Information on EC 2.3.1.96 - glycoprotein N-palmitoyltransferase

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The enzyme appears in viruses and cellular organisms

top print hide
EC NUMBER
COMMENTARY hide
2.3.1.96
-
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RECOMMENDED NAME
GeneOntology No.
glycoprotein N-palmitoyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
palmitoyl-CoA:glycoprotein N-palmitoyltransferase
Acts on mucins. Activated by 1,4-dithiothreitol.
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CAS REGISTRY NUMBER
COMMENTARY hide
97162-74-8
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
palmitoyl-CoA + glycoprotein
CoA + N-palmitoylglycoprotein
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
palmitoyl-CoA + glycoprotein
CoA + N-palmitoylglycoprotein
show the reaction diagram
top print hide
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NaF
-
required for activity, 25 mM, inhibition at higher concentration
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
-
inhibits at 10 mM
MgCl2
Sucralfate
-
antiulcer drug, 40% increase
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,4-dithiothreitol
Sofalcone
-
antiulcer drug, enhances acylation
Triton X-100
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00059
glycoprotein
-
mucus glycoprotein, submandibular enzyme
0.00056
mucin
-
gastric mucin
-
0.033
palmitoyl-CoA
-
submandibular enzyme
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00091
Sucralfate
-
competitive inhibition
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8 - 8
-
pH 6.8: 40-50% of activity maximum, pH 8.0: about 50% of activity maximum, fundic and antral mucosa enzyme
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
-
Golgi-rich membrane fraction
-
Manually annotated by BRENDA team
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20�C, solubilized enzyme
-
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LINKS TO OTHER DATABASES (specific for EC-Number 2.3.1.96)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)