Information on EC 2.3.2.14 - D-alanine gamma-glutamyltransferase

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The expected taxonomic range for this enzyme is: Pisum sativum

EC NUMBER
COMMENTARY
2.3.2.14
-
RECOMMENDED NAME
GeneOntology No.
D-alanine gamma-glutamyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
L-glutamine + D-alanine = NH3 + gamma-L-glutamyl-D-alanine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
aminoacyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-glutamine:D-alanine gamma-glutamyltransferase
D-Phenylalanine and D-2-aminobutyrate can also act as acceptors, but more slowly. The enzyme also catalyses some of the reactions of EC 2.3.2.2 (gamma-glutamyltransferase).
CAS REGISTRY NUMBER
COMMENTARY
9046-27-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
cv. Alaska
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
gamma-L-glutamylethylester + D-alanine
?
show the reaction diagram
-
equally effective as L-glutamine
-
-
?
L-glutamine + D-2-amino-n-butanoic acid
?
show the reaction diagram
-
-
-
-
?
L-glutamine + D-alanine
NH3 + gamma-L-glutamyl-D-alanine
show the reaction diagram
-
best substrate
-
?
reduced glutathione + D-alanine
?
show the reaction diagram
-
50% as effective as L-glutamine
-
-
?
L-glutamine + D-phenylalanine
NH3 + gamma-L-glutamyl-L-phenylalanine
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
no substrates are D-valine, D-leucine, D-aspartic acid, D-glutamic acid, D-serine, D-proline
-
-
-
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
6-diazo-5-oxo-L-norleucine
-
-
citrate
-
to some extent
L-Serine borate
-
-
additional information
-
no inhibition by Ca2+, Mg2+, NH4+, and maleate
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2.9
-
D-alanine
-
-
2
-
L-glutamine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.245
-
-
-
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
9.5
-
-
-
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
37
-
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
-
decotyledonized
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
partial
-