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Information on EC 2.4.1.133 - xylosylprotein 4-beta-galactosyltransferase and Organism(s) Rattus norvegicus and UniProt Accession P80225
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2.4.1.133 xylosylprotein 4-beta-galactosyltransferaseIUBMB Comments
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
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Word Map
- 2.4.1.133
- proteoglycans
- glycosaminoglycans
- ehlers-danlos
- beta-1,4-galts
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progeroid
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xylosyltransferase
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larsen
- hypermobility
- b3galt6
- laxity
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hypermobl
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reunion
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linkeropathies
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spondylodysplastic
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hyperextensibility
- drug development
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
galt i, b4galt7, galactosyltransferase i, beta-1,4-galt i, beta1,4-galt, beta-1,4-galt v, beta1,4-galt-i, galt-i, beta-1,4-galactosyltransferase i, beta4galt7, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
galactosyltransferase I
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galactosyltransferase, uridine diphosphogalactose-xylose
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UDP-D-galactose:D-xylose galactosyltransferase
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UDP-D-galactose:xylose galactosyltransferase
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UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
hexosyl group transfer
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
CAS REGISTRY NUMBER
COMMENTARY
52227-72-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-galactose + O-beta-D-xylosylprotein
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
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?
additional information
?
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enzyme catalyzes the transfer of galactose from the sugar nucleotide donor uridine diphosphate galactose to glycoside residues with a terminal N-acetylglucosamine moiety
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?
additional information
?
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enzyme transfers galactose to the terminal N-acetylglucosamine of N- and O-linked glycans in a beta-1,4-linkage
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-galactose + O-beta-D-xylosylprotein
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
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?
additional information
?
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enzyme catalyzes the transfer of galactose from the sugar nucleotide donor uridine diphosphate galactose to glycoside residues with a terminal N-acetylglucosamine moiety
-
-
?
additional information
?
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enzyme transfers galactose to the terminal N-acetylglucosamine of N- and O-linked glycans in a beta-1,4-linkage
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?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1,4-diamino-2,3-dicyano-1,4-bis-(2-aminophenylthio)butadiene
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0-10 microM of specific inhibitor U0126 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide
4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol
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10-30 microM of specific inhibitor SB202190 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide
pyrazolanthrone
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10-50 microM of specific inhibitor SP600125 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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mixed neuron-glial cultures prepared from the brains of embryonic days 16-17 rats
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OX-42-positive microglia in the lesion site after spinal cord injury
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
enzyme plays in important role in the synthesis of the backbone structure of adhesion molecules involved in leukocyte-endothelial cell interaction
malfunction
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an antibody against beta-1,4-GalT-I attenuates both lipopolysaccharide-induced microglial activation and phagocytosis
physiological function
physiological function
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beta-1,4-galactosyltransferase I is a key inflammatory mediator that plays a critical role in the initiation and maintenance of inflammatory reaction in diseases, beta-1,4-GalT-I is associated with E-selectin during the pathological process of secondary response after Spinal cord injury
physiological function
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beta-1,4-GalT I might play important roles in Schwann cells during the regeneration and degeneration of the injured sciatic nerve, enzyme plays in important role in Schwann cells in vivo and vitro during pathology, beta-1,4-GalT can catalyze the galactose from UDP-galactose to the terminal N-acetylglucosamine residues on elongating oligosaccharide chains, which are suggested to be involved in various cellular functions including cell-cell and cell-matrix interactions during embryogenesis
physiological function
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beta-1,4-GalT-I may play an important role in adhesion and migration of Schwann cells during inflammation, enzyme is a key inflammatory mediator that participates in the initiation and maintenance of inflammatory reaction in diseases, the long beta-1,4-GalT-I isoform, due to the extra 13 amino acids at the amino-termini, is implicated in targeting the protein to cell surface, and acts as a recognition molecule associated with a variety of biological functions, including sperm-egg interactions, morula compaction, embryonic maturation, embryonal carcinoma cell spreading, neurite extension, and mesenchymal cell migration
physiological function
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beta-1,4-GalT-I may play an important role in regulating immune cell migration into the inflammatory site and mediating microgliosis
physiological function
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beta1,4-GalT I might play important roles in the regeneration of the injuried sciatic nerve
physiological function
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beta1,4-GalT V might plays important roles in the regeneration of the injuried sciatic nerve
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). B4GT1_RAT
32
0
3137
Swiss-Prot
other Location (Reliability: 1)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
both anti-TNFR1 and anti-TNFR2 antibodies suppressed beta-1,4-GalT I mRNA expression induced by tumor necrosis factor-alpha or lipopolysaccharide
the expression level of beta-1,4-GalT I mRNA in cultured type-2 astrocytes is dose-dependent compared with the control group, it decreases at 0.1 ng/ml tumor necrosis factor-alpha, reaches at a peak at 1 ng/ml and then restores to normal level at 5 ng/ml. The expression in cultured type-2 astrocytes is time-dependent, it increases from 0.5 h, peaks at 4 h, then it decreases gradually to normal level after exposure to 1 ng/ml tumor necrosis factor-alpha. Lipopolysaccharide induces beta-1,4-GalT I mRNA expression in type-2 astrocytes in a time- and dose-dependent manner
beta-1,4-GalT I mRNA reaches peaks at 2 weeks after sciatic nerve crush, in situ hybridization shows that at day 1 after sciatic nerve crush, the expression levels of beta-1,4-GalT I mRNA is strong at the crush site, and decreases gradually from crush site to the distal segments, the expression of beta-1,4-GalTI mRNA is related to the injury site and injury time in peripheral nervous system
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beta-1,4-GalT V mRNA reaches peaks at 2 weeks after sciatic nerve crush, in situ hybridization shows that at day 1 after sciatic nerve crush, the expression levels of beta-1,4-GalT V mRNA is strong at the crush site, and decreases gradually from crush site to the distal segments
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beta-1,4-GalT-I is strongly induced in the ventral midbrain by intranigral injection of lipopolysaccharide, significant increase in beta-1,4-GalT-I mRNA at 8 h after focal injection of lipopolysaccharide, and lastes to 18 h, then decreases gradually
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beta-1,4-GalT-I mRNA is significant increased as early as 2 h after lipopolysaccharide stimulation (1 microM/ml), upregulation in a time- and concentration-dependent manner
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in injured spinal cords, enzyme is significantly increased after 8 h, beta-1,4-GalT-I mRNA reaches the peak at 1 day after spinal cord contusion, then gradually reduced from day 5 to day 7, recovers to the baseline level at 14 day
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the beta-1,4-GalT I mRNA reaches peaks at 2 weeks after sciatic nerve crush and 3 days after sciatic nerve transection in a dose-dependent manner, in inflammation, lipopolysaccharide administration affects beta-1,4-GalT I mRNA expression in sciatic nerve in a time- and dose-dependent manner, and beta-1,4-GalT I mRNA is expressed mainly in Schwann cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yan, M.; Xia, C.; Niu, S.; Cheng, C.; Shao, X.; Shen, A.
The role of TNF-alpha and its receptors in the production of beta-1,4-galactosyltransferase I mRNA by rat primary type-2 astrocytes
Cell. Mol. Neurobiol.
28
223-236
2008
Rattus norvegicus (P80225)
Yang, H.; Hu, L.; Chen, J.; Zhu, J.; Tao, T.; Zhang, F.; Li, X.; He, X.; Shen, A.; Cheng, C.
Lipopolysaccharide induced upregulation of beta-1,4-galactosyltransferase-I in Schwann cell
Inflammation
32
279-286
2009
Rattus norvegicus
Yang, H.; Yan, M.; Cheng, C.; Jiang, J.; Zhang, L.; Liu, J.; Zhou, Z.; Shen, A.
Expression of beta-1,4-galactosyltransferase I in rat Schwann cells
J. Cell. Biochem.
108
75-86
2009
Rattus norvegicus
Niu, S.; Fei, M.; Cheng, C.; Yan, M.; Gao, S.; Chen, M.; Wang, H.; Li, X.; Yu, X.; Qian, J.; Qin, J.; Zhao, J.; Gu, J.; Shen, A.
Altered beta-1,4-galactosyltransferase I expression during early inflammation after spinal cord contusion injury
J. Chem. Neuroanat.
35
245-256
2008
Rattus norvegicus
Yan, M.; Cheng, C.; Shao, X.; Qian, J.; Shen, A.; Xia, C.; Xia, C.
Expression change of beta-1,4 galactosyltransferase I, V mRNAs and Galbeta1,4GlcNAc group in rat sciatic nerve after crush
J. Mol. Histol.
39
317-328
2008
Rattus norvegicus
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