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chondroitin galactosaminyltransferase
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acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, II
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bifunctional CS synthase
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chondroitin galactosaminyltransferase
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chondroitin N-acetylgalactosaminyltransferase-1
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chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1
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chondroitin sulfate glucuronyltransferase
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chondroitin sulfate glycosyltransferase
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chondroitin sulfate N-acetylgalactosaminyltransferase-2
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chondroitin sulfate synthase 1
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chondroitin sulfate synthase-1
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chondroitin sulfate synthase-3
chondroitin synthase 1
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chondroitin synthase-1
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chondroitin synthase-2
based on the experimental results chondroitin sulfate synthase-3 is renamed into chondroitin synthase-2
chondroitin synthase-3
based on the experimental results CSGlcA-T renamed into chondroitin synthase-3
CS glycosyltransferase
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glucuronyl-N-acetylgalactosaminylproteoglycan beta1,4-N-acetylgalactosaminyltransferase
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N-acetylgalactosaminyltransferase II
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UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
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uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferasec II
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chondroitin sulfate synthase-3
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chondroitin sulfate synthase-3
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chondroitin synthase
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CHSY1
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CSS3
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additional information
the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
see also EC 2.4.1.226
additional information
the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
additional information
see also EC 2.4.1.226
additional information
the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
additional information
the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
additional information
the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
additional information
the enzyme shows no 3-beta-glucuronosyltransferase activity, EC 2.4.1.226
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
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UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
involved in chondroitin biosynthesis
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-
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain
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?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
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?
alpha-thrombomodulin + UDP-N-acetyl-D-galactosamine + UDP-glucuronic acid
?
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?
chondroitin + UDP-GalNAc
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chondroitin is the best substrate
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?
chondroitin + UDP-glucuronic acid
?
chondroitin is the best substrate
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?
chondroitin sulfate A + UDP-GalNAc
?
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?
chondroitin sulfate A + UDP-glucuronic acid
?
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?
chondroitin sulfate A10 + UDP-GalNAc
?
no activity with UDP-glucuronic acid
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?
chondroitin sulfate A11 + UDP-glucuronic acid
?
no activity with UDP-GalNAc
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?
chondroitin sulfate C + UDP-GalNAc
?
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?
chondroitin sulfate C + UDP-glucuronic acid
?
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?
chondroitin sulfate C10 + UDP-GalNAc
?
no activity with UDP-glucuronic acid
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?
chondroitin sulfate C11 + UDP-glucuronic acid
?
no activity with UDP-GalNAc
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?
chondroitin sulfate D + UDP-GalNAc
?
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?
chondroitin sulfate D + UDP-glucuronic acid
?
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?
chondroitin sulfate E + UDP-GalNAc
?
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?
chondroitin sulfate E + UDP-glucuronic acid
?
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?
dermatan sulfate + UDP-GalNAc
?
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?
dermatan sulfate + UDP-glucuronic acid
?
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?
GlcUAbeta1-3Galbeta1-O-C2H4NH-benzyloxycarbonyl + UDP-glucuronic acid
?
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?
GlcUAbeta1-3Galbeta1-O-C2H4NH-benzyloxycarbonyl + UDP-N-acetyl-D-galactosamine
?
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?
GlcUAbeta1-3Galbeta1-O-naphthalenemethanol + UDP-glucuronic acid
?
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?
GlcUAbeta1-3Galbeta1-O-naphthalenemethanol + UDP-N-acetyl-D-galactosamine
?
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?
hyaluronan + UDP-GalNAc
?
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?
hyaluronan + UDP-glucuronic acid
?
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?
UDP-glucuronic acid + chondroitin sulfate CS-11
?
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?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
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?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
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?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)7
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
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?
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
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?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
UDP-N-acetyl-D-galactosamine + chondroitin polysaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin polysaccharide
best acceptor substrate
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?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate C
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate C
11% activity compared to chondroitin
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?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate oligosaccharide
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?
additional information
?
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UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
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?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
low activity
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?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
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?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
low activity
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?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
involved in chondroitin biosynthesis
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?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
involved in chondroitin biosynthesis
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?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain
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?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain
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?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
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?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
low activity
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?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
best acceptor substrate
transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
best acceptor substrate
transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
acceptors are even-numbered chondroitin oligosaccharides with terminal glucuronyl-N-acetyl-1,3-beta-D-galactosamine sequence at non-reducing end, transfers N-acetyl-galactosamine to non-reducing glucuronic acid residues in beta-glycosidic linkage
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?
additional information
?
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the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
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?
additional information
?
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the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
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?
additional information
?
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low activity with sulfated oligosaccharide substrates
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?
additional information
?
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the enzyme shows no 3-beta-glucuronosyltransferase activity, EC 2.4.1.226
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?
additional information
?
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the enzyme shows no 3-beta-glucuronosyltransferase activity, EC 2.4.1.226
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?
additional information
?
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the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
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?
additional information
?
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the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
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?
additional information
?
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the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
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?
additional information
?
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chondroitin sulfates A, C, D, and E, and dermatan sulfate are poor acceptor substrates
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?
additional information
?
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the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
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?
additional information
?
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chondroitin sulfate A and D are very poor acceptor substrates
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?
additional information
?
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CSS3 is a glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities. It may make a contribution to CS biosynthesis that differs from that of CSS1
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?
additional information
?
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enzyme exhibits the glucuronyltransferase-II (GlcAT-II) and N-acetylgalactosaminyltransferase-II (GalNAcT-II) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate. Chondroitin polymerizing factor (ChPF) is required for chondroitin polymerizing activity
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?
additional information
?
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glucuronyltransferase and N-acetylgalactosaminyltransferase activities are observed when chondroitin, chondroitin sulfate polymer, and their corresponding oligosaccharides are used as the acceptor substrates, reaction products were shown to have a GlcAbeta(13)GalNAc linkage and a GalNAbeta(14)GlcA linkage in the nonreducing terminus of chondroitin
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?
additional information
?
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possess N-acetylgalactosaminyltransferase-II and glucuronyltransferase-II activities responsible for the elongation of chondroitin sulfate chains but cannot polymerize chondroitin chains by themselves
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?
additional information
?
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experimental data suggest that enzyme acts as a chondroitin polymerase through its interaction with other ChSy family members in the Golgi apparatus
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?
additional information
?
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experimental data suggest that enzyme acts as a chondroitin polymerase through its interaction with other ChSy family members in the Golgi apparatus
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?
additional information
?
-
chondroitin synthase-1 has two glycosyltransferase activities: it acts as a GlcUA and a GalNAc transferase and is responsible for adding repeated disaccharide units to growing chondroitin sulfate chains
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?
additional information
?
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chondroitin synthase-1 has two glycosyltransferase activities: it acts as a GlcUA and a GalNAc transferase and is responsible for adding repeated disaccharide units to growing chondroitin sulfate chains
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?
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UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
involved in chondroitin biosynthesis
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
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-
-
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
additional information
?
-
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
involved in chondroitin biosynthesis
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
involved in chondroitin biosynthesis
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain
-
-
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain
-
-
?
additional information
?
-
CSS3 is a glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities. It may make a contribution to CS biosynthesis that differs from that of CSS1
-
-
?
additional information
?
-
enzyme exhibits the glucuronyltransferase-II (GlcAT-II) and N-acetylgalactosaminyltransferase-II (GalNAcT-II) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate. Chondroitin polymerizing factor (ChPF) is required for chondroitin polymerizing activity
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-
?
additional information
?
-
possess N-acetylgalactosaminyltransferase-II and glucuronyltransferase-II activities responsible for the elongation of chondroitin sulfate chains but cannot polymerize chondroitin chains by themselves
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-
?
additional information
?
-
experimental data suggest that enzyme acts as a chondroitin polymerase through its interaction with other ChSy family members in the Golgi apparatus
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-
?
additional information
?
-
-
experimental data suggest that enzyme acts as a chondroitin polymerase through its interaction with other ChSy family members in the Golgi apparatus
-
-
?
additional information
?
-
chondroitin synthase-1 has two glycosyltransferase activities: it acts as a GlcUA and a GalNAc transferase and is responsible for adding repeated disaccharide units to growing chondroitin sulfate chains
-
-
?
additional information
?
-
-
chondroitin synthase-1 has two glycosyltransferase activities: it acts as a GlcUA and a GalNAc transferase and is responsible for adding repeated disaccharide units to growing chondroitin sulfate chains
-
-
?
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evolution
the enzyme is a member of the ChSy family
metabolism
the biosynthesis of chondroitin sulfate (CS) chains begins with the formation of a link between N-acetylgalactosamine (GalNAc) and a common tetrasaccharide structure at a serine residue on the core protein. The next step (polymerization) is catalyzed by a group of bifunctional enzymes that have beta1-3 glucuronosyltransferase and beta1-4 N-acetylgalactosaminyltransferase activities. A single CS chain can consist of up to 50 repeating GlcA-GalNAc subunits, which are modified with sulfate groups at various positions. Three bifunctional CS synthases, CHSY1, CHPF (CHSY2), and CHSY3, control polymerization of CS chains
malfunction
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knockdown of chondroitin expression results in the inhibition of fibroblast proliferation, adhesion and migration, as well as an increasing the number of cells that were arrested in the G2/M phase
malfunction
missense mutations in the ChGn-1 gene results in an altered amount of chondroitin sulfate proteoglycans
malfunction
two missense mutations occur in the CHSY1 gene in patients with neuropathy. These mutations are associated with a profound decrease in enzyme activity. The chondroitin synthase-1 F362S mutation in a patient with neuropathy results in a decrease in chondroitin polymerization activity and the mutant protein is defective in regulating the number of chondroitin sulfate chains via CHSY1. The progression of peripheral neuropathies may result from defects in these regulatory systems
malfunction
chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell (ASMC) migration through attenuating PDGFR phosphorylation. Effects of CHPF gene deletion on the development of atherosclerosis, overview
malfunction
correlation between clinicopathological features and expression of CS synthases in glioma patients. We explore the changes of cell surface CS and its contribution to malignant growth of glioma cells, by manipulating CS Synthase 1 (CHSY1) expression. Overexpression of CHSY1 inhibits PDGF-triggered decrease in PDGFRA levels, whereas CHSY1 knockdown accelerates PDGFRA decrease following PDGF stimulation. PDGFRA is highly expressed on the cell membrane of CHSY1-overexpressing GL261 tumor tissue sections. PDGFRA inhibition reverses CHSY1-mediated tumor growth in vitro and in vivo
physiological function
ChGn-1 is a key enzyme for production of chondroitin sulfate proteoglycans
physiological function
chondroitin sulfate synthase 1 (CHSY1) is the key biosynthetic enzyme forming the repeating chondroitin sulfate backbone disaccharide structure [4GlcAbeta1-3GalNAcbeta1], and polymerization of chondroitin chain by CHSY1 requires chondroitin polymerizing factors, including CHPF and CHPF2. The bifunctional enzyme CHSY1 exhibits both GlcAT-II and GalNAc-II activities
physiological function
the enzyme initiates the elongation of chondroitin sulfate chains
physiological function
chondroitin sulfate N-acetylgalactosaminyltransferase-2 (ChGn-2) is a vital Golgi transferase that participates in enzymatic elongation of GAGs. ChGn-2 is functionally involved in the progression of atherosclerosis both in its early and advanced stages. Crucial contributions of ChGn-2 for LDL retention in the intima. Platelet-derived growth factor (PDGF) signaling is heavily involved in the development of plaques and directly regulates SMCs via platelet-derived growth factor receptor, PDGFR-beta, phosphorylation to promote phenotypic changes including smooth muscle cell migration, enzyme chondroitin sulfate N-acetylgalactosaminyltransferase-2 has a regulatory function
physiological function
CHSY1 selectively modulates platelet derived growth factor receptor alpha (PDGFRA) signaling, and that survival of a mouse model of a CHSY1-expressing tumor is increased by using a PDGFR inhibitor. CHSY1 mediates CS formation in glioma cells. CHSY1 is a crucial enzyme to modulate CS formation in GBM cells in vitro. CHSY1 is a crucial enzyme to modulate CS formation in GBM cells in vitro. CHSY1 selectively regulates the PDGFRA pathway and enhances PDGFRA protein stability in glioblastoma cells
physiological function
the glycosyltransferase chondroitin sulfate synthase 1 (CHSY1) specifically functions in biosynthesis of the glycans chondroitin sulfate. The bifunctional CHSY1 exhibits both GlcAT-II and GalNAc-II activities, thus forming the GlcA-GalNAc disaccharide structure specific for chondroitin sulfate
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Gotoh, M.; Sato, T.; Akashima, T.; Iwasaki, H.; Kameyama, A.; Mochizuki, H.; Yada, T.; Inaba, N.; Zhang, Y.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Nishihara, S.; Watanabe, H.; Kimata, K.; Narimatsu, H.
Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis
J. Biol. Chem.
277
38189-38196
2002
Homo sapiens (Q8TDX6)
brenda
Uyama, T.; Kitagawa, H.; Tamura, J.I.; Sugahara, K.
Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase. The key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate
J. Biol. Chem.
277
8841-8846
2002
Homo sapiens (Q8TDX6)
brenda
Uyama, T.; Kitagawa, H.; Tanaka, J.; Tamura, J.i.; Ogawa, T.; Sugahara, K.
Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate
J. Biol. Chem.
278
3072-3078
2003
Homo sapiens (Q8N6G5), Homo sapiens (Q8TDX6)
brenda
Kitagawa, H.; Uyama, T.; Sugahara, K.
Molecular cloning and expression of a human chondroitin synthase
J. Biol. Chem.
276
38721-38726
2001
Homo sapiens (Q86X52)
brenda
Kitagawa, H.; Izumikawa, T.; Uyama, T.; Sugahara, K.
Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization
J. Biol. Chem.
278
23666-23671
2003
Homo sapiens (Q8IZ52)
brenda
Yada, T.; Sato, T.; Kaseyama, H.; Gotoh, M.; Iwasaki, H.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Watanabe, H.; Narimatsu, H.; Kimata, K.
Chondroitin sulfate synthase-3. Molecular cloning and characterization
J. Biol. Chem.
278
39711-39725
2003
Homo sapiens (Q70JA7)
brenda
Izumikawa, T.; Uyama, T.; Okuura, Y.; Sugahara, K.; Kitagawa, H.
Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor
Biochem. J.
403
545-552
2007
Homo sapiens (A2V663)
brenda
Izumikawa, T.; Koike, T.; Shiozawa, S.; Sugahara, K.; Tamura, J.; Kitagawa, H.
Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members
J. Biol. Chem.
283
11396-11406
2008
Homo sapiens (Q70JA7), Homo sapiens
brenda
Zou, X.H.; Jiang, Y.Z.; Zhang, G.R.; Jin, H.M.; Nguyen, T.M.; Ouyang, H.W.
Specific interactions between human fibroblasts and particular chondroitin sulfate molecules for wound healing
Acta Biomater.
5
1588-1595
2009
Homo sapiens
brenda
Tew, S.R.; Pothacharoen, P.; Katopodi, T.; Hardingham, T.E.
SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription
Biochem. J.
414
231-236
2008
Homo sapiens
brenda
Izumikawa, T.; Saigoh, K.; Shimizu, J.; Tsuji, S.; Kusunoki, S.; Kitagawa, H.
A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1
Biochim. Biophys. Acta
1830
4806-4812
2013
Homo sapiens (Q86X52), Homo sapiens
brenda
Momose, T.; Yoshimura, Y.; Harumiya, S.; Isobe, K.; Kito, M.; Fukushima, M.; Kato, H.; Nakayama, J.
Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance
Hum. Pathol.
50
15-23
2016
Homo sapiens (Q86X52)
brenda
Saigoh, K.; Yoshimura, S.; Izumikawa, T.; Miyata, S.; Tabara, Y.; Matsushita, T.; Miki, T.; Miyamoto, K.; Hirano, M.; Kitagawa, H.; Kira, J.I.; Kusunoki, S.
Chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: association with progression of multiple sclerosis
Neurosci. Res.
108
55-59
2016
Homo sapiens (Q86X52)
brenda
Adhikara, I.M.; Yagi, K.; Mayasari, D.S.; Ikeda, K.; Kitagawa, H.; Miyata, O.; Igarashi, M.; Hatakeyama, K.; Asada, Y.; Hirata, K.I.; Emoto, N.
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration
Biochem. Biophys. Res. Commun.
509
89-95
2019
Homo sapiens (Q8IZ52), Mus musculus (Q6IQX7), Mus musculus C57BL/6J (Q6IQX7)
brenda
Momose, T.; Yoshimura, Y.; Harumiya, S.; Isobe, K.; Kito, M.; Fukushima, M.; Kato, H.; Nakayama, J.
Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance
Hum. Pathol.
50
15-23
2016
Homo sapiens (Q86X52)
brenda
Liao, W.C.; Liao, C.K.; Tseng, T.J.; Ho, Y.J.; Chen, Y.R.; Lin, K.H.; Lai, T.J.; Lan, C.T.; Wei, K.C.; Liu, C.H.
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability
Oncogenesis
9
9
2020
Homo sapiens (Q86X52)
brenda