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Information on EC 2.4.1.182 - lipid-A-disaccharide synthase and Organism(s) Legionella pneumophila and UniProt Accession Q5WSK6

for references in articles please use BRENDA:EC2.4.1.182
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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.182 lipid-A-disaccharide synthase
IUBMB Comments
Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC 2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria.
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This record set is specific for:
Legionella pneumophila
UNIPROT: Q5WSK6
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Word Map
The taxonomic range for the selected organisms is: Legionella pneumophila
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine
+
=
+
a lipid A disaccharide
Synonyms
lipid a disaccharide synthase, lcsc/lpxb1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lcsC
paralogue of the lipid A disaccharide synthase lpxB, lpxB1 forms a transcriptional unit with gnnA encoding a putative UDP-GlcNAc oxidase
Legionella cytotoxic suppressor C
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lcsC
paralogue of the lipid A disaccharide synthase lpxB, lpxB1 forms a transcriptional unit with gnnA encoding a putative UDP-GlcNAc oxidase
Legionella cytotoxic suppressor C
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lipid A disaccharide synthase
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synthase, lipid A disaccharide
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additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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-
-
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PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine:2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine 1-phosphate 2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosaminyltransferase
Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC 2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria.
CAS REGISTRY NUMBER
COMMENTARY hide
105843-81-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
IpxB2, strain Lens; strains Philadelphia-1, Paris, and Lens, preferentially expressed in the exponential and early stationary phases, Acanthamoeba castellanii used as a host cell, construction of a insertion deletion
UniProt
Manually annotated by BRENDA team
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli MN7 (temperature sensitive lpxB mutant), expression of protein complements growth at 30 and 42°C
expressed in Escherichia coli MN7 (temperature sensitive lpxB mutant), expression of protein complements growth at 30 and 42°C
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Albers, U.; Tiaden, A.; Spirig, T.; Al Alam, D.; Goyert, S.M.; Gangloff, S.C.; Hilbi, H.
Expression of Legionella pneumophila paralogous lipid A biosynthesis genes under different growth conditions
Microbiology
153
3817-3829
2007
Legionella pneumophila (Q5WSK6), Legionella pneumophila (Q5WWX7), Legionella pneumophila (Q5X5J5), Legionella pneumophila
Manually annotated by BRENDA team