Information on EC 2.4.1.212 - hyaluronan synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
2.4.1.212
-
RECOMMENDED NAME
GeneOntology No.
hyaluronan synthase
SYSTEMATIC NAME
IUBMB Comments
Alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase
The enzyme from Streptococcus Group A and Group C requires Mg2+. The enzyme adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc [3]. The enzyme is highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA. Similar enzymes have been found in a variety of organisms.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
CHAS2
-
-
-
-
CHAS3
-
-
-
-
DG42 protein
-
-
-
-
HA synthase
-
-
-
-
HA synthase
-
-
HA synthase
Q92819
-
HA synthase
-
-
HA synthase
Pasteurella multocida type A
-
-
-
HA synthase
-
-
HA synthase
-
-
HAS
-
three isoforms, HAS1, HAS2, HAS3
HAS
-
-
HAS
Q27J86, Q27J87, Q27J88
-
HAS
Pasteurella multocida type A
-
-
-
HAS
O35776, Q8CH92, Q8CH93
-
HAS-1
-
-
HAS-1
Mus musculus C57Bl/6
-
-
-
HAS1
Q61647
-
HAS1
Q27J88
-
Has2
-
-
Has2
P70312
-
Has2
Q27J87
-
Has2
-
-
Has3
Q96RV2
-
Has3
-
-
Has3
O08650
-
Has3
Q27J86
-
HsHAS1
-
-
HuHAS1
-
-
-
-
hyaluronan synthase
Q92819, Q92839, Q96RV2
-
hyaluronan synthase
-
-
hyaluronan synthase
-
-
hyaluronan synthase
Q7BLV3
-
hyaluronan synthase
-
-
hyaluronan synthase
-
-
hyaluronan synthase 1
-
-
hyaluronan synthase 1
Q92839
-
hyaluronan synthase 2
-
-
hyaluronan synthase 2
Q92819
-
hyaluronan synthase 2
-
-
hyaluronan synthase 3
O00219
-
hyaluronan synthase-1
-
-
hyaluronan synthase-1
Mus musculus C57Bl/6
-
-
-
hyaluronan synthase-2
Q92819
-
hyaluronan synthases
Q27J86, Q27J87, Q27J88
-
hyaluronan synthethase
-
-
-
-
hyaluronate synthase
-
-
-
-
hyaluronate synthetase
-
-
-
-
hyaluronic acid synthase
-
-
-
-
PmHAS
Q7BLV3
-
XHAS1
-
-
-
-
XHAS2
-
-
-
-
XHAS3
-
-
-
-
hyaluronic acid synthetase
-
-
-
-
additional information
-
the enzyme of Pasteurella multocida belongs to the group of class II hyaluronan synthases
additional information
-
enzyme belongs to class I of hyaluronan synthases
additional information
-
the enzyme belongs to the class I hyaluronan synthases
additional information
-
the enzyme belongs to the group of class I hyaluronan synthases
additional information
-
enzyme belongs to class I of hyaluronan synthases
additional information
-
the enzyme belongs to the group of class I hyaluronan synthases
additional information
-
the enzyme of Streptococcus pyogenes belongs to the group of class I hyaluronan synthases
CAS REGISTRY NUMBER
COMMENTARY
39346-43-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
3 isozymes HAS1, HAS2, and HAS3 encoded by genes HAS1, HAS2, and HAS3
-
-
Manually annotated by BRENDA team
isoform HAS1
SwissProt
Manually annotated by BRENDA team
isoform HAS1; patients with multiple myeloma and Waldenstrom macroglobulinemia
SwissProt
Manually annotated by BRENDA team
isozyme HAS1
SwissProt
Manually annotated by BRENDA team
isozyme HAS2
-
-
Manually annotated by BRENDA team
isozyme HAS2
SwissProt
Manually annotated by BRENDA team
isozyme HAS3
SwissProt
Manually annotated by BRENDA team
isozymes HAS1, HAS2 and HAS3
-
-
Manually annotated by BRENDA team
recombinant
SwissProt
Manually annotated by BRENDA team
sequence used for preparation of siRNA
SwissProt
Manually annotated by BRENDA team
sequence used for preparation of siRNA
Q96RV2
UniProt
Manually annotated by BRENDA team
3 isozymes HAS1, HAS2, and HAS3 encoded by genes HAS1, HAS2, and HAS3
-
-
Manually annotated by BRENDA team
isozymes HAS2 and HAS3
-
-
Manually annotated by BRENDA team
pregnant mice, 3 isozymes HAS1, HAS2, and HAS3
-
-
Manually annotated by BRENDA team
Mus musculus C57Bl/6
-
-
-
Manually annotated by BRENDA team
HAS1 fragment; Spinifex hopping mouse
Q27J88
UniProt
Manually annotated by BRENDA team
HAS2 fragment; Spinifex hopping mouse
UniProt
Manually annotated by BRENDA team
HAS3 fragment; Spinifex hopping mouse
UniProt
Manually annotated by BRENDA team
avian pathogen, class II enzyme
-
-
Manually annotated by BRENDA team
Pasteurella multocida type A
type A
-
-
Manually annotated by BRENDA team
female Sprague-Dawley rat
-
-
Manually annotated by BRENDA team
isoform HAS2
SwissProt
Manually annotated by BRENDA team
isozyme HAS1; 3 isozymes HAS1, HAS2, and HAS3
SwissProt
Manually annotated by BRENDA team
isozyme HAS2; isozyme HAS2
SwissProt
Manually annotated by BRENDA team
isozyme HAS3
SwissProt
Manually annotated by BRENDA team
class I enzyme
-
-
Manually annotated by BRENDA team
human pathogen, single gene hasA in the has operon, class I enzyme
-
-
Manually annotated by BRENDA team
isozyme HAS1
-
-
Manually annotated by BRENDA team
Xenopus laevis protein DG42
-
-
-
Manually annotated by BRENDA team
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
120
-
UDP-D-glucuronate
-
recombinant enzyme, pH 7.0, 30C
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
4.5
-
ethylene glycol
-
recombinant enzyme, pH 7.0, 30C
3.3
-
glycerol
-
recombinant enzyme, pH 7.0, 30C
3.5
-
PEG 20000
-
recombinant enzyme, pH 7.0, 30C
1.2
-
Sucrose
-
recombinant enzyme, pH 7.0, 30C
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5.5
-
-
1 h, at 30C, loss of 74-90% activity
11.5
-
-
1 h, at 30C, loss of 40-50% activity
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
-
the enzyme is temperature labile, but is stabilized by substrate and cardiolipin