for hyaluronan synthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acute Lung Injury
Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Adenocarcinoma
Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.
Adenocarcinoma
Proteoglycans and WT1 as markers for distinguishing adenocarcinoma, epithelioid mesothelioma, and benign mesothelium.
Adrenocortical Carcinoma
Differential Expression Profiles of Cell-to-Matrix-Related Molecules in Adrenal Cortical Tumors: Diagnostic and Prognostic Implications.
Aortic Aneurysm, Abdominal
HAS-1 genetic polymorphism in sporadic abdominal aortic aneurysm.
Arthritis
Early inflammatory arthritis in the rabbit: the influence of intraarticular and systemic corticosteroids on mRNA levels in connective tissues of the knee.
Arthritis
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.
Arthritis, Rheumatoid
Differential stimulation of three forms of hyaluronan synthase by TGF-beta, IL-1beta, and TNF-alpha.
Arthritis, Rheumatoid
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.
Asthma
Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease.
Asthma
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Astrocytoma
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas.
Brain Ischemia
Translational event mediates differential production of tumor necrosis factor-alpha in hyaluronan-stimulated microglia and macrophages.
Brain Neoplasms
Role of HYAL1 expression in primary breast cancer in the formation of brain metastases.
Breast Neoplasms
ABC transporters do not contribute to extracellular translocation of hyaluronan in human breast cancer in vitro.
Breast Neoplasms
Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.
Breast Neoplasms
Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance.
Breast Neoplasms
Excessive hyaluronan production promotes acquisition of cancer stem cell signatures through the coordinated regulation of Twist and the transforming growth factor ? (TGF-?)-Snail signaling axis.
Breast Neoplasms
Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGF?-induced EMT in breast cancer.
Breast Neoplasms
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).
Breast Neoplasms
Hyaluronan synthase 2 (HAS2) regulates cell phenotype and invadopodia formation in luminal-like breast cancer cells.
Breast Neoplasms
Hyaluronan synthase 2 is an adverse prognostic marker in androgen receptor-negative breast cancer.
Breast Neoplasms
Hyaluronan synthase 2 overexpression is correlated with the tumorigenesis and metastasis of human breast cancer.
Breast Neoplasms
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells.
Breast Neoplasms
In Vitro Effects of HAS-2 Gene Silencing on the Proliferation and Apoptosis of the MCF-7 Human Breast Cancer Cell Line.
Breast Neoplasms
Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer.
Breast Neoplasms
Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.
Breast Neoplasms
Role of HYAL1 expression in primary breast cancer in the formation of brain metastases.
Breast Neoplasms
Silencing of HAS2-AS1 mediates PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and invasion in glioma.
Breast Neoplasms
Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells.
Breast Neoplasms
The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer.
Breast Neoplasms
The Secreted Protein C10orf118 Is a New Regulator of Hyaluronan Synthesis Involved in Tumour-Stroma Cross-Talk.
Carcinogenesis
Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.
Carcinogenesis
HAS3 underexpression as an indicator of poor prognosis in patients with urothelial carcinoma of the upper urinary tract and urinary bladder.
Carcinogenesis
Hyaluronan synthase 2 overexpression is correlated with the tumorigenesis and metastasis of human breast cancer.
Carcinogenesis
Long noncoding RNA HAS2-AS1 accelerates non-small cell lung cancer chemotherapy resistance by targeting LSD1/EphB3 pathway.
Carcinogenesis
Methods for measuring Class I membrane-bound hyaluronan synthase activity.
Carcinogenesis
Studies of carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts.
Carcinoma
CD44 exon variant 6 epitope and hyaluronate synthase are expressed on HT29 human colorectal carcinoma cells in a SCID mouse model of metastasis formation.
Carcinoma
Correlation between hyaluronic acid,hyaluronic Acid synthase and human renal clear cell carcinoma.
Carcinoma
Differential Expression Profiles of Cell-to-Matrix-Related Molecules in Adrenal Cortical Tumors: Diagnostic and Prognostic Implications.
Carcinoma
Expression cloning and molecular characterization of HAS protein, a eukaryotic hyaluronan synthase.
Carcinoma
Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.
Carcinoma
Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells.
Carcinoma
Hyaluronan content in experimental carcinoma is not correlated to interstitial fluid pressure.
Carcinoma
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion.
Carcinoma
Hyaluronan Synthase and Hyaluronidase Expression in Serous Ovarian Carcinoma is Related to Anatomic Site and Chemotherapy Exposure.
Carcinoma
Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells.
Carcinoma
Hyaluronan synthase expression in ovarian cancer.
Carcinoma
Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival.
Carcinoma
Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling.
Carcinoma
MicroRNA-125a suppresses cell migration, invasion, and regulates hyaluronic acid synthase 1 expression by targeting signal transducers and activators of transcription 3 in renal cell carcinoma cells.
Carcinoma
Role of hyaluronan synthase 2 to promote CD44-dependent oral cavity squamous cell carcinoma progression.
Carcinoma
Silencing of HAS2-AS1 mediates PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and invasion in glioma.
Carcinoma
[Differential expression of hyaluronic acid synthase family in human bladder transitional cell carcinoma and its clinical significance].
Carcinoma, Non-Small-Cell Lung
Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling.
Carcinoma, Renal Cell
MicroRNA-125a suppresses cell migration, invasion, and regulates hyaluronic acid synthase 1 expression by targeting signal transducers and activators of transcription 3 in renal cell carcinoma cells.
Carcinoma, Squamous Cell
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
Carcinoma, Squamous Cell
Role of hyaluronan synthase 2 to promote CD44-dependent oral cavity squamous cell carcinoma progression.
Carcinoma, Transitional Cell
[Differential expression of hyaluronic acid synthase family in human bladder transitional cell carcinoma and its clinical significance].
Cardiomegaly
Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat.
Cardiomyopathies
Hyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: a report from the children's oncology group.
Chondrosarcoma
Evidence for rapid metabolic turnover of hyaluronate synthetase in Swarm rat chondrosarcoma chondrocytes.
Colitis
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease.
Colitis
Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model.
Colonic Neoplasms
Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.
Colonic Neoplasms
Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.
Colonic Neoplasms
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Colorectal Neoplasms
CD44 exon variant 6 epitope and hyaluronate synthase are expressed on HT29 human colorectal carcinoma cells in a SCID mouse model of metastasis formation.
Colorectal Neoplasms
Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling.
COVID-19
Dysregulation of Pulmonary Responses in Severe COVID-19.
Cryptococcosis
Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection.
Cystitis, Interstitial
Uronate peaks and urinary hyaluronic acid levels correlate with interstitial cystitis severity.
Down Syndrome
New Insights into Pathobiology of Down Syndrome: Hyaluronan Synthase-2 Overexpression is Regulated by Collagen VI alpha-2 Chain.
Endometrial Neoplasms
Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer.
Endometrial Neoplasms
Role of hyaluronan and hyaluronan synthase in endometrial cancer.
Endometriosis
Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis.
Endotoxemia
Changes in DNA integrity and gene expression in ovarian follicular cells of lipopolysaccharide-treated female mice.
Familial Primary Pulmonary Hypertension
Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension.
Fatty Liver
Hyaluronan histochemistry-A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma.
Fibrosarcoma
bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells.
Fibrosarcoma
Inhibition of hyaluronate synthesis.
Glaucoma
Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration.
Glaucoma, Open-Angle
Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration.
Glioma
Characterization of hyaluronan synthase from a human glioma cell line.
Glioma
Interfering with hyaluronic acid metabolism suppresses glioma cell proliferation by regulating autophagy.
Glioma
Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity.
Graves Ophthalmopathy
Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy.
Graves Ophthalmopathy
Expression of hyaluronan synthase messenger ribonucleic acids and their induction by interleukin-1beta in human orbital fibroblasts: potential insight into the molecular pathogenesis of thyroid-associated ophthalmopathy.
Graves Ophthalmopathy
Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients.
Heart Septal Defects, Ventricular
A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect.
hyaluronan synthase deficiency
Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice.
Hypertension
Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension.
Hypertension
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Infections
Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection.
Infections
Induction of hyaluronan production by oncogenic KSHV and the contribution to viral pathogenesis in AIDS patients.
Infections
Mycobacteria exploit host hyaluronan for efficient extracellular replication.
Inflammatory Bowel Diseases
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease.
Influenza, Human
Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis.
Keloid
Altered expression of hyaluronan synthase and hyaluronidase mRNA may affect hyaluronic acid distribution in keloid disease compared with normal skin.
Keloid
Inhibition of Hyaluronan Synthase 2 Reduces the Abnormal Migration Rate of Keloid Keratinocytes.
Keloid
Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-?1.
Keloid
Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes.
Lichen Sclerosus et Atrophicus
UVA and UVB decrease the expression of CD44 and hyaluronate in mouse epidermis, which is counteracted by topical retinoids.
Lipoblastoma
PLAG1 fusion oncogenes in lipoblastoma.
Liver Cirrhosis
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.
Lung Injury
Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Lung Neoplasms
Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway.
Lung Neoplasms
Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice.
Lung Neoplasms
Role of the extracellular matrix in variations of invasive pathways in lung cancers.
Lung Neoplasms
Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling.
Lymphoma, B-Cell
Importance of the GDF9 signaling pathway on cumulus cell expansion and oocyte competency in sheep.
Marfan Syndrome
Cell-free synthesis of hyaluronic acid in Marfan syndrome.
Melanoma
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
Melanoma
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells.
Melanoma
Altered expression of versican and hyaluronan in melanocytic tumors of dogs.
Melanoma
Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma.
Melanoma
Effect of a hyaluronan synthase suppressor, 4-methylumbelliferone, on B16F-10 melanoma cell adhesion and locomotion.
Melanoma
Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion.
Melanoma
Increased synthesis of hyaluronate enhances motility of human melanoma cells.
Mesothelioma
Hyaluronan production increases the malignant properties of mesothelioma cells.
Mesothelioma
Proteoglycans and WT1 as markers for distinguishing adenocarcinoma, epithelioid mesothelioma, and benign mesothelium.
Mesothelioma, Malignant
Expression of hyaluronan synthases and hyaluronan in malignant mesothelioma cells.
Mesothelioma, Malignant
Hyaluronan synthase expression in pleural malignant mesotheliomas.
Mouth Neoplasms
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion.
Mouth Neoplasms
Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer.
Mucinoses
Hereditary cutaneous mucinosis in shar pei dogs is associated with increased hyaluronan synthase-2 mRNA transcription by cultured dermal fibroblasts.
Mucinoses
Reticular erythematous mucinosis syndrome with an infiltration of factor XIIIa+ and hyaluronan synthase 2+ dermal dendrocytes.
Multiple Myeloma
Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert pre-Mrna splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes.
Multiple Myeloma
Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients.
Multiple Myeloma
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia.
Multiple Myeloma
Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma.
Myopia
Increased Hyaluronan Synthase-2 mRNA Transcripts and Hyaluronan Accumulation Accompany Choroidal Thickening during the Recovery from Induced Myopia.
Nasal Polyps
Effect of Prostaglandin D2 on mRNA Expression of Three Isoforms of Hyaluronic Acid Synthase in Nasal Polyp Fibroblasts.
Neoplasm Metastasis
4-methylumbelliferone leads to growth arrest and apoptosis in canine mammary tumor cells.
Neoplasm Metastasis
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells.
Neoplasm Metastasis
CD44 exon variant 6 epitope and hyaluronate synthase are expressed on HT29 human colorectal carcinoma cells in a SCID mouse model of metastasis formation.
Neoplasm Metastasis
Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice.
Neoplasm Metastasis
HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells.
Neoplasm Metastasis
Hyaluronan synthase 2 overexpression is correlated with the tumorigenesis and metastasis of human breast cancer.
Neoplasm Metastasis
Melanoma cells block PEDF production in fibroblasts to induce the tumor-promoting phenotype of cancer-associated fibroblasts.
Neoplasm Metastasis
Methods for measuring Class I membrane-bound hyaluronan synthase activity.
Neoplasms
4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression.
Neoplasms
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits the tumor invasion associated with N-cadherin decreasement.
Neoplasms
A silk fibroin based hepatocarcinoma model and the assessment of the drug response in hyaluronan-binding protein 1 overexpressed HepG2 cells.
Neoplasms
A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse.
Neoplasms
Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression.
Neoplasms
Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer.
Neoplasms
Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.
Neoplasms
Age-Related Changes in Pericellular Hyaluronan Organization Leads to Impaired Dermal Fibroblast to Myofibroblast Differentiation.
Neoplasms
Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert pre-Mrna splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes.
Neoplasms
Altered hyaluronan biosynthesis in cancer progression.
Neoplasms
Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs.
Neoplasms
CD44 attenuates metastatic invasion during breast cancer progression.
Neoplasms
CD44-expressing undifferentiated carcinoma with rhabdoid features of the pancreas: Molecular analysis of aggressive invasion and metastasis.
Neoplasms
Differential Expression Profiles of Cell-to-Matrix-Related Molecules in Adrenal Cortical Tumors: Diagnostic and Prognostic Implications.
Neoplasms
Dissecting the role of hyaluronan synthases in the tumor microenvironment.
Neoplasms
Early inflammatory arthritis in the rabbit: the influence of intraarticular and systemic corticosteroids on mRNA levels in connective tissues of the knee.
Neoplasms
Effect of cytokines on hyaluronan synthase activity and response to oxidative stress by fibroblasts.
Neoplasms
Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer.
Neoplasms
Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer.
Neoplasms
Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.
Neoplasms
Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice.
Neoplasms
Expression of the interleukin-4 receptor alpha in human conjunctival epithelial cells.
Neoplasms
Fibroblast growth factor 17 and bone morphogenetic protein 15 enhance cumulus expansion and improve quality of in vitro-produced embryos in cattle.
Neoplasms
GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.
Neoplasms
Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration.
Neoplasms
High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome.
Neoplasms
Hyaluronan production enhances shedding of plasma membrane-derived microvesicles.
Neoplasms
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).
Neoplasms
Hyaluronan synthase 2 is an adverse prognostic marker in androgen receptor-negative breast cancer.
Neoplasms
Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer.
Neoplasms
Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells.
Neoplasms
Hyaluronan synthase expression in ovarian cancer.
Neoplasms
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells.
Neoplasms
Hyaluronan-coated extracellular vesicles--a novel link between hyaluronan and cancer.
Neoplasms
Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling.
Neoplasms
Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis.
Neoplasms
Identification of potential markers of oocyte competence expressed in bovine cumulus cells matured with follicle-stimulating hormone and/or phorbol myristate acetate in vitro.
Neoplasms
Importance of the GDF9 signaling pathway on cumulus cell expansion and oocyte competency in sheep.
Neoplasms
Increased mesangial cell hyaluronan expression in lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta.
Neoplasms
Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis.
Neoplasms
Inflammatory factor profiles one hour following vocal fold injury.
Neoplasms
Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer.
Neoplasms
Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast cancer.
Neoplasms
Inhibition of HAS2 induction enhances the radiosensitivity of cancer cells via persistent DNA damage.
Neoplasms
Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice.
Neoplasms
Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer.
Neoplasms
Melanoma cells block PEDF production in fibroblasts to induce the tumor-promoting phenotype of cancer-associated fibroblasts.
Neoplasms
Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance.
Neoplasms
Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion.
Neoplasms
Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.
Neoplasms
PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models.
Neoplasms
PKC? facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft model.
Neoplasms
Proinflammatory cytokines differentially regulate hyaluronan synthase isoforms in fetal and adult fibroblasts.
Neoplasms
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations.
Neoplasms
Regulation of hyaluronan synthase gene expression in human periodontal ligament cells by tumour necrosis factor-alpha, interleukin-1beta and interferon-gamma.
Neoplasms
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element binding protein and retinoid acid receptor signaling.
Neoplasms
Reversible meiotic arrest of bovine oocytes by EGFR inhibition and follicular hemisections.
Neoplasms
Role of the extracellular matrix in variations of invasive pathways in lung cancers.
Neoplasms
Stimulation of hyaluronan synthesis by tumor necrosis factor-alpha is mediated by the p50/p65 NF-kappa B complex in MRC-5 myofibroblasts.
Neoplasms
The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, ?-defensin 2 and tumor necrosis factor-? genes.
Neoplasms
The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep.
Neoplasms
The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44.
Neoplasms
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Neoplasms
Transforming Growth Factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, Hyaluronan Synthase-2 and synthesis of Hyaluronan in Malignant Osteosarcoma cells.
Neoplasms
Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes.
Neoplasms
Variations in contents of hyaluronan in the peritumoral micro-environment of human chondrosarcoma.
Neoplasms
Versican expression level in cumulus cells is associated with human oocyte developmental competence.
Neuroblastoma
Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3-induced mitophagy.
Neurofibrosarcoma
Hyaluronan expression as a significant prognostic factor in patients with malignant peripheral nerve sheath tumors.
Obesity
Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion.
Oligodendroglioma
Effect of hyaluronidase treatment of intact cells on hyaluronate synthetase activity.
Oligodendroglioma
Solubilization and partial purification of hyaluronate synthetase from oligodendroglioma cells.
Oligodendroglioma
Subcellular localization of hyaluronate synthetase in oligodendroglioma cells.
Osteoarthritis
Amelioration of osteoarthritis by intra-articular hyaluronan synthase 2 gene therapy.
Osteoarthritis
Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage.
Osteoarthritis
Differential stimulation of three forms of hyaluronan synthase by TGF-beta, IL-1beta, and TNF-alpha.
Osteoarthritis
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.
Osteoarthritis
Inhibition of glycolysis by targeting lactate dehydrogenase A facilitates hyaluronan synthase 2 synthesis in synovial fibroblasts of temporomandibular joint osteoarthritis.
Osteoarthritis
Inhibitors of hyaluronan export from hops prevent osteoarthritic reactions.
Osteoarthritis
Pirfenidone reduces subchondral bone loss and fibrosis after murine knee cartilage injury.
Osteoarthritis
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Osteogenesis Imperfecta
Synthesis of hyaluronic acid and collagen in skin fibroblasts cultured from patients with osteogenesis imperfecta.
Osteosarcoma
Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity.
Osteosarcoma
HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells.
Osteosarcoma
Overexpression of KIAA1199, a novel strong hyaluronidase, is a poor prognostic factor in patients with osteosarcoma.
Osteosarcoma
Silencing of HAS2-AS1 mediates PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and invasion in glioma.
Osteosarcoma
Transforming Growth Factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, Hyaluronan Synthase-2 and synthesis of Hyaluronan in Malignant Osteosarcoma cells.
Ovarian Neoplasms
Hyaluronan synthase expression in ovarian cancer.
Ovarian Neoplasms
PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models.
Pancreatic Neoplasms
4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells.
Pancreatic Neoplasms
Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.
Pancreatic Neoplasms
Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL).
Pneumonia
Treatment with the hyaluronic acid synthesis inhibitor 4-methylumbelliferone suppresses SEB-induced lung inflammation.
Premature Birth
Cervical hyaluronan biology in pregnancy, parturition and preterm birth.
Prostatic Neoplasms
Concurrent expression of hyaluronan biosynthetic and processing enzymes promotes growth and vascularization of prostate tumors in mice.
Prostatic Neoplasms
Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.
Pulmonary Arterial Hypertension
The human hyaluronan synthase 2 gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.
Pulmonary Disease, Chronic Obstructive
ADORA2B and Hyaluronan Modulate Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Alterations in plasma hyaluronic acid in patients with clinically stable COPD versus (non)smoking controls.
Pulmonary Disease, Chronic Obstructive
COPD Exacerbations Are Associated With Proinflammatory Degradation of Hyaluronic Acid.
Pulmonary Fibrosis
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis.
Pulmonary Fibrosis
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.
Rheumatic Fever
Antibodies against proteins of streptococcal hyaluronate synthase bind to human fibroblasts and are present in patients with rheumatic fever.
Rheumatic Fever
Molecular characterization of a locus required for hyaluronic acid capsule production in group A streptococci.
Sarcoma, Avian
Studies of carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts.
Scleromyxedema
Hyaluronic acid synthetase activity in lichen myxedematosus skin.
sphingomyelin phosphodiesterase deficiency
Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of hyaluronan Synthase 2 through decreased ceramide production and activation of Akt.
Squamous Cell Carcinoma of Head and Neck
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion.
Squamous Cell Carcinoma of Head and Neck
Role of hyaluronan synthase 2 to promote CD44-dependent oral cavity squamous cell carcinoma progression.
Squamous Cell Carcinoma of Head and Neck
Silencing of HAS2-AS1 mediates PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and invasion in glioma.
Stroke
Use of suppression subtractive hybridization for differential gene expression in stroke: discovery of CD44 gene expression and localization in permanent focal stroke in rats.
Thyroiditis
[Endocrine orbitopathy - the topic still alive].
Tuberculosis
c-Maf-dependent growth of Mycobacterium tuberculosis in a CD14(hi) subpopulation of monocyte-derived macrophages.
Tuberculosis
Mycobacteria exploit host hyaluronan for efficient extracellular replication.
Urinary Bladder Neoplasms
Involvement of glycogen debranching enzyme in bladder cancer.
Urinary Bladder Neoplasms
Orphan nuclear receptor HNF4G promotes bladder cancer growth and invasion through the regulation of the hyaluronan synthase 2 gene.
Varicose Veins
Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins.
Vascular System Injuries
Role for Hyaluronan Synthase 3 in the Response to Vascular Injury.
Ventilator-Induced Lung Injury
The role of hyaluronan synthase 3 in ventilator-induced lung injury.
Virus Diseases
Chitin synthesis in chlorovirus CVK2-infected chlorella cells.
Virus Diseases
Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis.
Waldenstrom Macroglobulinemia
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia.
Waldenstrom Macroglobulinemia
Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia.
Wiskott-Aldrich Syndrome
Differentially up-regulated genes in proliferating porcine neonatal pancreas cells caused by epidermal growth factor.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Asplund, T.; Brinck, J.; Suzuki, M.; Briskin, M.J.; Heldin, P.
Characterization of hyaluronan synthase from a human glioma cell line
Biochim. Biophys. Acta
1380
377-388
1998
Homo sapiens
brenda
Sayo, T.; Sugiyama, Y.; Takahashi, Y.; Ozawa, N.; Sakai, S.; Ishikawa, O.; Tamura, M.; Inoue, S.
Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes
J. Invest. Dermatol.
118
43-48
2002
Homo sapiens
brenda
Itano, N.; Kimata, K.
Mammalian hyaluronan synthases
IUBMB Life
54
195-199
2002
Homo sapiens, Mus musculus
brenda
Hoshi, H.; Nakagawa, H.; Nishiguchi, S.; Iwata, K.; Niikura, K.; Monde, K.; Nishimura, S.
An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli
J. Biol. Chem.
279
2341-2349
2004
Homo sapiens
brenda
Goentzel, B.J.; Weigel, P.H.; Steinberg, R.A.
Recombinant human hyaluronan synthase 3 is phosphorylated in mammalian cells
Biochem. J.
396
347-354
2006
Homo sapiens (O00219), Homo sapiens
brenda
Adamia, S.; Reiman, T.; Crainie, M.; Mant, M.J.; Belch, A.R.; Pilarski, L.M.
Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma
Blood
105
4836-4844
2005
Homo sapiens (Q92839), Homo sapiens
brenda
Nishida, Y.; Knudson, W.; Knudson, C.B.; Ishiguro, N.
Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity
Exp. Cell Res.
307
194-203
2005
Homo sapiens (Q92819), Homo sapiens
brenda
Nikitovic, D.; Zafiropoulos, A.; Katonis, P.; Tsatsakis, A.; Theocharis, A.D.; Karamanos, N.K.; Tzanakakis, G.N.
Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells
IUBMB Life
58
47-53
2006
Homo sapiens (Q92819), Homo sapiens
brenda
Adams, J.R.; Sander, G.; Byers, S.
Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line
Matrix Biol.
25
40-46
2006
Homo sapiens (O00219), Homo sapiens (Q92819)
brenda
Kyossev, Z.; Weigel, P.H.
An enzyme capture assay for analysis of active hyaluronan synthases
Anal. Biochem.
371
62-70
2007
Homo sapiens, Streptococcus dysgalactiae subsp. equisimilis
brenda
Kakizaki, I.; Itano, N.; Kimata, K.; Hanada, K.; Kon, A.; Yamaguchi, M.; Takahashi, T.; Takagaki, K.
Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation
Arch. Biochem. Biophys.
471
85-93
2008
Homo sapiens
brenda
Li, L.; Asteriou, T.; Bernert, B.; Heldin, C.H.; Heldin, P.
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB
Biochem. J.
404
327-336
2007
Homo sapiens, Mus musculus
brenda
Campo, G.M.; Avenoso, A.; Campo, S.; DAscola, A.; Ferlazzo, A.M.; Calatroni, A.
Differential effect of growth factors on hyaluronan synthase gene expression in fibroblasts exposed to oxidative stress
Biochemistry
72
974-982
2007
Homo sapiens
brenda
Stuhlmeier, K.M.
Prostaglandin E2: A potent activator of hyaluronan synthase 1 in type-B-synoviocytes
Biochim. Biophys. Acta
1770
121-129
2007
Homo sapiens
brenda
Bourguignon, L.Y.; Gilad, E.; Peyrollier, K.
Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration
J. Biol. Chem.
282
19426-19441
2007
Homo sapiens (Q92819), Homo sapiens (Q92839), Homo sapiens (Q96RV2), Homo sapiens
brenda
Bharadwaj, A.G.; Rector, K.; Simpson, M.A.
Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis
J. Biol. Chem.
282
20561-20572
2007
Homo sapiens
brenda
Meran, S.; Thomas, D.; Stephens, P.; Martin, J.; Bowen, T.; Phillips, A.; Steadman, R.
Involvement of hyaluronan in regulation of fibroblast phenotype
J. Biol. Chem.
282
25687-25697
2007
Homo sapiens
brenda
Stuhlmeier, K.M.
Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs
J. Biol. Chem.
283
16781-16789
2008
Homo sapiens
brenda
Sim, G.S.; Lee, D.H.; Kim, J.H.; An, S.K.; Choe, T.B.; Kwon, T.J.; Pyo, H.B.; Lee, B.C.
Black rice (Oryza sativa L. var. japonica) hydrolyzed peptides induce expression of hyaluronan synthase 2 gene in HaCaT keratinocytes
J. Microbiol. Biotechnol.
17
271-279
2007
Homo sapiens (Q92819), Homo sapiens
brenda
David-Raoudi, M.; Deschrevel, B.; Leclercq, S.; Galera, P.; Boumediene, K.; Pujol, J.P.
Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt
Arthritis Rheum.
60
760-770
2009
Homo sapiens (O00219), Homo sapiens (Q92819), Homo sapiens (Q92839), Homo sapiens
brenda
Berdiaki, A.; Nikitovic, D.; Tsatsakis, A.; Katonis, P.; Karamanos, N.K.; Tzanakakis, G.N.
bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells
Biochim. Biophys. Acta
1790
1258-1265
2009
Homo sapiens (Q92839)
brenda
Adamia, S.; Reichert, A.A.; Kuppusamy, H.; Kriangkum, J.; Ghosh, A.; Hodges, J.J.; Pilarski, P.M.; Treon, S.P.; Mant, M.J.; Reiman, T.; Belch, A.R.; Pilarski, L.M.
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia
Blood
112
5111-5121
2008
Homo sapiens (Q92839), Homo sapiens
brenda
Nykopp, T.; Rilla, K.; Sironen, R.; Tammi, M.; Tammi, R.; Hmlinen, K.; Heikkinen, A.; Komulainen, M.; Kosma, V.; Anttila, M.
Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: Inverse correlation between HYAL1 and hyaluronan content
BMC Cancer
9
143
2009
Homo sapiens (O00219), Homo sapiens (Q92819)
brenda
Campo, G.M.; Avenoso, A.; Campo, S.; DAscola, A.; Traina, P.; Calatroni, A.
Effect of cytokines on hyaluronan synthase activity and response to oxidative stress by fibroblasts
Br. J. Biomed. Sci.
66
28-36
2009
Homo sapiens (O00219), Homo sapiens (Q92819), Homo sapiens (Q92839)
brenda
Kultti, A.; Pasonen-Seppaenen, S.; Jauhiainen, M.; Rilla, K.J.; Kaernae, R.; Pyoeriae, E.; Tammi, R.H.; Tammi, M.I.
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
Exp. Cell Res.
315
1914-1923
2009
Homo sapiens (O00219), Homo sapiens (Q92819)
brenda
Makkonen, K.M.; Pasonen-Seppaenen, S.; Toerroenen, K.; Tammi, M.I.; Carlberg, C.
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling
J. Biol. Chem.
284
18270-18281
2009
Homo sapiens (Q92819), Homo sapiens
brenda
Ghosh, A.; Kuppusamy, H.; Pilarski, L.M.
Aberrant splice variants of HAS1 (hyaluronan synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer
J. Biol. Chem.
284
18840-18850
2009
Homo sapiens (Q92839), Homo sapiens
brenda
Vigetti, D.; Genasetti, A.; Karousou, E.; Viola, M.; Clerici, M.; Bartolini, B.; Moretto, P.; De Luca, G.; Hascall, V.C.; Passi, A.
Modulation of hyaluronan synthase activity in cellular membrane fractions
J. Biol. Chem.
284
30684-30694
2009
Homo sapiens
brenda
Dunn, K.M.; Lee, P.K.; Wilson, C.M.; Iida, J.; Wasiluk, K.R.; Hugger, M.; McCarthy, J.B.
Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity
Surgery
145
322-329
2009
Homo sapiens (O00219), Homo sapiens (Q92819)
brenda
Nykopp, T.K.; Rilla, K.; Tammi, M.I.; Tammi, R.H.; Sironen, R.; Haemaelaeinen, K.; Kosma, V.M.; Heinonen, S.; Anttila, M.
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
BMC Cancer
10
512
2010
Homo sapiens
brenda
Vigetti, D.; Clerici, M.; Deleonibus, S.; Karousou, E.; Viola, M.; Moretto, P.; Heldin, P.; Hascall, V.C.; De Luca, G.; Passi, A.
Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells
J. Biol. Chem.
286
7917-7924
2011
Homo sapiens (Q92819)
brenda
Vigetti, D.; Deleonibus, S.; Moretto, P.; Karousou, E.; Viola, M.; Bartolini, B.; Hascall, V.C.; Tammi, M.; De Luca, G.; Passi, A.
Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis
J. Biol. Chem.
287
35544-35555
2012
Homo sapiens
brenda
Rilla, K.; Oikari, S.; Jokela, T.A.; Hyttinen, J.M.; Kaernae, R.; Tammi, R.H.; Tammi, M.I.
Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3
J. Biol. Chem.
288
5973-5983
2013
Homo sapiens (O00219), Homo sapiens (Q92819), Homo sapiens (Q92839), Homo sapiens
brenda
Pure, E.; Krolikoski, M.; Monslow, J.
Role for hyaluronan synthase 3 in the response to vascular injury
Arterioscler. Thromb. Vasc. Biol.
36
224-225
2016
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
brenda
Siiskonen, H.; Kaernae, R.; Hyttinen, J.M.; Tammi, R.H.; Tammi, M.I.; Rilla, K.
Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat
Exp. Cell Res.
320
153-163
2014
Homo sapiens
brenda
Takabe, P.; Bart, G.; Ropponen, A.; Rilla, K.; Tammi, M.; Tammi, R.; Pasonen-Seppaenen, S.
Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion
Exp. Cell Res.
337
1-15
2015
Homo sapiens
brenda
Siiskonen, H.; Oikari, S.; Pasonen-Seppaenen, S.; Rilla, K.
Hyaluronan synthase 1: a mysterious enzyme with unexpected functions
Front. Immunol.
6
43
2015
Homo sapiens (Q92839)
brenda
Passi, A.; Vigetti, D.; Buraschi, S.; Iozzo, R.V.
Dissecting the role of hyaluronan synthases in the tumor microenvironment
FEBS J.
286
2937-2949
2019
Mus musculus (P70312), Homo sapiens (Q92819)
brenda
Yoshida, H.; Aoki, M.; Komiya, A.; Endo, Y.; Kawabata, K.; Nakamura, T.; Sakai, S.; Sayo, T.; Okada, Y.; Takahashi, Y.
HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts
J. Biol. Chem.
295
2483-2494
2020
Homo sapiens (Q92819), Homo sapiens
brenda
Mehic, M.; de Sa, V.K.; Hebestreit, S.; Heldin, C.H.; Heldin, P.
The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function
Oncogenesis
6
e348
2017
Homo sapiens (Q92819), Homo sapiens
brenda
Yang, Y.M.; Noureddin, M.; Liu, C.; Ohashi, K.; Kim, S.Y.; Ramnath, D.; Powell, E.E.; Sweet, M.J.; Roh, Y.S.; Hsin, I.F.; Deng, N.; Liu, Z.; Liang, J.; Mena, E.; Shouhed, D.; Schwabe, R.F.; Jiang, D.; Lu, S.C.; Noble, P.W.; Seki, E.
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis
Sci. Transl. Med.
11
eaat9284
2019
Mus musculus (P70312), Mus musculus, Homo sapiens (Q92819), Homo sapiens
brenda