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UDP-glucuronosyltransferase
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uridine diphosphate glucuronosyltransferase
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1-naphthol glucuronyltransferase
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1-naphthol-UDP-glucuronosyltransferase
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17-OH steroid UDPGT
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-
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17beta-hydroxysteroid UDP-glucuronosyltransferase
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-
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3-OH androgenic UDPGT
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-
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3alpha-hydroxysteroid UDP-glucuronosyltransferase
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-
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4-hydroxybiphenyl UDP-glucuronosyltransferase
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-
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4-methylumbelliferone UDP-glucuronosyltransferase
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-
-
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4-nitrophenol UDP-glucuronosyltransferase
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-
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4-nitrophenol UDP-glucuronyltransferase
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-
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4-nitrophenol UDPGT
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bile acid uridine 5'-diphosphoglucuronyltransferase
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bilirubin glucuronyltransferase
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bilirubin monoglucuronide glucuronyltransferase
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bilirubin UDP-glucuronosyltransferase
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bilirubin UDPglucuronosyltransferase
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bilirubin uridine diphosphoglucuronyltransferase
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ciramadol UDP-glucuronyltransferase
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estriol UDP-glucuronosyltransferase
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estrone UDP-glucuronosyltransferase
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glucuronosyltransferase, uridine diphospho-
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glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol
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glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl
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glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin
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-
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glucuronosyltransferase, uridine diphosphoglucuronate-estradiol
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glucuronosyltransferase, uridine diphosphoglucuronate-estriol
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glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-
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glucuronyltransferase, uridine diphospho-GT
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morphine glucuronyltransferase
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-
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p-hydroxybiphenyl UDP glucuronyltransferase
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-
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p-nitrophenol UDP-glucuronosyltransferase
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-
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p-nitrophenol UDP-glucuronyltransferase
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p-nitrophenylglucuronosyltransferase
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p-phenylphenol glucuronyltransferase
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phenyl-UDP-glucuronosyltransferase
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UDP glucuronate-estradiol-glucuronosyltransferase
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UDP glucuronate-estriol glucuronosyltransferase
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UDP glucuronic acid transferase
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UDP glucuronosyltransferase
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UDP glucuronyltransferase
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UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase
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UDP-glucuronate-bilirubin glucuronyltransferase
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UDP-glucuronosyltransferase
UDP-glucuronyltransferase
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UDPGA transferase
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UDPGA-glucuronyltransferase
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UDPglucuronate beta-D-glucuronosyltransferase
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UDPglucuronosyltransferase
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uridine 5'-diphosphoglucuronyltransferase
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uridine diphosphate glucuronyltransferase
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uridine diphosphoglucuronate-bilirubin glucuronosyltransferase
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uridine diphosphoglucuronosyltransferase
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uridine diphosphoglucuronyltransferase
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additional information
enzyme belongs to the 2B subfamily
UDP-glucuronosyltransferase
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UDP-glucuronosyltransferase
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UDP-glucuronosyltransferase
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naproxen + UDP-glucuronate
naproxen glucuronide + UDP
-
-
-
?
UDP-alpha-D-glucuronate + (S)-naproxen
UDP + beta-D-glucuronosyl (S)-naproxen
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low activity
-
?
UDP-glucuronate + 1-naphthol
UDP + beta-D-glucuronosyl-(1-naphthol)
-
-
-
?
UDP-glucuronate + 4-ethylphenol
UDP + beta-D-glucuronosyl-(4-ethylphenol)
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
-
-
-
?
UDP-glucuronate + 4-nitrophenol
UDP + beta-D-glucuronosyl-(4-nitrophenol)
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-
-
?
UDP-glucuronate + androstane-3,17-diol
UDP + beta-D-glucuronosyl-androstane-3,17-diol
-
-
-
?
UDP-glucuronate + eugenol
UDP + beta-D-glucuronosyl-eugenol
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-
-
?
UDP-glucuronate + gemfibrozil
UDP + beta-D-glucuronosyl-gemfibrozil
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-
-
?
UDP-glucuronate + ketoprofen
UDP + beta-D-glucuronosyl-ketoprofen
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low activity
-
?
UDP-glucuronate + lorazepam
UDP + beta-D-glucuronosyl-lorazepam
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-
-
?
UDP-glucuronate + morphine 3-glucuronide
UDP + morphine 3,6-diglucuronide
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-
-
?
UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
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-
-
?
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
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-
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
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-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
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-
formation of 2 product metabolites termed G1 and G2
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
UDP-glucuronate + epitestosterone
UDP + epitestosterone beta-D-glucuronoside
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-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
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-
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
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-
-
-
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
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-
-
-
?
UDP-glucuronate + testosterone
UDP + testosterone beta-D-glucuronoside
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-
-
?
additional information
?
-
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
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-
-
?
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
very low activity
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-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
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-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
low activity
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-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
good substrate
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
higher activity
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-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
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-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
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-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
low activity
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-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
high activity
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-
?
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
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-
-
?
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
very low activity
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-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
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-
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
very low activity
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-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
low activity
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-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
high activity
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-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
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-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
very low activity
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-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
low activity
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-
?
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
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-
-
?
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
low activity
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?
additional information
?
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enzyme UGT2B31 plays a crucial role in drug detoxificiation
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?
additional information
?
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enzyme UGT2B31 plays a crucial role in drug detoxificiation
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?
additional information
?
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substrate specificity, no substrates are hyodeoxycholic acid, lithocholic acid, diclofenac, furosemide, ibuprofen, valproic acid, codeine, hydromorphone, morphine 6-glucuronide, propofol, ethinylestradiol, and testosterone
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?
additional information
?
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substrate specificity, no substrates are hyodeoxycholic acid, lithocholic acid, diclofenac, furosemide, ibuprofen, valproic acid, codeine, hydromorphone, morphine 6-glucuronide, propofol, ethinylestradiol, and testosterone
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-
?
additional information
?
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no activity with bilirubin, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview
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-
?
additional information
?
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no activity with bilirubin, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview
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?
additional information
?
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no activity with imipramine
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?
additional information
?
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no or poor activity with 4-methylumbelliferone, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview
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-
?
additional information
?
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no or poor activity with 4-methylumbelliferone, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview
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-
?
additional information
?
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no or poor activity with bilirubin, ethinylestradiol, 17-alpha-estradiol, 17-beta-estradiol, levomedetomidine, dexmedetomidine, diclofenac, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
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-
?
additional information
?
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no or poor activity with bilirubin, ethinylestradiol, 17-alpha-estradiol, 17-beta-estradiol, levomedetomidine, dexmedetomidine, diclofenac, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
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no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
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-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
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no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, and (R)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, and (R)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
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-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, indomethacin, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, indomethacin, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with bilirubin,levomedetomidine, dexmedetomidine, diclofenac, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin,levomedetomidine, dexmedetomidine, diclofenac, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with levomedetomidine, 4-methylumbelliferone, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with levomedetomidine, 4-methylumbelliferone, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
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Soars, M.G.; Fettes, M.; O'Sullivan, A.C.; Riley, R.J.; Ethell, B.T.; Burchell, B.
Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily
Biochem. Pharmacol.
65
1251-1259
2003
Homo sapiens, Canis lupus familiaris (Q6K1J1), Canis lupus familiaris
brenda
Kaji, H.; Kume, T.
Regioselective glucuronidation of denopamine: marked species differences and identification of human UDP-glucuronosyltransferase isoform
Drug Metab. Dispos.
33
403-412
2005
Canis lupus familiaris, Oryctolagus cuniculus, Macaca fascicularis, Homo sapiens, Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Rattus norvegicus
brenda
Higashi, E.; Ando, A.; Iwano, S.; Murayama, N.; Yamazaki, H.; Miyamoto, Y.
Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig
Biopharm. Drug Dispos.
35
313-320
2014
Canis lupus familiaris, Macaca fascicularis, Mus musculus, Rattus norvegicus, Sus scrofa, Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens
brenda
Troberg, J.; Jaervinen, E.; Muniz, M.; Sneitz, N.; Mosorin, J.; Hagstroem, M.; Finel, M.
Dog UDP-glucuronosyltransferase enzymes of subfamily 1A: cloning, expression, and activity
Drug Metab. Dispos.
43
107-118
2015
Canis lupus familiaris, Canis lupus familiaris (Q95M37), Homo sapiens (O60656), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P35504), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
brenda