Reference on EC 2.3.1.86 - fatty-acyl-CoA synthase system
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Vagelos, R.P.
Acyl group transfer (acyl carrier protein)
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
8
155-199
1973
Saccharomyces cerevisiae, Escherichia coli, Euglena gracilis, Mycolicibacterium phlei
-
Worsham, L.M.S.; Williams, S.G.; Ernst-Fonberg, M.L.
Early catalytic steps of Euglena gracilis chloroplast type II fatty acid synthase
Biochim. Biophys. Acta
1170
62-71
1993
Euglena gracilis
Wakil, S.J.; Stoops, J.K.; Joshi, V.C.
Fatty acid synthesis and its regulation
Annu. Rev. Biochem.
52
537-579
1983
Saccharomyces cerevisiae, Mycolicibacterium smegmatis
Stuible, H.P.; Meurer, G.; Schweizer, E.
Heterologous expression and biochemical characterization of two functionally different type I fatty acid synthases from Brevibacterium ammoniagenes
Eur. J. Biochem.
247
268-273
1997
Corynebacterium ammoniagenes
Stuible, H.P.; Wagner, C.; Andreou, J.; Guter, G.; Haselmann, J.; Schweizer, E.
Identification and functional differentiation of two type I fatty acid synthases in Brevibacterium ammoniagenes
J. Bacteriol.
178
4787-4793
1996
Corynebacterium ammoniagenes
Schweizer, E.; Kniep, B.; Castorph, H.; Holzner, U.
Pantetheine-free mutants of the yeast fatty-acid-synthetase complex
Eur. J. Biochem.
39
353-362
1973
Saccharomyces cerevisiae, Saccharomyces cerevisiae X-2180-A
Ziegenhorn, J.; Niedermeier, R.; Nussler, C.; Lynen, F.
Study of the acetyltransferase component of fatty acid synthetase of yeast
Eur. J. Biochem.
30
285-300
1972
Saccharomyces cerevisiae
Wieland, F.; Renner, L.; Verfurth, C.; Lynen, F.
Studies on the multi-enzyme complex of yeast fatty-acid synthetase. Reversible dissociation and isolation of two polypeptide chains
Eur. J. Biochem.
94
189-197
1979
Saccharomyces cerevisiae
Stoops, J.K.; Wakil, S.J.
The isolation of the two subunits of yeast fatty acid synthetase
Biochem. Biophys. Res. Commun.
84
225-231
1978
Saccharomyces cerevisiae
Yein, F.; Brown, O.R.
Comparative inactivation of yeast fatty acid synthetase component enzymes by 100 atmospheres of oxygen
Biochim. Biophys. Acta
486
421-428
1977
Saccharomyces cerevisiae
Lynen, F.
Yeast fatty acid synthase
Methods Enzymol.
14
17-33
1969
Saccharomyces cerevisiae
-
Stoops, J.K.; Wakil, S.J.
Studies on the yeast fatty acid synthetase. Subunit composition and structural organization of a large multifunctional enzyme complex
J. Biol. Chem.
253
4464-4475
1978
Saccharomyces cerevisiae, Saccharomyces cerevisiae Fleishmann
Stoops, J.K.; Wakil, S.J.
Yeast fatty acid synthetase: structure-function relationship and nature of the beta-ketoacyl synthetase site
Proc. Natl. Acad. Sci. USA
77
4544-4548
1980
Saccharomyces cerevisiae
Engeser, H.; Hubner, K.; Straub, J.; Lynen, F.
Identity of malonyl and palmitoyl transferase of fatty acid synthetase from yeast. Functional interrelationships between the acyl transferases
Eur. J. Biochem.
101
407-412
1979
Saccharomyces cerevisiae
Engeser, H.; Hubner, K.; Straub, J.; Lynen, F.
Identity of malonyl and palmitoyl transferase of fatty acid synthetase from yeast. 2. A comparison of active-site peptides
Eur. J. Biochem.
101
413-422
1979
Saccharomyces cerevisiae
Vance, D.E.; Mitsuhashi, O.; Bloch, K.
Purification and properties of the fatty acid synthetase from Mycobacterium phlei
J. Biol. Chem.
248
2303-2309
1973
Mycolicibacterium phlei
Allen, E.E.; Bartlett, D.H.
Structure and regulation of the omega-3 polyunsaturated fatty acid synthase genes from the deep-sea bacterium Photobacterium profundum strain SS9
Microbiology
148
1903-1913
2002
Photobacterium profundum, Photobacterium profundum SS9
Dittrich, F.; Zajonc, D.; Huhne, K.; Hoja, U.; Ekici, A.; Greiner, E.; Klein, H.; Hofmann, J.; Bessoule, J.J.; Sperling, P.; Schweizer, E.
Fatty acid elongation in yeast. Biochemical characteristics of the enzyme system and isolation of elongation-defective mutants
Eur. J. Biochem.
252
477-485
1998
Saccharomyces cerevisiae
Jones, L.A.; Herbert, D.; Rutter, A.J.; Dancer, J.E.; Harwood, J.L.
Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (pisum sativum)
Biochem. J.
347
205-209
2000
Pisum sativum
-
Roughan, P.G.
Stromal concentrations of coenzyme A and its esters are insufficient to account for rates of chloroplast fatty acid synthesis: evidence for substrate channeling within the chloroplast fatty acid synthase
Biochem. J.
327
267-273
1997
Pisum sativum, Spinacia oleracea
-
Schuster, H.; Rautenstrauss, B.; Mittag, M.; Stratmann, D.; Schweizer, E.
Substrate and product binding sites of yeast fatty acid synthase. Stoichiometry and binding kinetics of wild-type and in vitro mutated enzymes
Eur. J. Biochem.
228
417-424
1995
Saccharomyces cerevisiae
Gong, H.; Byers, D.M.
Glutamate-41 of Vibrio harveyi acyl carrier protein is essential for fatty acid synthase but not acyl-ACP synthetase activity
Biochem. Biophys. Res. Commun.
302
35-40
2003
Vibrio harveyi
Zhang, L.; Joshi, A.K.; Smith, S.
Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein
J. Biol. Chem.
278
40067-40074
2003
Homo sapiens
Oura, T.; Kajiwara, S.
Cloning and functional characterization of a fatty acid synthase component FAS2 gene from Saccharomyces kluyveri
Curr. Genet.
49
393-402
2006
Lachancea kluyveri (Q765N2)
Jenni, S.; Leibundgut, M.; Maier, T.; Ban, N.
Architecture of a fungal fatty acid synthase at 5 A resolution
Science
311
1263-1267
2006
Thermomyces lanuginosus
Jenni, S.; Leibundgut, M.; Boehringer, D.; Frick, C.; Mikolasek, B.; Ban, N.
Structure of fungal fatty acid synthase and implications for iterative substrate shuttling
Science
316
254-261
2007
Thermomyces lanuginosus
Leibundgut, M.; Jenni, S.; Frick, C.; Ban, N.
Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase
Science
316
288-290
2007
Saccharomyces cerevisiae
Lomakin, I.B.; Xiong, Y.; Steitz, T.A.
The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together
Cell
129
319-332
2007
Saccharomyces cerevisiae
Nguyen, L.N.; Trofa, D.; Nosanchuk, J.D.
Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection
PLoS ONE
4
e8421
2009
Candida parapsilosis
Wallace, J.; Bowlin, N.O.; Mills, D.M.; Saenkham, P.; Kwasny, S.M.; Opperman, T.J.; Williams, J.D.; Rock, C.O.; Bowlin, T.L.; Moir, D.T.
Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay
Antimicrob. Agents Chemother.
59
5775-5787
2015
Pseudomonas aeruginosa
Van Dolah, F.; Zippay, M.; Pezzolesi, L.; Rein, K.; Johnson, J.; Morey, J.; Wang, Z.; Pistocchi, R.
Subcellular localization of dinoflagellate polyketide synthases and fatty acid synthase activity
J. Phycol.
49
1118-1127
2013
Karenia brevis, Karenia brevis Gerd Hansen
Runguphan, W.; Keasling, J.
Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived biofuels and chemicals
Metab. Eng.
21
103-113
2014
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Henritzi, S.; Fischer, M.; Grininger, M.; Oreb, M.; Boles, E.
An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae
Biotechnol. Biofuels
11
150
2018
Saccharomyces cerevisiae
Singh, K.; Graf, B.; Linden, A.; Sautner, V.; Urlaub, H.; Tittmann, K.; Stark, H.; Chari, A.
Discovery of a regulatory subunit of the yeast fatty acid synthase
Cell
180
1130-1143
2020
Saccharomyces cerevisiae (P07149 and P19097 and Q12513), Saccharomyces cerevisiae ATCC 204508 (P07149 and P19097 and Q12513)
Wernig, F.; Boles, E.; Oreb, M.
De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae
Metab. Eng. Commun.
10
e00111
2020
Saccharomyces cerevisiae
Gajewski, J.; Buelens, F.; Serdjukow, S.; Janssen, M.; Cortina, N.; Grubmueller, H.; Grininger, M.
Engineering fatty acid synthases for directed polyketide production
Nat. Chem. Biol.
13
363-365
2017
Corynebacterium ammoniagenes
Gajewski, J.; Pavlovic, R.; Fischer, M.; Boles, E.; Grininger, M.
Engineering fungal de novo fatty acid synthesis for short chain fatty acid production
Nat. Commun.
8
14650
2017
Saccharomyces cerevisiae (P07149 and P19097)
Fischer, M.; Joppe, M.; Mulinacci, B.; Vollrath, R.; Konstantinidis, K.; Koetter, P.; Ciccarelli, L.; Vonck, J.; Oesterhelt, D.; Grininger, M.
Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS)
Sci. Rep.
10
895
2020
Saccharomyces cerevisiae (P07149 and P19097), Saccharomyces cerevisiae ATCC 204508 (P07149 and P19097)
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