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Information on EC 2.4.1.102 - beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase and Organism(s) Homo sapiens and UniProt Accession Q9P109

for references in articles please use BRENDA:EC2.4.1.102
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EC Tree
IUBMB Comments
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 2.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: Q9P109
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein]
=
+
O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Synonyms
c2gnt, gcnt3, c2gnt-m, gcnt1, c2gnt1, core 2 glcnac-t, c2glcnact-i, c2gnt-1, c2gnt-l, core 2 beta-1,6-n-acetylglucosaminyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2beta-1,6-acetylglucosaminyltransferase
-
acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-
-
-
-
-
acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-, A
-
-
-
-
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
-
beta1,6-N-acetylglucosaminyltransferase
-
beta6-N-acetylglucosaminyltransferase
-
-
-
-
C2 beta6GnT1
-
C2GlcNAcT-I
-
C2GnT-1
-
-
C2GnT-I
-
-
core 2 acetylglucosaminyltransferase
-
-
-
-
core 2 beta-1, 6-N-acetylglucosaminyltransferase-1
-
core 2 beta-1,6 N-acetylglucosaminyltransferase
-
core 2 beta-1,6-N-acetylglucosaminyltransferase
-
-
core 2 beta1,6 N-acetylglucosaminyltransferase
-
-
core 2 beta1,6 N-acetylglucosaminyltransferase-I
-
-
core 2 beta1,6-N-acetylglucosaminyl transferase 1
-
-
core 2 beta1,6-N-acetylglucosaminyltransferase
-
-
core 2 beta1,6-N-acetylglucosaminyltransferase I
-
core 2 beta1,6-N-acetylglucosaminyltransferase-I
-
core 2 beta6-GlcNAc-transferase
-
-
core 2 beta6-N-acetylglucosaminyltransferase
-
-
core 2 GlcNAc-T
-
-
core 2 N-acetylglucosaminyltransferase
-
-
Core 2 N-acetylglucosaminyltransferase 2/M
-
core 2 N-acetylglucosaminyltransferase M
-
core 2 N-acetylglucosaminyltransferase-1
-
-
core 2beta-1,6-acetylglucosaminyltransferase
-
core 6-beta-GlcNAc-T
-
-
core 6-beta-GlcNAc-transferase A
-
-
-
-
core2 beta(1,6)-N-acetyglucosaminyltransferase-I
-
-
core2 beta-1,6-N-acetylglucosaminyltransferase
-
-
core2 beta-1,6-N-acetylglucosaminyltransferase-1
-
-
core2GnT
-
-
GCNT1
mucin-type core 2 1,6-N-acetylglucosaminyltransferase enzyme
-
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
-
-
-
-
uridine diphosphoacetylglucosamine-mucin beta-(1-6)-acetylglucosaminyltransferase
-
-
-
-
uridine diphosphoacetylglucosamine-mucin beta-(1-6)-acetylglucosaminyltransferase A
-
-
-
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-alpha-D-glucosamine:O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 2.
CAS REGISTRY NUMBER
COMMENTARY hide
87927-97-7
-
95978-15-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-glucosamine + asialo-alpha1 acid glycoprotein
?
show the reaction diagram
no activity
-
-
?
UDP-N-acetyl-D-glucosamine + asialo-submaxillary mucin
?
show the reaction diagram
UDP-N-acetyl-D-glucosamine + asialofetuin
?
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-glucosamine + asialoglycophorin A
?
show the reaction diagram
best substrate
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-methylumbelliferyl
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-methylumbelliferyl
show the reaction diagram
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
show the reaction diagram
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
show the reaction diagram
UDP-N-acetyl-D-glucosamine + fetuin
?
show the reaction diagram
no activity
-
-
?
UDP-GlcNAc + (Galbeta1-3GalNAcalpha1-)TAGV
UDP + (Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TAGV
show the reaction diagram
-
pH 7.0, 0.2 mM, 1250% activity
-
-
?
UDP-GlcNAc + 4-nitrophenyl 2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside
UDP + 4-nitrophenyl 2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-6)-[beta-D-galactopyranosyl-(1-3)]-2-(acetylamino)-2-deoxy-alpha-D-galactopyranoside
show the reaction diagram
-
pH 7.0, 0.2 mM, 100% activity
-
-
?
UDP-GlcNAc + Ac-G-(Galbeta1-3GalNAcalpha1-)TTTPIST-NH2
UDP + Ac-G-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TTTPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 100% activity
-
-
?
UDP-GlcNAc + Ac-G-(Galbeta1->3GalNAcbeta1->)TTTPIST-NH2
UDP + Ac-G-(Galbeta1->3[Glcbeta1->6]GalNAcbeta1->)TTTPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 75% activity
-
-
?
UDP-GlcNAc + Ac-GT-(Galbeta1-3GalNAcalpha1-)TTPIST-NH2
UDP + Ac-GT-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TTPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 100% activity
-
-
?
UDP-GlcNAc + Ac-GT-(Galbeta1->3GalNAcbeta1->)TTPIST-NH2
UDP + Ac-GT-(Galbeta1->3[Glcbeta1->6]GalNAcbeta1->)TTPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 150% activity
-
-
?
UDP-GlcNAc + Ac-GTT-(Galbeta1-3GalNAcalpha1-)TPIST-NH2
UDP + Ac-GTT-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 100% activity
-
-
?
UDP-GlcNAc + Ac-GTT-(Galbeta1->3GalNAcbeta1->)TPIST-NH2
UDP + Ac-GTT-(Galbeta1->3[Glcbeta1->6]GalNAcbeta1->)TPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 100% activity
-
-
?
UDP-GlcNAc + Ac-P-(Galbeta1-3GalNAcalpha1-)TTTGIST-NH2
UDP + Ac-P-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TTTGIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 50% activity
-
-
?
UDP-GlcNAc + Ac-P-(Galbeta1-3GalNAcalpha1-)TTTPIST-NH2
UDP + Ac-P-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TTTPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 100% activity
-
-
?
UDP-GlcNAc + Ac-P-(Galbeta1->3GalNAcbeta1->)TTTGIST-NH2
UDP + Ac-P-(Galbeta1->3[GlcNAcbeta1->6]GalNAcbeta1->)TTTGIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 200% activity
-
-
?
UDP-GlcNAc + Ac-P-(Galbeta1->3GalNAcbeta1->)TTTPIST-NH2
UDP + Ac-P-(Galbeta1->3[Glcbeta1->6]GalNAcbeta1->)TTTPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 175% activity
-
-
?
UDP-GlcNAc + Ac-PT-(Galbeta1-3GalNAcalpha1-)TTGIST-NH2
UDP + Ac-PT-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TTGIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 300% activity
-
-
?
UDP-GlcNAc + Ac-PT-(Galbeta1-3GalNAcalpha1-)TTPIST-NH2
UDP + Ac-PT-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TTPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 200% activity
-
-
?
UDP-GlcNAc + Ac-PT-(Galbeta1->3GalNAcbeta1->)TTGIST-NH2
UDP + Ac-PT-(Galbeta1->3[Glcbeta1->6]GalNAcbeta1->)TTGIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 95% activity
-
-
?
UDP-GlcNAc + Ac-PT-(Galbeta1->3GalNAcbeta1->)TTPIST-NH2
UDP + Ac-PT-(Galbeta1->3[GlcNAcbeta1->6]GalNAcbeta1->)TTPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 185% activity
-
-
?
UDP-GlcNAc + Ac-PTT-(Galbeta1-3GalNAcalpha1-)TGIST-NH2
UDP + Ac-PTT-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TGIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 200% activity
-
-
?
UDP-GlcNAc + Ac-PTT-(Galbeta1-3GalNAcalpha1-)TPIST-NH2
UDP + Ac-PTT-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 100% activity
-
-
?
UDP-GlcNAc + Ac-PTT-(Galbeta1->3GalNAcbeta1->)TPIST-NH2
UDP + Ac-PTT-(Galbeta1->3[GlcNAcbeta1->6]GalNAcbeta1->)TPIST-NH2
show the reaction diagram
-
pH 7.0, 0.2 mM, 10% activity
-
-
?
UDP-GlcNAc + AP-(Galbeta1-3GalNAcalpha1-)TSS
UDP + AP-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TSS
show the reaction diagram
-
pH 7.0, 0.2 mM, 250% activity
-
-
?
UDP-GlcNAc + T-(Galbeta1-3GalNAcalpha1-)TTVTPTPTG
UDP + T-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TTVTPTPTG
show the reaction diagram
-
pH 7.0, 0.2 mM, 75% activity
-
-
?
UDP-GlcNAc + TT-(Galbeta1-3GalNAcalpha1-)TVTPTPTG
UDP + TT-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TVTPTPTG
show the reaction diagram
-
pH 7.0, 0.2 mM, 75% activity
-
-
?
UDP-GlcNAc + TTTV -(Galbeta1-3GalNAcalpha1-)TPTPTG
UDP + TTTV -(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TPTPTG
show the reaction diagram
-
pH 7.0, 0.2 mM, 75% activity
-
-
?
UDP-GlcNAc + TTTVTP-(Galbeta1-3GalNAcalpha1-)TPTG
UDP + TTTVTP-(Galbeta1-3[GlcNAcbeta1-6]GalNAcalpha1-)TPTG
show the reaction diagram
-
pH 7.0, 0.2 mM, 50% activity
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl-R
show the reaction diagram
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-benzyl
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein]
UDP + O3-(beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl)-L-seryl/threonyl-[protein]
show the reaction diagram
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + porcine submaxillary mucin polypeptide
?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
UDP + 3-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
UDP + 4-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
?
show the reaction diagram
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosamine
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
show the reaction diagram
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-methyl
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-methyl
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-o-nitrophenyl
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-o-nitrophenyl
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
show the reaction diagram
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-phenyl
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-phenyl
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
show the reaction diagram
UDP-N-acetyl-D-glucosamine + fucosyl-alpha-1,2-galactosyl-beta-1,3-N-acetyl-D-galactosaminyl-R
UDP + fucosyl-alpha-1,2-galactosyl-beta-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
show the reaction diagram
-
low activity
-
-
?
UDP-N-acetyl-D-glucosamine + Galbeta(1-3)GalNAcalpha-p-nitrophenol
?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + Galbeta1,3GalNAc-O-p-nitrophenyl
?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + Galbeta1,3GalNAcalpha1-p-nitrophenyl
?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + N-acetylgalactosaminyl-Ser(Thr)-mucin
?
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + submaxillary mucin polypeptide
?
show the reaction diagram
-
porcine acceptor substrate
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12-O-tetradecanoylphorbol-13-acetate
5,5'-dithiobis-2-nitrobenzoic acid
-
inactivation is partially prevented by prior addition of donor or acceptor substrate and by sulfhydryl reducing agents. 1 mM inhibits 94%
beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
-
high concentration
beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
Cu2+
-
-
diethyldicarbonate
-
0.2 mM, 74% inhibition
Hydroxyphenylglyoxal
-
19% inhibition at 0.25 mM, complete inhibition at 5-10 mM
iodoacetate
-
0.2 mM inhibits the enzyme 70%
Mn2+
-
-
N-bromosuccinimide
-
5 mM, complete inhibition
NEM
-
inactivation is partially prevented by prior addition of donor or acceptor substrate and by sulfhydryl reducing agents. 0.2 mM inhibits 42%
substrate analogues lacking the 6-hydroxyl of the N-acetylgalactosamine
-
weak
-
talniflumate
tunicamycin
additional information
-
enzyme is fully active in presence of 5 mM EDTA
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
stimulates up to 20fold
dithiothreitol
-
stimulates up to 20fold
Triton X-100
-
activation, 0.1% v/v
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.3 - 4.5
3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
6.7 - 10
4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
21 - 37
beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
0.8 - 1.4
beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
0.36 - 0.43
beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
2
beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-o-nitrophenyl
-
AML cell line
0.6
beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
AML cell line
10
beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-phenyl
-
AML cell line
1.1 - 1.6
Galbeta(1-3)GalNAcalpha-p-nitrophenol
5.2
porcine submaxillary mucin polypeptide
-
-
-
1 - 5.6
UDP-N-acetyl-D-glucosamine
additional information
additional information
-
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.95 - 2.5
beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000048
-
normal granulocytes
0.0000056
-
untreated recombinant KM3 leukemia cell line
0.000013
-
unstimulated normal T-lymphocytes
0.00002
-
CML granulocytes
0.00004
-
EBV B-cell line from healthy individuals
0.000087
-
AML cells
0.00015
-
undifferentiated CaCo-2, colonic adenocarcinoma, cells
0.00034
-
CaCo-2, colonic adenocarcinoma, cells differentiated to enterocytes
0.00067
-
recombinant enzyme in Panc1-MUC1 cells
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isozyme 3
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
peripheral blood
Manually annotated by BRENDA team
high content
Manually annotated by BRENDA team
an EBVnGC cell line
Manually annotated by BRENDA team
an EBVnGC cell line
Manually annotated by BRENDA team
GCNT3 is elevated in skin and mesothelioma cells and in some lung and breast cancer cells
Manually annotated by BRENDA team
differential expression of GCNT3 gene among tumour samples from stage II colon cancer patients by quantitative reverse-transcription PCR, overview
Manually annotated by BRENDA team
GCNT3 gene expression is downregulated in colorectal cancer (CRC) samples in comparison to non-pathological colon tissue
Manually annotated by BRENDA team
-
maturation of dendritic cells leads to a rapid change in the expression of glycosyltransferases involved in O-linked glycosylation. A down-regulation of C2GnT1 mRNA and enzymatic activity is observed with a concurrent up-regulation of ST3Gal I and ST6GalNAc II mRNA resulting in a loss of the core 2 structures required for sLex expression as a P-selectin ligand
Manually annotated by BRENDA team
-
expression of C2GnT1 in 84 cases of endometrioid-type endometrial carcinoma, 15 cases of endometrial hyperplasia, and 30 normal endometria, immunohistochemic analysis, overview. C2GnT1 is strongly expressed at the invasive tumour front in several cases
Manually annotated by BRENDA team
GCNT3 expression analysis in a cohort of 56 EOC patients, followed by a meta-analysis of more than one thousand patients, overview
Manually annotated by BRENDA team
GCNT3 expression in Epstein-Barr virus (EBV)-associated gastric cancer cells and tissues is lower than in EBV-negative gastric cancer cells (EBVnGC) and tissues, and high expression is significantly associated with advanced tumor-lymph node metastasis. GCNT3 is closely related to the ERK signaling pathway and epithelial mesenchymal transition (EMT), regulating cell proliferation, migration, and invasion
Manually annotated by BRENDA team
an EBVaGC cell line
Manually annotated by BRENDA team
an EBVaGC cell line
Manually annotated by BRENDA team
an EBVnGC cell line
Manually annotated by BRENDA team
-
NCI498, ileo-caecal carcinoma cell line
Manually annotated by BRENDA team
-
transcription of core 2 beta1,6 N-acetylglucosaminyltransferase-I is controlled by Sp1 in lymphocytes and epithelial cells
Manually annotated by BRENDA team
-
erythroleukemia cell line
Manually annotated by BRENDA team
-
pre-B lymphocytic leukemia cell line
Manually annotated by BRENDA team
-
colonic adenocarcinoma cell line
Manually annotated by BRENDA team
-
YC2C2 lymphocytic leukemia cell line
Manually annotated by BRENDA team
GCNT3 is overexpressed in highly metastatic melanomas
Manually annotated by BRENDA team
GCNT3 is highly expressed in both NSCLC tissues and cell lines
Manually annotated by BRENDA team
an EBVnGC cell line
Manually annotated by BRENDA team
an EBVaGC cell line
Manually annotated by BRENDA team
-
colonic grade II tumour cell line
Manually annotated by BRENDA team
-
colonic grade III tumour cell line
Manually annotated by BRENDA team
-
colonic large ulcerating grade IV tumour cell line, low activity
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
secretion into medium of the recombinant enzyme from Sf9 cells
-
Manually annotated by BRENDA team
-
secretion into medium of the recombinant enzyme from Sf9 cells
-
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GCNT4_HUMAN
453
1
53052
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
58000
-
1 * 58000, SDS-PAGE
additional information
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
1 * 58000, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
phosphoprotein
-
phosphorylation increases activity
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C100S
-
mutant enzyme with 10% of wild-type activity
C151S
-
inactive mutant protein
C172S
-
inactive mutant protein
C199S
-
inactive mutant protein
C217S
-
mutant enzyme with 41% of wild-type activity. Similar Km and Vmax values for Galbeta(1-3)GalNAcalpha-p-nitrophenol, Km-value for UDP-N-acetyl-D-glucosamine is 2.9fold higher than wild-type value. In contrast to wild-type enzyme, the mutant enzyme is not inhibited by sulfhydryl reagents and is not stimulated by reducing agents
C372S
-
inactive mutant protein
C381S
-
inactive mutant protein
C413S
-
inactive mutant protein
C59S
-
inactive mutant protein
DELTA407-428
-
inactive mutant protein
T60A/T97A
additional information
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
decrease of activity, in the presence of Triton X-100
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
freeze-drying and resuspension in 10 mM Tris-HCl, pH 8.0, 1 mM EDTA, 95% remaining activity
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, crude enzyme extract, stable up to 1 year
-
-70°C, microsomal preparation, detergent-free 0.25 M sucrose suspension, several years
-
-80°C, stable for at least 6 months, wild-type enzyme
-
4°C, stable in solution or after lyophilization for several months
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partially, recombinant from Sf9 insect cells
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning and expression of isozyme 3 in Spodoptera frugiperda Sf9 insect cells via baculovirus infection, secretion of the enzyme
coexpression of isozyme 3 with leukosialin as substrate in CHO cells for in vivo activity assay of the enzyme
DNA sequence determination and analysis
cotransfection and expression of Epstein-Barr virus (EBV) miRNA miR-BART1-5p and GCNT3 in HEK-293T and SGC7901 cells
expression in human pancreatic cancer cell line Panc1-MUC1, which lacks enzyme C2GnT activity, alters the expression of MUC1-epitope in the same cell line
-
expression in Spodoptera frugiperda Sf9 insect cells via baculovirus infection, truncated enzyme form
-
expression of the soluble catalytic domain in insect cells
-
gene GCNT1 , recombinant expression in CHO-K1 cells. Glycosylation-related genes in CHO-K1 cells are present, but strictly suppressed and regulated. CHO cells are transiently co-transfected with plasmids encoding extended C1 beta3GnT3, C2 beta6GnT1, or C3 beta3GnT6 with or without ST6Gal I or CHST4, respectively, and resulting O-glycan and core chain spectrum, overview
gene Gcnt1, identification of the Gcnt1 promoter, identification of a putative distal regulatory element of the Gcnt1 gene by mapping H3K4me2 and H3K27me3 across the Gcnt1 locus, sequence comparisons, phylogenetic analysis of promoters, overview. The distal regulatory region is an enhancer forGcnt1 for which STAT4 is functionally important. Prolonged T-bet binding to the Gcnt1 enhancer
gene GCNT2, recombinant expression in COS7 cells
-
gene GCNT3 expression analysis in pancreatic cancer and in healthy pancreatic tissue, gene expression profiling and transcriptome analysis
gene GCNT3, quantitative reverse-transcription PCR enzyme expression analysis
gene GCNT3, recombinant expression of C-terminally 3xMyc-6His-tagged wild-type enzyme and deletion mutant mutGCNT3
gene GCNT3, recombinant overexpression in SW620 and SW5FU cell lines, genomic analysis of GCNT3 overexpression, quantitative RT-PCR enzyme expression analysis, genomic and proteomic landscapes of GCNT3 are linked to cell cycle and response to drug pathways. GCNT3 overexpression does not significantly change cell growth in Caov3 cells, VEGFA expression is downregulated in GCNT3 Caov3 cells
overexpression in KM3 leukemia cell line
-
recombinant expression of C-terminally c-Myc-tagged betaC2GnT-M in Panc1 cells, transient expression of GFP-tagged C2GnT-M in HeLa cells. Yeast two-hybrid analysis of the interactions between KRT1 protein head, tail, or rod domain and the cytoplasmic peptides of hC2GnT-M
transfection into JKT-1 cells
-
wild-type and mutant enzymes expressed in CHO-K1 cells
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
GCNT3 downregulation by shGCNT3 7, of several shRNAs targeting GCNT3 shGCNT3s, shGCNT3 7 has the best inhibitory capacity (protein and mRNA)
inhibitor talniflumate alone and in combination with low-dose gefitinib reduced GCNT3 expression, leading to the disrupted production of mucins in vivo and in vitro
modulation of GCNT3 expression in the presence of 5-fluorouracil (5FU) at 0.03 mM, a robust induction of GCNT3 expression is observed in SW family of non-resistant cells with a statistically significant 3.76fold increase in SW620 metastatic cells, while no such induction is observed in SW5FU cells or in HT-29 cell line, which has the highest levels of endogenous GCNT3
STAT4 controls Gcnt1 expression in Th1 cells, several conserved and non-conserved predicted STAT4 binding sites are determined
the three chemotherapeutic agents, with different mechanism of action, 5-fluorouracil, bortezomib and paclitaxel significantly induce GCNT3 expression in several cancer cells, but not in drug-unreponsive cells
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
medicine
molecular biology
-
beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl and other nitrophenyl-sugar-derivatives are useful as specific inhibitors and as affinity label
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schachter, H.; Brockhausen, I.; Hull, E.
High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis
Methods Enzymol.
179
351-397
1989
Bos taurus, Canis lupus familiaris, Homo sapiens, Oryctolagus cuniculus, Ovis aries, Platyrrhini, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Higgins, E.A.; Siminovitch, K.A.; Zhuang, D.; Brockhausen, I.; Dennis, J.W.
Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome
J. Biol. Chem.
266
6280-6290
1991
Homo sapiens
Manually annotated by BRENDA team
Kuhns, W.; Rutz, V.; Paulsen, H.; Matta, K.L.; Baker, M.A.; Barner, M.; Granovsky, M.; Brockhausen, I.
Processing O-glycan core 1, Galb1-3GalNAca-R. Specificities of core 2, UDP-GlcNAc: Galbeta1-3GalNAc-R(GlcNAc to GalNAc) beta6-N-acetylglucosaminyltransferase and CMP-sialic acid: Galbeta1-3GalNAc-R alpha3-sialyltransferase
Glycoconjugate J.
10
381-394
1993
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Vavasseur, F.; Yang, J.M.; Dole, K.; Paulsen, H.; Brockhausen, I.
Synthesis of O-glycan core 3: characterization of UDP-GlcNAc:GalNAc-R beta3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines
Glycobiology
5
351-357
1995
Homo sapiens
Manually annotated by BRENDA team
Toki, D.; Granovsky, M.A.; Reck, F.; Kuhns, W.; Baker, M.A.; Matta, K.L.; Brockhausen, I.
Inhibition of UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from acute myeloid leukaemia cells by photoreactive nitrophenyl substrate derivatives
Biochem. Biophys. Res. Commun.
198
417-423
1994
Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Toki, D.; Sarkar, M.; Yip, B.; Reck, F.; Joziasse, D.; Fukuda, M.; Schachter, H.; Brockhausen, I.
Expression of stable human O-glycan core 2 beta-1,6-N-acetylglycosaminyltransferase in Sf9 insect cells
Biochem. J.
325
63-69
1997
Homo sapiens
-
Manually annotated by BRENDA team
Nakamura, M.; Kudo, T.; Narimatsu, H.; Furukawa, Y.; Kikuchi, J.; Asakura, S.; Yang, W.; Iwase, S.; Hatake, K.; Miura, Y.
Single glycosyltransferase, core 2 beta1-6-N-acetylglucosaminyltransferase, regulates cell surface sialyl-Lex expression level in human pre-B lymphocytic leukemia cell line KM3 treated with phorbolester
J. Biol. Chem.
273
26779-26789
1998
Homo sapiens
Manually annotated by BRENDA team
Beum, P.V.; Singh, J.; Burdick, M.; Hollingsworth, M.A.; Cheng, P.W.
Expression of core 2 beta-1,6-N-acetylglucosaminyltransferase in a human pancreatic cancer cell line results in altered expression of MUC1 tumor-associated epitopes
J. Biol. Chem.
274
24641-24648
1999
Homo sapiens
Manually annotated by BRENDA team
Schwientek, T.; Yeh, J.C.; Levery, S.B.; Keck, B.; Merkx, G.; Van Kessel, A.G.; Fukuda, M.; Clausen, H.
Control of O-glycan branch formation: molecular cloning and characterization of a novel thymus-associated core 2 beta1,6-N-acetylglucosaminyltransferase
J. Biol. Chem.
275
11106-11113
2000
Homo sapiens (O95395), Homo sapiens (Q02742), Homo sapiens (Q9P109), Homo sapiens
Manually annotated by BRENDA team
Brockhausen, I.; Kuhns, W.; Schachter, H.; Matta K.L.; Sutherland, D.R.; Baker, M.A.
Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Galbeta3GalNAcalpha-R (GlcNAc to GalNAc) beta(1,6)-N-acetylglucosaminyltransferase in leikemic cells
Cancer Res.
51
1257-1263
1991
Homo sapiens
Manually annotated by BRENDA team
Brockhausen, I.; Romero, P.A.; Herscovics, A.
Glycosyltransferase changes upon differentiation of CaCo-2 human colonic adenocarcinoma cells
Cancer Res.
51
3136-3142
1991
Homo sapiens
Manually annotated by BRENDA team
Beum, P.V.; Basma, H.; Bastola, D.R.; Cheng, P.W.
Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line
Am. J. Physiol.
288
L116-124
2005
Homo sapiens
Manually annotated by BRENDA team
Yang, X.; Qin, W.; Lehotay, M.; Toki, D.; Dennis, P.; Schutzbach, J.S.; Brockhausen, I.
Soluble human core 2 beta6-N-acetylglucosaminyltransferase C2GnT1 requires its conserved cysteine residues for full activity
Biochim. Biophys. Acta
1648
62-74
2003
Homo sapiens
Manually annotated by BRENDA team
Prorok-Hamon, M.; Notel, F.; Mathieu, S.; Langlet, C.; Fukuda, M.; El-Battari, A.
N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin
Biochem. J.
391
491-502
2005
Homo sapiens
Manually annotated by BRENDA team
Ben-Mahmud, B.M.; Chan, W.H.; Abdulahad, R.M.; Datti, A.; Orlacchio, A.; Kohner, E.M.; Chibber, R.
Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy
Diabetologia
49
2185-2191
2006
Homo sapiens
Manually annotated by BRENDA team
Hagisawa, S.; Ohyama, C.; Takahashi, T.; Endoh, M.; Moriya, T.; Nakayama, J.; Arai, Y.; Fukuda, M.
Expression of core 2 beta1,6-N-acetylglucosaminyltransferase facilitates prostate cancer progression
Glycobiology
15
1016-1024
2005
Homo sapiens
Manually annotated by BRENDA team
Falkenberg, V.R.; Fregien, N.
Control of core 2 beta1,6 N-acetylglucosaminyltransferase-I transcription by Sp1 in lymphocytes and epithelial cells
Glycoconj. J.
24
511-519
2007
Homo sapiens
Manually annotated by BRENDA team
Kikuchi, J.; Ozaki, H.; Nonomura, C.; Shinohara, H.; Iguchi, S.; Nojiri, H.; Hamada, H.; Kiuchi, A.; Nakamura, M.
Transfection of antisense core 2 beta1,6-N-acetylglucosaminyltransferase-1 cDNA suppresses selectin ligand expression and tissue infiltration of B-cell precursor leukemia cells
Leukemia
19
1934-1940
2005
Homo sapiens
Manually annotated by BRENDA team
Valenzuela, H.F.; Pace, K.E.; Cabrera, P.V.; White, R.; Porvari, K.; Kaija, H.; Vihko, P.; Baum, L.G.
O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1
Cancer Res.
67
6155-6162
2007
Homo sapiens
Manually annotated by BRENDA team
Julien, S.; Grimshaw, M.J.; Sutton-Smith, M.; Coleman, J.; Morris, H.R.; Dell, A.; Taylor-Papadimitriou, J.; Burchell, J.M.
Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I
J. Immunol.
179
5701-5710
2007
Homo sapiens
Manually annotated by BRENDA team
Brockhausen, I.; Dowler, T.; Paulsen, H.
Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2
Biochim. Biophys. Acta
1790
1244-1257
2009
Homo sapiens
Manually annotated by BRENDA team
Hatakeyama, S.; Kyan, A.; Yamamoto, H.; Okamoto, A.; Sugiyama, N.; Suzuki, Y.; Yoneyama, T.; Hashimoto, Y.; Koie, T.; Yamada, S.; Saito, H.; Arai, Y.; Fukuda, M.; Ohyama, C.
Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor
Int. J. Cancer
127
10521-10529
2010
Homo sapiens
Manually annotated by BRENDA team
Sato, T.; Yoneyama, T.; Tobisawa, Y.; Hatakeyama, S.; Yamamoto, H.; Kojima, Y.; Mikami, J.; Mori, K.; Hashimoto, Y.; Koie, T.; Ohyama, C.
Core 2 beta-1, 6-N-acetylglucosaminyltransferase-1 expression in prostate biopsy specimen is an indicator of prostate cancer aggressiveness
Biochem. Biophys. Res. Commun.
470
150-156
2016
Homo sapiens (Q02742), Homo sapiens
Manually annotated by BRENDA team
Rao, C.; Janakiram, N.; Madka, V.; Kumar, G.; Scott, E.; Pathuri, G.; Bryant, T.; Kutche, H.; Zhang, Y.; Biddick, L.; Gali, H.; Zhao, Y.; Lightfoot, S.; Mohammed, A.
Small-molecule inhibition of GCNT3 disrupts mucin biosynthesis and malignant cellular behaviors in pancreatic cancer
Cancer Res.
76
1965-1974
2016
Homo sapiens (O95395), Homo sapiens, Mus musculus (Q5JCT0), Mus musculus, Mus musculus C57BL/6 (Q5JCT0)
Manually annotated by BRENDA team
Gonzalez-Vallinas, M.; Vargas, T.; Moreno-Rubio, J.; Molina, S.; Herranz, J.; Cejas, P.; Burgos, E.; Aguayo, C.; Custodio, A.; Reglero, G.; Feliu, J.; Ramirez de Molina, A.
Clinical relevance of the differential expression of the glycosyltransferase gene GCNT3 in colon cancer
Eur. J. Cancer
51
1-8
2015
Homo sapiens (O95395), Homo sapiens
Manually annotated by BRENDA team
Miyamoto, T.; Suzuki, A.; Asaka, R.; Ishikawa, K.; Yamada, Y.; Kobara, H.; Nakayama, J.; Shiozawa, T.
Immunohistochemical expression of core 2 beta1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor
Histopathology
62
986-993
2013
Homo sapiens
Manually annotated by BRENDA team
Petrosyan, A.; Ali, M.F.; Cheng, P.W.
Keratin 1 plays a critical role in Golgi localization of core 2 N-acetylglucosaminyltransferase M via interaction with its cytoplasmic tail
J. Biol. Chem.
290
6256-6269
2015
Homo sapiens (O95395), Homo sapiens
Manually annotated by BRENDA team
Liu, J.; Jin, C.; Cherian, R.M.; Karlsson, N.G.; Holgersson, J.
O-glycan repertoires on a mucin-type reporter protein expressed in CHO cell pools transiently transfected with O-glycan core enzyme cDNAs
J. Biotechnol.
199
77-89
2015
Homo sapiens (Q02742)
Manually annotated by BRENDA team
Kojima, Y.; Yoneyama, T.; Hatakeyama, S.; Mikami, J.; Sato, T.; Mori, K.; Hashimoto, Y.; Koie, T.; Ohyama, C.; Fukuda, M.; Tobisawa, Y.
Detection of core2 beta-1,6-N-acetylglucosaminyltransferase in post-digital rectal examination urine is a reliable indicator for extracapsular extension of prostate cancer
PLoS ONE
10
e0138520
2015
Homo sapiens
Manually annotated by BRENDA team
Tseng, T.H.; Lin, T.W.; Chen, C.Y.; Chen, C.H.; Lin, J.L.; Hsu, T.L.; Wong, C.H.
Substrate preference and interplay of fucosyltransferase 8 and N-acetylglucosaminyltransferases
J. Am. Chem. Soc.
139
9431-9434
2017
Homo sapiens (O95395)
Manually annotated by BRENDA team
Mardahl, M.; Schroeter, M.F.; Engelbert, D.; Pink, M.; Sperandio, M.; Hamann, A.; Syrbe, U.
Core 2 beta1,6-N-acetylglucosaminyltransferase-I, crucial for P-selectin ligand expression is controlled by a distal enhancer regulated by STAT4 and T-bet in CD4+ T helper cells 1
Mol. Immunol.
77
132-140
2016
Homo sapiens (Q02742)
Manually annotated by BRENDA team
Sumardika, I.W.; Youyi, C.; Kondo, E.; Inoue, Y.; Ruma, I.M.W.; Murata, H.; Kinoshita, R.; Yamamoto, K.I.; Tomida, S.; Shien, K.; Sato, H.; Yamauchi, A.; Futami, J.; Putranto, E.W.; Hibino, T.; Toyooka, S.; Nishibori, M.; Sakaguchi, M.
beta-1,3-Galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 increases MCAM stability, which enhances S100A8/A9-mediated cancer motility
Oncol. Res.
26
431-444
2018
Homo sapiens (O95395), Homo sapiens
Manually annotated by BRENDA team
Fernandez, L.P.; Sanchez-Martinez, R.; Vargas, T.; Herranz, J.; Martin-Hernandez, R.; Mendiola, M.; Hardisson, D.; Reglero, G.; Feliu, J.; Redondo, A.; Ramirez de Molina, A.
The role of glycosyltransferase enzyme GCNT3 in colon and ovarian cancer prognosis and chemoresistance
Sci. Rep.
8
8485
2018
Homo sapiens (O95395), Homo sapiens
Manually annotated by BRENDA team
Liu, J.; Zhang, Y.; Liu, W.; Zhang, Q.; Xiao, H.; Song, H.; Luo, B.
MiR-BART1-5p targets core 2beta-1,6-acetylglucosaminyltransferase GCNT3 to inhibit cell proliferation and migration in EBV-associated gastric cancer
Virology
541
63-74
2020
Homo sapiens (O95395), Homo sapiens
Manually annotated by BRENDA team