Information on EC 2.3.3.11 - 2-hydroxyglutarate synthase

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The expected taxonomic range for this enzyme is: Escherichia coli

EC NUMBER
COMMENTARY
2.3.3.11
-
RECOMMENDED NAME
GeneOntology No.
2-hydroxyglutarate synthase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
propanoyl-CoA + H2O + glyoxylate = 2-hydroxyglutarate + CoA
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
condensation
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
C5-Branched dibasic acid metabolism
-
SYSTEMATIC NAME
IUBMB Comments
propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating)
-
-
-
-
2-hydroxyglutaratic synthetase
-
-
-
-
2-hydroxyglutaric synthetase
-
-
-
-
alpha-hydroxyglutarate synthetase
-
-
-
-
EC 4.1.3.9
-
-
formerly
-
hydroxyglutarate synthase
-
-
-
-
synthase, 2-hydroxyglutarate
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9024-02-6
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
E-26; mutant E-26V
-
-
Manually annotated by BRENDA team
strain K 12 derivate K2PRP3
-
-
Manually annotated by BRENDA team
Escherichia coli E-26
E-26
-
-
Manually annotated by BRENDA team
Escherichia coli K
strain K 12 derivate K2PRP3
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
-
the enzyme is involved in the metabolism of propionate
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
-
the 2-hydroxyglutarate pathway is metabolically significant during growth of Escherichia coli E-26V on propionate by providing an auxiliary mechanism for the formation of C4 acids
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
-
the enzyme may play a role in the biosynthesis of cell constituents
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli E-26
-
the 2-hydroxyglutarate pathway is metabolically significant during growth of Escherichia coli E-26V on propionate by providing an auxiliary mechanism for the formation of C4 acids
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli E-26
-
the enzyme may play a role in the biosynthesis of cell constituents
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli K
-
the enzyme is involved in the metabolism of propionate
-
?
propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
show the reaction diagram
-
-
-
?
propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
show the reaction diagram
-
-
-
?
propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
show the reaction diagram
-
-
-
?
propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
show the reaction diagram
-
-
-
?
propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli E-26
-
-
-
?
propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli E-26
-
-
-
?
propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli E-26
-
-
-
?
propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli K
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
-
the enzyme is involved in the metabolism of propionate
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
-
the 2-hydroxyglutarate pathway is metabolically significant during growth of Escherichia coli E-26V on propionate by providing an auxiliary mechanism for the formation of C4 acids
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
-
the enzyme may play a role in the biosynthesis of cell constituents
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli E-26
-
the 2-hydroxyglutarate pathway is metabolically significant during growth of Escherichia coli E-26V on propionate by providing an auxiliary mechanism for the formation of C4 acids
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli E-26
-
the enzyme may play a role in the biosynthesis of cell constituents
-
?
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
show the reaction diagram
Escherichia coli K
-
the enzyme is involved in the metabolism of propionate
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
-
radioactive assay
additional information
-
-
-
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
-
no activity in E. coli strain K2
Manually annotated by BRENDA team
Escherichia coli K
-
no activity in E. coli strain K2
-
Manually annotated by BRENDA team
Escherichia coli E-26
-
;
-
Manually annotated by BRENDA team
Escherichia coli K
-
-
-
Manually annotated by BRENDA team