Information on EC 2.3.3.7 - 3-ethylmalate synthase

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The expected taxonomic range for this enzyme is: Gammaproteobacteria

EC NUMBER
COMMENTARY
2.3.3.7
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RECOMMENDED NAME
GeneOntology No.
3-ethylmalate synthase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
butanoyl-CoA + H2O + glyoxylate = 3-ethylmalate + CoA
show the reaction diagram
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PATHWAY
KEGG Link
MetaCyc Link
butanol and isobutanol biosynthesis (engineered)
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Glyoxylate and dicarboxylate metabolism
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SYSTEMATIC NAME
IUBMB Comments
butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)
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SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
2-ethyl-3-hydroxybutanedioate synthase
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3-ethylmalate glyoxylate-lyase (CoA-butanoylating)
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formerly 4.1.3.10
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CAS REGISTRY NUMBER
COMMENTARY
9024-01-5
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
butanoyl-CoA + H2O + glyoxylate
3-ethylmalate + CoA
show the reaction diagram
-
-
-
-
?
butanoyl-CoA + H2O + glyoxylate
3-ethylmalate + CoA
show the reaction diagram
-
-
-
-
?
butanoyl-CoA + H2O + glyoxylate
3-ethylmalate + CoA
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
butanoyl-CoA + H2O + glyoxylate
3-ethylmalate + CoA
show the reaction diagram
-
-
-
-
?
butanoyl-CoA + H2O + glyoxylate
3-ethylmalate + CoA
show the reaction diagram
-
-
-
-
?
butanoyl-CoA + H2O + glyoxylate
3-ethylmalate + CoA
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Mg2+
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reduced activity in absence of Mg2+
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.009
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activity in fraction of 40-60% (NH4)2SO4
additional information
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pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7
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complete inactivation
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20°C, inactivation in 24 h
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