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abc-type xenobiotic transporter deficiency
Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase--effect of cMOAT deficiency on hepatobiliary excretion in rats and of mdr1a/b gene disruption on tissue distribution in mice.
acetyl-coa c-acyltransferase deficiency
Clinical and biochemical features of fatty acid oxidation disorders.
acetyl-coa c-acyltransferase deficiency
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency and beta-ketothiolase deficiency: two case reports and reflections of congenital ketone body metabolism disorder.
Acidosis
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Acidosis
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Adenocarcinoma
Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
Adenoma
Infusion of sodium butyrate promotes rumen papillae growth and enhances expression of genes related to rumen epithelial VFA uptake and metabolism in neonatal twin lambs.
Alzheimer Disease
Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases.
Angina, Stable
Expression of HMG-CoA reductase in human coronary atherosclerotic plaques and relationship to plaque destabilisation.
Angina, Unstable
Carotid intima-media thickness as predictor of secondary events after coronary angioplasty.
Aortic Aneurysm, Abdominal
Inhibitory effect of statins on inflammation-related pathways in human abdominal aortic aneurysm tissue.
Aortic Valve Disease
Deciphering the gene expression profile of peroxisome proliferator-activated receptor signaling pathway in the left atria of patients with mitral regurgitation.
Arthritis
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Arthritis, Rheumatoid
Effect of Atorvastatin on the Disease Activity and Severity of Rheumatoid Arthritis: Double-Blind Randomized Controlled Trial.
Arthritis, Rheumatoid
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Atherosclerosis
Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits.
Atherosclerosis
Efficacy of Oral Curcuminoid Fraction from Curcuma xanthorrhiza and Curcuminoid Cider in High-cholesterol Fed Rats.
Atherosclerosis
Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages.
Atrial Fibrillation
Perioperative Statin Use May Reduce Postoperative Arrhythmia Rates After Total Joint Arthroplasty.
Blindness
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Brain Diseases
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Brain Ischemia
Coenzyme A and short-chain acyl-CoA species in control and ischemic rat brain.
Breast Neoplasms
Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells.
Breast Neoplasms
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.
Breast Neoplasms
Influence of DMBA-induced mammary cancer on the liver CPT I, mit HMG-CoA synthase and PPARalpha mRNA expression in rats fed a low or high corn oil diet.
Breast Neoplasms
Meta-Analysis of Tumor Stem-Like Breast Cancer Cells Using Gene Set and Network Analysis.
Breast Neoplasms
Patients with clinical/radiological hyperplasia of mammary glands show pathological persistence of temperature of skin points.
Breast Neoplasms
The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer.
Carcinogenesis
Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis.
Carcinogenesis
HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma.
Carcinoma
A New Survival Model Based on Cholesterol Biosynthesis-Related Genes for Prognostic Prediction in Clear Cell Renal Cell Carcinoma.
Carcinoma
FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast.
Carcinoma
Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site.
Carcinoma
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Carcinoma
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
Carcinoma
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
Carcinoma
The STAT3-miR-223-TGFBR3/HMGCS1 axis modulates the progression of cervical carcinoma.
Carcinoma, Hepatocellular
ATF6? Stimulates Cholesterogenic Gene Expression and de Novo Cholesterol Synthesis.
Carcinoma, Hepatocellular
Chicken ovalbumin upstream-promoter transcription factor (COUP-TF) could act as a transcriptional activator or repressor of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene.
Carcinoma, Hepatocellular
Co-ordinate regulation of low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase and synthase gene expression in HepG2 cells.
Carcinoma, Hepatocellular
HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study.
Carcinoma, Hepatocellular
HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Involvement of nutrients and nutritional mediators in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression.
Carcinoma, Hepatocellular
miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma.
Carcinoma, Hepatocellular
NMR-based metabolomic profile of hypercholesterolemic human sera: Relationship with in vitro gene expression?
Carcinoma, Hepatocellular
Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.
Carcinoma, Squamous Cell
The STAT3-miR-223-TGFBR3/HMGCS1 axis modulates the progression of cervical carcinoma.
Cardiomyopathies
Exercise Training Reverses Lipotoxicity-induced Cardiomyopathy by Inhibiting HMGCS2.
Cardiomyopathies
Neuro, cardio, and reno protective activities of rosuvastatin in streptozotocin-induced type 2 diabetic rats undergoing treatment with metformin and glimepiride.
Cardiovascular Diseases
Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases.
Cardiovascular Diseases
Enhancement of drug solubility in supramolecular and colloidal systems.
Cardiovascular Diseases
High-dose statin therapy for secondary prevention of stroke: stroke prevention by aggressive reduction in cholesterol levels study review.
Cardiovascular Diseases
Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors.
Cardiovascular Diseases
MDR reversal and pro-apoptotic effects of statins and statins combined with flavonoids in colon cancer cells.
Cardiovascular Diseases
Statins and clinical outcomes in heart failure.
Cardiovascular Diseases
Statins: HMG-CoA Reductase Inhibitors as Potential Anticancer Agents against Malignant Neoplasms in Women.
Cerebral Infarction
[Role of HMG-CoA inhibitor (statin) in prevention of cerebral infarction]
Cholestasis
Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: characterization and mechanism.
Choroideremia
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Clostridium Infections
Statin Effects on Incidence, Treatment Success, and Mortality of Clostridium difficile Infections.
Coinfection
Validation of a High-Throughput Multiplex Genetic Detection System for Helicobacter pylori Identification, Quantification, Virulence, and Resistance Analysis.
Colitis
Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism.
Colitis, Ulcerative
Ketogenesis alleviates TNF?-induced apoptosis and inflammatory responses in intestinal cells.
Colonic Neoplasms
Cholesterol metabolism and colon cancer.
Colonic Neoplasms
Dipyridamole Enhances the Cytotoxicities of Trametinib against Colon Cancer Cells through Combined Targeting of HMGCS1 and MEK Pathway.
Colonic Neoplasms
HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers.
Colonic Neoplasms
Ketogenesis alleviates TNF?-induced apoptosis and inflammatory responses in intestinal cells.
Colonic Neoplasms
Ketogenesis contributes to intestinal cell differentiation.
Colonic Neoplasms
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
Colonic Neoplasms
Regulation of Ketogenic Enzyme HMGCS2 by Wnt/?-catenin/PPAR? Pathway in Intestinal Cells.
Colonic Neoplasms
The bioinformatics aspects of gene screening of HT-29, human colon cell line treated with caffeic acid.
Colorectal Neoplasms
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Colorectal Neoplasms
Hydroxymethylglutaryl-coenzyme a synthase 2 expression is associated with chemoradiotherapy responses in colorectal cancer.
Colorectal Neoplasms
Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker.
Colorectal Neoplasms
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
Coma
Fasting hypoketotic coma in a child with deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.
Coma
Genetic basis of mitochondrial HMG-CoA synthase deficiency.
Coma
Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
Coronary Artery Disease
Increased expression of interleukin-1 in coronary artery disease with downregulatory effects of HMG-CoA reductase inhibitors.
Coronary Disease
Cost-effectiveness of HMG-CoA reductase inhibition for primary and secondary prevention of coronary heart disease.
Coronary Disease
Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.
Coronary Disease
Guinea pigs as models to study the hypocholesterolemic effects of drugs.
Coronary Disease
High-dose statin therapy for secondary prevention of stroke: stroke prevention by aggressive reduction in cholesterol levels study review.
Coronary Disease
Rosuvastatin for the treatment of patients with hypercholesterolemia.
Coronary Disease
Statin use and cancer risk: a comprehensive review.
Coronary Disease
[Pharmacoeconomic evaluation of pravastatin in the secondary prevention of coronary heart disease in patients with average cholesterol levels. An analysis for Germany based on the CARE study]
Craniofacial Abnormalities
Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development.
Crohn Disease
Ketogenesis alleviates TNF?-induced apoptosis and inflammatory responses in intestinal cells.
Cysts
FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast.
Dehydration
Mitochondrial dysfunction, AMPK activation and peroxisomal metabolism: A coherent scenario for non-canonical 3-methylglutaconic acidurias.
Diabetes Mellitus
HMG-CoA reductase inhibitors suppress the development and progression of carotid artery intimal-medial thickening in hypercholesterolemic type 2 diabetic patients.
Diabetes Mellitus, Type 1
HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk.
Diabetes Mellitus, Type 2
HMG-CoA reductase inhibitors suppress the development and progression of carotid artery intimal-medial thickening in hypercholesterolemic type 2 diabetic patients.
Diabetic Cardiomyopathies
Silencing of peroxisome proliferator-activated receptor-alpha alleviates myocardial injury in diabetic cardiomyopathy by downregulating 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 expression.
Diabetic Neuropathies
RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice.
Diabetic Retinopathy
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Down Syndrome
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Drug Eruptions
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Drug-Related Side Effects and Adverse Reactions
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Dyslipidemias
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases.
Dyslipidemias
Quantitation of plasma mevalonic acid using gas chromatography-electron capture mass spectrometry.
Encephalomyelitis
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Encephalomyelitis
Toward a role for statins in immunomodulation.
Encephalomyelitis, Autoimmune, Experimental
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
Toward a role for statins in immunomodulation.
Epilepsy
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Epilepsy, Temporal Lobe
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Erectile Dysfunction
Correction to: Inactivation of the Ras/MAPK/PPAR? signaling axis alleviates diabetic mellitus-induced erectile dysfunction through suppression of corpus cavernosal endothelial cell apoptosis by inhibiting HMGCS2 expression.
Erectile Dysfunction
Inactivation of the Ras/MAPK/PPAR? signaling axis alleviates diabetic mellitus-induced erectile dysfunction through suppression of corpus cavernosal endothelial cell apoptosis by inhibiting HMGCS2 expression.
Erythema Multiforme
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Esophageal Squamous Cell Carcinoma
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
Essential Hypertension
[Beneficial effects of statins and angiotensin converting enzyme inhibitors on aggregability of red blood cells in hypertensive patients]
Fatty Liver
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Fatty Liver
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Gastroenteritis
Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses.
Glioblastoma
Cellular and tumoural heterogeneity of EGFR gene amplification in human malignant gliomas.
Glioma
Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Gene-nutrient interactions in G6PD-deficient subjects--implications for cardiovascular disease susceptibility.
Glucosephosphate Dehydrogenase Deficiency
Gene-nutrient interactions in G6PD-deficient subjects--implications for cardiovascular disease susceptibility.
Gonadal Dysgenesis
The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice.
Hearing Loss
Genotype-based databases for variants causing rare diseases.
Hepatitis C
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme a synthase.
Hepatoblastoma
The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells.
Hepatomegaly
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Hepatomegaly
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Hepatomegaly
Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.
hydroxymethylglutaryl-coa synthase deficiency
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
hydroxymethylglutaryl-coa synthase deficiency
Association of a novel homozygous mutation in the HMGCS2 gene with an HMGCSD in an Iranian patient.
hydroxymethylglutaryl-coa synthase deficiency
Clinical and biochemical features of fatty acid oxidation disorders.
hydroxymethylglutaryl-coa synthase deficiency
Clinical, biochemical, molecular and therapeutic characteristics of four new patients of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
hydroxymethylglutaryl-coa synthase deficiency
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
hydroxymethylglutaryl-coa synthase deficiency
Expanding phenotypic and mutational spectra of mitochondrial HMG-CoA synthase deficiency.
hydroxymethylglutaryl-coa synthase deficiency
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
hydroxymethylglutaryl-coa synthase deficiency
Genetic basis of mitochondrial HMG-CoA synthase deficiency.
hydroxymethylglutaryl-coa synthase deficiency
Hepatic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme a synthase deficiency.
hydroxymethylglutaryl-coa synthase deficiency
Human Mitochondrial HMG-CoA Synthase Deficiency: Role of Enzyme Dimerization Surface and Characterization of Three New Patients.
hydroxymethylglutaryl-coa synthase deficiency
Hypoglycemia is not a defining feature of metabolic crisis in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: Further evidence of specific biochemical markers which may aid diagnosis.
hydroxymethylglutaryl-coa synthase deficiency
Japanese patients with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: In vitro functional analysis of five novel HMGCS2 mutations.
hydroxymethylglutaryl-coa synthase deficiency
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency and beta-ketothiolase deficiency: two case reports and reflections of congenital ketone body metabolism disorder.
hydroxymethylglutaryl-coa synthase deficiency
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients.
hydroxymethylglutaryl-coa synthase deficiency
Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.
hydroxymethylglutaryl-coa synthase deficiency
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: urinary organic acid profiles and expanded spectrum of mutations.
hydroxymethylglutaryl-coa synthase deficiency
Mitochondrial HMG-CoA synthase deficiency: identification of two further patients carrying two novel mutations.
hydroxymethylglutaryl-coa synthase deficiency
MRI and MRS in HMG-CoA lyase deficiency.
hydroxymethylglutaryl-coa synthase deficiency
New case of mitochondrial HMG-CoA synthase deficiency. Functional analysis of eight mutations.
hydroxymethylglutaryl-coa synthase deficiency
Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
hydroxymethylglutaryl-coa synthase deficiency
Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency.
hydroxymethylglutaryl-coa synthase deficiency
Severe clinical manifestation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency associated with two novel mutations: a case report.
hydroxymethylglutaryl-coa synthase deficiency
The diagnosis of mitochondrial HMG-CoA synthase deficiency.
hydroxymethylglutaryl-coa synthase deficiency
[Mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase deficiency: a case report and literature review].
Hypercholesterolemia
Amiodarone-induced hypercholesterolemia is associated with a decrease in liver LDL receptor mRNA.
Hypercholesterolemia
CB1-05: Development of Reusable Logic for Calculating Statin Exposure-Time from Electronic Medical Record Notes and Orders.
Hypercholesterolemia
Experimental lovastatin myopathy.
Hypercholesterolemia
Exploration of virtual candidates for human HMG-CoA reductase inhibitors using pharmacophore modeling and molecular dynamics simulations.
Hypercholesterolemia
HMG-CoA reductase inhibitors suppress the development and progression of carotid artery intimal-medial thickening in hypercholesterolemic type 2 diabetic patients.
Hypercholesterolemia
HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.
Hypercholesterolemia
MicroRNA-223 coordinates cholesterol homeostasis.
Hypercholesterolemia
Potential antitumor effects of statins (Review).
Hypercholesterolemia
Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.
Hypercholesterolemia
The effects of the intestinal glucosidase inhibitor acarbose on cholesterogenesis in corpulent rats.
Hypercholesterolemia
[Beneficial effects of statins and angiotensin converting enzyme inhibitors on aggregability of red blood cells in hypertensive patients]
Hypercholesterolemia
[Clinical trial of lovastatin versus gemfibrozil in the treatment of primary hypercholesterolemia]
Hypercholesterolemia
[The use of statins, a new approach to the treatment of autoimmune diseases]
Hyperglycemia
Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia.
Hyperlipidemias
Cassia auriculata flower extract attenuates hyperlipidemia in male Wistar rats by regulating the hepatic cholesterol metabolism.
Hyperlipoproteinemia Type II
Effects of pravastatin sodium and simvastatin on plasma fibrinogen level and blood rheology in type II hyperlipoproteinemia.
Hyperlipoproteinemias
Effect of medication with pravastatin sodium on hemorheological parameters in patients with hyperlipoproteinemia.
Hyperlipoproteinemias
Effects of pravastatin sodium and simvastatin on plasma fibrinogen level and blood rheology in type II hyperlipoproteinemia.
Hypertension
Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2.
Hypoglycemia
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Hypoglycemia
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Hypoglycemia
Hypoglycemia is not a defining feature of metabolic crisis in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: Further evidence of specific biochemical markers which may aid diagnosis.
Hypoglycemia
Ketone body metabolism and its defects.
Hypoglycemia
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients.
Hypoglycemia
Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.
Hypoglycemia
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: urinary organic acid profiles and expanded spectrum of mutations.
Hypoglycemia
Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
Infections
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Infections
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.
Infections
Increased Rates of Rhabdomyolysis in Male Hematopoietic Cell Transplantation Recipients Taking Sirolimus and Trimethoprim/Sulfamethoxazole.
Infections
Lipid Metabolism in Vascular Smooth Muscle Cells Infuenced by HCMV Infection.
Infections
Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model.
Infections
Statin Effects on Incidence, Treatment Success, and Mortality of Clostridium difficile Infections.
Infections
The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being.
Infections
Validation of a High-Throughput Multiplex Genetic Detection System for Helicobacter pylori Identification, Quantification, Virulence, and Resistance Analysis.
Inflammatory Bowel Diseases
Differences between intestinal segments and soybean mealinduced changes in intestinal mucus composition of common carp Cyprinus carpio L.
Influenza, Human
Functional glycomic analysis of human milk glycans reveals the presence of virus receptors and embryonic stem cell biomarkers.
Ischemic Stroke
[Pathogenetic justification of statin use in ischaemic stroke prevention according to inflammatory theory in development of atherosclerosis].
Ketosis
Aspects of ketogenesis: control and mechanism of ketone-body formation in isolated rat-liver mitochondria.
Ketosis
Effect of polyphenols on 3-hydroxy-3-methylglutaryl-coenzyme A lyase activity in human hepatoma HepG2 cell extracts.
Ketosis
Effect of Saccharomyces cerevisiae fermentation product on feed intake parameters, lactation performance, and metabolism of transition dairy cattle.
Ketosis
Fatty acid and ketone body metabolism in the rat: response to diet and exercise.
Ketosis
Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2.
Ketosis
Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.
Ketosis
Silibinin inhibits in vitro ketosis by regulating HMGCS2 and NF-kB: elucidation of signaling molecule relationship under ketotic conditions.
Leber Congenital Amaurosis
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Lethargy
A Japanese case of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency who presented with severe metabolic acidosis and fatty liver without hypoglycemia.
Lethargy
Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review.
Lethargy
Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.
Leukemia
Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase.
Leukemia
Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.
Leukemia, Erythroblastic, Acute
Isoprenoid synthesis during the cell cycle. Studies of 3-hydroxy-3-methylglutaryl-coenzyme A synthase and reductase and isoprenoid labeling in cells synchronized by centrifugal elutriation.
Leukemia, Myeloid, Acute
HMGCS1 drives drug-resistance in acute myeloid leukemia through endoplasmic reticulum-UPR-mitochondria axis.
Liver Diseases
Exercise in mice ameliorates high-fat diet-induced nonalcoholic fatty liver disease by lowering HMGCS2.
Liver Diseases
HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma.
Liver Diseases
Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model.
Liver Neoplasms
Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer.
Lupus Erythematosus, Systemic
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Lupus Erythematosus, Systemic
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Lymphoma
Signalling pathways identified in salivary glands from primary Sjögren's syndrome patients reveal enhanced adipose tissue development.
Lymphoma, B-Cell
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Melanoma
HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers.
Metabolic Diseases
Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma.
Mouth Neoplasms
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Multiple Sclerosis
Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination.
Multiple Sclerosis
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Multiple Sclerosis
Toward a role for statins in immunomodulation.
Multiple Sclerosis, Chronic Progressive
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Multiple Sclerosis, Relapsing-Remitting
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Muscular Diseases
Evaluation of myopathy risk for HMG-CoA reductase inhibitors by urethane infusion method.
Muscular Diseases
Genotype-based databases for variants causing rare diseases.
Muscular Diseases
Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes.
Muscular Diseases
Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia.
Muscular Diseases
Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors.
Muscular Diseases
Simultaneous analysis of the total plasma concentration of atorvastatin and its five metabolites and the unbound plasma concentration of atorvastatin: Application in a clinical pharmacokinetic study of single oral dose.
Muscular Diseases
Statin-associated immune-mediated necrotizing myopathy: a retrospective analysis of individual case safety reports from VigiBase.
Muscular Diseases
The role of cytochrome P450-mediated drug-drug interactions in determining the safety of statins.
Myotoxicity
Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors.
Neoplasm Metastasis
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Neoplasm Metastasis
HMGCS2 functions as a tumor suppressor and has a prognostic impact in prostate cancer.
Neoplasm Metastasis
HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma.
Neoplasm Metastasis
Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer.
Neoplasm Metastasis
Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
Neoplasm Metastasis
Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker.
Neoplasms
A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer.
Neoplasms
Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting.
Neoplasms
Arsenic exposure alters expression of cell cycle and lipid metabolism genes in the liver of adult zebrafish (Danio rerio).
Neoplasms
Cellular and tumoural heterogeneity of EGFR gene amplification in human malignant gliomas.
Neoplasms
Chicken ovalbumin upstream-promoter transcription factor (COUP-TF) could act as a transcriptional activator or repressor of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene.
Neoplasms
Contribution of steroidogenic factor 1 to the regulation of cholesterol synthesis.
Neoplasms
Correlation between protein accumulation profiles and conventional toxicological findings using a model antiandrogenic compound, flutamide.
Neoplasms
Development and validation of a lipogenic genes panel for diagnosis and recurrence of colorectal cancer.
Neoplasms
Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial.
Neoplasms
FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast.
Neoplasms
Genetic variants in the cholesterol biosynthesis pathway genes and risk of prostate cancer.
Neoplasms
HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers.
Neoplasms
HMGCS1 drives drug-resistance in acute myeloid leukemia through endoplasmic reticulum-UPR-mitochondria axis.
Neoplasms
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Neoplasms
HMGCS2 functions as a tumor suppressor and has a prognostic impact in prostate cancer.
Neoplasms
HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study.
Neoplasms
Influence of DMBA-induced mammary cancer on the liver CPT I, mit HMG-CoA synthase and PPARalpha mRNA expression in rats fed a low or high corn oil diet.
Neoplasms
Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data.
Neoplasms
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
Neoplasms
Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer.
Neoplasms
Meta-Analysis of Tumor Stem-Like Breast Cancer Cells Using Gene Set and Network Analysis.
Neoplasms
Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
Neoplasms
miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma.
Neoplasms
Molecular regulation of cholesterol biosynthesis: implications in carcinogenesis.
Neoplasms
NCI-CONNECT: Comprehensive Oncology Network Evaluating Rare CNS Tumors-Histone Mutated Midline Glioma Workshop Proceedings.
Neoplasms
Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer.
Neoplasms
Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker.
Neoplasms
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
Neoplasms
Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis.
Neoplasms
Regulation of Ketogenic Enzyme HMGCS2 by Wnt/?-catenin/PPAR? Pathway in Intestinal Cells.
Neoplasms
Second hand smoke stimulates tumor angiogenesis and growth.
Neoplasms
Tailor-Making Fluorescent Hyaluronic Acid Microgels via Combining Microfluidics and Photoclick Chemistry for Sustained and Localized Delivery of Herceptin in Tumors.
Neoplasms
The bioinformatics aspects of gene screening of HT-29, human colon cell line treated with caffeic acid.
Neoplasms
The effects of glycosylation inhibitors on the proliferation of a spontaneously transformed cell line (3T6) in vitro.
Neoplasms
The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer.
Neoplasms
The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy.
Neoplasms
The STAT3-miR-223-TGFBR3/HMGCS1 axis modulates the progression of cervical carcinoma.
Neoplasms
[Significance of hydroxymethylglutaryl-CoA synthase 2 on prognosis of esophageal squamous cell carcinoma].
Neuritis
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Neuritis, Autoimmune, Experimental
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Non-alcoholic Fatty Liver Disease
Exercise in mice ameliorates high-fat diet-induced nonalcoholic fatty liver disease by lowering HMGCS2.
Non-alcoholic Fatty Liver Disease
Expression of genes encoding mitochondrial proteins can distinguish nonalcoholic steatosis from steatohepatitis.
Obesity
Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases.
Obesity
Extracting time-dependent obese-diabetic specific networks in hepatic proteome analysis.
Obesity
Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma.
Ovarian Hyperstimulation Syndrome
Effect of prolactin in an experimental model of the ovarian hyperstimulation syndrome.
Overweight
Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.
Pancreatitis, Chronic
[Inhibition of the stellate cells using lisinopril and lovastatin for prophylaxis of pancreatic stump fibrosis after performance of distal resection in a model of chronic alcoholic pancreatitis].
Peripheral Nerve Injuries
HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial cells in dorsal root ganglia and are differentially regulated by peripheral nerve injury.
Pheochromocytoma
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Prostatic Neoplasms
HMGCS2 functions as a tumor suppressor and has a prognostic impact in prostate cancer.
Prostatic Neoplasms
Lovastatin-induced E2F-1 modulation and its effect on prostate cancer cell death.
Prostatic Neoplasms
Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients.
Prostatic Neoplasms
Stromal regulation of prostate cancer cell growth by mevalonate pathway enzymes HMGCS1 and HMGCR.
Pulmonary Disease, Chronic Obstructive
Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease.
Rectal Neoplasms
The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy.
Renal Insufficiency, Chronic
Atorvastatin preserves renal function in chronic complete unilateral ureteral obstruction.
Respiratory Tract Infections
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.
Retinal Diseases
Choroideremia: molecular mechanisms and development of AAV gene therapy.
Rhabdomyolysis
Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors.
Seizures
Increased Rates of Rhabdomyolysis in Male Hematopoietic Cell Transplantation Recipients Taking Sirolimus and Trimethoprim/Sulfamethoxazole.
Seizures
Regulation of the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in astrocytes and meningeal fibroblasts. Implications in normal brain development and seizure neuropathologies.
Sleep Deprivation
Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis.
Squamous Cell Carcinoma of Head and Neck
HMGCS2 enhances invasion and metastasis via direct interaction with PPAR? to activate Src signaling in colorectal cancer and oral cancer.
Starvation
CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy.
Starvation
Gene expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in a poorly ketogenic mammal: effect of starvation during the neonatal period of the piglet.
Starvation
Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21.
Starvation
Low activity of mitochondrial HMG-CoA synthase in liver of starved piglets is due to low levels of protein despite high mRNA levels.
Starvation
Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.
Starvation
Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes.
Starvation
Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis.
Status Epilepticus
Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
Stevens-Johnson Syndrome
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Stomach Neoplasms
Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
Stroke
High-dose statin therapy for secondary prevention of stroke: stroke prevention by aggressive reduction in cholesterol levels study review.
Stroke
Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors.
Tuberculosis, Bovine
Genome-Wide Scanning for Signatures of Selection Revealed the Putative Genomic Regions and Candidate Genes Controlling Milk Composition and Coat Color Traits in Sahiwal Cattle.
Vascular Diseases
Pleiotropic Effects and Cholesterol-Lowering Therapy.
Waldenstrom Macroglobulinemia
The HMG-CoA inhibitor, simvastatin, triggers in vitro anti-tumour effect and decreases IgM secretion in Waldenstrom macroglobulinaemia.
Xanthomatosis
Interaction of galectin-7 with HMGCS1 in vitro may facilitate cholesterol deposition in cultured keratinocytes.
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Greenspan, M.D.; Yudkovitz, J.B.; Lo, C.Y.L.; Chen, J.S.; Alberts, A.W.; Hunt, V.M.; Chang, M.N.; Yang, S.S.; Thompson, K.L.; Chiang, Y.C.P.; Chabala, J.C.; Monaghan, R.L.; Schwartz, R.L.
Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L659,699
Proc. Natl. Acad. Sci. USA
84
7488-7492
1987
Gallus gallus, Cricetulus griseus, Homo sapiens, Rattus norvegicus
brenda
Rokosz, L.L.; Boulton, D.A.; Butkiewicz, E.A.; Sanyal, G.; Cueto, M.A.; Lachance, P.A.; Hermes, J.D.
Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, andcharacterization of recombinant wild-type and cys-129 mutant enzymes
Arch. Biochem. Biophys.
312
1-13
1994
Gallus gallus, Cricetulus griseus, Homo sapiens, Rattus norvegicus
brenda
Misra, I.; Charlier, H.A.; Miziorko, H.M.
Avian cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase. Evaluation of the role of cysteines in reaction chemistry
Biochim. Biophys. Acta
1247
253-259
1995
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus, Cricetulus griseus (P13704), Blattella germanica (P54870), Blattella germanica (P54961)
brenda
Montamat, F.; Guilloton, M.; Karst, F.; Delrot, S.
Isolation and characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-coenzyme A synthase
Gene
167
197-201
1995
Arabidopsis thaliana, Catharanthus roseus, Gallus gallus, Cricetulus griseus, Homo sapiens, Raphanus sativus, Rattus norvegicus
brenda
Scharnagl, H.; Mrz, W.; Schliack, M.; Lser, R.; Gross, W.
A novel assay of cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity using reversed-phase ion-pair chromatography: demonstration that Lifibrol (K12.148) modulates the enzyme activity
J. Lipid Res.
36
622-627
1995
Bos taurus, Gallus gallus, Cricetulus griseus, Homo sapiens, Mesocricetus auratus, Rattus norvegicus
brenda
Misra, I.; Miziorko, H.M.
Evidence for the interaction of avian 3-hydroxy-3-methylglutaryl-CoA synthase H264 with acetoacetyl-CoA
Biochemistry
35
9610-9616
1996
Bos taurus, Saccharomyces cerevisiae, Gallus gallus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Blattella germanica (P54870), Blattella germanica (P54961)
brenda
Chun, K.Y.; Vinarov, D.A.; Miziorko, H.M.
3-Hydroxy-3-methylglutaryl-CoA synthase: Participation of invariant acidic residues in formation of the acetyl-S-enzyme reaction intermediate
Biochemistry
39
14670-14681
2000
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P54839), Gallus gallus, Gallus gallus (P23228), Homo sapiens, Homo sapiens (P54868), Homo sapiens (Q01581), Mesocricetus auratus, Methanothermobacter thermautotrophicus, Sus scrofa (O02734), Borreliella burgdorferi (O51626), Cricetulus griseus (P13704), Rattus norvegicus (P17425), Rattus norvegicus (P22791), Mus musculus (P54869), Blattella germanica (P54870), Blattella germanica (P54961), Caenorhabditis elegans (P54871), Arabidopsis thaliana (P54873), Schizosaccharomyces pombe (P54874), Pinus sylvestris (P93773)
brenda
Chun, K.Y.; Vinarov, D.A.; Zajicek, J.; Miziorko, H.M.
3-hydroxy-3-methylglutaryl-CoA synthase. A role for glutamate 95 in general acid/base catalysis of C-C bond formation
J. Biol. Chem.
275
17946-17953
2000
Gallus gallus, Gallus gallus (P23228), Homo sapiens, Homo sapiens (P54868), Methanothermobacter thermautotrophicus, Sus scrofa (O02734), Borreliella burgdorferi (O51626), Rattus norvegicus (P22791), Mus musculus (P54869), Blattella germanica (P54870), Blattella germanica (P54961), Arabidopsis thaliana (P54873), Schizosaccharomyces pombe (P54874), Pinus sylvestris (P93773)
brenda
Sutherlin, A.; Hedl, M.; Sanchez-Neri, B.; Burgner, J.W.; Stauffacher, C.V.; Rodwell, V.W.
Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis
J. Bacteriol.
184
4065-4070
2002
Blattella germanica, Borreliella burgdorferi, Bos taurus, Streptomyces sp., Gallus gallus, Streptococcus pneumoniae, Enterococcus faecalis, Homo sapiens, Mesocricetus auratus, Staphylococcus aureus, Mus musculus, Rattus norvegicus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Streptococcus pyogenes, Sus scrofa
brenda
Camarero, N.; Mascaro, C.; Mayordomo, C.; Vilardell, F.; Haro, D.; Marrero, P.F.
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer
Mol. Cancer Res.
4
645-653
2006
Homo sapiens
brenda
Castro, J.; Amigo, L.; Miquel, J.F.; Gaelman, C.; Crovari, F.; Raddatz, A.; Zanlungo, S.; Jalil, R.; Rudling, M.; Nervi, F.
Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease
Hepatology
45
1261-1266
2007
Homo sapiens
brenda
Liu, M.H.; Li, J.; Shen, P.; Husna, B.; Tai, E.S.; Yong, E.L.
A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin
Mol. Endocrinol.
22
1078-1092
2008
Homo sapiens
brenda
Andrew Skaff, D.; Miziorko, H.M.
A visible wavelength spectrophotometric assay suitable for high-throughput screening of 3-hydroxy-3-methylglutaryl-CoA synthase
Anal. Biochem.
396
96-102
2010
Homo sapiens
brenda
Shafqat, N.; Turnbull, A.; Zschocke, J.; Oppermann, U.; Yue, W.W.
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design
J. Mol. Biol.
398
497-506
2010
Homo sapiens (P54868), Homo sapiens (Q01581), Homo sapiens
brenda
Puisac, B.; Ramos, M.; Arnedo, M.; Menao, S.; Gil-Rodriguez, M.C.; Teresa-Rodrigo, M.E.; Pie, A.; de Karam, J.C.; Wesselink, J.J.; Gimenez, I.; Ramos, F.J.; Casals, N.; Gomez-Puertas, P.; Hegardt, F.G.; Pie, J.
Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway
Mol. Biol. Rep.
39
4777-4785
2012
Homo sapiens
brenda
Liao, P.; Wang, H.; Hemmerlin, A.; Nagegowda, D.A.; Bach, T.J.; Wang, M.; Chye, M.L.
Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway
Plant Cell Rep.
33
1005-1022
2014
Arabidopsis thaliana (P54873), Brassica juncea (Q9M6U3), Camptotheca acuminata (B3GDB1), Catharanthus roseus, Gallus gallus (P23228), Hevea brasiliensis (Q94ET0), Hevea brasiliensis, Homo sapiens (A0A024R059), Melampsora larici-populina, Mesocricetus auratus, Pinus sylvestris (P93773), Populus trichocarpa x Populus deltoides, Rattus norvegicus (P17425), Salvia miltiorrhiza (D2DS62), Solanum lycopersicum (A9LRT6), Sus scrofa (O02734), Taxus x media (Q693N8)
brenda
Zhao, L.; Fan, J.; Xia, S.; Pan, Y.; Liu, S.; Qian, G.; Qian, Z.; Kang, H.B.; Arbiser, J.L.; Pollack, B.P.; Kudchadkar, R.R.; Lawson, D.H.; Rossi, M.; Abdel-Wahab, O.; Merghoub, T.; Khoury, H.J.; Khuri, F.R.; Boise, L.H.; Lonial, S.; Chen, F.; Chen, J.; Lin, R.
HMG-CoA synthase 1 is a synthetic lethal partner of BRAFV600E in human cancers
J. Biol. Chem.
292
10142-10152
2017
Homo sapiens (Q01581), Homo sapiens
brenda
2.3.3.10 hydroxymethylglutaryl-CoA synthase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
