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Information on EC 2.4.1.17 - glucuronosyltransferase and Organism(s) Canis lupus familiaris and UniProt Accession Q6K1J1

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.17 glucuronosyltransferase
IUBMB Comments
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
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This record set is specific for:
Canis lupus familiaris
UNIPROT: Q6K1J1
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Word Map
The taxonomic range for the selected organisms is: Canis lupus familiaris
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
ugt1a1, udp-glucuronosyltransferase, ugt2b7, ugt1a9, ugt1a6, ugt1a, ugt2b17, ugt1a4, udp-glucuronyltransferase, udpgt, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
UDP-glucuronosyltransferase
-
uridine diphosphate glucuronosyltransferase
-
1-naphthol glucuronyltransferase
-
-
-
-
1-naphthol-UDP-glucuronosyltransferase
-
-
-
-
17-OH steroid UDPGT
-
-
-
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17beta-hydroxysteroid UDP-glucuronosyltransferase
-
-
-
-
3-OH androgenic UDPGT
-
-
-
-
3alpha-hydroxysteroid UDP-glucuronosyltransferase
-
-
-
-
4-hydroxybiphenyl UDP-glucuronosyltransferase
-
-
-
-
4-methylumbelliferone UDP-glucuronosyltransferase
-
-
-
-
4-nitrophenol UDP-glucuronosyltransferase
-
-
-
-
4-nitrophenol UDP-glucuronyltransferase
-
-
-
-
4-nitrophenol UDPGT
-
-
-
-
bile acid uridine 5'-diphosphoglucuronyltransferase
-
-
-
-
bilirubin glucuronyltransferase
-
-
-
-
bilirubin monoglucuronide glucuronyltransferase
-
-
-
-
bilirubin UDP-glucuronosyltransferase
-
-
-
-
bilirubin UDPglucuronosyltransferase
-
-
-
-
bilirubin UDPGT
-
-
-
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bilirubin uridine diphosphoglucuronyltransferase
-
-
-
-
ciramadol UDP-glucuronyltransferase
-
-
-
-
estriol UDP-glucuronosyltransferase
-
-
-
-
estrone UDP-glucuronosyltransferase
-
-
-
-
glucuronosyltransferase, uridine diphospho-
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estradiol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estriol
-
-
-
-
glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-
-
-
-
-
glucuronyltransferase, uridine diphospho-GT
-
-
-
-
morphine glucuronyltransferase
-
-
-
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p-hydroxybiphenyl UDP glucuronyltransferase
-
-
-
-
p-nitrophenol UDP-glucuronosyltransferase
-
-
-
-
p-nitrophenol UDP-glucuronyltransferase
-
-
-
-
p-nitrophenylglucuronosyltransferase
-
-
-
-
p-phenylphenol glucuronyltransferase
-
-
-
-
phenyl-UDP-glucuronosyltransferase
-
-
-
-
PNP-UDPGT
-
-
-
-
UDP glucuronate-estradiol-glucuronosyltransferase
-
-
-
-
UDP glucuronate-estriol glucuronosyltransferase
-
-
-
-
UDP glucuronic acid transferase
-
-
-
-
UDP glucuronosyltransferase
-
-
-
-
UDP glucuronyltransferase
-
-
-
-
UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase
-
-
-
-
UDP-glucuronate-bilirubin glucuronyltransferase
-
-
-
-
UDP-glucuronosyltransferase
UDP-glucuronyltransferase
-
-
-
-
UDPGA transferase
-
-
-
-
UDPGA-glucuronyltransferase
-
-
-
-
UDPglucuronate beta-D-glucuronosyltransferase
-
-
-
-
UDPglucuronosyltransferase
-
-
-
-
UDPGT
-
-
-
-
uridine 5'-diphosphoglucuronyltransferase
-
-
-
-
uridine diphosphate glucuronyltransferase
-
-
-
-
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase
-
-
-
-
uridine diphosphoglucuronosyltransferase
-
-
-
-
uridine diphosphoglucuronyltransferase
-
-
-
-
additional information
enzyme belongs to the 2B subfamily
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
CAS REGISTRY NUMBER
COMMENTARY hide
37205-52-0
-
37277-52-4
-
37277-66-0
-
61969-98-0
-
62213-43-8
-
62213-47-2
-
9030-08-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
naproxen + UDP-glucuronate
naproxen glucuronide + UDP
show the reaction diagram
-
-
-
?
UDP-alpha-D-glucuronate + (S)-naproxen
UDP + beta-D-glucuronosyl (S)-naproxen
show the reaction diagram
-
low activity
-
?
UDP-glucuronate + 1-naphthol
UDP + beta-D-glucuronosyl-(1-naphthol)
show the reaction diagram
-
-
-
?
UDP-glucuronate + 4-ethylphenol
UDP + beta-D-glucuronosyl-(4-ethylphenol)
show the reaction diagram
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
show the reaction diagram
-
-
-
?
UDP-glucuronate + 4-nitrophenol
UDP + beta-D-glucuronosyl-(4-nitrophenol)
show the reaction diagram
-
-
-
?
UDP-glucuronate + androstane-3,17-diol
UDP + beta-D-glucuronosyl-androstane-3,17-diol
show the reaction diagram
-
-
-
?
UDP-glucuronate + eugenol
UDP + beta-D-glucuronosyl-eugenol
show the reaction diagram
-
-
-
?
UDP-glucuronate + gemfibrozil
UDP + beta-D-glucuronosyl-gemfibrozil
show the reaction diagram
-
-
-
?
UDP-glucuronate + ketoprofen
UDP + beta-D-glucuronosyl-ketoprofen
show the reaction diagram
-
low activity
-
?
UDP-glucuronate + lorazepam
UDP + beta-D-glucuronosyl-lorazepam
show the reaction diagram
-
-
-
?
UDP-glucuronate + morphine 3-glucuronide
UDP + morphine 3,6-diglucuronide
show the reaction diagram
-
-
-
?
UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
show the reaction diagram
-
-
formation of 2 product metabolites termed G1 and G2
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + epitestosterone
UDP + epitestosterone beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + testosterone
UDP + testosterone beta-D-glucuronoside
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
DMSO
-
2% v/v reduces enzyme activity in liver microsomes
additional information
-
no effect by 1% v/v DMSO and 2% v/v methanol on denopamine glucuronidation
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.22
1-naphthol
pH 7.4, 37°C
0.013
androstanediol
pH 7.4, 37°C
0.139
gemfibrozil
pH 7.4, 37°C
1.695
Ketoprofen
pH 7.4, 37°C
1.425
morphine 3-glucuronide
pH 7.4, 37°C
0.58
naproxen
pH 7.4, 37°C
3.51 - 10.18
denopamine
additional information
additional information
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000009
microsomes, substrate ketoprofen
0.000011
microsomes, substrate naproxen
0.000028
microsomes, substrate morphine 3-glucuronide
0.000032
microsomes, substrate 4-nitrophenol
0.000037
microsomes, substrate androstanediol
0.00006
microsomes, substrate lorazepam
0.00007
0.000075
microsomes, substrate 4-methylumbelliferone
0.00008
microsomes, substrate 1-naphthol
0.000082
microsomes, substrate eugenol
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
physiological function
-
glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
UDB31_CANLF
530
1
60706
Swiss-Prot
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, screening of dog cDNA library, expression in chinese hamster lung fibroblast V79 cells, sequence comparison, phylogenetic analysis
gene UGT1A1, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
gene UGT1A10, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
gene UGT1A11, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
gene UGT1A2, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
gene UGT1A3, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
gene UGT1A4, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
gene UGT1A6, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
gene UGT1A7, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
gene UGT1A8, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
gene UGT1A9, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Soars, M.G.; Fettes, M.; O'Sullivan, A.C.; Riley, R.J.; Ethell, B.T.; Burchell, B.
Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily
Biochem. Pharmacol.
65
1251-1259
2003
Homo sapiens, Canis lupus familiaris (Q6K1J1), Canis lupus familiaris
Manually annotated by BRENDA team
Kaji, H.; Kume, T.
Regioselective glucuronidation of denopamine: marked species differences and identification of human UDP-glucuronosyltransferase isoform
Drug Metab. Dispos.
33
403-412
2005
Canis lupus familiaris, Oryctolagus cuniculus, Macaca fascicularis, Homo sapiens, Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Rattus norvegicus
Manually annotated by BRENDA team
Higashi, E.; Ando, A.; Iwano, S.; Murayama, N.; Yamazaki, H.; Miyamoto, Y.
Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig
Biopharm. Drug Dispos.
35
313-320
2014
Canis lupus familiaris, Macaca fascicularis, Mus musculus, Rattus norvegicus, Sus scrofa, Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens
Manually annotated by BRENDA team
Troberg, J.; Jaervinen, E.; Muniz, M.; Sneitz, N.; Mosorin, J.; Hagstroem, M.; Finel, M.
Dog UDP-glucuronosyltransferase enzymes of subfamily 1A: cloning, expression, and activity
Drug Metab. Dispos.
43
107-118
2015
Canis lupus familiaris, Canis lupus familiaris (Q95M37), Homo sapiens (O60656), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P35504), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
Manually annotated by BRENDA team