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Information on EC 2.4.1.11 - glycogen(starch) synthase and Organism(s) Macaca mulatta and UniProt Accession Q8MJ26

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.11 glycogen(starch) synthase
IUBMB Comments
The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).
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This record set is specific for:
Macaca mulatta
UNIPROT: Q8MJ26
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Word Map
The taxonomic range for the selected organisms is: Macaca mulatta
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
glycogen synthase, gbssi, granule-bound starch synthase, starch synthase i, granule bound starch synthase, gsy2p, glycogen synthase 2, gys-2, cg-gys, tvag_258220, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glucosyltransferase, uridine diphosphoglucose-glycogen
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glycogen synthetase (starch)
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GSY2p
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UDP-glucose-glycogen glucosyltransferase
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UDP-glycogen synthase
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UDPG-glycogen synthetase
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UDPG-glycogen transglucosylase
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uridine diphosphoglucose-glycogen glucosyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:glycogen 4-alpha-D-glucosyltransferase
The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).
CAS REGISTRY NUMBER
COMMENTARY hide
9014-56-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-glucose + glycogen
glycogen + UDP
show the reaction diagram
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-
-
-
?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-glucose + glycogen
glycogen + UDP
show the reaction diagram
-
-
-
-
?
additional information
?
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Insulin
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increased activity after insulin infusion
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GYS1_MACMU
737
0
83787
Swiss-Prot
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ortmeyer, H.K.; Bodkin, N.L.; Hansen, B.C.
Insulin regulates liver glycogen synthase and glycogen phosphorylase activity reciprocally in rhesus monkeys
Am. J. Physiol.
272
E133-138
1997
Macaca mulatta
Manually annotated by BRENDA team
Ortmeyer, H.K.; Adall, Y.; Marciani, K.R.; Katsiaras, A.; Ryan, A.S.; Bodkin, N.L.; Hansen, B.C.
Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeys
Am. J. Physiol. Regul. Integr. Comp. Physiol.
288
R1509-R1517
2005
Macaca mulatta (Q8MJ26), Macaca mulatta
Manually annotated by BRENDA team