Information on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase

New: Word Map on EC 2.3.2.5
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Search Reference ID:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.3.2.5
-
RECOMMENDED NAME
GeneOntology No.
glutaminyl-peptide cyclotransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aminoacyl group transfer
SYSTEMATIC NAME
IUBMB Comments
L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)
Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.
CAS REGISTRY NUMBER
COMMENTARY hide
37257-21-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
; expressed in Pichia pastoris
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
39SrpL21 protein
?
show the reaction diagram
-
-
-
?
Acp33A protein
?
show the reaction diagram
-
-
-
?
ALDH2 protein
?
show the reaction diagram
-
-
-
?
amyloid beta(3-40)
pyroglutamyl-amyloid beta(3-40) + NH3
show the reaction diagram
-
-
-
-
?
amyloid peptide Abeta(3-40,42)
Abeta(3[pE]-40,42) + H2O
show the reaction diagram
-
-
-
-
?
amyloid peptide Abeta(3-40/42)
pGluAbeta(3-40/42) + H2O
show the reaction diagram
-
-
significant portion of Abeta peptides of amyloid plaques in Alzheimer's disease brains
-
?
DIM-10 protein
?
show the reaction diagram
-
-
-
?
EFRH-NH2
pEFRH-NH2 + H2O
show the reaction diagram
EFRHHDSGYE-NH2
pEFRHHDSGYE-NH2 + H2O
show the reaction diagram
Gln
L-5-oxoproline + NH3
show the reaction diagram
-
-
-
-
?
Gln
pyroglutamate + NH3
show the reaction diagram
-
-
-
-
?
Gln(3)-amyloid-beta peptide 3-11 amide
?
show the reaction diagram
-
-
-
-
?
Gln(3)-amyloid-beta peptide 3-21 amide
?
show the reaction diagram
-
-
-
-
?
Gln(3)-amyloid-beta peptide 3-40 amide
?
show the reaction diagram
-
-
-
-
?
Gln-2-naphthylamide
2-oxoprolyl-2-naphthylamide + NH3
show the reaction diagram
-
-
-
-
?
Gln-2-naphthylamide
pyroglutamyl-2-naphthylamide + NH3
show the reaction diagram
-
-
-
-
?
Gln-4-methylcoumarinylamide
2-oxoprolyl-4-methylcoumarinylamide + NH3
show the reaction diagram
-
-
-
-
?
Gln-7-amido-4-methylcoumarin
L-pyroglutamyl-4-methylcoumarin-7-amide + NH3
show the reaction diagram
-
-
-
-
?
Gln-7-amido-4-methylcoumarin
pyroglutamic acid-7-amido-4-methylcoumarin + NH3
show the reaction diagram
Gln-Ala
Glp-Ala + NH3
show the reaction diagram
Gln-Ala
pyroglutamic acid-Ala + NH3
show the reaction diagram
Gln-Ala-Ala-Ala-Ala-NH2
pyroglutamic acid-Ala-Ala-Ala-Ala-NH2 + NH3
show the reaction diagram
Gln-Ala-Ala-NH2
pyroglutamic acid-Ala-Ala-NH2 + NH3
show the reaction diagram
Gln-Ala-Ala-Ser-Ala-Ala-NH2
pyroglutamic acid-Ala-Ala-Ser-Ala-Ala-NH2 + NH3
show the reaction diagram
Gln-Arg-Gly-Ile-NH2
pyroglutamic acid-Arg-Gly-Ile-NH2 + NH3
show the reaction diagram
Gln-Arg-Tyr-Phe-NH2
pyroglutamic acid-Arg-Tyr-Phe-NH2 + NH3
show the reaction diagram
Gln-Asn-Gly-Ile-NH2
pyroglutamic acid-Asn-Gly-Ile-NH2 + NH3
show the reaction diagram
Gln-beta-naphthylamide
pyroglutamic acid-beta-naphthylamide + NH3
show the reaction diagram
-
-
-
-
?
Gln-beta-naphthylamide
pyroglutamic acid-beta-naphthylamine + NH3
show the reaction diagram
-
-
-
-
?
Gln-Gln
5-oxoprolyl-Gln + NH3
show the reaction diagram
Gln-Gln
Glp-Gln + NH3
show the reaction diagram
Gln-Gln
L-5-oxoprolyl-Gln + NH3
show the reaction diagram
-
-
-
-
?
Gln-Gln
pGlu-Gln + NH3
show the reaction diagram
Gln-Gln
pyroglutamic acid-Gln + NH3
show the reaction diagram
Gln-Gln
pyroglutamyl-Gln + NH3
show the reaction diagram
-
-
-
-
?
Gln-Gln-Gln
Glp-Gln-Gln + NH3
show the reaction diagram
Gln-Gln-Tyr-Phe-NH2
pyroglutamic acid-Gln-Tyr-Phe-NH2 + NH3
show the reaction diagram
Gln-Glu
Glp-Glu + NH3
show the reaction diagram
Gln-Glu
pGlu-Glu + NH3
show the reaction diagram
Gln-Glu
pyroglutamic acid-Glu + NH3
show the reaction diagram
Gln-Glu-Ala-Ala-NH2
pyroglutamic acid-Glu-Ala-Ala-NH2 + NH3
show the reaction diagram
Gln-Glu-Ala-Phe-NH2
pyroglutamic acid-Glu-Ala-Phe-NH2 + NH3
show the reaction diagram
Gln-Glu-Asp-Leu-NH2
pyroglutamic acid-Glu-Asp-Leu-NH2 + NH3
show the reaction diagram
Gln-Glu-Tyr-Ala-NH2
pyroglutamic acid-Glu-Tyr-Ala-NH2 + NH3
show the reaction diagram
Gln-Glu-Tyr-NH2
pyroglutamic acid-Glu-Tyr-NH2 + NH3
show the reaction diagram
Gln-Glu-Tyr-Phe-NH2
pyroglutamic acid-Glu-Tyr-Phe-NH2 + NH3
show the reaction diagram
Gln-Gly
5-oxoprolyl-Gly + NH3
show the reaction diagram
Gln-Gly
Glp-Gly + NH3
show the reaction diagram
Gln-Gly
pGlu-Gly + NH3
show the reaction diagram
Gln-Gly
pyroglutamic acid-Gly + NH3
show the reaction diagram
Gln-Gly-Pro
Glp-Gly-Pro + NH3
show the reaction diagram
-
-
-
-
?
Gln-Gly-Pro
pGlu-Gly-Pro + NH3
show the reaction diagram
Gln-Gly-Pro
pyroglutamic acid-Gly-Pro + NH3
show the reaction diagram
Gln-His-Pro
pyroglutamyl-His-Pro
show the reaction diagram
-
-
-
-
?
Gln-His-Pro-NH2
L-5-oxoprolyl-His-Pro-NH2 + NH3
show the reaction diagram
-
-
-
-
?
Gln-His-Tyr-Phe-NH2
pyroglutamic acid-His-Tyr-Phe-NH2 + NH3
show the reaction diagram
Gln-Lys-Arg-Leu-NH2
pyroglutamic acid-Lys-Arg-Leu-NH2 + NH3
show the reaction diagram
Gln-NH2
Glp-amide + NH3
show the reaction diagram
Gln-Phe-Ala
pGlu-Phe-Ala + NH3
show the reaction diagram
Gln-Phe-Ala-NH2
pyroglutamic acid-Phe-Ala-NH2 + NH3
show the reaction diagram
Gln-Pro-Tyr-Phe-NH2
pyroglutamic acid-Pro-Tyr-Phe-NH2 + NH3
show the reaction diagram
Gln-Ser-Tyr-Phe-NH2
pyroglutamic acid-Ser-Tyr-Phe-NH2 + NH3
show the reaction diagram
Gln-tert-butyl ester
pyroglutamyl-tert-butyl ester + NH3
show the reaction diagram
Gln-Trp-Ala-NH2
pyroglutamic acid-Trp-Ala-NH2 + NH3
show the reaction diagram
Gln-Tyr
pyroglutamic acid-Tyr + NH3
show the reaction diagram
-
-
-
-
?
Gln-Tyr-Ala
pGlu-Tyr-Ala + NH3
show the reaction diagram
Gln-Tyr-Ala
pyroglutamic acid-Tyr-Ala + NH3
show the reaction diagram
Gln-Tyr-Ala-OH
L-5-oxoprolyl-Tyr-Ala + NH3
show the reaction diagram
-
-
-
-
?
Gln-Val
Glp-Val + NH3
show the reaction diagram
-
-
-
-
?
Gln-Val
pyroglutamic acid-Val + NH3
show the reaction diagram
-
-
-
-
?
Glu-2-naphthylamide
?
show the reaction diagram
-
-
-
-
?
glucagon(3-29)
?
show the reaction diagram
-
-
-
-
?
H-Gln-7-amido-4-methylcoumarin
5-oxoprolyl-7-amido-4-methylcoumarin + NH3
show the reaction diagram
H-Gln-7-amido-4-methylcoumarin
? + NH3
show the reaction diagram
H-Gln-Ala-OH
5-oxoprolyl-Ala-OH + NH3
show the reaction diagram
H-Gln-Asp-Glu-Leu-NH2
5-oxoprolyl-Asp-Glu-Leu-NH2 + NH3
show the reaction diagram
H-Gln-beta-naphthylamide
5-oxoprolyl-beta-naphthylamide + NH3
show the reaction diagram
H-Gln-Glu-Ala-Phe-NH2
5-oxoprolyl-Glu-Ala-Phe-NH2 + NH3
show the reaction diagram
H-Gln-Glu-OH
5-oxoprolyl-Glu-OH + NH3
show the reaction diagram
H-Gln-Glu-Tyr-Ala-NH2
5-oxoprolyl-Glu-Tyr-Ala-NH2 + NH3
show the reaction diagram
-
-
-
?
H-Gln-Glu-Tyr-Phe-NH2
5-oxoprolyl-Glu-Tyr-Phe-NH2 + NH3
show the reaction diagram
H-Gln-Gly-Pro-OH
5-oxoprolyl-Gly-Pro-OH + NH3
show the reaction diagram
H-Gln-Lys-Arg-Leu-NH2
5-oxoprolyl-Lys-Arg-Leu-NH2 + NH3
show the reaction diagram
H-Gln-NH2
? + NH3
show the reaction diagram
H-Gln-Phe-Ala-NH2
5-oxoprolyl-Phe-Ala-NH2 + NH3
show the reaction diagram
H-Gln-Phe-Ala-OH
5-oxoprolyl-Phe-Ala-OH + NH3
show the reaction diagram
H-Gln-Phe-Arg-His-NH2
5-oxoprolyl-Phe-Arg-His-NH2 + NH3
show the reaction diagram
-
-
-
-
?
H-Gln-Ser-Tyr-Phe-NH2
5-oxoprolyl-Ser-Tyr-Phe-NH2 + NH3
show the reaction diagram
-
-
-
?
H-Gln-Tyr-Ala-OH
5-oxoprolyl-Tyr-Ala-OH + NH3
show the reaction diagram
H-Gln-Val-Ala-OH
5-oxoprolyl-Val-Ala-OH + NH3
show the reaction diagram
L-Gln(3)-amyloid-beta peptide 3-42
L-pyroglutamyl(3)-amyloid-beta peptide 3-42 + NH3
show the reaction diagram
L-Gln-2-naphthylamide
5-oxoprolyl-2-naphthylamide + NH3
show the reaction diagram
L-Gln-2-naphthylamide
L-pyroglutamyl-2-naphthylamide + NH3
show the reaction diagram
L-Gln-7-amido-4-methylcoumarin
5-oxoprolyl-4-methylcoumarin-7-amide + NH3
show the reaction diagram
L-Gln-7-amido-4-methylcoumarin
5-oxoprolyl-7-amido-4-methylcoumarin + NH3
show the reaction diagram
L-Gln-7-amido-4-methylcoumarin
L-pyroglutamyl-4-methylcoumarin-7-amide + NH3
show the reaction diagram
L-Gln-7-amido-4-methylcoumarin
pyroglutamate-7-amido-4-methylcoumarin + NH3
show the reaction diagram
-
-
-
-
?
L-Gln-amide
5-oxoprolyl-amide + NH3
show the reaction diagram
L-Gln-Gly
5-oxoprolyl-Gly + NH3
show the reaction diagram
L-Gln-Gly
5-oxoprolylglycine + NH3
show the reaction diagram
L-Gln-Gly
L-pyroglutamyl-Gly + NH3
show the reaction diagram
L-Gln-Gly-L-Pro
5-oxoprolyl-Gly-L-Pro + NH3
show the reaction diagram
L-Gln-Gly-L-Pro
pyroglutamyl-Gly-L-Pro + NH3
show the reaction diagram
L-Gln-L-Ala
L-pyroglutamyl-L-Ala + NH3
show the reaction diagram
L-Gln-L-Arg-Gly-L-Ile-NH2
pyroglutamyl-L-Arg-Gly-L-Ile-NH2 + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Asn-Gly-L-Ile-NH2
L-pyroglutamyl-L-Asn-Gly-L-Ile-NH2 + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Asp-L-Glu-L-Leu-NH2
pyroglutamyl-L-Asp-L-Glu-L-Leu-NH2 + NH3
show the reaction diagram
L-Gln-L-Gln
5-oxoprolyl-L-Gln + NH3
show the reaction diagram
L-Gln-L-Gln
L-pyroglutamyl-L-Gln + NH3
show the reaction diagram
L-Gln-L-Gln-OH
5-oxoprolyl-L-Gln + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Glu
5-oxoprolyl-L-Glu + NH3
show the reaction diagram
L-Gln-L-Glu
L-pyroglutamyl-L-Glu + NH3
show the reaction diagram
L-Gln-L-Glu-L-Ala-L-Phe-NH2
pyroglutamyl-L-Glu-L-Ala-L-Phe-NH2 + NH3
show the reaction diagram
L-Gln-L-Glu-L-Asp-L-Leu-NH2
5-oxoprolyl-L-Glu-L-Asp-L-Leu-NH2 + NH3
show the reaction diagram
L-Gln-L-Glu-L-Tyr-L-Ala-NH2
pyroglutamic acid-L-Glu-L-Tyr-L-Ala-NH2 + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Glu-L-Tyr-L-Phe-NH2
pyroglutamyl-L-Glu-L-Tyr-L-Phe-NH2 + NH3
show the reaction diagram
L-Gln-L-Glu-OH
5-oxoprolyl-L-Glu + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Lys-L-Arg-L-Leu
5-oxoprolyl-L-Lys-L-Arg-L-Leu + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Lys-L-Arg-L-Leu-NH2
5-oxoprolyl-L-Lys-L-Arg-L-Leu-NH2 + NH3
show the reaction diagram
L-Gln-L-Lys-L-Arg-L-Leu-NH2
pyroglutamyl-L-Lys-L-Arg-L-Leu-NH2 + NH3
show the reaction diagram
L-Gln-L-Phe-L-Ala
5-oxoprolyl-L-Phe-L-Ala + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Phe-L-Ala-NH2
5-oxoprolyl-L-Phe-L-Ala-NH2 + NH3
show the reaction diagram
L-Gln-L-Phe-L-Ala-NH2
L-pyroglutamyl-L-Phe-L-Ala-NH2 + NH3
show the reaction diagram
L-Gln-L-Ser-L-Tyr-L-Phe-NH2
pyroglutamic acid-L-Ser-L-Tyr-L-Phe-NH2 + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Thr-Gly-L-Ile-NH2
L-pyroglutamyl-L-Thr-Gly-L-Ile-NH2 + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Trp-L-Ala-NH2
L-pyroglutamyl-L-Trp-L-Ala-NH2 + NH3
show the reaction diagram
-
-
-
?
L-Gln-L-Val-L-Ala-NH2
L-pyroglutamyl-L-Val-L-Ala-NH2 + NH3
show the reaction diagram
L-Gln-NH2
L-pyroglutamyl amide + NH3
show the reaction diagram
L-Gln-tert-butyl ester
5-oxoprolyl-tert-butyl ester
show the reaction diagram
L-Gln-tert-butyl ester
L-pyroglutamyl-tert-butyl ester + NH3
show the reaction diagram
L-Glu(3)-amyloid-beta peptide 3-42
L-pyroglutamyl(3)-amyloid-beta peptide 3-42 + H2O
show the reaction diagram
L-glutamine tert-butyl ester
L-pyroglutamate tert-butyl ester + NH3
show the reaction diagram
-
-
-
-
?
L-glutaminyl-2-naphthylamide
L-5-oxoprolyl-2-naphthylamide + NH3
show the reaction diagram
-
-
-
-
-
L-glutaminyl-4-methylcoumarinylamide
L-5-oxoprolyl-4-methylcoumarinylamide + NH3
show the reaction diagram
-
-
-
-
-
L-glutaminyl-7-amido-4-methylcoumarin
pGlu-7-amido-4-methylcoumarin + NH3
show the reaction diagram
L-glutaminyl-beta-naphthylamide
pGlu-beta-naphthylamide + NH3
show the reaction diagram
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
show the reaction diagram
MCCB protein
?
show the reaction diagram
-
-
-
?
NPLP4 protein
?
show the reaction diagram
-
-
-
?
QAAE
5-oxoprolyl-AAE + NH3
show the reaction diagram
QAAF
5-oxoprolyl-AAF + NH3
show the reaction diagram
QAAR
5-oxoprolyl-AAR + NH3
show the reaction diagram
-
-
-
?
QAEA
5-oxoprolyl-AEA + NH3
show the reaction diagram
QAFA
5-oxoprolyl-AFA + NH3
show the reaction diagram
QARA
5-oxoprolyl-ARA + NH3
show the reaction diagram
QEAA
5-oxoprolyl-EAA + NH3
show the reaction diagram
QEDL
pEEDL + NH3
show the reaction diagram
QEYF
pEEYF + NH3
show the reaction diagram
QFAA
5-oxoprolyl-FAA + NH3
show the reaction diagram
QFRH-NH2
pEFRH-NH2 + H2O
show the reaction diagram
QFRH-NH2
pEFRH-NH2 + NH3
show the reaction diagram
-
-
-
-
?
QGGG
5-oxoprolyl-GGG + NH3
show the reaction diagram
QRAA
5-oxoprolyl-RAA + NH3
show the reaction diagram
rho-7 protein
?
show the reaction diagram
-
-
-
?
[Gln1]-fertilization promoting peptide
[pyroglutamyl]-fertilization promoting peptide + NH3
show the reaction diagram
[Gln1]-gastrin
[pyroglutamyl]-gastrin + NH3
show the reaction diagram
[Gln1]-gonadotropin releasing-hormone
[pyroglutamyl]-gonadotropin releasing-hormone + NH3
show the reaction diagram
[Gln1]-neurotensin
[pyroglutamyl]-neurotensin + NH3
show the reaction diagram
[Gln1]-thyrotropin releasing-hormone
[pyroglutamyl]-thyrotropin releasing-hormone + NH3
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
39SrpL21 protein
?
show the reaction diagram
Q86PD7, Q9VRQ9
-
-
-
?
Acp33A protein
?
show the reaction diagram
Q86PD7, Q9VRQ9
-
-
-
?
ALDH2 protein
?
show the reaction diagram
Q86PD7, Q9VRQ9
-
-
-
?
DIM-10 protein
?
show the reaction diagram
Q86PD7, Q9VRQ9
-
-
-
?
L-glutaminyl-peptide
5-oxoprolyl-peptide + NH3
show the reaction diagram
MCCB protein
?
show the reaction diagram
Q86PD7, Q9VRQ9
-
-
-
?
NPLP4 protein
?
show the reaction diagram
Q86PD7, Q9VRQ9
-
-
-
?
rho-7 protein
?
show the reaction diagram
Q86PD7, Q9VRQ9
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
contains a calcium ion
Co2+
-
enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be restored partially by Co2+ or Mn2+
Mn2+
-
enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be restored partially by Co2+ or Mn2+
Zn
equimolar protein-bound zinc
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3,4-dichlorophenyl)-2-cyano-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)guanidine
-
-
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)guanidine
-
-
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(3,4-dimethoxyphenyl)guanidine
-
-
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(4-(trifluoromethyl)phenyl)guanidine
-
-
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(4-isopropylphenyl)guanidine
-
-
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(4-methoxyphenyl)guanidine
-
-
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-(cyclopropylmethyl)guanidine
-
-
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-methylguanidine
-
-
(3-(1H-imidazol-1-yl)propyl)-2-cyano-3-phenylguanidine
-
-
(3-(1H-imidazol-1-yl)propyl)-3-(4-bromophenyl)-2-cyanoguanidine
-
-
(3-(4-methyl-1H-imidazol-1-yl)propyl)-2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)guanidine
-
-
(3-(5-methyl-1H-imidazol-1-yl)propyl)-2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)guanidine
-
-
1,10-phenanthroline
1,4-bis-(imidazol-1-yl)methyl-2,5-dimethylbenzene
-
-
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
-
1-(2,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
-
1-(2-oxo-2-phenylethyl)-imidazole
-
-
1-(3,4-dimethoxybenzyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
-
1-(3,4-dimethoxyphenyl)-3-(2-[1-(1H-imidazol-1-yl)cyclopropyl]ethyl)thiourea
-
-
1-(3,4-dimethoxyphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)propyl)thiourea
-
-
1-(3,4-dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)thiourea
-
-
1-(3,4-dimethoxyphenyl)-3-[(3R)-3-(1H-imidazol-1-yl)butyl]thiourea
-
-
1-(3,4-dimethoxyphenyl)-3-[(3S)-3-(1H-imidazol-1-yl)butyl]thiourea
-
-
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]urea
-
-
1-(3,4-dimethoxyphenyl)-3-[4-(1H-imidazol-1-yl)butyl]thiourea
-
-
1-(3,4-dimethoxyphenyl)-N-(3-(4-methyl-1H-imidazol-1-yl)propyl)cyclopropanecarbothioamide
-
-
1-(3,4-dimethoxyphenyl)-N-(3-(5-methyl-1H-imidazol-1-yl)propyl)cyclopropanecarbothioamide
-
-
1-(3,5-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
-
1-(3-aminopropyl)-imidazole
-
-
1-(4-acetylphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
-
1-(4-ethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
-
1-(4-ethylphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
-
1-(6-phenoxyhexyl)-1H-imidazole
-
-
1-Benzylimidazole
1-methyl-4-(beta-aminoethyl)-imidazole
-
-
1-methyl-5-(beta-aminoethyl)-imidazole
-
-
1-Methylimidazole
1-vinylimidazole
-
-
1-[3-(1H-imidazol-1-yl)propyl]-3-(1-naphthyl)thiourea
-
-
1-[3-(1H-imidazol-1-yl)propyl]-3-(3,4,5-trimethoxyphenyl)thiourea
-
-
1-[3-(1H-imidazol-1-yl)propyl]-3-(3-methoxyphenyl)thiourea
-
-
1-[3-(1H-imidazol-1-yl)propyl]-3-(4-methoxyphenyl)thiourea
-
-
1-[3-(1H-imidazol-1-yl)propyl]-3-(4-methylphenyl)thiourea
-
-
1-[3-(1H-imidazol-1-yl)propyl]-3-[4-(methylthio)phenyl]thiourea
-
-
1-[4-(benzyloxy)phenyl]-3-[3-(1H-imidazol-1-yl)propyl]thiourea
-
-
2,3-dihydro-3-(3-(4-methyl-1H-imidazol-1-yl)propyl)-2-thioxoquinazolin-4(1H)-one
-
-
2,3-dihydro-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)-2-thioxoquinazolin-4(1H)-one
-
-
2,3-dihydro-6-methyl-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one
-
-
2,6-dipicolinic acid
time-dependent inactivation
2-aminobenzimidazole
-
-
2-cyano(3,4,5-trimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)guanidine
-
-
2-cyano(3-(5-methyl-1H-imidazol-1-yl)propyl)-3-(3,4-dimethylphenyl)guanidine
-
-
2-cyano-1-[3-(5-methyl-1H-imidazol-1-yl)propyl]-4-phenylbenzene-1-guanidine
-
-
2-ethyl-4-methyl-imidazole
-
-
2-mercaptoethanol
-
2-methyl-benzylimidazole
-
-
3,5-diamino-1,2-S4-triazole
-
0.14 mM, 10% inhibition
3-(3-(1H-imidazol-1-yl)propyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
-
-
3-(3-(1H-imidazol-1-yl)propyl)-2,3-dihydro-7-methyl-2-thioxothieno[3,2-d]pyrimidin-4(1H)-one
-
-
3-Amino-1,2,4-triazole
-
0.14 mM, 15% inhibition
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxo-1,2,3,5,6,7-hexahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one
-
-
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxo-2,3,5,6,7,8,9,10-octahydrocycloocta[4,5]thieno[2,3-d]pyrimidin-4(1H)-one
-
-
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxo-2,3,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-one
-
-
3-[3-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one
-
-
3-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,5,6,7,8,9,10-octahydrocycloocta[4,5]-thieno[2,3-d]pyrimidin-4(1H)-one
-
-
3-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-one
-
-
4-(2-imidazol-1-yl-ethoxy)-benzoic acid
-
-
4-imidazole-carboxaldehyde
-
-
4-methylimidazole
-
4-phenyl-1,2,4-triazoleine-3,5-dione
-
0.14 mM, 22% inhibition
5-(methylthio)-1-H-tetrazole
-
0.14 mM, 11% inhibition
5-amino-3H-imidazole-4-carboxylic acid amide
-
-
5-hydroxymethyl-4-methyl-imidazole
-
-
6-benzyl-2,3-dihydro-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one
-
-
6-methylpterin
-
-
8-hydroxyquinoline
time-dependent inactivation
ascorbate
-
-
benzimidazole
benzylimidazole
cacodylate
;
Citric acid
inactivation at pH 5.5, Zn2+ protects
CuCl2
-
0.1 mM
cysteamine
diethyl dicarbonate
-
rapid inactivation by modification of three essential His residues, at neutral pH, partial reactivation with hydroxylamine
dipicolinic acid
-
inactivated enzyme can be fully restored by addition of Zn2+ in the presence of equimolar concentrations of EDTA, little reactivation by Co2+ and Mn2+
EDTA
-
-
EFRH-NH2
EFRHHDSGYE-NH2
ethanolamine
-
ethyl-1H-tetrazole-4-acetate
-
0.14 mM, 9% inhibition
ethylamine
-
ethylenediamine
-
ethylmercaptane
-
FADH2
-
2 mM
Gln-tert-butyl ester
H-Gln-7-amido-4-methylcoumarin
H-Gln-beta-naphthylamide
H-His-Trp-OH
-
-
imidazol-4-carbonic acid methylester
-
-
imidazole
L-Gln-2-naphthylamide
substrate inhibition
L-glutamine-4-nitroanilide
substrate inhibition; substrate inhibition, isoDromeQC
L-glutaminyl-7-amido-4-methylcoumarin
-
substrate inhibition
L-glutaminyl-beta-naphthylamide
L-histamine
-
-
L-histidinamide
-
-
L-histidine
-
-
L-Histidinol
-
-
methylimidazole
N,N-dimethylcysteamine
-
-
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-2,3-dihydrobenzo[b][1,4]-dioxin-6-amine
-
-
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-3,4-dimethoxy-benzenamine
-
-
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-(trifluoromethyl)-benzenamine
-
-
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-chlorobenzenamine
-
-
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-methoxybenzenamine
-
-
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)benzenamine
-
-
N-(1-(3-(1H-imidazol-1-yl)propylamino)-2-nitrovinyl)naphthalen-1-amine
-
-
N-(1-(3-(4-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-2,3-dihydrobenzo[b][1,4]-dioxin-6-amine
-
-
N-(1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-2,3-dihydrobenzo[b][1,4]-dioxin-6-amine
-
-
N-(1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-(trifluoromethyl)benzenamine
-
-
N-(1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-chloro-benzenamine
-
-
N-(1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)cyclohexanamine
-
-
N-(1-(3-(5-methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)naphthalen-1-amine
-
-
N-(3-(1H-imidazol-1-yl)propyl)-N-cyclohexyl-2-nitroethene-1,1-diamine
-
-
N-(3-(1H-imidazol-1-yl)propyl)-N-methyl-2-nitroethene-1,1-diamine
-
-
N-(4-chlorophenyl)-N'-[2-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one
-
-
N-(trimethylsilyl)-imidazole
-
-
N-Acetylimidazole
-
-
N-benzoylimidazole
-
-
N-diethylcysteamine
N-dimethylcysteamine
N-methylimidazole
-
-
N-omega-acetylhistamine
N-[3-(1H-imidazol-1-yl)propyl]-5-methoxy-1,3-benzothiazol-2-amine
-
-
N-[3-(1H-imidazol-1-yl)propyl]-6-methoxy-1,3-benzothiazol-2-amine
-
-
NEM
-
-
NH4Cl
-
1.0 M
NiCl2
-
0.1 mM
nitron
-
0.14 mM, 39% inhibition
Nomega-acetylhistamine
oxalic acid diimidazolidide
-
-
P150/03
; isoDromeQC
-
PBD150
ZnCl2
-
0.1 mM
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
-
stimulates
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6
EFRH-NH2
-
at pH 6.5, 10times higher compared to KM-value of Gln substrate
4.6
EFRHHDSGYE-NH2
-
-
16
Gln
-
-
0.042
Gln 7-amido-4-methylcoumarin
-
pH 8.0, 30C
0.087 - 0.155
Gln(3)-amyloid-beta peptide 3-11 amide
0.162
Gln(3)-amyloid-beta peptide 3-21 amide
-
pH 6.0, 30C, 1% DMSO
-
0.089
Gln(3)-amyloid-beta peptide 3-40 amide
-
pH 6.0, 30C, 1% DMSO
-
0.058 - 1.1
Gln-2-naphthylamide
0.054
Gln-7-amido-4-methylcoumarin
-
pH 8.0, 30C
0.143 - 1.3
Gln-Ala
0.065 - 0.197
Gln-Ala-Ala-Ala-Ala-NH2
0.087 - 0.164
Gln-Ala-Ala-NH2
0.079 - 0.216
Gln-Ala-Ala-Ser-Ala-Ala-NH2
0.065 - 0.143
Gln-Arg-Gly-Ile-NH2
0.055 - 0.124
Gln-Arg-Tyr-Phe-NH2
0.153 - 0.172
Gln-Asn-Gly-Ile-NH2
0.07
Gln-beta-naphthylamide
-
pH 8.0, 30C
0.038
Gln-beta-naphthylamine
-
pH 8.0, 30C
0.044 - 29.53
Gln-Gln
0.31 - 0.53
Gln-Gln-Gln
0.148
Gln-Gln-OH
-
30C, recombinant enzyme, expressed in Pichia pastoris
0.041 - 0.045
Gln-Gln-Tyr-Phe-NH2
0.094 - 0.61
Gln-Glu
0.077 - 0.102
Gln-Glu-Ala-Ala-NH2
0.039 - 0.081
Gln-Glu-Ala-Phe-NH2
0.055 - 0.107
Gln-Glu-Asp-Leu-NH2
0.069 - 0.113
Gln-Glu-Tyr-Ala-NH2
0.079 - 0.103
Gln-Glu-Tyr-NH2
0.047 - 0.1
Gln-Glu-Tyr-Phe-NH2
0.16 - 1.88
Gln-Gly
0.102 - 0.333
Gln-Gly-Pro
0.09
Gln-His-Pro-NH2
-
30C, recombinant enzyme, expressed in Pichia pastoris
0.068 - 0.092
Gln-His-Tyr-Phe-NH2
0.034 - 0.118
Gln-Lys-Arg-Leu-NH2
0.401 - 7.15
Gln-NH2
0.06 - 0.1
Gln-Phe-Ala
0.069 - 0.111
Gln-Phe-Ala-NH2
0.149 - 18.89
Gln-Pro-Tyr-Phe-NH2
0.055 - 0.135
Gln-Ser-Tyr-Phe-NH2
0.223 - 6.7
Gln-tert-butyl ester
0.132
Gln-Thr-Ala
-
-
0.05 - 0.078
Gln-Trp-Ala-NH2
0.211
Gln-Tyr
-
pH 8.0, 30C
0.058 - 0.101
Gln-Tyr-Ala
0.101 - 0.153
Gln-Tyr-Ala-OH
0.12 - 0.196
Gln-Val
0.019
glucagon(3-29)
-
pH 6.0, 30C, 1% DMSO
-
0.32
glutamine tert-butyl ester
-
-
0.063
gonadotropin releasing hormone
-
-
-
0.017 - 0.105
H-Gln-7-amido-4-methylcoumarin
0.294 - 5
H-Gln-Ala-OH
0.487 - 2.3
H-Gln-Asp-Glu-Leu-NH2
0.028 - 0.17
H-Gln-beta-naphthylamide
0.053 - 1.5
H-Gln-Gln-OH
0.08 - 0.742
H-Gln-Glu-Ala-Phe-NH2
0.265 - 29.5
H-Gln-Glu-OH
0.33
H-Gln-Glu-Tyr-Ala-NH2
pH 8.0, 30C
0.065 - 0.41
H-Gln-Glu-Tyr-Phe-NH2
0.424 - 7.1
H-Gln-Gly-OH
0.214 - 4.1
H-Gln-Gly-Pro-OH
0.06 - 0.448
H-Gln-Lys-Arg-Leu-NH2
0.48 - 2.048
H-Gln-NH2
0.106 - 0.44
H-Gln-Phe-Ala-NH2
0.128 - 0.35
H-Gln-Phe-Ala-OH
0.247
H-Gln-Ser-Tyr-Phe-NH2
pH 8.0, 30C
0.72
H-Gln-Tyr-Ala-OH
30C, isoDromeQC
0.014 - 0.282
H-Gln-Val-Ala-OH
0.028 - 0.5
L-Gln-2-naphthylamide
0.048 - 0.3
L-Gln-7-amido-4-methylcoumarin
2.7 - 2.9
L-Gln-amide
0.41 - 3.8
L-Gln-Gly
0.17 - 1.791
L-Gln-Gly-L-Pro
0.294 - 1.838
L-Gln-L-Ala
0.32
L-Gln-L-Arg-Gly-L-Ile-NH2
pH 8.0, 30C
0.36
L-Gln-L-Asn-Gly-L-Ile-NH2
pH 8.0, 30C
0.487 - 1.74
L-Gln-L-Asp-L-Glu-L-Leu-NH2
0.053 - 20.4
L-Gln-L-Gln
0.265 - 4.2
L-Gln-L-Glu
0.08 - 0.742
L-Gln-L-Glu-L-Ala-L-Phe-NH2
0.33
L-Gln-L-Glu-L-Tyr-L-Ala-NH2
pH 8.0, 30C
0.086 - 0.41
L-Gln-L-Glu-L-Tyr-L-Phe-NH2
0.06 - 0.448
L-Gln-L-Lys-L-Arg-L-Leu-NH2
0.106 - 0.44
L-Gln-L-Phe-L-Ala-NH2
0.247
L-Gln-L-Ser-L-Tyr-L-Phe-NH2
pH 8.0, 30C
0.16
L-Gln-L-Thr-Gly-L-Ile-NH2
pH 8.0, 30C
0.072
L-Gln-L-Trp-L-Ala-NH2
pH 8.0, 30C
0.014 - 0.272
L-Gln-L-Val-L-Ala-NH2
0.48 - 2.048
L-Gln-NH2
0.151 - 8.2
L-Gln-tert-butyl ester
0.379 - 1.3
L-glutamine tert-butyl ester
0.205 - 0.31
L-glutaminyl 4-methylcoumarin-7-amide
0.06
L-glutaminyl-2-naphthylamide
-
30C, recombinant enzyme, expressed in Pichia pastoris
0.051
L-glutaminyl-4-methylcoumarinylamide
-
30C, recombinant enzyme, expressed in Pichia pastoris
0.03
L-glutaminyl-7-amido-4-methylcoumarin
0.032 - 0.035
L-glutaminyl-beta-naphthylamide
0.063
N1-naphthalen-2-yl-L-glutamamide
-
pH 8.0, 30C, 0.5 M KCl
1.1 - 1.6
QAAE
0.1 - 0.8
QAAF
0.4
QAAR
in 0.1 M MES, pH 7.5, temperature not specified in the publication
0.2 - 0.7
QAEA
2.1 - 2.5
QAFA
0.1 - 24.4
QARA
1 - 1.1
QEAA
0.16
QEDL
0.029 - 0.04
QEYF
1.9 - 3.5
QFAA
0.1 - 5.6
QGGG
0.9 - 2.9
QRAA
0.088
[Gln1,Gly4]-thyrotropin releasing hormone
-
-
-
0.087 - 0.151
[Gln1]-fertilization promoting peptide
0.031 - 0.033
[Gln1]-gastrin
0.053 - 0.054
[Gln1]-gonadotropin releasing-hormone
0.023 - 0.037
[Gln1]-neurotensin
0.09
[Gln1]-thyrotropin releasing-hormone
-
pH 8.0, 30C
-
additional information
additional information
-
-
-